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https://read.qxmd.com/read/30845926/limited-overlap-in-significant-hits-between-genome-wide-association-studies-on-two-airflow-obstruction-definitions-in-the-same-population
#1
Diana A van der Plaat, Judith M Vonk, Lies Lahousse, Kim de Jong, Alen Faiz, Ivana Nedeljkovic, Najaf Amin, Cleo C van Diemen, Guy G Brusselle, Yohan Bossé, Corry-Anke Brandsma, Ke Hao, Peter D Paré, Cornelia M van Duijn, Dirkje S Postma, H Marike Boezen
BACKGROUND: Airflow obstruction is a hallmark of chronic obstructive pulmonary disease (COPD), and is defined as either the ratio between forced expiratory volume in one second and forced vital capacity (FEV1 /FVC) < 70% or < lower limit of normal (LLN). This study aimed to assess the overlap between genome-wide association studies (GWAS) on airflow obstruction using these two definitions in the same population stratified by smoking. METHODS: GWASes were performed in the LifeLines Cohort Study for both airflow obstruction definitions in never-smokers (NS = 5071) and ever-smokers (ES = 4855)...
March 7, 2019: BMC Pulmonary Medicine
https://read.qxmd.com/read/30825924/recurrence-risk-of-preeclampsia-in-a-linked-population-based-cohort-effects-of-first-pregnancy-maximum-diastolic-blood-pressure-and-gestational-age
#2
Thomas P Bernardes, Ben W Mol, Anita C J Ravelli, Paul P van den Berg, H Marike Boezen, Henk Groen
OBJECTIVE: To estimate preeclampsia occurrence and recurrence risk in the 2nd pregnancy and analyze associated risk factors such as 1st pregnancy maximum diastolic blood pressure (maxDBP) and gestational age at delivery (GA). STUDY DESIGN: Linked cohort of 1st and 2nd pregnancies of 272,551 women from the Dutch Perinatal Registry collected between 2000 and 2007. We defined preeclampsia as hypertension (maxDBP ≥90 mmHg or documented hypertension) plus proteinuria (≥300 mg/24 h) and analyzed its 2nd pregnancy occurrence with logistic regression...
January 2019: Pregnancy Hypertension
https://read.qxmd.com/read/30804561/genetic-landscape-of-chronic-obstructive-pulmonary-disease-identifies-heterogeneous-cell-type-and-phenotype-associations
#3
Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F Reeve, Anna L Guyatt, Victoria E Jackson, Nick Shrine, Dandi Qiao, Traci M Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C Latourelle, Xingnan Li, Jarrett D Morrow, Ma'en Obeidat, Annah B Wyss, Per Bakke, R Graham Barr, Terri H Beaty, Steven A Belinsky, Guy G Brusselle, James D Crapo, Kim de Jong, Dawn L DeMeo, Tasha E Fingerlin, Sina A Gharib, Amund Gulsvik, Ian P Hall, John E Hokanson, Woo Jin Kim, David A Lomas, Stephanie J London, Deborah A Meyers, George T O'Connor, Stephen I Rennard, David A Schwartz, Pawel Sliwinski, David Sparrow, David P Strachan, Ruth Tal-Singer, Yohannes Tesfaigzi, Jørgen Vestbo, Judith M Vonk, Jae-Joon Yim, Xiaobo Zhou, Yohan Bossé, Ani Manichaikul, Lies Lahousse, Edwin K Silverman, H Marike Boezen, Louise V Wain, Martin D Tobin, Brian D Hobbs, Michael H Cho
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 × 10-8 ; 47 of these were previously described in association with either COPD or population-based measures of lung function...
