keyword
https://read.qxmd.com/read/38536649/emergent-coronary-thrombectomy-for-acute-myocardial-infarction-immediately-following-craniotomy-with-tumor-resection
#1
JOURNAL ARTICLE
Curtis R Ginder, Giselle A Suero-Abreu, Saad S Ghumman, Brian A Bergmark, Omar Arnaout, Robert P Giugliano
The management of perioperative acute myocardial infarction (AMI) following oncologic neurosurgery requires balancing competing risks of myocardial ischemia and postoperative bleeding. There are limited human data to establish the safest timing of antiplatelet or anticoagulation therapy following neurosurgical procedures. For patients with malignancy experiencing AMI in the acute postoperative period, staged percutaneous coronary intervention (PCI) with upfront coronary aspiration thrombectomy followed by delayed completion PCI may offer an opportunity for myocardial salvage while minimizing postoperative bleeding risks...
March 27, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38533432/nicotinamide-ribose-ameliorates-myocardial-ischemia-reperfusion-injury-by-regulating-autophagy-and-regulating-oxidative-stress
#2
JOURNAL ARTICLE
Chen Yuan, Heng Yang, Wanqi Lan, Juesheng Yang, Yanhua Tang
Nicotinamide riboside (NR) has been reported to play a protective role in myocardial ischemia-reperfusion (I/R) injury when used in association with other drugs; however, the individual effect of NR is unknown. In the present study Evan's blue/triphenyl tetrazolium chloride staining, hematoxylin and eosin staining, echocardiography, western blotting, reverse transcription-quantitative PCR, and the detection of myocardial injury-associated markers and oxidative stress metabolites were used to explore the ability of NR to alleviate cardiac I/R injury and the relevant mechanisms of action...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38531800/the-value-of-combined-detection-of-serum-bnp-cardiac-troponin-i-and-dynamic-electrocardiogram-in-early-clinical-diagnosis-and-prognosis-of-patients-with-acute-myocardial-infarction
#3
JOURNAL ARTICLE
Qinxia Yu, Shuyan Yu
BACKGROUND: Acute myocardial infarction (AMI) is a prevalent cardiovascular disease resulting from myocardial ischemia and necrosis due to coronary artery occlusion. AMI is characterized by a sudden onset and high mortality, underscoring the significance of early diagnosis and treatment for improving patient prognosis. This study endeavors to assess the utility of a combined assessment involving serum brain natriuretic peptide (BNP), cardiac troponin-I (cTnI), and dynamic electrocardiogram (ECG) in the early clinical diagnosis and prognosis prediction of AMI...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38528077/nuciferine-reduces-vascular-leakage-and-improves-cardiac-function-in-acute-myocardial-infarction-by-regulating-the-pi3k-akt-pathway
#4
JOURNAL ARTICLE
Wei Xie, Shumin Chen, Wenzhe Wang, Xichun Qin, Chuiyu Kong, Dongjin Wang
The destruction of the microvascular structure and function can seriously affect the survival and prognosis of patients with acute myocardial infarction (AMI). Nuciferine has a potentially beneficial effect in the treatment of cardiovascular disease, albeit its role in microvascular structure and function during AMI remains unclear. This study aimed to investigate the protective effect and the related mechanisms of nuciferine in microvascular injury during AMI. Cardiac functions and pathological examination were conducted in vivo to investigate the effect of nuciferine on AMI...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38527629/machine-learning-to-identify-a-composite-indicator-to-predict-cardiac-death-in-ischemic-heart-disease
#5
JOURNAL ARTICLE
Alessandro Pingitore, Chenxiang Zhang, Cristina Vassalle, Paolo Ferragina, Patrizia Landi, Francesca Mastorci, Rosa Sicari, Alessandro Tommasi, Cesare Zavattari, Giuseppe Prencipe, Alina Sîrbu
BACKGROUND: Machine learning (ML) employs algorithms that learn from data, building models with the potential to predict events by aggregating a large number of variables and assessing their complex interactions. The aim of this study is to assess ML potential in identifying patients with ischemic heart disease (IHD) at high risk of cardiac death (CD). METHODS: 3987 (mean age 68 ± 11) hospitalized IHD patients were enrolled. We implemented and compared various ML models and their combination into ensembles...
