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Ruth Horn
The announcement of the French Plan 'France Médecine Génomique 2015' demonstrates the will of the public authorities to make genomic medicine one of the flagships of public health and scientific research. It is against this backdrop that France announced its cooperation with Great Britain, one of the global leaders in genomics. The cooperation at an international level requires a common normative framework that addresses the new ethical challenges presented by genomic medicine. In order for such a framework to be adapted to different national contexts, it is important to identify and analyse the emerging ethical questions in general as well as within their specific national contexts...
February 2019: Médecine Sciences: M/S
Vincent Lavoué, Sofiane Bendifallah, Pierre Collinet, Olivier Graesslin, Marcos Ballester, Cherif Akladios, Xavier Carcopino, Alexandre Bricou, Martin Koskas, Geoffroy Canlorbe, Charles Coutant, Pierre Adrien Bolze, Lobna Ouldamer, Emile Daraï, Cyril Touboul, Cyrille Huchon
No abstract text is available yet for this article.
February 11, 2019: Bulletin du Cancer
Emma Day, Tina Broder, Julie Bruneau, Sally Cruse, Melisa Dickie, Suzanne Fish, Celine Grillon, Niklas Luhmann, Kate Mason, Elizabeth McLean, Stacey Trooskin, Carla Treloar, Jason Grebely
It is estimated that 6.1 million people with recent injecting drug use (PWID) are living with hepatitis C virus (HCV). Although HCV-related morbidity and mortality among PWID continues to increase, the advent of direct acting antiviral (DAA) HCV regimens with cure rates >95% provides an opportunity to reverse the rising burden of disease. Additionally, given evidence that opioid substitution therapy and high-coverage needle and syringe programs can reduce HCV incidence by up to 80%, there is an opportunity to reduce HCV transmission with increased coverage of harm reduction services...
February 8, 2019: International Journal on Drug Policy
Rufin Marie Kouipou Toghueo, Eugénie Aimée Madiesse Kemgne, Pierre Eke, Michelle Ines Mbekou Kanko, Darline Dize, Dinkar Sahal, Fabrice Fekam Boyom
ETHNOPHARMACOLOGICAL RELEVANCE: Annona muricata (Annonaceae) is a commonly used medicinal plants in Cameroonian traditional medecines to treat various diseases including malaria. Previous studies have shown that extracts from this plant have antiplasmodial activity. AIM OF THE STUDY: This study aimed to explore the endophyic fungi associated with some parts of this plant for their ability to produce antiplasmodial metabolites. MATERIALS AND METHODS: One hundred and fifty-two endophytic fungi isolated from twelve different organs of A...
February 6, 2019: Journal of Ethnopharmacology
Fabien Fily, Jean-Baptiste Ronat, Nada Malou, Rupa Kanapathipillai, Caroline Seguin, Nagham Hussein, Rasheed M Fakhri, Céline Langendorf
BACKGROUND: War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bacteria (FLAR) among PTO cases in civilians from Syria, Iraq and Yemen admitted to the reconstructive surgical program of Médecins Sans Frontières (MSF) in Amman, Jordan, and to identify risk factors for developing PTO with FLAR bacteria. METHODS: We retrospectively analyzed the laboratory database of the MSF program...
January 31, 2019: BMC Infectious Diseases
Shona Horter, Alison Wringe, Zanele Thabede, Velibanti Dlamini, Bernhard Kerschberger, Munyaradzi Pasipamire, Nomthandazo Lukhele, Barbara Rusch, Janet Seeley
INTRODUCTION: Treat-all is being implemented in several African settings, in accordance with 2015 World Health Organisation guidelines. The factors known to undermine adherence to antiretroviral therapy (ART) may change in the context of Treat-all, where people living with HIV (PLHIV) increasingly initiate ART at earlier, asymptomatic stages of disease, soon after diagnosis. This paper aimed to examine the asymptomatic PLHIV's experiences engaging with early ART initiation under the Treat-all policy, including how they navigate treatment-taking over the longer term...
January 2019: Journal of the International AIDS Society
N Fyhrquist, T Werfel, M B Bilò, N Mülleneisen, R Gerth van Wijk
The high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the current status of allergy care is not well documented. For this reason a survey among European and a few non-European countries was launched by the National Allergy Society Committee from the European Academy of Allergy and Clinical Immunology and the Union Européenne des Médecins Spécialistes section and board of Allergology...