March 2019: Nature Genetics
https://read.qxmd.com/read/30798479/randomized-controlled-trials-comparing-surgery-to-non-operative-management-in-neurosurgery-a-systematic-review
#4
REVIEW
Enrico Martin, Ivo S Muskens, Joeky T Senders, Aislyn C DiRisio, Aditya V Karhade, Hasan A Zaidi, Wouter A Moojen, Wilco C Peul, Timothy R Smith, Marike L D Broekman
BACKGROUND: A randomized controlled trial (RCT) remains the pinnacle of clinical research design. However, RCTs in neurosurgery, especially those comparing surgery to non-operative treatment, are rare and their relevance and applicability have been questioned. This study set out to assess trial design and quality and identify their influence on outcomes in recent neurosurgical trials that compare surgery to non-operative treatment. METHODS: From 2000 to 2017, PubMed and Embase databases and four trial registries were searched...
February 23, 2019: Acta Neurochirurgica
https://read.qxmd.com/read/30795752/prevalence-and-factors-associated-with-asthma-among-adolescents-and-adults-in-uganda-a-general-population-based-survey
#5
Bruce J Kirenga, Corina de Jong, Winceslaus Katagira, Samuel Kasozi, Levicatus Mugenyi, Marike Boezen, Thys van der Molen, Moses R Kamya
BACKGROUND: Recent large-scale population data on the prevalence of asthma and its risk factors are lacking in Uganda. This survey was conducted to address this data gap. METHODS: A general population based survey was conducted among people ≥12 years. A questionnaire was used to collect participants socio-demographics, respiratory symptoms, medical history, and known asthma risk factors. Participants who reported wheeze in the past 12 months, a physician diagnosis of asthma or current use of asthma medications were classified as having asthma...
February 22, 2019: BMC Public Health
https://read.qxmd.com/read/30787463/genome-wide-association-study-of-germline-variants-and-breast-cancer-specific-mortality
#6
Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K Bolla, Qin Wang, Jean Abraham, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L Auer, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bram Boeckx, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Adam Brentnall, Louise Brinton, Per Broberg, Ian W Brock, Sara Y Brucker, Barbara Burwinkel, Carlos Caldas, Trinidad Caldés, Daniele Campa, Federico Canzian, Angel Carracedo, Brian D Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Georgia Chenevix-Trench, Ting-Yuan David Cheng, Suet-Feung Chin, Christine L Clarke, Emilie Cordina-Duverger, Fergus J Couch, David G Cox, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Janet A Dunn, Alison M Dunning, Lorraine Durcan, Miriam Dwek, Helena M Earl, Arif B Ekici, A Heather Eliassen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, D Gareth Evans, Jonine Figueroa, Dieter Flesch-Janys, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Eva Galle, Susan M Gapstur, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Angela George, Vassilios Georgoulias, Graham G Giles, Gord Glendon, David E Goldgar, Anna González-Neira, Grethe I Grenaker Alnæs, Mervi Grip, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Susan Hankinson, Elaine F Harkness, Patricia A Harrington, Steven N Hart, Jaana M Hartikainen, Alexander Hein, Peter Hillemanns, Louise Hiller, Bernd Holleczek, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Anthony Howell, Guanmengqian Huang, Keith Humphreys, David J Hunter, Wolfgang Janni, Esther M John, Michael E Jones, Arja Jukkola-Vuorinen, Audrey Jung, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Michael J Kerin, Sofia Khan, Elza Khusnutdinova, Johanna I Kiiski, Cari M Kitahara, Julia A Knight, Yon-Dschun Ko, Linetta B Koppert, Veli-Matti Kosma, Peter Kraft, Vessela N Kristensen, Ute Krüger, Tabea Kühl, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Lian Li, Annika Lindblom, Sara Lindström, Martha Linet, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jan Lubiński, Michael P Lux, Robert J MacInnis, Melanie Maierthaler, Tom Maishman, Enes Makalic, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Pooja Middha, Nicola Miller, Roger L Milne, Fernando Moreno, Anna Marie Mulligan, Claire Mulot, Rami Nassir, Susan L Neuhausen, William T Newman, Sune F Nielsen, Børge G Nordestgaard, Aaron Norman, Håkan Olsson, Nick Orr, V Shane Pankratz, Tjoung-Won Park-Simon, Jose I A Perez, Clara Pérez-Barrios, Paolo Peterlongo, Christos