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https://read.qxmd.com/read/30746387/a-rare-case-of-bartonella-encephalitis-with-hemiplegia
#1
Laura Rosas, Kavya Rao, Christine McGough, Ashley Becker
The authors describe a 12-year-old girl with an atypical presentation of Bartonella encephalitis. She presented with fever and altered mental status and developed flaccid paralysis of her left upper extremity a day later. An electroencephalogram showed slowing over her right hemisphere. She had mild leukocytosis and bandemia, but her imaging and cerebrospinal studies were unrevealing. After five days, her symptoms resolved and she was discharged home on doxycycline due to suspicion for Bartonella encephalitis...
2019: Child Neurology Open
https://read.qxmd.com/read/30733101/the-cerebral-palsy-profile-of-health-and-function-upper-extremity-domain-s-sensitivity-to-change-following-musculoskeletal-surgery
#2
Namrata Grampurohit, Mary Slavin, Pengsheng Ni, Scott Kozin, Alan Jette, MaryJane Mulcahey
PURPOSE: The Cerebral Palsy Profile of Health and Function (CP-PRO) Computerized Adaptive Tests (CAT) are quality of life measures developed specifically for use in children with cerebral palsy. This study examined the ability of the upper-extremity (UE) CP-PRO CAT to detect change in function after UE surgery compared with the Pediatric Outcomes Data Collection Instrument (PODCI), ABILHAND-Kids, and Box and Blocks test. METHODS: From 2009 to 2013, children with cerebral palsy who had UE musculoskeletal surgery completed the UE CP-PRO CAT, PODCI-UE, ABILHAND-Kids, and Box and Blocks tests before surgery (97 children) and at 3 postoperative intervals: 6 months (80 children), 12 months (73 children), and 24 months (52 children)...
February 4, 2019: Journal of Hand Surgery
https://read.qxmd.com/read/30676146/validity-of-the-wst-and-the-wst-q-in-children-with-spina-bifida-a-pilot-project
#3
Micah Huegel, Sango Otieno, Lisa K Kenyon
OBJECTIVE: To begin exploring use of the manual wheelchair versions of the Wheelchair Skills Test (WST) and the Wheelchair Skills Test-Questionnaire (WST-Q) in children with spina bifida who use manual wheelchairs. DESIGN: Cross-sectional, psychometric study. SETTING: A university-based laboratory setting. SUBJECTS: A total of 12 children 5-21 years of age with spina bifida participated in the study. INTERVENTIONS: Assessment of manual wheelchair skills by direct observation and parent report...
January 24, 2019: Disability and Rehabilitation. Assistive Technology
https://read.qxmd.com/read/30654198/perceived-versus-actual-aeroallergen-sensitization-in-urban-children
#4
Michele N Pham, Jade Andrade, Michelle Mishoe, Yoojin Chun, Supinda Bunyavanich
BACKGROUND: Individuals often report allergy to specific aeroallergens, but allergy testing can reveal disparate sensitization. OBJECTIVE: To characterize the agreement between perceived and actual sensitization to individual aeroallergens in an urban pediatric population. METHODS: 253 children were enrolled from pediatric clinics in New York, NY. Detailed questionnaires regarding perceived sensitization and serum specific IgE measurements to ten common aeroallergens were completed...
January 14, 2019: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/30643937/pediatric-neck-masses-how-clinical-and-radiological-features-can-drive-diagnosis
#5
Giuseppe Riva, Matteo Sensini, Federica Peradotto, Carlo Scolfaro, Gianpaolo Di Rosa, Paolo Tavormina
Pediatric neck masses are a common occurrence and often represent a diagnostic challenge. The primary aim of this retrospective study was to evaluate the clinical and radiological features of neck masses in children and how they can drive diagnosis. The secondary aim was to create a diagnostic algorithm based on clinical features. We evaluated 190 children with neck masses who needed hospitalization. Clinical data and imaging findings were collected. The patients were divided into six groups: congenital/developmental lesions, tumors, acute and subacute lymphadenopathies, chronic nonspecific lymphadenopathies, cat-scratch disease, and mycobacteriosis...
