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Antimicrobials in dentistry

Maxime Ducret, Alexandra Montembault, Jérôme Josse, Marielle Pasdeloup, Alexis Celle, Rafiqa Benchrih, Frédéric Mallein-Gerin, Brigitte Alliot-Licht, Laurent David, Jean-Christophe Farges
OBJECTIVE: Regenerating a functional dental pulp in the pulpectomized root canal has been recently proposed as a novel therapeutic strategy in dentistry. To reach this goal, designing an appropriate scaffold able to prevent the growth of residual endodontic bacteria, while supporting dental pulp tissue neoformation, is needed. Our aim was to create an innovative cellularized fibrin hydrogel supplemented with chitosan to confer this hydrogel antibacterial property. METHODS: Several fibrin-chitosan formulations were first screened by rheological analyses, and the most appropriate for clinical use was then studied in terms of microstructure (by scanning electron microscopy), antimicrobial effect (analysis of Enterococcus fæcalis growth), dental pulp-mesenchymal stem/stromal cell (DP-MSC) viability and spreading after 7 days of culture (LiveDead® test), DP-MSC ultrastructure and extracellular matrix deposition (transmission electron microscopy), and DP-MSC proliferation and collagen production (RT-qPCR and immunohistochemistry)...
January 31, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Beatriz Martines de Souza, Daiana Moreli Soares Dos Santos, Ana Carolina Magalhães
The occurrence of caries lesions adjacent to restorations is a serious problem in Dentistry. Therefore, new antimicrobial restorative materials could help to prevent recurrent carious lesions. This study evaluated the effect of a new glass ionomer cement (Ion Z) on the viability of a microcosm biofilm and on the development of enamel demineralization. Enamel samples were filled with the following materials (n=9): A) Ion-Z (FGM Ltda); B) Maxxion R (FGM Ltda); C) Ketac Fil Plus (3M ESPE) and D) no restoration (control)...
November 2018: Brazilian Dental Journal
Amrik Singh Gill, Hana Morrissey, Ayesha Rahman
Background and objectives: The use of antibiotic prophylaxis in extraction and implant dentistry is still controversial, with varying opinions regarding their necessity. The overuse of antibiotics has led to widespread antimicrobial resistance and the emergence of multi drug resistant strains of bacteria. The main aim of this work was to determine whether there is a genuine need for antibiotic prophylaxis in two common dental procedures; dental implants and tooth extractions. Methods: Electronic searches were conducted across databases such as Cochrane Register of Controlled Trials, the UK National Health Service, Centre for reviews, Science Direct, PubMed and the British Dental Journal to identify clinical trials of either dental implants or tooth extractions, whereby the independent variable was systemic prophylactic antibiotics used as part of treatment in order to prevent postoperative complications such as implant failure or infection...
December 1, 2018: Medicina
Hicham Mansour, Mireille Feghali, Nadine Saleh, Mona Zeitouny
Objectives: Explore antibiotic use, assess conformity with evidence-practice guidelines, and describe knowledge and attitudinal factors among Lebanese dentists. Methods: National cross-sectional telephonic survey, using a standardized questionnaire addressing demographic, educational and professional data, usual antibiotics prophylactic and curative prescription pattern and influential factors, knowledge concerning antibiotics use in selected patient-populations, and attitude regarding antimicrobial resistance...
July 2018: Pharmacy Practice
Preena Sidhu, Swapnil Shankargouda, Avita Rath, Priyadarshini Hesarghatta Ramamurthy, Bennete Fernandes, Ashish Kumar Singh
Oral health influences general well-being and quality of life. Oral diseases can be debilitating and are a major heath concern worldwide. Medicinal plants have been used for thousands of years for treating human diseases. Considering the emergence of multi-drug resistant pathogens and financial difficulties in developing countries, there is an urgent need for developing new antimicrobial compounds which are safe, efficient and cost effective. Liquorice also known as yashtimadhu, sweetwood or mulhatti is one such herbal remedy which has shown to have immense potential in treatment of orofacial diseases...
