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Myocardial ischemia and infarction

Cem Doğan, Zübeyde Bayram, Murat Çap, Flora Özkalaycı, Tuba Unkun, Emrah Erdoğan, Abdulkadir Uslu, Rezzan Deniz Acar, Busra Guvendi, Özgur Yaşar Akbal, Ali Karagöz, Aykun Hakgor, Ahmet Karaduman, Samet Uysal, Ahmet Aykan, Cihangir Kaymaz, Nihal Özdemir
Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention...
February 15, 2019: Medicina
Kitti Szőke, Attila Czompa, István Lekli, Péter Szabados-Fürjesi, Mihály Herczeg, Magdolna Csávás, Anikó Borbás, Pál Herczegh, Árpád Tósaki
Ischemic heart conditions are among the main causes of sudden cardiac death worldwide. One of the strategies for avoiding myocardial infarction is the low-dose, prophylactic use of acetylsalicylic acid (ASA), an inhibitor of platelet aggregation. To avoid the gastrointestinal damage, ASA prodrugs bearing nitric oxide (NO)-donating moiety covalently conjugated to ASA have been synthesized and evaluated extensively worldwide. Herein the synthesis of a new hybrid ASA ester covalently attached to the NO donor linsidomine, an active metabolite of molsidomine (MOL) is reported...
February 16, 2019: European Journal of Pharmaceutical Sciences
Siwen Liang, Hongwei Li, Xuhua Shen, Ruifeng Liu
BACKGROUND: Previous studies suggested that adiponectin (APN) could ameliorate ischemia/reperfusion injury and endothelial dysfunction in patients with acute myocardial infarction. However, the relationship between serum APN level and coronary flow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) is unclear. METHODS: A total of 144 patients with STEMI treated by PPCI were enrolled and divided into two groups based on the mean serum APN level on admission...
February 19, 2019: Journal of Clinical Laboratory Analysis
Y Zhou, D-D Peng, H Chong, S-Q Zheng, F Zhu, G Wang
OBJECTIVE: To investigate the effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS: A total of 36 specific-pathogen-free (SPF) Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12) and isoflurane group (n=12). In model group and isoflurane group, the myocardial ischemia-reperfusion injury model was established via the ligation of left anterior descending coronary artery (ischemia for 30 min and reperfusion for 3 h)...
February 2019: European Review for Medical and Pharmacological Sciences
Andrei C Sposito, Helison R Carmo, Joaquim Barreto, Lufan Sun, Luiz Sergio F Carvalho, Steve B Feinstein, Ilaria Zanotti, Anatol Kontush, Alan Remaley
It is now apparent that a variety of deleterious mechanisms intrinsic to myocardial infarction (MI) exists and underlies its high residual lethality. Indeed, despite effective coronary patency therapies, ischemia and reperfusion (I/R) injury accounts for about 50% of the infarcted mass. In this context, recent studies in animal models have demonstrated that coronary reperfusion with high-density lipoproteins (HDL) may reduce MI size in up to 30%. A spectrum of mechanisms mediated by either HDL-related apolipoproteins or phospholipids attenuates myocardial cell death...
February 18, 2019: Cardiovascular Drugs and Therapy
N R Bonetti, C Diaz-Cañestro, L Liberale, M Crucet, A Akhmedov, M Merlini, M F Reiner, S Gobbato, S Stivala, G Kollias, F Ruschitzka, T F Lüscher, J H Beer, G G Camici
Rheumatoid Arthritis (RA) is a chronic inflammatory disorder where incidence and severity of myocardial infarction are increased. Data on the incidence and outcome of stroke are conflicting. Thus, we investigated outcome after Ischemia/Reperfusion (I/R) brain injury in a mouse model of RA and assessed for the role of the tumour necrosis factor-α (TNF-α) inhibitor Infliximab herein. We used a TNF-α reliant mouse model of RA. RA and wildtype (WT) animals were treated with vehicle (RA/WT) or Infliximab (RA Infliximab) for 4 weeks, before undergoing I/R brain injury...
February 18, 2019: Scientific Reports
Besma Nejim, Devin Zarkowsky, Caitlin W Hicks, Satinderjit Locham, Hanaa Dakour Aridi, Mahmoud Malas
BACKGROUND: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. METHODS: The Vascular Quality Initiative database was explored from 2003 to 2017...