January 14, 2019: European Journal of Pediatrics
https://read.qxmd.com/read/30638893/a-systematic-review-of-capacity-assessment-tools-in-pediatric-surgery-global-assessment-in-pediatric-surgery-gaps-phase-i
#6
REVIEW
Yasmine Yousef, Etienne St-Louis, Robert Baird, Emily R Smith, Elena Guadagno, Dickens St-Vil, Dan Poenaru
BACKGROUND: The Lancet Commission on Global Surgery highlighted global surgical need but offered little insight into the specific surgical challenges of children in low-resource settings. Efforts to strengthen the quality of global pediatric surgical care have resulted in a proliferation of partnerships between low-and middle-income countries (LMICs) and high-income countries (HICs). Standardized tools able to reliably measure gaps in delivery and quality of care are important aids for these partnerships...
December 13, 2018: Journal of Pediatric Surgery
https://read.qxmd.com/read/30609319/promis-physical-and-emotional-health-scores-are-worse-in-musculoskeletal-patients-presenting-to-physiatrists-than-to-other-orthopedic-specialists
#7
Abby L Cheng, Ryan Calfee, Graham Colditz, Heidi Prather
BACKGROUND: Physiatrists' unique training in person-centered biopsychosocial management of complex problems may influence musculoskeletal patients' expectations and self- and/or physician-referral patterns to physiatrists. Consequently, average patient complexity and need for multi-disciplinary services may be increased in physiatric patients. OBJECTIVE: To compare musculoskeletal patients' self-reported physical and emotional health according to provider specialty...
January 4, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/30576788/the-challenges-of-multisource-feedback-feasibility-and-acceptability-of-gathering-patient-feedback-for-pediatric-residents
#8
David Mahoney, Alyssa Bogetz, Amanda Hirsch, Katherine Killmond, Elisa Phillips, Vasudha Bhavaraju, Alisa McQueen, Nicola Orlov, Rebecca Blankenburg, Caroline E Rassbach
OBJECTIVE: The ACGME calls for residency programs to incorporate multisource feedback, which may include patient feedback, into resident competency assessments. Program directors face numerous challenges in gathering this feedback. This study assesses the feasibility and acceptability of patient feedback collection in the inpatient and outpatient setting at three institutions. METHODS: Patient feedback was collected using a modified version of the Communication Assessment Tool (CAT)...
December 18, 2018: Academic Pediatrics
https://read.qxmd.com/read/30538953/interactions-between-pseudomonas-immunotoxins-and-the-plasma-membrane-implications-for-cat-8015-immunotoxin-therapy
#9
Monika Bokori-Brown, Jeremy Metz, Peter G Petrov, Francis Mussai, Carmela De Santo, Neil J Smart, Sarah Saunders, Bridget Knight, Ira Pastan, Richard W Titball, C Peter Winlove
Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the Pseudomonas immunotoxin CAT-8015. Although CAT-8015 has potent anti-leukemia activity, with a 32% objective response rate in a phase 1 study of childhood ALL, haemolytic-uremic syndrome (HUS) and vascular leak syndrome (VLS), major dose-limiting toxicities, have limited the use of this therapeutic approach in children...
2018: Frontiers in Oncology
https://read.qxmd.com/read/30452422/phase-1-study-of-edasalonexent-cat-1004-an-oral-nf-%C3%AE%C2%BAb-inhibitor-in-pediatric-patients-with-duchenne-muscular-dystrophy
#10
Erika Finanger, Krista Vandenborne, Richard S Finkel, H Lee Sweeney, Gihan Tennekoon, Sabrina Yum, Maria Mancini, Pradeep Bista, Andrew Nichols, Hanlan Liu, Angelika Fretzen, Joanne M Donovan
BACKGROUND: Edasalonexent is an orally administered small molecule designed to inhibit NF-κB, which is activated from infancy in Duchenne muscular dystrophy and is central to causing muscle damage and preventing muscle regeneration. OBJECTIVE: Evaluate the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of three doses of edasalonexent in ambulatory males ≥4 to <8 years of age with genetically confirmed Duchenne muscular dystrophy. METHODS: This was a 1-week, open-label, multiple-dose study with 3 sequential ascending doses (33, 67 and 100 mg/kg/day) of edasalonexent administered under different dietary conditions to 17 males with a mean age of 5...