March 23, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38524576/cardioprotective-effect-of-antioxidant-combination-therapy-a-highlight-on-mitoq-plus-alpha-lipoic-acid-beneficial-impact-on-myocardial-ischemia-reperfusion-injury-in-aged-rats
#6
JOURNAL ARTICLE
Zohreh Zavvari Oskuye, Keyvan Mehri, Behnaz Mokhtari, Soleyman Bafadam, Samira Nemati, Reza Badalzadeh
OBJECTIVE: (s): Considering the poor prognosis of ischemic heart disease and the diminished effectiveness of cardioprotective interventions in the elderly, it becomes necessary to investigate the interaction of aging with protection during myocardial ischemia/reperfusion injury (IRI). This study was conducted to assess the impact of mitoquinone (MitoQ) and alpha-lipoic acid (ALA) preconditioning on cardioprotection following IRI in aged rats. METHODS: Fifty aged male Wistar rats (22-24 months old) were divided into five groups including Sham, IR, and treatment groups receiving ALA and/or MitoQ...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38520176/coronary-microvascular-dysfunction-assessment-a-comparative-analysis-of-procedural-aspects
#7
JOURNAL ARTICLE
Ilan Merdler, Ryan Wallace, Avantika Banerjee, Giorgio A Medranda, Pavan Reddy, Matteo Cellamare, Cheng Zhang, Sevket Tolga Ozturk, Vaishnavi Sawant, Kassandra Lopez, Itsik Ben-Dor, Ron Waksman, Brian C Case, Hayder D Hashim
BACKGROUND: Full adoption of coronary microvascular dysfunction (CMD) assessment faces challenges due to its invasive nature and concerns about prolonged procedure time and increased contrast and/or radiation exposure. We compared procedural aspects of CMD invasive assessment to diagnostic left heart catheterization (DLHC) in patients with chest pain who were not found to have obstructive coronary artery disease. METHODS: A total of 227 patients in the Coronary Microvascular Disease Registry were compared to 1592 patients who underwent DLHC from August 2021 to November 2023...
March 23, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38518962/diagnosis-and-treatment-of-ischemia-producing-coronary-stenoses-improves-5-year-survival-of-patients-undergoing-major-vascular-surgery
#8
JOURNAL ARTICLE
Dainis K Krievins, Edgars Zellans, Gustavs Latkovskis, Indulis Kumsars, Agate K Krievina, Sanda Jegere, Andrejs Erglis, Aigars Lacis, Erika Plopa, Peteris Stradins, Patricija Ivanova, Christopher K Zarins
BACKGROUND: Patients undergoing vascular surgery procedures have poor long-term survival due to coexisting coronary artery disease (CAD) which is often asymptomatic, undiagnosed and undertreated. We sought to determine whether pre-operative diagnosis of asymptomatic (silent) coronary ischemia using coronary CT -derived fractional flow reserve (FFRCT ) together with post-operative ischemia-targeted coronary revascularization can reduce adverse cardiac events and improve long-term survival following major vascular surgery...
March 20, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38518637/exploring-the-role-and-mechanism-of-hyperoside-against-cardiomyocyte-injury-in-mice-with-myocardial-infarction-based-on-jak2-stat3-signaling-pathway
#9
JOURNAL ARTICLE
Tingcai Rao, Hua Tong, Jing Li, Jiahao Huang, Yanyan Yin, Junyan Zhang
BACKGROUND: Myocardial infarction (MI) is one of the most deadly diseases in the world. Hyperoside (Hyp) has been shown to have a protective effect on cardiovascular function through various signaling pathways, but whether it can protect myocardial infarction by regulating JAK2/STAT3 signaling pathway is unknown. AIM OF THE STUDY: To investigate whether Hyp could protect the heart against myocardial infarction injury in mice by modulating JAK2/STAT3 signaling pathway and its potential mechanism...
