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https://read.qxmd.com/read/30765686/psychobiological-factors-of-resilience-and-depression-in-late-life
#1
Kelsey T Laird, Beatrix Krause, Cynthia Funes, Helen Lavretsky
In contrast to traditional perspectives of resilience as a stable, trait-like characteristic, resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long interactions between internal and environmental resources. We review psychosocial and neurobiological factors associated with resilience to late-life depression (LLD). Recent research has identified both psychosocial characteristics associated with elevated LLD risk (e.g., insecure attachment, neuroticism) and psychosocial processes that may be useful intervention targets (e...
February 14, 2019: Translational Psychiatry
https://read.qxmd.com/read/30765023/the-diagnosis-and-treatment-of-carbon-monoxide-poisoning
#2
Lars Eichhorn, Marcus Thudium, Björn Jüttner
BACKGROUND: The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging from dizziness and headache to unconsciousness and death. A German national guideline on the diagnosis and treatment of this condition is lacking at present. METHODS: This review is based on a selective literature search in the PubMed and Cochrane databases, as well as on existing guidelines from abroad and expert recommendations on diagnosis and treatment. RESULTS: The initiation of 100% oxygen breathing as early as possible is the most important treatment for carbon monoxide poisoning...
December 24, 2018: Deutsches Ärzteblatt International
https://read.qxmd.com/read/30759363/plausible-biochemical-mechanisms-of-chemotherapy-induced-cognitive-impairment-chemobrain-a-condition-that-significantly-impairs-the-quality-of-life-of-many-cancer-survivors
#3
REVIEW
Xiaojia Ren, Diana Boriero, Luksana Chaiswing, Subbarao Bondada, Daret K St Clair, D Allan Butterfield
Increasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called "chemobrain" or "chemofog" by patients, brings enormous challenges to cancer survivors following successful chemotherapeutic treatment. Decreased abilities of learning, memory, attention, executive function and processing speed in cancer survivors with CICI, are some of the challenges that greatly impair survivors' quality of life...
February 10, 2019: Biochimica et biophysica acta. Molecular basis of disease
https://read.qxmd.com/read/30757955/long-term-cognitive-dysfunction-after-radiation-therapy-for-primary-brain-tumors
#4
Lene Haldbo-Classen, Ali Amidi, Lisa M Wu, Slavka Lukacova, Gorm von Oettingen, Hanne Gottrup, Robert Zachariae, Morten Høyer
BACKGROUND: The extent of radiation therapy (RT)-induced changes in cognitive function is unknown. RT with protons instead of photons spares the healthy brain tissue more and is believed to reduce the risk of cognitive dysfunction. There is modest knowledge on which parts of the brain we need to spare, to prevent cognitive dysfunction. To uncover which cognitive domains is most affected, we compared cognitive functioning in brain tumor patients treated with neurosurgery and RT with brain tumor patients treated with neurosurgery alone...
February 13, 2019: Acta Oncologica
https://read.qxmd.com/read/30756278/theoretical-rationale-and-case-illustration-of-mindfulness-based-cognitive-therapy-for-fear-of-cancer-recurrence
#5
Christina M Luberto, Daniel L Hall, Emma Chad-Friedman, Elyse R Park
Fear of cancer recurrence (FCR) is a common problem among cancer survivors and evidence-based interventions grounded in theoretical models are needed. Mindfulness-Based Cognitive Therapy (MBCT) is an evidence-based intervention for reducing health anxiety that could be useful to apply to FCR. However, there has only been one study of MBCT for FCR to date, and the theoretical rationale and practical application of MBCT for FCR has not been described. The purpose of this paper is to offer an evidence-based rationale for MBCT to treat FCR based on a health anxiety model; describe the process of adapting MBCT to target FCR; and present a case study of the adapted protocol for treating FCR in a young adult breast cancer survivor to illustrate its delivery, feasibility, acceptability, and associated changes in outcomes...
