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JOURNAL ARTICLE
Sandra Deiser, Marike Drexler, Guillermo Moreno-Alcántar, Maximilian Irl, Claudia Schmidt, Thomas Günther, Angela Casini
Self-assembled supramolecular coordination complexes (SCCs) hold promise for biomedical applications in cancer therapy, although their potential in the field of nuclear medicine is still substantially unexplored. Therefore, in this study an exo -functionalized cationic [Pd2 L2 ]4+ metallacycle (L = 3,5-bis(3-ethynylpyridine)phenyl), targeted to the somatostatin-2 receptor (sst2R) and featuring the DOTA chelator (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) in order to bind the β- - and γ-emitter lutetium-177, was synthesized by self-assembly following ligand synthesis via standard solid-phase peptide synthesis (SPPS)...
August 9, 2023: Inorganic Chemistry
#22
JOURNAL ARTICLE
Iris van Doorne, Marike A de Meij, Juliette L Parlevliet, Vera M W van Schie, Dick L Willems, Bianca M Buurman, Marjon van Rijn
BACKGROUND: To improve transmural palliative care for older adults acutely admitted to hospital, the PalliSupport intervention, comprising an educational programme and transmural palliative care pathway, was developed. This care pathway involves timely identification of palliative care needs, advance care planning, multidisciplinary team meetings, warm handover, and follow-up home visits. With this study, we evaluate changes in patient-related outcomes and transmural collaboration after implementation of the care pathway...
August 2, 2023: BMC Palliative Care
#23
JOURNAL ARTICLE
Gabriel Bsteh, Wolfgang Marik, Nik Krajnc, Stefan Macher, Christoph Mitsch, Philip Pruckner, Klaus Novak, Christian Wöber, Berthold Pemp
BACKGROUND: In idiopathic intracranial hypertension (IIH), certain MRI features are promising diagnostic markers, but whether these have prognostic value is currently unknown. METHODS: We included patients from the Vienna-Idiopathic-Intracranial-Hypertension (VIIH) database with IIH according to Friedman criteria and cranial MRI performed at diagnosis. Presence of empty sella (ES), perioptic subarachnoid space distension (POSD) with or without optic nerve tortuosity (ONT), posterior globe flattening (PGF) and transverse sinus stenosis (TSS) was assessed and multivariable regression models regarding visual outcome (persistent visual impairment/visual worsening) and headache outcome (headache improvement/freedom of headache) were fitted...
July 28, 2023: Journal of Headache and Pain
#24
JOURNAL ARTICLE
Gabriel Bsteh, Wolfgang Marik, Stefan Macher, Victor Schmidbauer, Nik Krajnc, Philip Pruckner, Christoph Mitsch, Klaus Novak, Christian Wöber, Berthold Pemp
BACKGROUND: In idiopathic intracranial hypertension (IIH), MRI features are promising diagnostic markers, but impact of rater experience and specific referral question is unknown. METHODS: From Vienna-Idiopathic-Intracranial-Hypertension (VIIH) database, we included patients with definitive IIH and routine cranial MRI performed during diagnostic work-up. Frequencies of partial empty sella (ES), optic nerve sheath distension (ONSD), optic nerve tortuosity (ONT), posterior globe flattening (PGF) and transverse sinus stenosis (TSS) was compared in three settings: 1) real-world rating, 2) junior neuroradiologist without special IIH training, and 3) senior neuroradiologist with experience in IIH imaging (gold standard)...
July 21, 2023: European Journal of Neurology
#25
JOURNAL ARTICLE
Nik Krajnc, Bianca Itariu, Stefan Macher, Wolfgang Marik, Jürgen Harreiter, Martin Michl, Klaus Novak, Christian Wöber, Berthold Pemp, Gabriel Bsteh
BACKGROUND: In idiopathic intracranial hypertension (IIH), sustained weight loss is the main pillar in modifying disease course, whereby glucagon-like peptide-1 receptor agonists (GLP-1-RAs) could present an attractive treatment option. METHODS: In this open-label, single-center, case-control pilot study, patients with IIH (pwIIH) and a body mass index (BMI) of ≥ 30 kg/m2 were offered to receive a GLP-1-RA (semaglutide, liraglutide) in addition to the usual care weight management (UCWM)...