2019: Clinical and Translational Allergy
Pierre-Yves Salaün, Ronan Abgral, Olivier Malard, Solène Querellou-Lefranc, Gilles Quere, Myriam Wartski, Romain Coriat, Elif Hindie, David Taieb, Antoine Tabarin, Antoine Girard, Jean-François Grellier, Isabelle Brenot-Rossi, David Groheux, Caroline Rousseau, Désirée Deandreis, Jean-Louis Alberini, Caroline Bodet-Milin, Emmanuel Itti, Olivier Casasnovas, Françoise Kraeber-Bodere, Philippe Moreau, Arnaud Philip, Corinne Balleyguier, Alain Lucian, Florent Cachin
Positron Emission Tomography (PET) is a functional nuclear medicine imaging technique which clinical value in oncology has been demonstrated. PET indications are constantly evolving, thanks to the contribution of research. The use of PET in oncology has been the subject of recommendations according to the Standard-Options-Recommendations methodology from the Fédération Nationale des Centres de Lutte Contre le Cancer in 2002, updated in 2003. However, many scientific works have been published since 2003 and new tracers have also obtained a marketing authorization in France...
January 22, 2019: Bulletin du Cancer
Jean-Luc Teillaud
No abstract text is available yet for this article.
January 2019: Médecine Sciences: M/S
Robert A Harrison, Nicholas R Casewell, Stuart A Ainsworth, David G Lalloo
Like the other WHO-listed Neglected Tropical Diseases (NTDs), snakebite primarily affects rural, impoverished tropical communities that lack adequate health resources. The annual 138 000 deaths and 400 000 disabilities suffered by these subsistence farming communities means that snakebite is an additional cause and consequence of tropical poverty. Unlike most of the NTDs, however, snakebite is a medical emergency, and requires rapid treatment in a hospital equipped with effective antivenom, beds and appropriately trained staff...
January 21, 2019: Transactions of the Royal Society of Tropical Medicine and Hygiene
Aline Hurtaud, Michèle Aubin, Emilie Ferrat, Julien Lebreton, Elena Paillaud, Etienne Audureau, Sylvie Bastuji-Garin, Christos Chouaid, Philippe Boisnault, Pascal Clerc, Florence Canouï-Poitrine
BACKGROUND: At cancer diagnosis, it is unclear whether continuity of care (COC) between the patient and GP is safeguarded. AIM: To identify patient-GP loss of COC around the time of, and in the year after, a cancer diagnosis, together with its determinants. DESIGN AND SETTING: A post-hoc analysis of data from a prospective cohort of GPs in France, taken from a survey by the Observatoire de la Médecine Générale. METHOD: A prospective GP cohort ( n = 96) filed data on patients who were diagnosed with incident cancer between 1 January 2000 and 31 December 2010...
January 14, 2019: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Chhorvy Sun, Momoko Iwamoto, Aurelie Calzia, Bun Sreng, Sokchea Yann, Sorphorn Pin, Celine Lastrucci, San Kimchamroeun, Chhit Dimanche, Jean-Philippe Dousset, Mickael Le Paih, Suna Balkan, Tonia Marquardt, Valentina Carnimeo, Pascale Lissouba, David Maman, Anne Loarec
BACKGROUND: Simplifying hepatitis C virus (HCV) screening is a key step in achieving the elimination of HCV as a global public health threat by 2030. OBJECTIVES: The objective of this study was to demonstrate the agreement of capillary blood and venipuncture specimens when using SD Bioline© HCV, a low-cost rapid diagnostic test (RDT), prequalified by WHO in 2016 on venous blood samples. STUDY DESIGN: Recruitment was conducted prospectively among adult patients presenting for HCV testing at the Médecins Sans Frontières (MSF) clinic of Preah Kossamak Hospital (Phnom Penh, Cambodia) between October and November 2017...
December 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Richard Brown, Robert Gagnon, Marie-France Delisle
OBJECTIF: La présente directive clinique vise à fournir aux cliniciens un cadre à utiliser pour déterminer quelles femmes présentent un risque accru d'insuffisance cervicale et dans quelles situations le cerclage aurait une valeur potentielle. DONNéES PROBANTES: Nous avons examiné des études publiées récupérées au moyen de recherches dans PubMed, Medline, CINAHL et The Cochrane Library en 2018 à l'aide d'une terminologie (p. ex., uterine cervical incompetence) et de mots-clés (p...
February 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Rose Burns, Joana Borges, Philippe Blasco, Alexandra Vandenbulcke, Irene Mukui, Denview Magalasi, Lucas Molfino, Rolanda Manuel, Birgit Schramm, Alison Wringe
Increasing numbers of people living with HIV (PLHIV) in sub-Saharan Africa are experiencing failure of first-line antiretroviral therapy and transitioning onto second-line regimens. However, there is a dearth of research on their treatment experiences. We conducted in-depth interviews with 43 PLHIV on second- or third-line antiretroviral therapy and 15 HIV health workers in Kenya, Malawi and Mozambique to explore patients' and health workers' perspectives on these transitions. Interviews were audio-recorded, transcribed and translated into English...
