Manuel O Jakob, Daniel Spari, Daniel Sànchez Taltavull, Lilian Salm, Bahtiyar Yilmaz, Rémi Doucet Ladevèze, Catherine Mooser, David Pereyra, Ye Ouyang, Theresa Schmidt, Irene Mattiola, Patrick Starlinger, Deborah Stroka, Franziska Tschan, Daniel Candinas, Georg Gasteiger, Christoph S N Klose, Andreas Diefenbach, Mercedes Gomez de Agüero, Guido Beldi
It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a large cohort of patients with infections following major surgery, we identified that the causative bacteria are mainly of intestinal origin. Postoperative infections of intestinal origin were also found in mice undergoing partial hepatectomy. CCR6+ group 3 innate lymphoid cells (ILC3s) limited systemic bacterial spread...
March 17, 2023: Cell Reports