October 31, 2018: Journal of Ayurveda and Integrative Medicine
Marcela Leticia Leal Gonçalves, Ana Carolina Costa da Mota, Alessandro Melo Deana, Guelton Hirano Guedes, Lisyanne Araújo de Souza Cavalcante, Renato Araújo Prates, Anna Carolina Ratto Tempestini Horliana, Christiane Pavani, Lara Jansiski Motta, Greice de Brito Bitencourt, Kristianne Porta Santos Fernandes, Monica da Consolação Canuto Salgueiro, Raquel Agnelli Mesquita-Ferrari, Daniela Fátima Teixeira da Silva, Cristiane Miranda França, Sandra Kalil Bussadori
BACKGROUND: Halitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as "urucum" is a plant native to Brazil. The seeds are used to produce a dye that is largely used in the food, textile, paint and cosmetic industries. The aim of this study is to verify whether aPDT with Bixa orellana extract and blue light-emitting diodes (LEDs) is effective in reducing halitosis...
October 29, 2018: Trials
Dinesh Rokaya, Viritpon Srimaneepong, Janak Sapkota, Jiaqian Qin, Krisana Siraleartmukul, Vilailuck Siriwongrungson
The use of polymeric materials (PMs) and polymeric films (PMFs) has increased in medicine and dentistry. This increasing interest is attributed to not only the excellent surfaces of PMs and PMFs but also their desired mechanical and biological properties, low production cost, and ease in processing, allowing them to be tailored for a wide range of applications. Specifically, PMs and PMFs are used in dentistry for their antimicrobial, drug delivery properties; in preventive, restorative and regenerative therapies; and for corrosion and friction reduction...
November 2018: Journal of Advanced Research
Teddy Tite, Adrian-Claudiu Popa, Liliana Marinela Balescu, Iuliana Maria Bogdan, Iuliana Pasuk, José M F Ferreira, George E Stan
High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase...
October 24, 2018: Materials
L S Gu, X Cai, J M Guo, D H Pashley, L Breschi, H H K Xu, X Y Wang, F R Tay, L N Niu
Instability of resin-dentin bonds is the Achilles' heel of adhesive dentistry. To address this problem, a chelate-and-rinse extrafibrillar dentin demineralization strategy has been developed that keeps intrafibrillar minerals within collagen fibrils intact to prevent activation of endogenous proteases that are responsible for collagen degradation within hybrid layers. The objective of the present study was to evaluate the potential of using chitosan >40 kDa as an antimicrobial extrafibrillar dentin-chelating agent to enhance bond durability...
October 16, 2018: Journal of Dental Research
Seetharam Charannya, Dasarathan Duraivel, Krishnan Padminee, Saravanan Poorni, Cruz Nishanthine, Manali Ramakrishnan Srinivasan
Context: Silver nanoparticle (AgNP) is a potent antimicrobial that is widely used in several fields of medicine. Chlorhexidine (CHX) gluconate is a well-known agent used in dentistry to eliminate oral microbial flora. Aims: The aim of this study is to evaluate the efficacy of AgNPs, 2% CHX gluconate, and the combination of two solutions against endodontic pathogens such as Enterococcus faecalis , Klebsiella pneumoniae , and Candida albicans . These organisms are frequently found in the root canal space and their persistence may lead to endodontic failure...
September 2018: Contemporary Clinical Dentistry
Carly C Dixon, Francesca J Thomson, Siobhan M Barry
Autoimmune neutropenia is a self-limiting condition characterized by the presence of granulocyte-specific autoantibodies. This case report describes a 2-year-old female who presented to the Department of Pediatric Dentistry with a history of oral ulceration, complicated by high temperature, gingival hypertrophy and gingival hemorrhage. These symptoms had precipitated an admission to a district general hospital and diagnosis of viral tonsillitis. The severity of the presentation to the Pediatric Dental Department prompted a review of recent discharge blood investigations, which revealed a neutrophil count of 0...
2019: Journal of Clinical Pediatric Dentistry
Kelli Stein, Julie Farmer, Sonica Singhal, Fawziah Marra, Susan Sutherland, Carlos Quiñonez
BACKGROUND: To describe antibiotic prescribing behaviors in dentistry, including clinical and nonclinical indications for their use, the type and regimen of antibiotics prescribed, and factors influencing their prescription, the authors conducted a scoping review. TYPES OF STUDIES REVIEWED: The authors conducted a scoping review of published literature by searching multiple databases. Key search terms included dentist, antibiotic, antimicrobial, antibacterial, prophylaxis, prescription, pattern, habit, knowledge, and practice...
