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https://read.qxmd.com/read/30780116/complex-cardiac-vagal-regulation-to-mental-and-physiological-stress-in-adolescent-major-depression
#1
Andrea Mestanikova, Michal Mestanik, Igor Ondrejka, Igor Hrtanek, Dana Cesnekova, Alexander Jurko, Zuzana Visnovcova, Nikola Sekaninova, Ingrid Tonhajzerova
BACKGROUND: Cardiovagal control is known to be reduced in major depressive disorder (MDD), however, the neurocardiac reflex control to distinct types of stressors is still unclear. We aimed to study parasympathetically mediated cardiac reflex functioning in response to mental and physiological stressors using heart rate variability (HRV) linear and nonlinear analysis in adolescent MDD. METHODS: We examined 60 adolescents (40 girls) with MDD (age 14.9 ± 0.3 years) and 60 age and gender-matched controls...
February 13, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30763786/differentiation-of-fasciculoventricular-fibers-from-anteroseptal-accessory-pathways-using-the-surface-electrocardiogram
#2
Edward T O'Leary, Elizabeth S Dewitt, Douglas Y Mah, Kimberlee Gauvreau, Edward P Walsh, Vassilios J Bezzerides
BACKGROUND: Fasciculoventricular fibers (FVFs) are responsible for 1-5% of cases of asymptomatic pre-excitation on surface electrocardiogram (ECG). Unlike ventricular pre-excitation seen in Wolff-Parkinson-White (WPW) syndrome, FVFs are not associated with sudden cardiac death from pre-excited atrial fibrillation. OBJECTIVE: To identify surface ECG variables that differentiate FVFs from true WPW syndrome. METHODS: Retrospective case-control study comparing surface ECG characteristics in patients diagnosed with a FVF (cases) to WPW patients with anteroseptal accessory pathways (APs; controls) via intracardiac electrophysiology (EP) testing at a single institution from 2005-2017...
February 11, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30760868/ambient-and-controlled-exposures-to-particulate-air-pollution-and-acute-changes-in-heart-rate-variability-and-repolarization
#3
Susanne Breitner, Annette Peters, Wojciech Zareba, Regina Hampel, David Oakes, Jelani Wiltshire, Mark W Frampton, Philip K Hopke, Josef Cyrys, Mark J Utell, Cathleen Kane, Alexandra Schneider, David Q Rich
Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act on this time scale is still unclear. We hypothesized that increases in PM are associated with rapid changes in measures of heart rate variability and repolarization. We used data from panel studies in Augsburg, Germany, and Rochester, New York, USA, and two controlled human exposure studies in Rochester...
February 13, 2019: Scientific Reports
https://read.qxmd.com/read/30758987/toll-like-receptor-3-controls-qt-interval-on-the-electrocardiogram-by-targeting-the-degradation-of-kv4-2-4-3-channels-in-the-endoplasmic-reticulum
#4
Xueting Gao, Siyun Gao, Yi Guan, Lin Huang, Jiale Huang, Li Lin, Yuan Liu, Hong Zhao, Bijun Huang, Tianyou Yuan, Yi Liu, Dandan Liang, Yangyang Zhang, Xiue Ma, Li Li, Jun Li, Daizhan Zhou, Dan Shi, Liang Xu, Yi-Han Chen
TLRs have been proven to be essential mediators for the early innate immune response. Overactivation of TLR-mediated immune signaling promotes deterioration of cardiovascular diseases; however, the role of TLRs in the heart under physiologic conditions remains neglected. Here, we show that Tlr3 deficiency induced the endoplasmic reticulum (ER) retention of Kv4.2/4.3 proteins and consequent degradation via the ubiquitin-proteasome pathway. Knockout of Tlr3 resulted in a prolonged QT interval (the space between the start of the Q wave and the end of the T wave) in mice with no significant signs of inflammation and tissue abnormality in cardiac muscles...