February 15, 2019: Journal of Vascular Surgery
Carlos A Molina, S Claiborne Johnston, Per Ladenvall, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Mikael Knutsson, Kazuo Minematsu, Joachim Röther, Yongjun Wang, K S Lawrence Wong
Background and Purpose- Recurrent ischemia risk is high in the acute period after cerebral ischemic events. Effects of antiplatelet agents may vary by time to loading dose (TLD). We explored the risk of recurrent events and safety and efficacy of ticagrelor versus aspirin in relation to TLD. Methods- We randomized 13 199 patients with noncardioembolic, nonsevere ischemic stroke, or high-risk transient ischemic attack to 90-day ticagrelor or aspirin treatment within 24 hours of symptom onset. For this analysis, 13 126 patients were categorized by TLD as <12 hours or ≥12 hours from start of index event...
February 19, 2019: Stroke; a Journal of Cerebral Circulation
Janet R Manning, Dharendra Thapa, Manling Zhang, Michael W Stoner, Javier Traba, Charles F McTiernan, Catherine Corey, Sruti Shiva, Michael N Sack, Iain Scott
GCN5L1 regulates mitochondrial protein acetylation, cellular bioenergetics, reactive oxygen species (ROS) generation, and organelle positioning in a number of diverse cell types. However, the functional role of GCN5L1 in the heart is currently unknown. As many of the factors regulated by GCN5L1 play a major role in ischemia-reperfusion (I/R) injury, we sought to determine if GCN5L1 is an important nexus in the response to cardiac ischemic stress. Deletion of GCN5L1 in cardiomyocytes resulted in impaired myocardial post-ischemic function and increased infarct development in isolated work-performing hearts...
February 15, 2019: Journal of Molecular and Cellular Cardiology
Jun Ma, Ge Jin
Alleviating the oxidant stress associated with myocardial ischemia reperfusion has been demonstrated as a potential therapeutic approach to limit ischemia reperfusion (I/R)-induced cardiac damage. It's reported that EGFR/erbB2 signaling is an important cardiac survival pathway in cardiac function and activation of EGFR has a cardiovascular effect in global ischemia. Epidermal growth factor (EGF), a typical EGFR ligand, was considered to have a significant role in activating EGFR. However, no evidence has been published whether exogenous EGF has protective effects on myocardial ischemia reperfusion...
February 18, 2019: Free Radical Research
Yu Du, Yingxin Zhao, Yong Zhu, Chenping Hu, Jianwei Zhang, Qingwei Ji, Wei Liu, Hongya Han, Lixia Yang, Dai Zhang, Shan Tong, Zhijian Wang, Yonghe Guo, Xiaoli Liu, Yujie Zhou
AIM: Several members of secreted frizzled-related protein (SFRP) are involved in the process of myocardial ischemia-reperfusion injury. However, little is known about the role of SFRP5 in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: In this cross-sectional study, 85 patients with first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 patients without coronary artery disease (CAD) were enrolled...
February 15, 2019: Journal of Atherosclerosis and Thrombosis
Zhonglin Liu, Christy Barber, Akash Gupta, Li Wan, Young-Wook Won, Lars R Furenlid, Qin Chen, Ankit A Desai, Ming Zhao, David A Bull, Evan C Unger, Diego R Martin
INTRODUCTION: The objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using 99m Tc-duramycin SPECT imaging. METHODS: Rat hearts with Ischemia-reperfusion (I/R) was prepared by coronary ligation for 45-min followed by reperfusion. The feasibility of 99m Tc-duramycin in detecting myocardial I/R injury and its kinetic profile were first verified in the ischemic hearts with 2-h reperfusion (n = 6)...
January 17, 2019: Nuclear Medicine and Biology
Pearl Quijada, Adwiteeya Misra, Lissette S Velasquez, Ryan M Burke, Janet K Lighthouse, Deanne M Mickelsen, Ronald A Dirkx, Eric M Small
Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are essential for epicardium-derived progenitor cell (EPDC)-mobilization during heart development; however, the impact of developmental EPDC deficiencies on adult cardiac physiology has not been evaluated. Here, we utilize the Wilms Tumor-1 (Wt1)-Cre to delete Mrtfs or Srf in the epicardium, which reduced the number of EPDCs in the adult cardiac interstitium. Deficiencies in Wt1-lineage EPDCs prevented the development of cardiac fibrosis and diastolic dysfunction in aged mice...
February 13, 2019: Journal of Molecular and Cellular Cardiology
Anna Lisowska, Przemysław Święcki, Małgorzata Knapp, Monika Gil, Włodzimierz J Musiał, Karol Kamiński, Tomasz Hirnle, Agnieszka Tycińska
PURPOSE: The role of insulin-like growth factor-binding protein-7 (IGFBP-7) in atherosclerosis is still not well-known. The objective of this study was to find out the following: 1) whether IGFBP-7 may act as a biomarker of coronary artery disease (CAD) occurrence and extent; 2) whether IGFBP-7 is potentially related to the classical and new markers of cardiovascular risk (carotid intima-media thickness - cIMT); 3) whether IGFBP-7 may be a marker of mortality in the group of patients with myocardial infarction (MI)...
