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"Early Cancer" AND (Gastric OR Gastro*)

Xingwei Chen, Chi Xu, Shengjun Hong, Xian Xia, Yaqiang Cao, Joseph McDermott, Yonglin Mu, Jing-Dong J Han
Although chronic inflammation increases many cancers' risk, how inflammation facilitates cancer development is still not well studied. Recognizing whether and when inflamed tissues transition to cancerous tissues is of utmost importance. To unbiasedly infer molecular events, immune cell types, and secreted factors contributing to the inflammation-to-cancer (I2C) transition, we develop a computational package called "SwitchDetector" based on liver, gastric, and colon cancer I2C data. Using it, we identify angiogenesis associated with a common critical transition stage for multiple I2C events...
February 12, 2019: Cell Reports
Benjamin Walter, Simone Schmidbaur, Yannick Krieger, Alexander Meining
Background  En-bloc resection of large, flat lesions or early stages of cancer is challenging. No bimanual tasks are possible using standard endoscopes. Dual-channel endoscopes are not available everywhere and have a small distance between the channels. Patients and methods  A new external additional working channel (AWC) (Ovesco, Tuebingen, Germany) was designed and developed potentially enabling bimanual tasks. Fixed to the tip of a standard gastroscope or pediatric colonoscope, a second endoscopic tool can be inserted through the AWC and used for tissue retraction during endoscopic resection...
February 2019: Endoscopy International Open
Charles A Riley, Michael J Marino, Mei-Chin Hsieh, Eric L Wu, Xiao-Cheng Wu, Edward D McCoul
BACKGROUND: An association is suggested between gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR) and malignancy of the larynx in elderly patients in the United States. Early detection with flexible fiberoptic laryngoscopy (FFL) or CT remains poorly defined. METHODS: The Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database was queried from 2003 to 2011.A case-cohort design evaluated patients aged 66 and older with a diagnosis of GERD and/or LPR for the occurrence of FFL or CT within 6 months of the exposure diagnosis...
January 25, 2019: Head & Neck
Kenneth J Chang
In this paper, I reviewed the emerging field of endoscopic surgery and present data supporting the contention that endoscopy can now be used to treat many foregut diseases that have been traditionally treated surgically. Within each topic, the content will progress as follows: "lessons learned", "technical considerations" and "future opportunities". Lessons learned will provide a brief background and update on the most current literature. Technical considerations will include my personal experience, including tips and tricks that I have learned over the years...
January 7, 2019: World Journal of Gastroenterology: WJG
Stefan Harmsen, Stephan Rogalla, Ruimin Huang, Massimilano Spaliviero, Volker Neuschmelting, Yoku Hayakawa, Yoomi Lee, Yagnesh Tailor, Ricardo Toledo-Crow, Jeon Woong Kang, Jason M Samii, Hazem Karabeber, Ryan M Davis, Julie R White, Matt van de Rijn, Sanjiv S Gambhir, Christopher H Contag, Timothy Wang, Moritz F Kircher
Cancers of the gastrointestinal (GI) tract are among the most frequent and most lethal cancers worldwide. An important reason for this high mortality is that early disease is typically asymptomatic, and patients often present with advanced, incurable disease. Even in high-risk patients who routinely undergo endoscopic screening, lesions can be missed due to their small size or subtle appearance. Thus, current imaging approaches lack the sensitivity and specificity to accurately detect incipient GI tract cancers...
January 9, 2019: ACS Nano
Shinya Yamada, Waku Hatta, Tooru Shimosegawa, Kohei Takizawa, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Shiro Oka, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Naoki Nakaya, Takuji Gotoda
BACKGROUND AND AIMS: Cancer recurrence is observed in some patients without additional radical surgery after endoscopic submucosal dissection (ESD) that does not fulfill the curability criteria for early gastric cancer (EGC), categorized as "noncurative resection" or "curability C-2" in the guidelines. However, time to cancer recurrence is different in such patients. Thus, we aimed to identify the risk factors of early and late cancer recurrences in these patients...