Petridis, Mila Pinchev, Karoliona Prajzendanc, Ross Prentice, Nadege Presneau, Darya Prokofieva, Katri Pylkäs, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Gadi Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Rebecca Roylance, Emmanouil Saloustros, Elinor J Sawyer, Daniel F Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Minouk J Schoemaker, Fredrick Schumacher, Lukas Schwentner, Rodney J Scott, Christopher Scott, Caroline Seynaeve, Mitul Shah, Jacques Simard, Ann Smeets, Christof Sohn, Melissa C Southey, Anthony J Swerdlow, Aline Talhouk, Rulla M Tamimi, William J Tapper, Manuel R Teixeira, Maria Tengström, Mary Beth Terry, Kathrin Thöne, Rob A E M Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Constance Turman, Clare Turnbull, Hans-Ulrich Ulmer, Michael Untch, Celine Vachon, Christi J van Asperen, Ans M W van den Ouweland, Elke M van Veen, Camilla Wendt, Alice S Whittemore, Walter Willett, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Yan Zhang, Douglas F Easton, Peter A Fasching, Heli Nevanlinna, Diana M Eccles, Paul D P Pharoah, Marjanka K Schmidt
BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients...
February 21, 2019: British Journal of Cancer
https://read.qxmd.com/read/30768499/icu-survivors-have-a-substantial-higher-risk-of-developing-new-chronic-conditions-compared-to-a-population-based-control-group
#7
Ilse van Beusekom, Ferishta Bakhshi-Raiez, Marike van der Schaaf, Wim B Busschers, Nicolette F de Keizer, Dave A Dongelmans
OBJECTIVES: To describe the types and prevalence of chronic conditions in an ICU population and a population-based control group during the year before ICU admission and to quantify the risk of developing new chronic conditions in ICU patients compared with the control group. DESIGN: We conducted a retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data in the timeframe 2012-2014 were combined with clinical data of patients who had been admitted to an ICU during 2013...
March 2019: Critical Care Medicine
https://read.qxmd.com/read/30742815/the-influence-of-suction-on-chest-drain-duration-after-lobectomy-using-electronic-chest-drainage
#8
Marike Lijkendijk, Peter B Licht, Kirsten Neckelmann
BACKGROUND: Management of chest drains following thoracic surgery remains an area with little consensus. To optimize our chest drainage algorithms with electronic chest drainage systems we conducted a randomized controlled trial comparing low variable suction (-5 cm H2 O) versus high variable suction (-20 cm H2 O). METHODS: We did a prospective open label randomized trial in patients undergoing lobectomy. Sample size was calculated from a clinical relevant difference in chest drain duration as one full day...
February 8, 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30626934/longitudinal-changes-of-cardiac-troponin-and-inflammation-reflect-progressive-myocyte-stretch-and-likelihood-for-hypertension-in-a-black-male-cohort-the-sabpa-study
#9
Esmé Jansen van Vuren, Leoné Malan, Roland von Känel, Leandi Lammertyn, Marike Cockeran, Nicolaas T Malan
Inflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic peptide) are associated with hypertension and ECG left ventricular hypertrophy (ECG-LVH) is unclear. The first prospective analysis in Africa assessing these associations included a cohort of Black and White teachers (N = 338; aged 20-63 years). Fasting blood samples were obtained to measure tumor necrosis factor-alpha (TNF-α), cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)...
January 10, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/30579282/international-practice-variation-in-postoperative-imaging-of-chronic-subdural-hematoma-patients
#10
Alexander F C Hulsbergen, Sandra C Yan, Brittany M Stopa, Aislyn DiRisio, Joeky T Senders, Max J van Essen, Stéphanie M E van der Burgt, Timothy R Smith, William B Gormley, Marike L D Broekman
OBJECTIVEThe value of CT scanning after burr hole surgery in chronic subdural hematoma (CSDH) patients is unclear, and practice differs between countries. At the Brigham and Women's Hospital (BWH) in Boston, Massachusetts, neurosurgeons frequently order routine postoperative CT scans, while the University Medical Center Utrecht (UMCU) in the Netherlands does not have this policy. The aim of this study was to compare the use of postoperative CT scans in CSDH patients between these hospitals and to evaluate whether there are differences in clinical outcomes...