July 18, 2023: Journal of Headache and Pain
#26
JOURNAL ARTICLE
Mark P van Opijnen, Filip Y F de Vos, Rob J A Nabuurs, Tom J Snijders, Rishi D S Nandoe Tewarie, Walter Taal, Joost J C Verhoeff, Jacobus J M van der Hoeven, Marike L D Broekman
BACKGROUND: Despite current best treatment options, a glioblastoma almost inevitably recurs after primary treatment. However, in the absence of clear evidence, current guidelines on recurrent glioblastoma are not well-defined. Re-resection is one of the possible treatment modalities, though it can be challenging to identify those patients who will benefit. Therefore, treatment decisions are made based on multidisciplinary discussions. This study aimed to investigate the current practice variation between neuro-oncology specialists...
August 2023: Neuro-oncology Practice
#27
JOURNAL ARTICLE
Gisella Figlioli, Amandine Billaud, Qin Wang, Manjeet K Bolla, Joe Dennis, Michael Lush, Anders Kvist, Muriel A Adank, Thomas U Ahearn, Natalia N Antonenkova, Päivi Auvinen, Sabine Behrens, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Thomas Brüning, Nicola J Camp, Archie Campbell, Jose E Castelao, Melissa H Cessna, Nbcs Collaborators, Kamila Czene, Peter Devilee, Thilo Dörk, Mikael Eriksson, Peter A Fasching, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, Gord Glendon, Encarna B Gómez Garcia, Anna González-Neira, Felix Grassmann, Pascal Guénel, Eric Hahnen, Ute Hamann, Peter Hillemanns, Maartje J Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, kConFab Investigators, Anna Jakubowska, Elza K Khusnutdinova, Vessela N Kristensen, Annika Lindblom, Maria A Loizidou, Jan Lubiński, Arto Mannermaa, Tabea Maurer, Dimitrios Mavroudis, William G Newman, Nadia Obi, Mihalis I Panayiotidis, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Matthias Ruebner, Emmanouil Saloustros, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Mitul Shah, Melissa C Southey, Ian Tomlinson, Thérèse Truong, Elke M van Veen, Camilla Wendt, Xiaohong R Yang, Kyriaki Michailidou, Alison M Dunning, Paul D P Pharoah, Douglas F Easton, Irene L Andrulis, D Gareth Evans, Antoinette Hollestelle, Jenny Chang-Claude, Roger L Milne, Paolo Peterlongo
FANCM germline protein truncating variants (PTVs) are moderate-risk factors for ER-negative breast cancer. We previously described the spectrum of FANCM PTVs in 114 European breast cancer cases. In the present, larger cohort, we report the spectrum and frequency of four common and 62 rare FANCM PTVs found in 274 carriers detected among 44,803 breast cancer cases. We confirmed that p.Gln1701* was the most common PTV in Northern Europe with lower frequencies in Southern Europe. In contrast, p.Gly1906Alafs*12 was the most common PTV in Southern Europe with decreasing frequencies in Central and Northern Europe...
June 23, 2023: Cancers
#28
JOURNAL ARTICLE
Anna Morra, Maartje A C Schreurs, Irene L Andrulis, Hoda Anton-Culver, Annelie Augustinsson, Matthias W Beckmann, Sabine Behrens, Stig E Bojesen, Manjeet K Bolla, Hiltrud Brauch, Annegien Broeks, Saundra S Buys, Nicola J Camp, Jose E Castelao, Melissa H Cessna, Jenny Chang-Claude, Wendy K Chung, Sarah V Colonna, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Tanja N Fehm, Jonine D Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Jeanine Genkinger, Felix Grassmann, Melanie Gündert, Eric Hahnen, Christopher A Haiman, Ute Hamann, Patricia A Harrington, Jaana M Hartikainen, Reiner Hoppe, John L Hopper, Richard S Houlston, Anthony Howell, Anna Jakubowska, Wolfgang Janni, Helena Jernström, Esther M John, Nichola Johnson, Michael E Jones, Vessela N Kristensen, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Michael P Lux, Arto Mannermaa, Dimitrios Mavroudis, Anna Marie Mulligan, Taru A Muranen, Heli Nevanlinna, Ines Nevelsteen, Patrick Neven, William G Newman, Nadia Obi, Kenneth Offit, Andrew F Olshan, Tjoung-Won Park-Simon, Alpa V Patel, Paolo Peterlongo, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Eric C Polley, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Mark Robson, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Sabine Schuetze, Christopher Scott, Mitul Shah, Snezhana Smichkoska, Melissa C Southey, William J Tapper, Lauren R Teras, Rob A E M Tollenaar, Katarzyna Tomczyk, Ian Tomlinson, Melissa A Troester, Celine M Vachon, Elke M van Veen, Qin Wang, Camilla Wendt, Hans Wildiers, Robert Winqvist, Argyrios Ziogas, Per Hall, Paul D P Pharoah, Muriel A Adank, Antoinette Hollestelle, Marjanka K Schmidt, Maartje J Hooning
BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS. METHODS: Analyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9...