February 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30758978/impaired-neonatal-cardiorespiratory-responses-to-hypoxia-in-mice-lacking-pac1-or-vpac2-receptors
#5
Karlene T Barrett, Shabih U Hasan, Morris H Scantlebury, Richard J A Wilson
The stress peptide, PACAP, and its specific receptor, PAC1, have been implicated in Sudden Infant Death Syndrome (SIDS). PACAP is also critical to the neonatal cardiorespiratory response to homeostatic stressors identified in SIDS, including hypoxia. However, which of PACAP's three receptors, PAC1, VPAC1 and/or VPAC2, are involved is unknown. In this study, we hypothesized that PAC1, but not VPAC2, is involved in mediating the cardiorespiratory response to hypoxia during neonatal development. To test this hypothesis, head-out plethysmography and surface ECG electrodes were used to assess the cardiorespiratory variables of unanesthetized postnatal day 4 PAC1 and VPAC2 knockout (KO) and wild-type (WT) mice in response to a 10% hypoxic challenge...
February 13, 2019: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/30745877/sudden-heart-rate-reduction-upon-optogenetic-release-of-acetylcholine-from-cardiac-parasympathetic-neurons-in-perfused-hearts
#6
Angel Moreno, Kendal Endicott, Matthew Skancke, Mary Kate Dwyer, Jaclyn Brennan, Igor R Efimov, Gregory Trachiotis, David Mendelowitz, Matthew W Kay
The balance of sympathetic and parasympathetic tone provides exquisite control of heart rate and contractility and has also been shown to modulate coronary flow and inflammation. Understanding how autonomic balance is altered by cardiac disease is an active area of research, and developing new ways to control this balance provides insights into disease therapies. However, achieving acute neuron-specific stimulation of autonomic neurons can be difficult in experiments that measure the acute effects of nerve stimulation on the heart...
2019: Frontiers in Physiology
https://read.qxmd.com/read/30740651/rsa-reactivity-in-response-to-viewing-bullying-film-and-adolescent-social-adjustment
#7
Lixian Cui, Xutong Zhang, Benjamin J Houltberg, Michael M Criss, Amanda S Morris
This study assessed adolescent respiratory sinus arrhythmia (RSA) reactivity while watching a bullying film clip from Boyz'n the Hood. We emphasized the importance of considering measurement context of RSA and examined whether RSA reactivity moderated the links between environmental factors (i.e., neighborhood violence, parental psychological control, and parental acceptance) and adolescent social adjustment. Data were collected from 57 adolescents and their primary caregivers. Electrocardiogram (ECG) and respiration data were obtained from adolescents...
February 10, 2019: Developmental Psychobiology
https://read.qxmd.com/read/30738114/pka-%C3%AE-2-ar-gs-gi-signaling-pathway-is-associated-with-anti-inflammatory-and-pro-apoptotic-effects-of-fuzi-and-banxia-combination-on-rats-subjected-to-pressure-overload
#8
Fengjiao Sun, Yingying Huang, Lili Li, Yuming Wang, Pengwei Zhuang, Yanjun Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Either Aconite Lateralis Radix Praeparata (Fuzi) or Pinelliae Rhizoma (Banxia) exerts anti-inflammatory activity and their combination has long been used in China for treating cardiovascular diseases. However, combination of two drugs is controversially prohibited in clinical prescriptions because it serves a representative incompatible pairs in "eighteen antagonisms". Up to date, whether the combination of Fuzi and Banxia could be used for treating heart failure with preserved ejection fraction (HFpEF) especially charactered by systemic inflammation and the potential mechanisms have not been elucidated...
February 6, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30736073/the-effect-of-pedaling-cadence-on-skeletal-muscle-oxygenation-during-cycling-at-moderate-exercise-intensity
#9
Federico Formenti, Cameron Dockerill, Lasitha Kankanange, Luyu Zhang, Tetsuo Takaishi, Koji Ishida
The aim of this study was to assess the changes determined by increased cadence on skeletal muscle oxygenation during cycling at an exercise intensity equal to the ventilatory threshold (Tvent ).Nine healthy, active individuals with different levels of cycling experience exercised at a power output equal to Tvent , pedaling at cadences of 40, 50, 60, 70, 80 and 90 rpm, each for 4 min. Cadences were tested in a randomized counterbalanced sequence. Cardiopulmonary and metabolic responses were studied using an ECG for heart rate, and gas calorimetry for pulmonary oxygen uptake and carbon dioxide production...