October 2018: Journal of the American Dental Association
Preetika Chandna, Nikhil Srivastava, Alpana Sharma, Vrinda Sharma, Nidhi Gupta, Vivek Kumar Adlakha
Aim: This study aimed to quantitatively assess the levels of Scardovia wiggsiae in caries-free and early childhood caries (ECC)- and severe ECC (SECC)-affected children using real-time polymerase chain reaction (RT-PCR). Methods: Forty-five children aged <71 months were randomly recruited from the Outpatient Clinic at the Department of Pedodontics and Preventive Dentistry at Subharti Dental College and Hospital, Meerut, India. Fifteen children suffering from ECC, 15 with SECC, and 15 children without ECC were enrolled in the study...
July 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
P A Calderón-Ávila, J A Garrocho-Rangel, J A Cepeda-Bravo, M S Ruiz-Rodríguez, M Pierdant-Pérez, A Pozos-Guillén
BACKGROUND: Eisenmenger syndrome (ES) is a heart cyanotic condition characterised by elevated pulmonary vascular resistance and an intra-cardiac right-to-left shunting of blood through a systemic-to-pulmonary circulation connection. Affected children usually exhibit severe hypoxia, clubbing of fingers/toes, haemoptysis, anaemia, and organ damage. CASE REPORT: During autumn 2015, the patient and her parents arrived at the paediatric dentistry clinic. The patient presented with the main complaint of generalised inflamed gingival tissues, severely protruded upper incisors, and evident abnormal mouth breathing...
December 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Thanawat Kaewjiaranai, Ratchapin Laovanitch Srisatjaluk, Watus Sakdajeyont, Verasak Pairuchvej, Natthamet Wongsirichat
Topical anesthetics are commonly used in oral & maxillofacial surgery to control pain in the oral cavity mucosa before local anesthetic injection. These anesthetic agents come in many forms, developed for different usages, to minimize adverse reactions, and for optimal anesthetic efficiency. Earlier studies have revealed that these agents may also limit the growth of microorganisms in the area of anesthetic application. Many topical anesthetic agents show different levels of antimicrobial activity against various bacterial strains and Candida...
August 2018: Journal of Dental Anesthesia and Pain Medicine
Hanaa M Elgamily, Hoda S El-Sayed, Ali Abdelnabi
Introduction: Bacteria residing in the oral cavity penetrate freely through the resultant fissures under the fillings, which might lead to the development of secondary caries. Nowadays dentistry, different nanotechnological materials with antibacterial activity are being developed for oral cavity disinfection. Aim: This study aims to investigate the antibacterial activity of a new cavity disinfectant NanoCare Plus Silver Gold® (NanoCare) in comparison to (0.2%) chlorhexidine (CHX) gluconate disinfectant against Streptococcus mutans growth and colony count using Agar well diffusion method and contact test, respectively, and also, to assess the nanoparticles (NPs) size distribution and Zeta potential of a NanoCare disinfectant...
July 2018: Contemporary Clinical Dentistry
Ali Saafan, Mohamed H Zaazou, Marwa K Sallam, Osama Mosallam, Heba A El Danaf
AIM: To assess the antibacterial competence of 650 nm diode laser, Methylene Blue (MB) and Silver Nano-Particles (Ag NPs) on Streptococcus mutans in biofilm-induced caries models. MATERIAL AND METHODS: One hundred eighty specimens were prepared and equally divided into 6 groups. One group was untreated (control), and the others were subjected to either MB, laser, Ag NPs, the combination of MB and Laser or MB, laser and Ag NPs. RESULTS: Comparison of the log10 mean Colony Forming Units per millilitre (CFU/ml) values of each of the treated 5 groups and the control group was found statistically significant (P-value < 0...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Ranjeet A Bapat, Tanay V Chaubal, Chaitanya P Joshi, Prachi R Bapat, Hira Choudhury, Manisha Pandey, Bapi Gorain, Prashant Kesharwani
Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Ning Zhang, Ke Zhang, Michael D Weir, David J Xu, Mark A Reynolds, Yuxing Bai, Hockin H K Xu
Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability...
June 21, 2018: International Journal of Oral Science
Marta Ribeiro, Joana Malheiro, Liliana Grenho, Maria Helena Fernandes, Manuel Simões
Background: Dental caries remains the most prevalent and costly oral infectious disease worldwide, encouraging the search for new and more effective antimicrobials. Therefore, the aim of this work was to study the antimicrobial action of selected phytochemicals (eugenol, citronellol, sabinene hydrate, trans-cinnamaldehyde, terpineol and cinnamic acid) against Streptococcus mutans in planktonic and biofilm states as well as the cytotoxicity of these compounds. Methods: The antibacterial activity of the selected compounds was evaluated by the determination of the minimal bactericidal concentration...
2018: PeerJ
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