Ebba Alkhunaizi, Jenna Plamondon Albrecht, Mahmoud Aarabi, Selma F Witchel, Diane Wherrett, Riyana Babul-Hirji, Annie Dupuis, Lyne Chiniara, Eric Chater-Diehl, Mary Shago, Cheryl Shuman, Aleksandar Rajkovic, Svetlana A Yatsenko, David Chitayat
45,X/46,XY chromosomal mosaicism presents a range of clinical manifestations, including phenotypes from Turner syndrome through genital abnormalities to apparently unaffected phenotypic males; however, the full clinical spectrum has not yet been fully delineated since prior studies on the clinical phenotype and associated risk of gonadal tumors included small cohorts and limited follow-up. To better describe the clinical manifestations and long-term outcome of patients with 45,X/46,XY mosaicism. We conducted a retrospective chart review of patients with 45,X/46,XY from three health centers (Hospital for Sick Children and Mount Sinai Hospital in Canada, and University of Pittsburgh Medical Center in United States)...
October 26, 2023: American Journal of Medical Genetics. Part A