December 21, 2018: Journal of Neurosurgery
https://read.qxmd.com/read/30578430/treatment-and-survival-of-osteosarcoma-and-ewing-sarcoma-of-the-skull-a-seer-database-analysis
#11
Enrico Martin, Joeky T Senders, P Valerie Ter Wengel, Timothy R Smith, Marike L D Broekman
BACKGROUND: Common primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival. METHODS: Skull OSC and EWS cases were obtained from the SEER database. Patient and tumor characteristics, treatment modalities, and survival were extracted...
December 21, 2018: Acta Neurochirurgica
https://read.qxmd.com/read/30554720/polygenic-risk-scores-for-prediction-of-breast-cancer-and-breast-cancer-subtypes
#12
Nasim Mavaddat, Kyriaki Michailidou, Joe Dennis, Michael Lush, Laura Fachal, Andrew Lee, Jonathan P Tyrer, Ting-Huei Chen, Qin Wang, Manjeet K Bolla, Xin Yang, Muriel A Adank, Thomas Ahearn, Kristiina Aittomäki, Jamie Allen, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Paul L Auer, Päivi Auvinen, Myrto Barrdahl, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Michael Bremer, Hermann Brenner, Adam Brentnall, Ian W Brock, Angela Brooks-Wilson, Sara Y Brucker, Thomas Brüning, Barbara Burwinkel, Daniele Campa, Brian D Carter, Jose E Castelao, Stephen J Chanock, Rowan Chlebowski, Hans Christiansen, Christine L Clarke, J Margriet Collée, Emilie Cordina-Duverger, Sten Cornelissen, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Isabel Dos-Santos-Silva, Martine Dumont, Lorraine Durcan, Miriam Dwek, Diana M Eccles, Arif B Ekici, A Heather Eliassen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Asta Försti, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Vassilios Georgoulias, Graham G Giles, Irina R Gilyazova, Gord Glendon, Mark S Goldberg, David E Goldgar, Anna González-Neira, Grethe I Grenaker Alnæs, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Susan E Hankinson, Elaine F Harkness, Steven N Hart, Wei He, Alexander Hein, Jane Heyworth, Peter Hillemanns, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Anthony Howell, Guanmengqian Huang, Keith Humphreys, David J Hunter, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Esther M John, Nichola Johnson, Michael E Jones, Arja Jukkola-Vuorinen, Audrey Jung, Rudolf Kaaks, Katarzyna Kaczmarek, Vesa Kataja, Renske Keeman, Michael J Kerin, Elza Khusnutdinova, Johanna I Kiiski, Julia A Knight, Yon-Dschun Ko, Veli-Matti Kosma, Stella Koutros, Vessela N Kristensen, Ute Krüger, Tabea Kühl, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Jenna Lilyquist, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jirong Long, Jan Lubiński, Michael P Lux, Robert J MacInnis, Tom Maishman, Enes Makalic, Ivana Maleva Kostovska, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John W M Martens, Maria Elena Martinez, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Usha Menon, Pooja Middha, Nicola Miller, Fernando Moreno, Anna Marie Mulligan, Claire Mulot, Victor M Muñoz-Garzon, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, William G Newman, Sune F Nielsen, Børge G Nordestgaard, Aaron Norman, Kenneth Offit, Janet E Olson, Håkan Olsson, Nick Orr, V Shane Pankratz, Tjoung-Won Park-Simon, Jose I A Perez, Clara Pérez-Barrios, Paolo Peterlongo, Julian Peto, Mila Pinchev, Dijana Plaseska-Karanfilska, Eric C Polley, Ross Prentice, Nadege Presneau, Darya Prokofyeva, Kristen Purrington, Katri Pylkäs, Brigitte Rack, Paolo Radice, Rohini Rau-Murthy, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Mark Robson, Atocha Romero, Kathryn J Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Daniel F Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Minouk J Schoemaker, Fredrick Schumacher, Peter