July 3, 2023: Cancer Medicine
#29
JOURNAL ARTICLE
Wendy Walrabenstein, Carlijn A Wagenaar, Marieke van de Put, Marike van der Leeden, Martijn Gerritsen, Jos W R Twisk, Martin van der Esch, Henriët van Middendorp, Peter J M Weijs, Leo D Roorda, Dirkjan van Schaardenburg
OBJECTIVE: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA). DESIGN: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome...
June 14, 2023: Osteoarthritis and Cartilage
#30
JOURNAL ARTICLE
Robin C H Kwakman, Eric L Voorn, Juultje Sommers, Karin Gerrits, Frans Nollet, Raoul H H Engelbert, Marike van der Schaaf
BACKGROUND: To avoid overexertion in critically ill patients, information on the physical demand, i.e., metabolic load, of daily care and active exercises is warranted. OBJECTIVE: The objective of this study was toassess the metabolic load during morning care activities and active bed exercises in mechanically ventilated critically ill patients. METHODS: This study incorporated an explorative observational study executed in a university hospital intensive care unit...
June 5, 2023: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
#31
JOURNAL ARTICLE
Ryan K Doss, Marike Palmer, David A Mead, Brian P Hedlund
Viruses have developed sophisticated biochemical and genetic mechanisms to manipulate and exploit their hosts. Enzymes derived from viruses have been essential research tools since the first days of molecular biology. However, most viral enzymes that have been commercialized are derived from a small number of cultivated viruses, which is remarkable considering the extraordinary diversity and abundance of viruses revealed by metagenomic analysis. Given the explosion of new enzymatic reagents derived from thermophilic prokaryotes over the past 40 years, those obtained from thermophilic viruses should be equally potent tools...
May 24, 2023: Essays in Biochemistry
#32
JOURNAL ARTICLE
Marike S Lombaers, Karlijn M C Cornel, Nicole C M Visser, Johan Bulten, Heidi V N Küsters-Vandevelde, Frédéric Amant, Dorry Boll, Peter Bronsert, Eva Colas, Peggy M A J Geomini, Antonio Gil-Moreno, Dennis van Hamont, Jutta Huvila, Camilla Krakstad, Arjan A Kraayenbrink, Martin Koskas, Gemma Mancebo, Xavier Matías-Guiu, Huy Ngo, Brenda M Pijlman, Maria Caroline Vos, Vit Weinberger, Marc P L M Snijders, Sebastiaan W van Koeverden, Enitec-Consortium, Ingfrid S Haldorsen, Casper Reijnen, Johanna M A Pijnenborg
Patients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in high-grade EC are limited, we aimed to study primarily the predictive value of CA125, and secondarily the contributive value of computed tomography (CT) for advanced stage and LNM. Patients with high-grade EC (n = 333) and available preoperative CA125 were included retrospectively. The association of CA125 and CT findings with LNM was analyzed by logistic regression...
May 4, 2023: Cancers
#33
JOURNAL ARTICLE
Marike R van Lingen, Lucas C Breedt, Jeroen J G Geurts, Arjan Hillebrand, Martin Klein, Mathilde C M Kouwenhoven, Shanna D Kulik, Jaap C Reijneveld, Cornelis J Stam, Philip C De Witt Hamer, Mona L M Zimmermann, Fernando A N Santos, Linda Douw
Many patients with glioma, primary brain tumors, suffer from poorly understood executive functioning deficits before and/or after tumor resection. We aimed to test whether frontoparietal network centrality of multilayer networks, allowing for integration across multiple frequencies, relates to and predicts executive functioning in glioma. Patients with glioma (n = 37) underwent resting-state magnetoencephalography and neuropsychological tests assessing word fluency, inhibition, and set shifting before (T1) and one year after tumor resection (T2)...