November 15, 2018: Journal of Neuromuscular Diseases
https://read.qxmd.com/read/30446895/effectiveness-of-antibiotic-therapy-in-pediatric-patients-with-cat-scratch-disease
#11
Loujain A Shorbatli, Katalin I Koranyi, Milap C Nahata
Background Appropriate antibiotic treatment of cat scratch disease (CSD) in pediatrics is not well established. Objective The purpose of this study was to evaluate the response rates of antibiotic therapy in pediatrics with CSD. Methods The electronic medical records of a cohort of pediatric patients with confirmed diagnosis of CSD (2006-2016) were reviewed, retrospectively. Data collection included patient demographics, clinical and laboratory results, antibiotic treatment and follow-up evaluations. Results One hundred and seventy-five patients (aged 7...
November 16, 2018: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/30368034/the-effect-of-faculty-coaching-on-resident-attitudes-confidence-and-patient-rated-communication-a-multi-institutional-randomized-controlled-trial
#12
Caroline E Rassbach, Alyssa L Bogetz, Nicola Orlov, Alisa McQueen, Vasudha Bhavaraju, David Mahoney, Collin Leibold, Rebecca L Blankenburg
OBJECTIVE: Despite a national focus on physician-patient communication, there is a paucity of literature on how patient and family feedback (PFF) can be used as a tool to help residents learn communication skills. The purpose of this study was to assess the effect of coaching on residents' attitudes towards PFF, self-confidence in communication, and patient-rated communication skills. METHODS: This was an institutional review board-approved, randomized-controlled trial with pediatric residents at 3 institutions from 2015 to 2016...
October 24, 2018: Academic Pediatrics
https://read.qxmd.com/read/30345955/assessment-of-the-location-of-the-mandibular-lingula-in-pediatric-patients-using-cone-beam-computed-tomography-images
#13
Johan K M Aps, Leslie Yuan Gazdeck, Travis Nelson, Rebecca L Slayton, JoAnna M Scott
Purpose: The purpose of this study was to determine the position of the mandibular lingula in a sample of cone beam computed tomography (CBCT) images taken on pediatric patients. Methods: A sample of 280 outpatient CBCT (i-CAT) scans (153 males and 127 females) were divided into three age groups: six to nine years (n=103), 10 to 13 years (n=103), and 14 to 18 years (n=74). The position of the lingula was determined relative to the anterior and posterior border of the ramus, mandibular notch, inferior border of the mandible, and mandibular plane...
May 15, 2018: Journal of Dentistry for Children
https://read.qxmd.com/read/30275747/qualitative-analysis-of-the-psychosocial-adaptation-process-in-children-with-chronic-kidney-disease-toward-effective-support-during-transition-from-childhood-to-adulthood
#14
Haruka Aoto, Hikaru Nakatani, Shunsuke Kanayama, Shin-Ichi Okada, Mika Fukada, Keiichi Hanaki
Background: Pediatric chronic renal disease only shows abnormal values in a urinalysis in the initial stage, and subjective signs and symptoms are rare. If adolescents with chronic renal disease face a disease crisis combined with the usual developmental crisis, this may cause psychosocial maladaptation. We analyzed psychosocial adaptation in Japanese children with chronic renal disease in order to identify factors influencing healthy adaptation. Methods: Ten children and adult patients with chronic kidney disease attending Tottori University Hospital, Japan in 2016 participated in a semi-structured interview (a modified version of the grounded theory approach) comprising questions about episodes since disease onset and thoughts/feelings at onset...
September 2018: Yonago Acta Medica
https://read.qxmd.com/read/30232023/the-impact-of-social-deprivation-on-pediatric-promis-health-scores-after-upper-extremity-fracture
#15
Ugochi C Okoroafor, William Gerull, Melissa Wright, Jason Guattery, Brinkley Sandvall, Ryan P Calfee
PURPOSE: Although social deprivation is acknowledged to influence physical and mental health in adults, it is unclear if and how social deprivation influences perceived health in children. This study was conducted to evaluate the impact of social deprivation on Patient-Reported Outcomes Measurement Information System (PROMIS) scores in children presenting for treatment of upper extremity fractures. METHODS: This cross-sectional evaluation analyzed data from 975 new pediatric patients (8-17 years old) with upper extremity fractures presenting to a tertiary orthopedic center between June 1, 2016, and June 1, 2017...
