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Anupama Ranganathan, Shirley J Gee, Bruce D Hammock
Triclosan-O-glucuronide (TCSG) is one of the primary urinary metabolites of the antibacterial compound triclosan or TCS that is found in many personal care products and consumer goods. We have developed a competitive, indirect heterologous ELISA for the detection of the target TCSG in urine. Such an ELISA for TCSG could be developed as a useful tool to measure this important biomarker of human exposure to TCS. Immunogens were prepared by conjugating TCSG to thyroglobulin, via heterobifunctional cross-linkers AEDP or 3-[(2-aminoethyl)dithio] propionic acid•hydrochloride and TFCS or N-[ε-trifluoroacetylcaproyloxy]succinimide ester...
September 2015: Analytical and Bioanalytical Chemistry
Li Yu, Lin Cai, Hao Hu, Yi Zhang
Epirubicin (EPI) is a broad spectrum antineoplastic drug, commonly used as a chemotherapy method to treat osteosarcoma. However, its application has been limited by many side-effects. Therefore, targeted drug delivery to bone has been the aim of current anti-bone-tumor drug studies. Due to the exceptional affinity of Bisphosphonates (BP) to bone, 1-amino-ethylene-1, 1-dephosphate acid (AEDP) was chosen as the bone targeting moiety for water-soluble macromolecular drug delivery systems of oxidized-dextran (OXD) to transport EPI to bone in this article...
May 2014: Journal of Drug Targeting
Motolani Sakeye, Jan-Henrik Smått
Amino-modified metal oxide materials are essential in a wide range of applications, including chromatography, ion adsorption, and as biomaterials. The aim of this study is to compare different functionalization techniques on a selection of metal oxides (SiO(2), TiO(2), ZrO(2), and SnO(2)) in order to determine which combination has the optimal properties for a certain application. We have used the nanocasting approach to synthesize micrometer-sized TiO(2), ZrO(2), and SnO(2) particles, which have similar morphologies and porosities as the starting mesoporous SiO(2) microparticles (Lichroprep Si 60)...
December 11, 2012: Langmuir: the ACS Journal of Surfaces and Colloids
Kari Gleiser, Julian D Ford, Diana Fosha
In this paper, the authors compare and contrast two psychotherapy paradigms for the treatment of complex posttraumatic stress disorder (PTSD): a behavioral therapy (prolonged exposure; PE) and an experiential therapy (Accelerated Experiential Dynamic Psychotherapy; AEDP). PE has received strong research support as an effective treatment for PTSD. The scientific evidence for experiential therapy is sparser, but also positive. In addition, clinical and research evidence suggest that (a) experiential processes are inherently embedded in PE, and may influence PE outcomes; and that (b) AEDP addresses several clinical and relational factors that are negative prognostic factors for PE (e...
September 2008: Psychotherapy
Julie Shi, Russell N Johnson, Joan G Schellinger, Peter M Carlson, Suzie H Pun
Biodegradability can be incorporated into cationic polymers via use of disulfide linkages that are degraded in the reducing environment of the cell cytosol. In this work, N-(2-hydroxypropyl)methacrylamide (HPMA) and methacrylamido-functionalized oligo-l-lysine peptide monomers with either a non-reducible 6-aminohexanoic acid (AHX) linker or a reducible 3-[(2-aminoethyl)dithiol] propionic acid (AEDP) linker were copolymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Both of the copolymers and a 1:1 (w/w) mixture of copolymers with reducible and non-reducible peptides were complexed with DNA to form polyplexes...
May 1, 2012: International Journal of Pharmaceutics
Diana Fosha
Three investigative realms with widely divergent methodologies arrive at uncannily similar conclusions about the vital role of positive affective phenomena in optimal adaptation, resilience, affect regulation, cardiac health, and subjective well-being: research on resilience and human flourishing; Indo-Tibetan practices and the emergent yogic sciences; and the practice of AEDP (Accelerated Experiential Dynamic Psychotherapy), a healing-oriented, transformation-based model of psychotherapy. AEDP has explored the vital role of positive emotions in the process of change in general, and, more specifically, in therapeutic work with painful and overwhelming emotional experience, and has identified and descried a phenomenology of positive affective experiences, including the healing affects, and core state, which signal the operation of healing transformational processes...
August 2009: Annals of the New York Academy of Sciences
Craig J Richmond, Alexis D C Parenty, Yu-Fei Song, Graeme Cooke, Leroy Cronin
A switchable organic system involving four distinct states that can be interconverted by use of both pH and redox chemistry as control parameters has been developed. The key molecules involved in this system are the phenanthridine-based heterocycles 1-isobutyl-1,2,3,12b-tetrahydroimidazo[1,2-f]phenanthridine (TIP) and 5-[2-(isobutylamino)ethyl]phenanthridinium (AEP). These two states are interchangeable via pH control, and in addition they can also be further manipulated by oxidation or reduction to convert them to their "pH-inert" forms: 1-isobutyl-2,3-dihydro-1H-imidazo[1,2-f]phenanthridinium (DIP) and 5-[2-(isobutylamino)ethyl]-5,6-dihydrophenanthridine (AEDP), respectively...
