Arwa Rekik, Carlo Santoro, Karolina Poplawska-Domaszewicz, Mubasher Ahmad Qamar, Lucia Batzu, Salvatore Landolfo, Silvia Rota, Cristian Falup-Pecurariu, Iulia Murasan, Kallol Ray Chaudhuri
Parkinson's disease (PD) has been linked to a vast array of vitamins among which vitamin B12 (Vit B12) is the most relevant and often investigated specially in the context of intrajejunal levodopa infusion therapy. Vit B12 deficiency, itself, has been reported to cause acute parkinsonism. Nevertheless, concrete mechanisms through which B12 deficiency interacts with PD in terms of pathophysiology, clinical manifestation and progression remains unclear. Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction...
April 11, 2024: Journal of Neural Transmission