Kanishk Kaushik, Anna M de Kort, Rosemarie van Dort, Reinier G J van der Zwet, Bob Siegerink, Sabine Voigt, Erik W van Zwet, Maaike C van der Plas, Emma A Koemans, Ingeborg Rasing, Roy P C Kessels, Huub A M Middelkoop, Floris H B M Schreuder, Catharina J M Klijn, Marcel M Verbeek, Gisela M Terwindt, Ellis S van Etten, Marieke J H Wermer
BACKGROUND: Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes of intracerebral hemorrhage (ICH) and dementia in the elderly, remains unclear. We investigated NPS, with emphasis on apathy and irritability in sporadic (sCAA) and Dutch-type hereditary (D-)CAA. METHODS: We included patients with sCAA and (pre)symptomatic D-CAA, and controls from four prospective cohort studies. We assessed NPS per group, stratified for history of ICH, using the informant-based Neuropsychiatric Inventory (NPI-Q), Starkstein Apathy scale (SAS), and Irritability Scale...
April 6, 2024: Alzheimer's Research & Therapy