December 25, 2023: Phytomedicine
https://read.qxmd.com/read/38518600/emerging-regulatory-mechanisms-in-cardiovascular-disease-ferroptosis
#10
REVIEW
Sijie Jin, He Wang, Xiaohao Zhang, Mengyang Song, Bin Liu, Wei Sun
Ferroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a novel iron-dependent regulated cell death characterized by the accumulation of lipid peroxides and redox imbalance with distinct morphological, biochemical, and genetic features. Dysregulation of iron homeostasis, the disruption of antioxidative stress pathways and lipid peroxidation are crucial in ferroptosis. Ferroptosis is involved in the pathogenesis of several cardiovascular diseases, including atherosclerosis, cardiomyopathy, myocardial infarction, ischemia-reperfusion injury, abdominal aortic aneurysm, aortic dissection, and heart failure...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38516440/japanese-traditional-herbal-medicine-rikkunshito-partially-suppresses-inflammatory-responses-in-myocardial-ischemia-reperfusion-injury
#11
JOURNAL ARTICLE
Tomoe Sato, Yasuaki Sawashita, Yusuke Yoshikawa, Michiaki Yamakage
INTRODUCTION: Myocardial ischemia/reperfusion (I/R) injury can cause additional damage to an ischemic myocardium, even after successful reperfusion therapy. Inflammation is a mechanism that exacerbates myocardial damage after I/R injury. Rikkunshito   (RKT) is a traditional Japanese herbal medicine widely used to treat gastrointestinal symptoms. It attenuates inflammation and fibrosis in some diseases of the heart; however, it remains unclear whether RKT exerts cardioprotective effects against myocardial I/R injury...
February 2024: Curēus
https://read.qxmd.com/read/38515760/crosstalk-between-ubiquitin-ligases-and-ncrnas-drives-cardiovascular-disease-progression
#12
REVIEW
Jia-Rui You, Zeng-Jin Wen, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Hui Xin, Pei-Feng Li, Yin-Feng Zhang, Rui Zhang
Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin-proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515365/ischemia-induced-cardiac-dysfunction-is-exacerbated-in-adiponectin-knockout-mice-due-to-impaired-autophagy-flux
#13
JOURNAL ARTICLE
Hye Kyoung Sung, Jialing Tang, James Won Suk Jahng, Erfei Song, Yee Kwan Chan, Abdul Hadee Lone, Jeffrey Peterson, Ali Abdul-Sater, Gary Sweeney
Strategies to enhance autophagy flux have been suggested to improve outcomes in cardiac ischemic models. We explored the role of adiponectin in mediating cardiac autophagy under ischemic conditions induced by permanent coronary artery ligation. We studied the molecular mechanisms underlying adiponectin's cardio-protective effects in adiponectin knockout (Ad-KO) compared with wild-type (WT) mice subjected to ischemia by coronary artery ligation and H9c2 cardiomyocyte cell line exposed to hypoxia. Systemic infusion of a cathepsin-B activatable near-infrared probe as a biomarker for autophagy and detection via noninvasive three-dimensional fluorescence molecular tomography combined with computerized tomography to quantitate temporal changes, indicated increased activity in the myocardium of WT mice after myocardial infarction which was attenuated in Ad-KO...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38514522/effects-of-ivabradine-on-myocardial-perfusion-in-chronic-angina-a-prospective-preliminary-open-label-single-arm-study
#14
JOURNAL ARTICLE
Olímpio R França Neto, Miguel M Fernandes-Silva, Rodrigo J Cerci, Carlos A Cunha-Pereira, Margaret Masukawa, João V Vitola
INTRODUCTION: Ivabradine reduces heart rate (HR), episodes of angina, and nitrate consumption, and increases exercise capacity in patients with chronic angina (CA). In this exploratory study, myocardial perfusion scintigraphy (MPS) was used to evaluate changes in the percentage of myocardial ischemia after ivabradine therapy in patients with CA. METHODS: This prospective, open-label, single-arm study included patients with CA receiving maximum tolerated doses of beta blockers, who had a resting HR ≥ 70 bpm and had experienced ischemia according to MPS during an exercise test at baseline...
March 22, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38511326/remnant-cholesterol-not-ldl-cholesterol-explains-peripheral-artery-disease-risk-conferred-by-apob-a-cohort-study
#15
JOURNAL ARTICLE
Benjamin N Wadström, Kasper M Pedersen, Anders B Wulff, Børge G Nordestgaard
BACKGROUND: Elevated apoB-containing lipoproteins (=remnants+LDLs [low-density lipoproteins]) are a major risk factor for atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) and myocardial infarction. We tested the hypothesis that remnants and LDL both explain part of the increased risk of PAD conferred by elevated apoB-containing lipoproteins. For comparison, we also studied the risk of chronic limb-threatening ischemia and myocardial infarction. METHODS: apoB, remnant cholesterol, and LDL cholesterol were measured in 93 461 individuals without statin use at baseline from the Copenhagen General Population Study (2003-2015)...