October 1, 2008: Journal of the American Chemical Society
Jerry Lamagna, Kari A Gleiser
In this paper, we introduce Intra-Relational AEDP (I-R) as an attachment-based experiential approach to trauma treatment. Integrating Accelerated Experiential Dynamic Psychotherapy (AEDP) (Fosha, 2000a,b, 2002, 2003) with ego-state methodology, intra-relational interventions specifically seeks to help clients by (1) fostering capacities for self-regulation through shared states of affective resonance between therapist, client, and dissociated self-states; (2) facilitating authentic, open internal dialogue between self-states which can alter engrained patterns of intra-psychic conflict and self-punishment; (3) developing abilities for self-reflection and emotional processing by co-mingling previously disowned affect and emotional memories with here and now experience; and (4) attending to positive affects evoked through experiences of transformation, self-compassion, and self-affirmation...
2007: Journal of Trauma & Dissociation
Diana Fosha
Three ideas are discussed from the vantage point of accelerated experiential dynamic psychotherapy (AEDP): Quantum changes operate not only in trauma, but also in healing; attachment plays a major role in whether fear or excitement is the response to novelty; experientially exploring the experience of transformation can itself lead to quantum change. Vignettes from an AEDP session show a patient's grappling with the startling novelty of experience that the transformational process, particularly when occurring in quantum leaps, evokes, and illustrate the phenomenology of cascading transformations...
May 2006: Journal of Clinical Psychology
L Qingnuan, Z Xiaodong, S Rong, L Wenxin
The synthesis of the Re (V) complex and preparation of 188Re-AEDP are described using 188Re which was obtained from the alumina-based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of 188Re-AEDP were 92-93% for carrier-free 188Re and 95-98% for carrier-added 188Re. The stability of 188Re-AEDP at pH approximately 6 was studied and it is found that the carrier has a significant effect on the stability of 188Re-AEDP...
December 2000: Applied Radiation and Isotopes
D Fosha, M L Slowiaczek
The techniques described above outline specific ways to deepen the patient's affective experience within an emotionally close therapeutic relationship. When effective, they all enhance the patient/therapist bond, raise self-esteem, reduce defensiveness and anxiety, and facilitate emotional healing. Psychodynamic treatment, long or short, is a complex process uniquely constructed by each therapist/patient pair. AEDP strategies are not intended as recipes for treatment. Good dynamic work depends on the therapist's ability to grasp the patient's capacities and limitations, understand relational dynamics, and interact with the patient in an empathically attuned, emotionally receptive, and flexible way...
1997: American Journal of Psychotherapy
E Rosenthal, D Carroll, R Vincent, D A Chamberlain
Twelve samples of ventricular fibrillation were fed into nine automated external defibrillator-pacemakers ( AEDP , "Heart Aid") of recent design. All the devices recognised and defibrillated ventricular fibrillation in seven of the samples within 30 sec. None of the devices reacted to two of the samples; in the remaining three there was inter-device variation ranging from an appropriate response to no response, as well as inappropriate pacing or delay in recognition and treatment. Poor recognition of some ventricular fibrillation waveforms with considerable inter-device variation limits the usefulness of this model...
April 1984: International Journal of Cardiology
A L Aronson, B Haggar
Prompt defibrillation is the cornerstone of therapy for out-of-hospital sudden cardiac arrest. Overwhelming evidence indicates that victims whose cardiac arrest is witnessed and whose ECG rhythm is ventricular fibrillation can be successfully resuscitated, with significant prolongation of life. The automatic external defibrillator-pacemaker (AEDP) is designed to be used by family members of patients with known heart disease, by basic level technicians in emergency rescue systems, and by lay rescuers in corporate-industrial-public environments...
January 1986: Medical Instrumentation
J M White, R M Nowak, G B Martin, R Best, D L Carden, M C Tomlanovich
Approximately 25% of patients in prehospital cardiac arrest present in bradyasystolic rhythms, and their long-term prognosis is very poor. Our study was undertaken to determine the utility of immediate emergency department (ED) external cardiac pacing in this situation. Twenty patients presenting with bradyasystolic prehospital cardiac arrest were entered in the study. All received the usual advanced cardiac life support therapy, but also were externally paced immediately using an automated external defibrillator and pacemaker (AEDP)...
April 1985: Annals of Emergency Medicine
J N Nanas, S N Nanas, C E Charitos, D Kontoyiannis, A D Poyiadjis, G Stamatopoulos, A Melkaoui, G Kokollis, S D Moulopoulos
A valveless, single orifice counterpulsation device (CD) with maximum stroke volume of 100 ml was implanted on the ascending aorta of nine dogs. Its pneumatic driver was gaited by the ECG to provide aortic diastolic augmentation, with a stroke volume of 60-70 ml. In the same animals a 20 ml intraaortic balloon (IAB) was placed into the descending aorta. An attempt was made to evaluate the effectiveness of the CD on severe cardiogenic shock and to compare its hemodynamic effects with those of the IABP. Severe cardiogenic shock was induced by coronary artery ligation, propranolol administration, and fluid infusion and was characterized by a LVEDP of 22...
July 1988: ASAIO Transactions
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