April 17, 2023: Brain Imaging and Behavior
#34
JOURNAL ARTICLE
Marike Palmer, Jonathan K Covington, En-Min Zhou, Scott C Thomas, Neeli Habib, Cale O Seymour, Dengxun Lai, Juliet Johnston, Ameena Hashimi, Jian-Yu Jiao, Alise R Muok, Lan Liu, Wen-Dong Xian, Xiao-Yang Zhi, Meng-Meng Li, Leslie P Silva, Benjamin P Bowen, Katherine Louie, Ariane Briegel, Jennifer Pett-Ridge, Peter K Weber, Elitza I Tocheva, Tanja Woyke, Trent R Northen, Xavier Mayali, Wen-Jun Li, Brian P Hedlund
Although the phylum Chloroflexota is ubiquitous, its biology and evolution are poorly understood due to limited cultivability. Here, we isolated two motile, thermophilic bacteria from hot spring sediments belonging to the genus Tepidiforma and class Dehalococcoidia within the phylum Chloroflexota. A combination of cryo-electron tomography, exometabolomics, and cultivation experiments using stable isotopes of carbon revealed three unusual traits: flagellar motility, a peptidoglycan-containing cell envelope, and heterotrophic activity on aromatics and plant-associated compounds...
April 11, 2023: ISME Journal
#35
JOURNAL ARTICLE
Thomas S van Solinge, Shadi Mahjoum, Stefano Ughetto, Alessandro Sammarco, Marike L D Broekman, Xandra O Breakefield, Killian P O'Brien
Tools to effectively demonstrate and quantify functional delivery in cellular communication have been lacking. This study reports the use of a fluorescently labeled split Nanoluc reporter system to demonstrate and quantify functional transfer between cells in vitro and in a subcutaneous tumor mouse model. Our construct allows monitoring of direct, indirect, and specifically extracellular vesicle-mediated functional communication.
February 27, 2023: Cell Rep Methods
#36
JOURNAL ARTICLE
Cale O Seymour, Marike Palmer, Eric D Becraft, Ramunas Stepanauskas, Ariel D Friel, Frederik Schulz, Tanja Woyke, Emiley Eloe-Fadrosh, Dengxun Lai, Jian-Yu Jiao, Zheng-Shuang Hua, Lan Liu, Zheng-Han Lian, Wen-Jun Li, Maria Chuvochina, Brianna K Finley, Benjamin J Koch, Egbert Schwartz, Paul Dijkstra, Duane P Moser, Bruce A Hungate, Brian P Hedlund
Candidate bacterial phylum Omnitrophota has not been isolated and is poorly understood. We analysed 72 newly sequenced and 349 existing Omnitrophota genomes representing 6 classes and 276 species, along with Earth Microbiome Project data to evaluate habitat, metabolic traits and lifestyles. We applied fluorescence-activated cell sorting and differential size filtration, and showed that most Omnitrophota are ultra-small (~0.2 μm) cells that are found in water, sediments and soils. Omnitrophota genomes in 6 classes are reduced, but maintain major biosynthetic and energy conservation pathways, including acetogenesis (with or without the Wood-Ljungdahl pathway) and diverse respirations...
March 16, 2023: Nature Microbiology
#37
JOURNAL ARTICLE
Tiina Santonen, Selma Mahiout, Paula Alvito, Petra Apel, Jos Bessems, Wieneke Bil, Teresa Borges, Stephan Bose-O'Reilly, Jurgen Buekers, Ana Isabel Cañas Portilla, Argelia Castaño Calvo, Mercedes de Alba González, Noelia Domínguez-Morueco, Marta Esteban López, Ingrid Falnoga, Antje Gerofke, María Del Carmen González Caballero, Milena Horvat, Pasi Huuskonen, Normunds Kadikis, Marike Kolossa-Gehring, Rosa Lange, Henriqueta Louro, Carla Martins, Matthieu Meslin, Lars Niemann, Susana Pedraza Díaz, Veronika Plichta, Simo P Porras, Christophe Rousselle, Bernice Scholten, Maria João Silva, Zdenka Šlejkovec, Janja Snoj Tratnik, Agnes Šömen Joksić, Jose V Tarazona, Maria Uhl, An Van Nieuwenhuyse, Susana Viegas, Anne Marie Vinggaard, Marjolijn Woutersen, Greet Schoeters
One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA...