March 21, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38510502/elevated-high-density-lipoprotein-cholesterol-and-adverse-outcomes-in-women-with-symptoms-of-ischemic-heart-disease
#16
JOURNAL ARTICLE
Sachini Ranasinghe, Yujie Cui, Amer Muhyieddeen, Okezi Obrutu, Janet Wei, Martha Gulati, Vera Bittner, Steven Reis, Eileen Handberg, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Emerging data in the general population and those with coronary artery disease demonstrate higher risk of adverse outcomes with high (>70 mg/dL) HDL-C levels. There are limited data on the risk of adverse outcomes in women with suspected ischemic heart disease. OBJECTIVE: To investigate relationships between high (>70 mg/dL), average (50-70 mg/dL), and low (<50 mg/dL) HDL-C levels with major adverse cardiac events (MACE) (death, myocardial infarction, stroke, and heart failure hospitalization), and all-cause mortality in women referred for coronary angiography for suspected myocardial ischemia...
April 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38508437/oxidized-dj-1-activates-the-p-ikk-nf-%C3%AE%C2%BAb-beclin1-pathway-by-binding-pten-to-induce-autophagy-and-exacerbate-myocardial-ischemia-reperfusion-injury
#17
JOURNAL ARTICLE
Huiru Liu, Xueying Wang, Kang He, Zihan Chen, Xiaoqi Li, Jianmin Ren, Xiaoyan Zhao, Song Liu, Tingting Zhou, Heping Chen
Patients with myocardial infarction have a much worse prognosis when they have myocardial ischemia-reperfusion (I/R) injury. Further research into the molecular basis of myocardial I/R injury is therefore urgently needed, as well as the identification of novel therapeutic targets and linkages to interventions. Three cysteine residues are present in DJ-1 at amino acids 46, 53, and 106 sites, with the cysteine at position 106 being the most oxidation-prone. This study sought to understand how oxidized DJ-1(C106) contributes to myocardial I/R damage...
March 18, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38507809/fabrication-of-a-tailor-made-conductive-polyaniline-ascorbic-acid-coated-nanofibrous-mat-as-a-conductive-and-antioxidant-cell-free-cardiac-patch
#18
JOURNAL ARTICLE
Farzad Moradikhah, Iman Shabani, Mohammad Tafazzoli-Shadpour
Polyaniline (PANI) was in-situ polymerized on nanofibrous polycaprolactone mats as cell-free antioxidant cardiac patches (CPs), providing electrical conductivity and antioxidant properties. The fabricated CPs took advantage of intrinsic and additive antioxidant properties in the presence of PANI backbone and ascorbic acid as a biocompatible dopant of PANI. The antioxidant nature of CPs may reduce the serious repercussions of oxidative stress, produced during the ischemia-reperfusion (I/R) process following myocardial infarction...
March 20, 2024: Biofabrication
https://read.qxmd.com/read/38504186/effect-of-residual-myocardial-ischemia-on-recovery-of-left-ventricular-function-after-primary-percutaneous-coronary-intervention
#19
JOURNAL ARTICLE
Mohamed Aly Abdelhafez, Karim M E Aly, Amr A A Youssef
BACKGROUND: It is unknown whether the existence of severe bystander damage will affect left ventricular (LV) healing following primary percutaneous coronary intervention (PPCI). The aim of the present analysis was to follow LV recovery using 2D speckle tracking echocardiography (2-D STE) in cases with single versus multiple vessel disease with acute myocardial infarction (AMI) who underwent PPCI and to assess major adverse cardiovascular events (MACEs) within 3 months. PATIENTS AND METHODS: This work was conducted at Assiut University Heart Hospital...
March 19, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38503934/mir-181a-protects-the-heart-against-myocardial-infarction-by-regulating-mitochondrial-fission-via-targeting-programmed-cell-death-protein-4
#20
JOURNAL ARTICLE
Jianbing Zhu, Qian Wang, Zeqi Zheng, Leilei Ma, Junjie Guo, Hongtao Shi, Ru Ying, Beilei Gao, Shanshan Chen, Siyang Yu, Bin Yuan, Xiaoping Peng, Junbo Ge
Worldwide, myocardial infarction (MI) is the leading cause of death and disability-adjusted life years lost. Recent researches explored new methods of detecting biomarkers that can predict the risk of developing myocardial infarction, which includes identifying genetic markers associated with increased risk. We induced myocardial infarction in mice by occluding the left anterior descending coronary artery and performed TTC staining to assess cell death. Next, we performed ChIP assays to measure the enrichment of histone modifications at the promoter regions of key genes involved in mitochondrial fission...
March 19, 2024: Scientific Reports
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