October 2018: Journal of Hand Surgery
https://read.qxmd.com/read/30138013/results-from-the-child-adolescent-anxiety-multimodal-longitudinal-study-camels-functional-outcomes
#16
RANDOMIZED CONTROLLED TRIAL
Anna J Swan, Philip C Kendall, Thomas Olino, Golda Ginsburg, Courtney Keeton, Scott Compton, John Piacentini, Tara Peris, Dara Sakolsky, Boris Birmaher, Anne Marie Albano
OBJECTIVE: To report functional outcomes from the multisite Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), which examined the impact of youth anxiety treatment (cognitive-behavioral therapy [CBT], coping cat; Sertraline, SRT; COMB [CBT + SRT]; pill placebo) on (a) global and (b) domain-specific functioning assessed an average of 3.1 times, 3- to 12-years postrandomization (first assessment = mean 6.5 years postrandomization). METHOD: Three-hundred and 19 of 488 families from the Child/Adolescent Anxiety Multimodal Study (CAMS; Walkup et al...
September 2018: Journal of Consulting and Clinical Psychology
https://read.qxmd.com/read/30130519/measuring-the-reliability-and-construct-validity-of-the-pediatric-evaluation-of-disability-inventory-computer-adaptive-test-pedi-cat-in-children-with-cerebral-palsy
#17
Benjamin J Shore, Benjamin G Allar, Patricia E Miller, Travis H Matheney, Brian D Snyder, Maria Fragala Pinkham
OBJECTIVE: The purpose of this study was to (1) investigate the construct validity and (2) test-retest reliability of the Pediatric Evaluation of Disability Inventory - Computer Adaptive Test (PEDI-CAT) in children with cerebral palsy (CP). DESIGN: A prospective convenience cross-sectional sample SETTING: Multidisciplinary CP clinic in a tertiary level pediatric children's hospital PARTICIPANTS: One hundred and one, English and Spanish speaking school aged children with a diagnosis of CP, stratified by Gross Motor Function Classification System level, who presented to our multidisciplinary clinic...
August 18, 2018: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/30102478/allergen-variability-and-house-dust-mite-sensitivity-in-pre-school-children-with-allergic-complaints
#18
Selçuk Yazıcı, Soner Güneş, Melike Kurtuluş-Çokboz, Özlem Kemer, Gülce Baranlı, Sezin Aşık-Akman, Demet Can
Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G, Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49. The increase in the prevalence of allergic diseases in pre-school children who are often at home may be due to an increase in house dust mite sensitivity, which is rarely expected in this age group. In our study, it was aimed to investigate allergen sensitivities, especially house dust mite sensitivity in pre-school children with allergic disease complaints by skin prick test (SPT)...
2018: Turkish Journal of Pediatrics
https://read.qxmd.com/read/30092382/measuring-the-involvement-in-family-life-of-children-with-autism-spectrum-disorder-a-dbpnet-study
#19
Justin Schwartz, Noelle Huntington, Marisa Toomey, Michele Laverdiere, Katherine Bevans, Nathan Blum, Carolyn Bridgemohan
BACKGROUND: Children with Autism Spectrum Disorder (ASD) have social and communication deficits that impair their involvement in family life. No measures of child involvement in the family have been validated for the ASD population. AIM: To evaluate the validity of a measure of Family Involvement (FI) of children ages 5-12 with ASD. METHOD: Parents of children ages 5-12 with ASD (n = 114) completed FI items from the PROMIS® pediatric Family Relationships item bank in computerized adaptive testing (CAT) format, as well as measures of ASD symptom burden, parenting stress, and parental depression...
August 6, 2018: Research in Developmental Disabilities
https://read.qxmd.com/read/30081662/performance-of-pediatric-promis-cats-in-children-with-upper-extremity-fractures
#20
William D Gerull, Ugochi C Okoroafor, Jason Guattery, Charles A Goldfarb, Lindley B Wall, Ryan P Calfee
BACKGROUND: This study was designed to quantify the performance of the pediatric Patient-Reported Outcome Measurement Information System (PROMIS) when delivered as part of routine care to children with upper extremity (UE) fractures. METHODS: This cross-sectional study analyzed 964 new pediatric patients presenting with an UE fracture. All patients completed PROMIS computer adaptive tests for pain interference, peer relationships, UE function, and mobility domains at clinic registration...
August 6, 2018: Hand: Official Journal of the American Association for Hand Surgery
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