February 11, 2019: Journal of Clinical Psychology in Medical Settings
https://read.qxmd.com/read/30755338/magnetic-resonance-imaging-predictors-of-psychotherapy-treatment-response-in-post-traumatic-stress-disorder-a-role-for-the-salience-network
#6
REVIEW
Philip R Szeszko, Rachel Yehuda
The earliest neuroimaging studies in post-traumatic stress disorder (PTSD) utilized positron emission tomography (PET) to examine the brain's response to glucocorticoid administration given predominant neurobiological models of the stress response focusing on that neuroendocrine system. This work revealed that the anterior cingulate cortex and amygdala, which is now considered part of the salience network, play a role in treatment response, and set the stage for subsequent magnetic resonance (MR) imaging studies focused on understanding the role of the salience network in the neurobiology of treatment response in PTSD...
February 2, 2019: Psychiatry Research
https://read.qxmd.com/read/30744034/assessment-and-management-of-hiv-associated-cognitive-impairment-experience-from-a-multidisciplinary-memory-service-for-people-living-with-hiv
#7
Kate Alford, Sube Banerjee, Eileen Nixon, Clara O'Brien, Olivia Pounds, Andrew Butler, Claire Elphick, Phillip Henshaw, Stuart Anderson, Jaime H Vera
As the HIV population ages, the prevalence of cognitive impairment (CI) is increasing, yet few services exist for the assessment and management of these individuals. Here we provide an initial description of a memory assessment service for people living with HIV and present data from a service evaluation undertaken in the clinic. We conducted an evaluation of the first 52 patients seen by the clinic. We present patient demographic data, assessment outcomes, diagnoses given and interventions delivered to those seen in the clinic...
February 8, 2019: Brain Sciences
https://read.qxmd.com/read/30742471/therapeutic-alliance-across-trauma-focused-and-non-trauma-focused-psychotherapies-among-veterans-with-ptsd
#8
Jessica A Chen, John C Fortney, Hannah E Bergman, Kendall C Browne, Kathleen M Grubbs, Teresa J Hudson, Patrick J Raue
Trauma-focused psychotherapies for posttraumatic stress disorder (PTSD) are not widely utilized. Clinicians report concerns that direct discussion of traumatic experiences could undermine the therapeutic alliance, which may negatively impact retention and outcome. Studies among adolescents with PTSD found no difference in alliance between trauma-focused and non-trauma-focused psychotherapies, but this has not been tested among adults. The present study is a secondary analysis of a randomized trial of collaborative care, also known as care management, for PTSD...
February 11, 2019: Psychological Services
https://read.qxmd.com/read/30741438/patients-experiences-of-brief-cognitive-behavioral-therapy-for-eating-disorders-a-qualitative-investigation
#9
Jessica I Hoskins, Lauren Blood, Holly R Stokes, Madeleine Tatham, Glenn Waller, Hannah Turner
OBJECTIVE: Although it is important to analyze the effectiveness of new therapies, it is also necessary to consider how patients experience them. This is particularly important if we are to maximize treatment acceptability and reduce attrition. This study examined patient experiences of a new 10-session cognitive-behavioral therapy (CBT-T), using a qualitative approach. METHOD: The sample was 17 patients with a diagnosis of bulimia nervosa who had received CBT-T (including treatment completers and non-completers) within the previous 2 years...
February 11, 2019: International Journal of Eating Disorders
https://read.qxmd.com/read/30740313/adapting-an-internet-delivered-intervention-for-depression-for-a-colombian-college-student-population-an-illustration-of-an-integrative-empirical-approach
#10
Alicia Salamanca-Sanabria, Derek Richards, Ladislav Timulak
Background: Culturally adapted psychotherapy (CAP) studies are limited and until now there are few published examples that illustrate the process of cultural adaptation with internet-delivered treatments. Aim: This paper aims to illustrate an integrative approach to the cultural adaptation of an evidence-based internet-delivered cognitive-behavioural therapy intervention for depression ( Space from Depression programme). Method: Mixed method approach utilising quantitative and qualitative methods to assist in the cultural adaptation of the Space from Depression programme was used...