November 19, 2018: Gastrointestinal Endoscopy
Andrew F Feczko, Brian E Louie
The article is a review of the principles behind endoscopic resection of esophageal dysplasia and early cancers. The techniques of endoscopic mucosal resection and endoscopic submucosal dissection are reviewed, and the supporting literature compared. Endoscopic resection is compared with esophagectomy for the management of these lesions and current areas of controversy with regard to T1b lesions and gastroesophageal reflux following resection are addressed.
November 2018: Thoracic Surgery Clinics
Xing Zhang, Dongtao Shi, Zhuwen Yu, Rui Li, Weichang Chen, Feihu Bai, Xudong Wu, Cuie Cheng, Ruihua Shi, Pengfei Liu
BACKGROUND AND AIM: Endoscopic submucosal tunnel dissection (ESTD) has been used for dissection of esophageal and gastric lesions. However, outcomes of ESTD for large lesions in the lesser gastric curvature had not been acknowledged because previous reports had the limitations of being single-center studies. We aimed to clarify the outcomes of ESTD for large lesser gastric curvature superficial neoplasms and provide our experience to accelerate its application. METHODS: Between July 2014 and July 2016, 87 patients with early cancer in the lesser gastric curvature treated at six Chinese institutions were enrolled...
September 27, 2018: Surgical Endoscopy
Pablo Priego, Marta Cuadrado, Araceli Ballestero, Julio Galindo, Eduardo Lobo
INTRODUCTION: Open gastrectomy (OG) has long been the preferred surgical approach worldwide for treatment of gastric cancer (GC). Nowadays, several randomized prospective trials have confirmed improvements in postoperative outcomes for laparoscopic gastrectomy (LG) compared with open procedures, with similar oncologic outcomes. However, many of these studies come from Eastern countries. MATERIALS AND METHODS: A prospective nonrandomized study was conducted with all patients operated of GC at Ramón y Cajal University Hospital from January 2015 to December 2017...
September 25, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Frances Notman, Terry Porteous, Peter Murchie, Christine M Bond
OBJECTIVES: Limited awareness of cancer symptoms results in patient delay in seeking help and contributes to delay in diagnosis. Few UK studies have investigated the potential for community pharmacists to facilitate earlier detection of cancer. This study aimed to investigate what actions patients take to manage their early cancer symptoms, to identify the extent of current community pharmacy involvement and to consider the potential role for community pharmacists to facilitate appropriate management and appraisal of potential early cancer symptoms...
September 25, 2018: International Journal of Pharmacy Practice
Jing-Jing Wan, Su-Juan Fei, Sheng-Xiang Lv, Shu-Tang Han, Xing-Gang Ma, Dong-Sheng Xu, Hong-Mei Chen, Ju Zhang
The present case study aimed to evaluate the effect of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer. A total of 513 patients who were diagnosed with gastric ulcers using gastroscopy between January 1999 and December 2013 were included in the present study and were divided into either the experimental or the control group. In the control group, samples were only taken from the ulcer margin, whereas in the experimental group samples were taken from the ulcer margin and from the ulcer base...
October 2018: Oncology Letters
Rin Yamada, Shin-Ichiro Horiguchi, Tomoko Onishi, Toru Motoi, Tsunekazu Hishima
Gastric carcinoma with enteroblastic differentiation (GCED) is a rare variant of gastric carcinoma, and a part of GCED produces alpha-fetoprotein. GCED is characterized by cells with clear cytoplasm and a tubulopapillary and solid growth pattern resembling those in the primitive gut. GCED is typically overlaid by a conventional adenocarcinoma (CA) component, implying that CA in the mucosa differentiates into GCED during tumor invasion and proliferation. We present the case of a 73-year-old woman with a 10-mm superficial elevated lesion and a slight central depression at the anterior wall of the lower gastric body...
2018: Case Reports in Pathology
In-Seob Lee, Hyo Jeong Kang, Young-Soo Park, Min-Hee Ryu, Jeong-Hwan Yook, Yoon-Koo Kang, Byung-Sik Kim
BACKGROUND: In addition to the TNM stage, an additional prognostic factor is needed to assess the prognosis of gastric cancer. Moreover, there is no consensus on high-risk group of recurrence and adjuvant strategy in stage 1B gastric cancers. We aimed to investigate the prognostic significance of extranodal extension (ENE) in stage 1B gastric carcinomas and assess whether ENE can indicate the need for adjuvant treatment. METHODS: The clinicopathological characteristics of 1588 patients who underwent curative gastrectomy with more than D1 plus lymphadenectomy for stage 1B gastric cancer from 2003 to 2010 were reviewed...