Schürmann, Lukas Schwentner, Christopher Scott, Rodney J Scott, Caroline Seynaeve, Mitul Shah, Mark E Sherman, Martha J Shrubsole, Xiao-Ou Shu, Susan Slager, Ann Smeets, Christof Sohn, Penny Soucy, Melissa C Southey, John J Spinelli, Christa Stegmaier, Jennifer Stone, Anthony J Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Kathrin Thöne, Rob A E M Tollenaar, Ian Tomlinson, Thérèse Truong, Maria Tzardi, Hans-Ulrich Ulmer, Michael Untch, Celine M Vachon, Elke M van Veen, Joseph Vijai, Clarice R Weinberg, Camilla Wendt, Alice S Whittemore, Hans Wildiers, Walter Willett, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Drakoulis Yannoukakos, Yan Zhang, Wei Zheng, Argyrios Ziogas, Alison M Dunning, Deborah J Thompson, Georgia Chenevix-Trench, Jenny Chang-Claude, Marjanka K Schmidt, Per Hall, Roger L Milne, Paul D P Pharoah, Antonis C Antoniou, Nilanjan Chatterjee, Peter Kraft, Montserrat García-Closas, Jacques Simard, Douglas F Easton
Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets...
December 5, 2018: American Journal of Human Genetics
https://read.qxmd.com/read/30449631/genome-wide-interaction-study-of-gene-by-occupational-exposures-on-respiratory-symptoms
#13
Xiang Zeng, Judith M Vonk, Diana A van der Plaat, Alen Faiz, Peter D Paré, Philippe Joubert, David Nickle, Corry-Anke Brandsma, Hans Kromhout, Roel Vermeulen, Xijin Xu, Xia Huo, Kim de Jong, H Marike Boezen
Respiratory symptoms are important indicators of respiratory diseases. Both genetic and environmental factors contribute to respiratory symptoms development but less is known about gene-environment interactions. We aimed to assess interactions between single nucleotide polymorphisms (SNPs) and occupational exposures on respiratory symptoms cough, dyspnea and phlegm. As identification cohort LifeLines I (n = 7976 subjects) was used. Job-specific exposure was estimated using the ALOHA + job exposure matrix...
November 15, 2018: Environment International
https://read.qxmd.com/read/30419575/fasciotomy-for-lateral-lower-leg-chronic-exertional-compartment-syndrome
#14
Aniek Philomena Maria van Zantvoort, Johan Anthonius de Bruijn, Henricus P H Hundscheid, Marike van der Cruijsen-Raaijmakers, Joep A W Teijink, Marc R Scheltinga
Exercise-induced lower leg pain may be caused by chronic exertional compartment syndrome (CECS). Anterior or deep posterior compartments are usually affected. Knowledge about CECS of the lateral compartment (lat-CECS) is limited and outcome after fasciotomy is unknown. The purpose of this study is to report on success rates of fasciotomy in patients with lat-CECS. Surgical success rates in patients with lat-CECS diagnosed with a dynamic intracompartmental pressure (ICP) measurement were studied using a questionnaire (success: excellent or good as judged by the patient; unsuccessful: moderate, fair or poor)...
November 12, 2018: International Journal of Sports Medicine
https://read.qxmd.com/read/30352726/prokaryotic-species-are-sui-generis-evolutionary-units
#15
REVIEW
Marike Palmer, Stephanus N Venter, Martin P A Coetzee, Emma T Steenkamp
Many gene flow barriers associated with genetic isolation during eukaryotic species divergence, are lacking in prokaryotes. In these organisms the processes associated with horizontal gene transfer (HGT) may provide both the homogenizing force needed for genetic cohesion and the genetic variation essential to speciation. This is because HGT events can broadly be grouped into genetic conversions (where endogenous genetic material are replaced with homologs acquired from external sources) and genetic introductions (where novel genetic material is acquired from external sources)...