February 12, 2019: Advances in Medical Sciences
Johanna Magga, Laura Vainio, Teemu Kilpiö, Juha J Hulmi, Saija Taponen, Ruizhu Lin, Markus Räsänen, Zoltán Szabó, Erhe Gao, Lea Rahtu-Korpela, Tarja Alakoski, Johanna Ulvila, Mika Laitinen, Arja Pasternack, Walter J Koch, Kari Alitalo, Riikka Kivelä, Olli Ritvos, Risto Kerkelä
Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury. Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) and subjected to myocardial ischemia followed by reperfusion for 6 or 24 h. Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function following IR...
January 24, 2019: Molecular Therapy: the Journal of the American Society of Gene Therapy
Ahmed AlBadri, C Noel Bairey Merz, B Delia Johnson, Janet Wei, Puja K Mehta, Galen Cook-Wiens, Steven E Reis, Sheryl F Kelsey, Vera Bittner, George Sopko, Leslee J Shaw, Carl J Pepine, Bina Ahmed
BACKGROUND: Currently as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery disease (CAD), and abnormal coronary reactivity (CR) is commonly found. OBJECTIVES: The authors prospectively investigated CR and longer-term adverse cardiovascular outcomes in women with and with no obstructive CAD in the National Heart, Lung, and Blood Institute-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. METHODS: Women (n = 224) with signs and symptoms of ischemia underwent CR testing...
February 19, 2019: Journal of the American College of Cardiology
Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
The development of new capillary networks in engineered constructs is essential for their survival and their integration with the host tissue. It has recently been demonstrated that ELR-based hydrogels encoding different bioactivities are able to modulate their interaction with the host after injection or implantation, as indicated by an increase in cell adhesion and the ability to trigger vascularization processes. Accordingly, the aim of this study was to increase their angiogenic ability both in vitro and in vivo using a small VEGF mimetic peptide named QK, which was tethered chemically to ELR-based hydrogels containing cell-adhesion sequences in their backbone, such as REDV and RGD, as well as a proteolytic site (VGVAPG)...
February 14, 2019: Journal of Materials Science. Materials in Medicine
Jinxuan Zhao, Xueling Li, Jiaxin Hu, Fu Chen, Shuaihua Qiao, Xuan Sun, Ling Gao, Jun Xie, Biao Xu
Aims: Mesenchymal stem cells (MSCs) gradually become attractive candidates for cardiac inflammation modulation, yet understanding of the mechanism remains elusive. Strikingly, recent studies indicated that exosomes secreted by MSCs might be a novel mechanism for the beneficial effect of MSCs transplantation after myocardial infarction. We therefore explored the role of MSC-derived exosomes (MSC-Exo) in the immunomodulation of macrophages after myocardial ischemia/reperfusion (I/R) and its implications in cardiac injury repair...
February 8, 2019: Cardiovascular Research
Stefano Toldo, Adolfo Gabriele Mauro, Zachary Cutter, Benjamin W Van Tassell, Eleonora Mezzaroma, Marco Giuseppe Del Buono, Andrea Prestamburgo, Nicola Potere, Antonio Abbate
BACKGROUND: Activation of the NLRP3 inflammasome is a primary driver of sterile inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of the NLRP3 inflammasome are being developed. We proposed that OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could preserve myocardial function after ischemia reperfusion injury in the mouse. METHODS: We used an experimental murine model of myocardial ischemia reperfusion injury through transient ligation of the left coronary artery, and measured the effects of OLT1177 (6, 60 or 600 mg/kg intraperitoneal dose) on infarct size at pathology and on systolic cardiac function at echocardiography...
February 8, 2019: Journal of Cardiovascular Pharmacology
S Claiborne Johnston, Pierre Amarenco, Hans Denison, Scott R Evans, Anders Himmelmann, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A Molina, Yongjun Wang
RATIONALE: In patients with acute cerebral ischemia, the rate of stroke, myocardial infarction, or death during 90 days was reported to be non-significantly lower with ticagrelor compared with aspirin, with no increase in major hemorrhage. Dual antiplatelet therapy may be more effective in this setting. AIM: To investigate whether ticagrelor combined with aspirin are superior to aspirin alone in preventing stroke or death in patients with non-severe, non-cardioembolic ischemic stroke or high-risk transient ischemic attack...
February 12, 2019: International Journal of Stroke: Official Journal of the International Stroke Society
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