March 2019: Internet Interventions: the Application of Information Technology in Mental and Behavioural Health
https://read.qxmd.com/read/30737647/emotions-in-play-young-people-s-and-clinicians-experience-of-thinking-about-emotions-group
#11
Lucia Giombini, Sophie Nesbitt, Jenni Leppanen, Hannah Cox, Anna Foxall, Abigail Easter, Kate Tchanturia
PURPOSE: Emotional difficulties in young people (YP) with anorexia nervosa (AN) are well recognised. Improved strategies are needed to support inpatients to tolerate group therapy and to help them to better identify and manage their emotions. Cognitive Remediation and Emotion Skills Training (CREST) for AN adults, aimed at improving emotional processing skills, has been found beneficial in adult AN groups. A case series of CREST was conducted in an inpatient ward for YP (CREST-YP) to evaluate its suitability for a younger population...
February 8, 2019: Eating and Weight Disorders: EWD
https://read.qxmd.com/read/30734100/identification-and-management-of-domestic-and-sexual-violence-in-primary-care-in-the-metoo-era-an-update
#12
REVIEW
Kelsey Hegarty, Laura Tarzia
PURPOSE OF REVIEW: We discuss recent evidence around the identification and response to domestic and sexual violence in primary care for perpetrators and victims, in the context of feminist social media movements such as #MeToo. RECENT FINDINGS: There is no recent research on identification and response to perpetrators in health settings. There is some limited recent evidence for how health settings can address domestic and sexual violence for female victims and their children...
February 8, 2019: Current Psychiatry Reports
https://read.qxmd.com/read/30725252/probenecid-relieves-cerebral-dysfunction-of-sepsis-by-inhibiting-pannexin-1-dependent-atp-release
#13
Zhanqin Zhang, Yi Lei, Chaoying Yan, Xiaopeng Mei, Tao Jiang, Zhi Ma, Qiang Wang
Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes...
February 6, 2019: Inflammation
https://read.qxmd.com/read/30724647/antimuscarinic-drug-therapy-for-overactive-bladder-syndrome-in-the-elderly-are-the-concerns-justified
#14
Jay Khastgir
The use of antimuscarinic drugs is common in the management of the overactive bladder (OAB). Concerns have been raised over their use in the elderly population in whom the use of these drugs is highly prevalent, consequent to the reported link between these drugs and cognitive impairment and dementia. Areas covered: Recent publications have heightened concerns regarding antimuscarinic drug use in the elderly. In this review, the author discusses the available evidence upon which conclusions have been based and has presented the need for cortical review and need for caution in interpreting the data...
February 6, 2019: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/30723778/the-a-lzheimer-s-disease-the-rapy-with-ne-uroaid-athene-study-protocol-assessing-the-safety-and-efficacy-of-neuroaid-ii-mlc901-in-patients-with-mild-to-moderate-alzheimer-s-disease-stable-on-cholinesterase-inhibitors-or-memantine-a-randomized-double-blind-placebo
#15
Christopher L H Chen, Purabi Reang Sharma, Boon Yeow Tan, Casuarine Low, Narayanaswamy Venketasubramanian
Background: Dementia is a large and growing health care burden globally, and its major cause is Alzheimer's disease (AD). MLC901 (Neuroaid II) is a simplified form of MLC601 (Neuroaid), a Traditional Chinese Medicine with neuroprotective and neuroproliferative properties in cellular and animal models of brain injury. MLC601 has been shown to modulate amyloid precursor protein (APP) processing in human neuroblastoma cell cultures and increase the levels of soluble APPα. In addition, MLC901 has been shown to reduce tau phosphorylation in vitro...