March 2, 2023: International Journal of Hygiene and Environmental Health
#38
JOURNAL ARTICLE
Yan-Ni Qu, Yang-Zhi Rao, Yan-Ling Qi, Yu-Xian Li, Andrew Li, Marike Palmer, Brian P Hedlund, Wen-Sheng Shu, Paul N Evans, Guo-Xing Nie, Zheng-Shuang Hua, Wen-Jun Li
The biology of Korarchaeia remains elusive due to the lack of genome representatives. Here, we reconstruct 10 closely related metagenome-assembled genomes from hot spring habitats and place them into a single species, proposed herein as Panguiarchaeum symbiosum. Functional investigation suggests that Panguiarchaeum symbiosum is strictly anaerobic and grows exclusively in thermal habitats by fermenting peptides coupled with sulfide and hydrogen production to dispose of electrons. Due to its inability to biosynthesize archaeal membranes, amino acids, and purines, this species likely exists in a symbiotic lifestyle similar to DPANN archaea...
February 22, 2023: Cell Reports
#39
Anna Morra, Maartje A C Schreurs, Irene L Andrulis, Hoda Anton-Culver, Annelie Augustinsson, Matthias W Beckmann, Sabine Behrens, Stig E Bojesen, Manjeet K Bolla, Hiltrud Brauch, Annegien Broeks, Saundra S Buys, Nicola J Camp, Jose E Castelao, Melissa H Cessna, Jenny Chang-Claude, Wendy K Chung, Nbcs Collaborators, Sarah V Colonna, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Tanja N Fehm, Jonine D Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Jeanine Genkinger, Felix Grassmann, Melanie Gündert, Eric Hahnen, Christopher A Haiman, Ute Hamann, Patricia A Harrington, Jaana M Hartikainen, Reiner Hoppe, John L Hopper, Richard S Houlston, Anthony Howell, Abctb Investigators, kConFab Investigators, Anna Jakubowska, Wolfgang Janni, Helena Jernström, Esther M John, Nichola Johnson, Michael E Jones, Vessela N Kristensen, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Michael P Lux, Arto Mannermaa, Dimitrios Mavroudis, Anna Marie Mulligan, Taru A Muranen, Heli Nevanlinna, Ines Nevelsteen, Patrick Neven, William G Newman, Nadia Obi, Kenneth Offit, Andrew F Olshan, Tjoung-Won Park-Simon, Alpa V Patel, Paolo Peterlongo, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Eric C Polley, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Mark Robson, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Sabine Schuetze, Christopher Scott, Mitul Shah, Snezhana Smichkoska, Melissa C Southey, William J Tapper, Lauren R Teras, Rob A E M Tollenaar, Katarzyna Tomczyk, Ian Tomlinson, Melissa A Troester, Celine M Vachon, Elke M van Veen, Qin Wang, Camilla Wendt, Hans Wildiers, Robert Winqvist, Argyrios Ziogas, Per Hall, Paul D P Pharoah, Muriel A Adank, Antoinette Hollestelle, Marjanka K Schmidt, Maartje J Hooning
Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. We aimed to assess the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS. Analyses were based on 82,701 women diagnosed with invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations of treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model...
February 13, 2023: Research Square
#40
JOURNAL ARTICLE
Yanying Ma, Camilla Taxvig, Andrea Rodríguez-Carrillo, Vicente Mustieles, Lena Reiber, Anja Kiesow, Nathalie Michelle Löbl, Mariana F Fernández, Tina Vicky Alstrup Hansen, Maria João Valente, Marike Kolossa-Gehring, Madlen David, Anne Marie Vinggaard
BACKGROUND: Scientific evidence for underestimated toxicity from unintentional exposure to chemical mixtures is mounting. Yet, harmonized approaches on how to assess the actual risk of mixtures is lacking. As part of the European Joint programme 'Human Biomonitoring for Europe' we explored a novel methodology for mixture risk assessment of chemicals affecting male reproductive function. METHODOLOGY: We explored a methodology for chemical mixture risk assessment based on human in vitro data combined with human exposure data, thereby circumventing the drawbacks of using hazard data from rodents and estimated exposure intake levels...
February 11, 2023: Environment International
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