June 2018: Surgical Oncology
Gail L Matters, John F Harms
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016 , 13 , 74⁻75). There is an unmet need for reagents that can reliably identify early cancerous or precancerous lesions through various imaging modalities or could be employed to deliver anticancer treatments specifically to tumor cells. However, to date, many PDAC tumor-targeting strategies lack selectivity and are unable to discriminate between tumor and nontumor cells, causing off-target effects or unclear diagnoses...
June 2, 2018: Biomedicines
Tsung-Hsing Chen, Cheng-Tang Chiu, Chieh Lee, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Ren-Chin Wu, Ta-Sen Yeh, Kwang-Huei Lin
BACKGROUND: Gastric cancer has a poor outcome and identifying useful biomarkers from peripheral blood or tissue could allow its early detection, or potentially precancerous changes, thus improving the curative rates. MicroRNAs (miRNAs) have been shown to offer great potential in cancer diagnosis and prediction. AIM: Here, we investigated the role of plasma miRNAs in the natural course of gastric cancer, from intestinal metaplasia to early cancer. The findings were used to understand whether patients at a high risk of malignancy could be given appropriate interventions in the early disease process, such as using endoscopic submucosal dissection to treat gastric dysplasia or early gastric cancer...
May 7, 2018: Digestive Diseases and Sciences
Yan Li, Joseph Jing, Junxiao Yu, Buyun Zhang, Tiancheng Huo, Qiang Yang, Zhongping Chen
Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo. This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs...
May 1, 2018: Optics Letters
Ayse Z Sahan, Tapas K Hazra, Soumita Das
Pathogenic and commensal microbes induce various levels of inflammation and metabolic disease in the host. Inflammation caused by infection leads to increased production of reactive oxygen species (ROS) and subsequent oxidative DNA damage. These in turn cause further inflammation and exacerbation of DNA damage, and pose a risk for cancer development. Helicobacter pylori -mediated inflammation has been implicated in gastric cancer in many previously established studies, and Fusobacterium nucleatum presence has been observed with greater intensity in colorectal cancer patients...
2018: Frontiers in Microbiology
M Ebert
The follow-up care of patients with gastrointestinal cancer is poorly defined. Prospective trials showing that regular follow-up care is advantageous are largely lacking. Follow-up is primarily based on symptom evaluation, as well as on an assessment of nutritional status and the need for psycho-oncological care. Whereas the evidence for regular endoscopic follow-up is well defined in early cancers, the role of follow-up care in advanced cancers is less well defined. This deficit is mainly due to the lack of therapeutic consequences in the case of recurrence...
May 2018: Der Internist
Qiang Shi, Di Sun, Shi-Lun Cai, Mei-Dong Xu, Zhi-Peng Qi, Bing Li, Li-Qing Yao, Yun-Shi Zhong, Ping-Hong Zhou
OBJECTIVE: With the improvement of endoscopic diagnosis, the discovery rate of the synchronous multiple primary early cancers in esophagus and stomach is gradually increased, while the traditional surgery bringing serious damages. Endoscopic submucosal dissection (ESD) has become the first treatment option of early cancer in the digestive tract partly. This study intends to explore the feasibility, safety, and effectiveness of ESD in the treatment of the synchronous multiple early gastric cancer or precancerous lesions in the esophagus and stomach...
September 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hae Dong Woo, Nora Fernandez-Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young-Il Kim, Jeongseon Kim, Zdenko Herceg
The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with cancer risk independent of H. pylori. A discovery set of normal gastric mucosa from GC cases (n = 42) and controls (n = 42), nested in a large case-control study and stratified by H. pylori status, were subjected to genome-wide methylation profiling...
August 1, 2018: International Journal of Cancer. Journal International du Cancer
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