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Aspergillus Galactomannan for Diagnosing Invasive Aspergillosis miceli

Marisa H Miceli, Carol A Kauffman
No abstract text is available yet for this article.
September 26, 2017: JAMA: the Journal of the American Medical Association
Marisa H Miceli, Johan Maertens
An established diagnosis of invasive aspergillus is seldom achieved premortem. Conventional laboratory diagnostic methods such as culture and microscopy, although very useful when positive, are insensitive and time-consuming, resulting in late diagnosis and treatment and contributing to high mortality rates. As a result, routine antifungal prophylaxis and early empirical treatment have been recommended. The use of sensitive and rapid non-culture-based diagnostic assays for the detection of Aspergillus antigens (using commercially available tests to detect galactomannan and 1, 3 β-D-glucan) or detection of genomic DNA sequences may allow a shift in emphasis from empirical to preemptive therapy, especially when substantiated by suggestive radiological findings...
October 2015: Seminars in Respiratory and Critical Care Medicine
Valério R Aquino, Luciano Z Goldani, Alesssandro C Pasqualotto
The diagnosis of invasive fungal infections (IFI) remains a challenge, particularly for diseases caused by filamentous fungi such as Aspergillus species. Unfortunately, many patients affected by these conditions are not identified before autopsy. Therefore, there is a need for new diagnostic methods for IFI. Galactomannan is a soluble antigen released during hyphal growth in tissues. A commercially available sandwich ELISA assay that detects galactomannan has been used in Europe for many years and is now approved for use in the USA...
April 2007: Mycopathologia
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