2019: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/30720791/community-resilience-learning-collaborative-and-research-network-c-learn-study-protocol-with-participatory-planning-for-a-randomized-comparative-effectiveness-trial
#16
Benjamin F Springgate, Armen C Arevian, Ashley Wennerstrom, Arthur J Johnson, David P Eisenman, Olivia K Sugarman, Catherine G Haywood, Edward J Trapido, Cathy D Sherbourne, Ashley Everett, Michael McCreary, Diana Meyers, Sheryl Kataoka, Lingqi Tang, Jennifer Sato, Kenneth B Wells
This manuscript presents the protocol and participatory planning process for implementing the Community Resilience Learning Collaborative and Research Network (C-LEARN) study. C-LEARN is designed to determine how to build a service program and individual client capacity to improve mental health-related quality of life among individuals at risk for depression, with exposure to social risk factors or concerns about environmental hazards in areas of Southern Louisiana at risk for events such as hurricanes and storms...
August 7, 2018: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30715544/hallucinations-beyond-voices-a-conceptual-review-of-the-phenomenology-of-altered-perception-in-psychosis
#17
Elizabeth Pienkos, Anne Giersch, Marie Hansen, Clara Humpston, Simon McCarthy-Jones, Aaron Mishara, Barnaby Nelson, Sohee Park, Andrea Raballo, Rajiv Sharma, Neil Thomas, Cherise Rosen
Recent psychiatric research and treatment initiatives have tended to move away from traditional diagnostic categories and have focused instead on transdiagnostic phenomena, such as hallucinations. However, this emphasis on isolated experiences may artificially limit the definition of such phenomena and ignore the rich, complex, and dynamic changes occurring simultaneously in other domains of experience. This article reviews the literature on a range of experiential features associated with psychosis, with a focus on their relevance for hallucinations...
February 1, 2019: Schizophrenia Bulletin
https://read.qxmd.com/read/30713997/exogenous-neural-precursor-cell-transplantation-results-in-structural-and-functional-recovery-in-a-hypoxic-ischemic-hemiplegic-mouse-model
#18
Prakasham Rumajogee, Svetlana Altamentova, Lijun Li, Junyi Li, Jian Wang, Alan Kuurstra, Mohamad Khazaei, Stephanie Beldick, Ravi S Menon, Derek van der Kooy, Michael G Fehlings
Cerebral palsy (CP) is a common pediatric neurodevelopmental disorder, frequently resulting in motor and developmental deficits and often accompanied by cognitive impairments. A regular pathobiological hallmark of CP is oligodendrocyte maturation impairment resulting in white matter (WM) injury and reduced axonal myelination. Regeneration therapies based on cell replacement are currently limited, but neural precursor cells (NPCs), as cellular support for myelination, represent a promising regeneration strategy to treat CP, although the transplantation parameters (e...
September 2018: ENeuro
https://read.qxmd.com/read/30704681/the-alzheimer-s-disease-clinical-spectrum-diagnosis-and-management
#19
REVIEW
Alireza Atri
Alzheimer's disease (AD) care requires timely diagnosis and multidisciplinary management. Evaluation involves structured patient and caregiver history and symptom-function reviews, examination, and testing (laboratory and neuroimaging) to delineate impairment level, determine the cognitive-behavioral syndrome, and diagnose cause. Clinical biomarkers are available to aid high confidence in etiologic diagnosis. Management uses psychoeducation, shared goal setting, and patient-caregiver dyad decision making. When combined, pharmacologic and nonpharmacologic therapies mitigate symptoms and reduce clinical progression and care burden...
March 2019: Medical Clinics of North America
https://read.qxmd.com/read/30701661/-it-was-me-answering-my-own-questions-experiences-of-method-of-levels-therapy-amongst-people-with-first-episode-psychosis
#20
Robert Griffiths, Warren Mansell, Dawn Edge, Timothy A Carey, Heather Peel, Sara J Tai
In this study, we aimed to understand how people with first-episode psychosis experienced a transdiagnostic cognitive therapy called method of levels (MOL). Semistructured interviews were conducted with 12 individuals who were participants of a feasibility randomized controlled trial of MOL for first-episode psychosis. Interviews were analysed using thematic analysis. Four superordinate themes were identified: 'The therapist's approach'; 'I was in control'; 'Thinking and talking'; and 'Looking at problems from a different perspective'...
January 31, 2019: International Journal of Mental Health Nursing
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