October 11, 2018: Systematic and Applied Microbiology
https://read.qxmd.com/read/30294958/physical-health-status-of-older-adults-with-severe-mental-illness-the-phismi-e-cohort-study
#16
Noortje Houben, Eveline P C J Janssen, Marike R C Hendriks, Digna van der Kellen, Bas P J van Alphen, Berno van Meijel
The objective was to use various somatic parameters as basis for investigating the physical health of older adults with severe mental illnesses (SMI). A cross-sectional study design is performed by using baseline data from the Physical Health in SMI-elderly (PHiSMI-E) study. Data were collected using the Nursing Monitoring of Somatic Status and Lifestyle - Mental Health instrument in adults aged over 60 with SMI in a large Dutch mental health institute. Ninety-nine elderly SMI patients were included. Somatic comorbidity (84...
October 7, 2018: International Journal of Mental Health Nursing
https://read.qxmd.com/read/30284020/a-coil-in-the-hair-a-case-report-of-percutaneous-coil-migration
#17
Bart De Boer, Alfred P See, H Bart Brouwers, Gabriël Rinkel, Ciro Princiotta, Marike L D Broekman
Coil migration following cerebral aneurysm treatment has been described and may result in stroke, recurrent aneurysm, or local mass effect. Cerebral coil embolization is also applied in arteriovenous malformations and arteriovenous fistulas, but these pathologies are relatively rare and coil migration is not as well described. Furthermore, these cases are more commonly treated with combinations of multiple modalities to achieve cure. Embolization, surgery, and radiation each have risks and benefits and combinations may have synergistic risks and benefits not seen in monotherapy...
October 3, 2018: Acta Neurochirurgica
https://read.qxmd.com/read/30241519/the-impact-of-hiv-on-the-prevalence-of-asthma-in-uganda-a-general-population-survey
#18
Bruce J Kirenga, Levicatus Mugenyi, Corina de Jong, J Lucian Davis, Winceslaus Katagira, Thys van der Molen, Moses R Kamya, Marike Boezen
BACKGROUND: HIV and asthma are highly prevalent diseases in Africa but few studies have assessed the impact of HIV on asthma prevalence in high HIV burden settings. The objective of this analysis was to compare the prevalence of asthma among persons living with HIV (PLHIV) and those without HIV participating in the Uganda National Asthma Survey (UNAS). METHODS: UNAS was a population-based survey of persons aged ≥12 years. Asthma was diagnosed based on either self-reported current wheeze concurrently or within the prior 12 months; physician diagnosis; or use of asthma medication...
September 21, 2018: Respiratory Research
https://read.qxmd.com/read/30227170/c679x-loss-of-function-pcsk9-variant-lowers-fasting-glucose-levels-in-a-black-south-african-population-a-longitudinal-study
#19
Tinashe Chikowore, Marike Cockeran, Karin R Conradie, Tertia van Zyl
AIMS: To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. METHODS: We conducted a five year, longitudinal study, nested within the Prospective Urban and Rural Epidemiology study, among 737 apparently healthy, male and female black South Africans of the North West province. Genotyping of the C679X and A443T PCSK9 variants was achieved using Taqman assays from Applied Biosystems...
October 2018: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/30191671/restraint-interventions-in-people-with-moderate-to-profound-intellectual-disabilities-perspectives-of-support-staff-and-family-members
#20
Petri J C M Embregts, Annemarieke Negenman, Jolanda M Habraken, Marike E de Boer, Brenda J M Frederiks, Cees M P M Hertogh
BACKGROUND: Due to incompatibilities in communication, it is key that family members and support staff can take the perspective of people with moderate to profound intellectual disabilities (ID) whilst putting aside their own perspectives. METHOD: Ten vignettes describing types of restraint interventions (RIs) were presented to 20 unique pairs of support staff and family members related to individuals with moderate to profound ID. RESULTS: In taking their own perspective, more than half of the support staff and family members perceived all RIs as involuntary and severe...
September 7, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
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