January 11, 2019: Global Public Health
Nicole Karam, Sophie Bataille, Eloi Marijon, Muriel Tafflet, Hakim Benamer, Christophe Caussin, Philippe Garot, Jean-Michel Juliard, Virginie Pires, Thévy Boche, François Dupas, Gaelle Le Bail, Lionel Lamhaut, Benoît Simon, Alexandre Allonneau, Mireille Mapouata, Aurélie Loyeau, Jean-Philippe Empana, Frederic Lapostolle, Christian Spaulding, Xavier Jouven, Yves Lambert
BACKGROUND: Mortality of ST-segment-elevation myocardial infarction (STEMI) decreased drastically, mainly through reduction in inhospital mortality. Prehospital sudden cardiac arrest (SCA) became one of the most feared complications. We assessed the incidence, outcome, and prognosis' predictors of prehospital SCA occurring after emergency medical services (EMS) arrival. METHODS AND RESULTS: Data were taken between 2006 and 2014 from the e-MUST study (Evaluation en Médecine d'Urgence des Strategies Thérapeutiques des infarctus du myocarde) that enrolls all STEMI managed by EMS in the Greater Paris Area, including those dead before hospital admission...
January 2019: Circulation. Cardiovascular Interventions
Sarina Yaghobian, Robin Ohannessian, Alexandre Mathieu-Fritz, Thierry Moulin
INTRODUCTION: Telemedicine is a remote medical practice using information communication technology (ICT), and has been increasing in France since 2009. With all new forms of medical practice, education and training (ET) is required for quality and safety. To date, implementation of telemedicine ET has not been assessed in France. The objective of this study was to describe the implementation of telemedicine ET and evaluate the knowledge, attitudes and practices (KAP) of deans and associate deans from all medical schools in France...
January 2, 2019: Journal of Telemedicine and Telecare
Gul Ghuttai Khalid, Khine Wut Yee Kyaw, Christine Bousquet, Rosa Auat, Dmytro Donchuk, Adam Trickey, Saeed Hamid, Huma Qureshi, Valentina Mazzeo, Khawar Aslam, Salima Khowaja, Rafael Van den Bergh
Background: In the high-prevalence setting of Pakistan, screening, diagnosis and treatment services for chronic hepatitis C (CHC) patients are commonly offered in specialized facilities. We aimed to describe the cascade of care in a Médecins Sans Frontières primary health care clinic offering CHC care in an informal settlement in Karachi, Pakistan. Methods: This was a retrospective cohort analysis using routinely collected data. Three different screening algorithms were assessed among patients with one or more CHC risk factors...
December 28, 2018: International Health
Ballah Akawu Denue, Cecilia Balla Akawu, Salihu Aliyu Kwayabura, Ibrahim Kida
Background: Cholera is endemic in sub-Saharan Africa, especially in areas affected by natural disaster and human conflict. Northeastern Nigeria is experiencing a health crisis due to the destruction of essential amenities such as health infrastructure, sanitation facilities, water supplies, and human resources by Boko Haram insurgents. In 2017, a cholera outbreak occurred in five local government areas (LGAs) hosting internally displaced persons. The Nigeria Center for Disease Control, World Health Organization, Mĕdecins Sans Frontiĕres International, and several other organizations supported disease containment...
October 2018: Annals of African Medicine
Ally Murji, Stephanie Scott, Sony Sukhbir Singh, Olga Bougie, Nicholas Leyland, Philippe-Yves Laberge, George A Vilos
OBJECTIF: La présente directive clinique conseille les gynécologues quant au recours au morcellement tissulaire pendant une chirurgie gynécologique. RéSULTATS: Le morcellement effectué au cours d'une chirurgie gynécologique peut permettre l'ablation de masses utérines volumineuses, offrant ainsi aux femmes une solution chirurgicale à effraction minimale. Les conséquences oncologiques indésirables du morcellement tissulaire devraient être atténuées par l'amélioration de la sélection des patientes, la tenue d'examens préopératoires et l'adoption de techniques novatrices réduisant au minimum la dispersion tissulaire...
January 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Julie Ann Francis, Lua Eiriksson, Erin Dean, Alexandra Sebastianelli, Boris Bahoric, Shannon Salvador
OBJECTIF: Cette directive clinique porte sur l'évaluation clinique et la prise en charge du cancer spinocellulaire (CSC) de la vulve, plus particulièrement sur son diagnostic, sa prise en charge primaire au moyen de la chirurgie, de la radiothérapie ou de la chimiothérapie et la nécessité d'une chimiothérapie et/ou d'une radiothérapie adjuvante. Cette directive clinique ne traite pas des autres diagnostics pathologiques de cancer de la vulve. UTILISATEURS CIBLES: La première partie de ce document, qui comprend les recommandations 1 à 3, s'adresse aux gynécologues, aux obstétriciens, aux médecins de famille, aux infirmières autorisées, aux infirmières praticiennes, aux résidents et aux fournisseurs de soins généralistes; elle est axée sur la présentation et le diagnostic de la maladie, et fournit des renseignements à jour sur les chirurgies effectuées par les professionnels surspécialisés...
January 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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