February 8, 2019: International Journal of Sports Medicine
https://read.qxmd.com/read/30734153/fusion-of-heart-rate-variability-and-salivary-cortisol-for-stress-response-identification-based-on-adverse-childhood-experience
#10
Noor Aimie-Salleh, M B Malarvili, Anna C Whittaker
Adverse childhood experiences have been suggested to cause changes in physiological processes and can determine the magnitude of the stress response which might have a significant impact on health later in life. To detect the stress response, biomarkers that represent both the Autonomic Nervous System (ANS) and Hypothalamic-Pituitary-Adrenal (HPA) axis are proposed. Among the available biomarkers, Heart Rate Variability (HRV) has been proven as a powerful biomarker that represents ANS. Meanwhile, salivary cortisol has been suggested as a biomarker that reflects the HPA axis...
February 7, 2019: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/30720738/an-innovative-unobtrusive-approach-to-investigate-smartphone-interaction-in-nonaddicted-subjects-based-on-wearable-sensors-a-pilot-study
#11
Alessandro Tonacci, Lucia Billeci, Francesco Sansone, Antonella Masci, Anna Paola Pala, Claudio Domenici, Raffaele Conte
Background and objectives: Smartphones are playing a pivotal role in everyday life, due to the opportunity they grant in terms of simplifying communication, entertainment, education and many other daily activities. Against such positive characteristics, smartphone interaction can result, in particular cases, in dangerous smartphone addiction patterns, possibly leading to several long-term detrimental psychophysiological conditions. Therefore, this pilot aims at assessing the feasibility of using an innovative approach, based on unobtrusive wearable sensors, used for the first time in this specific topic, and psychological questionnaires, to investigate the links between stress and emotions in a group of young, nonaddicted individuals performing smartphone interaction...
February 4, 2019: Medicina
https://read.qxmd.com/read/30711246/conduction-delay-induced-j-wave-augmentation-in-patients-with-coronary-heart-disease
#12
Masafumi Nakayama, Kazuhiro Satomi, Mikio Yuhara, Takashi Uchiyama, Yoshiyasu Aizawa, Yoshifusa Aizawa
Electrocardiogram records were surveyed for the presence of an atrial premature beat (APB) and J waves in patients with coronary heart disease and patients with noncardiac diseases. The prevalence and response of J waves to sudden shortening of the RR interval on the conducted APB were determined and compared between the 2 patients groups. The change in the QRS complexes on the APB was also determined. Among 17,013 patients, 243 patients who underwent percutaneous coronary intervention for acute myocardial infarction or angina pectoris had an APB, and J waves were observed in 16 patients (6...
January 24, 2019: American Journal of Cardiology
https://read.qxmd.com/read/30708356/towards-patient-connected-imaging-with-acrobeat-adaptive-cardiac-cone-beam-computed-tomography
#13
Tess Reynolds, Chun-Chien Shieh, Paul J Keall, Ricky T O'Brien
Robotic C-arm Cone Beam Computed Tomography (CBCT) systems are playing an increasingly pivotal role in interventional cardiac procedures and high precision radiotherapy treatments. One of the main challenges in any form of cardiac imaging is mitigating the intrinsic motion of the heart, which causes blurring and artefacts in the 3D reconstructed image. Most conventional 3D cardiac CBCT acquisition techniques attempt to combat heart motion through retrospective gating techniques, whereby acquired projections are sorted into the desired cardiac phase after the completion of the scan...
February 1, 2019: Physics in Medicine and Biology
https://read.qxmd.com/read/30706798/the-effects-of-healthy-ageing-on-cerebral-blood-flow-responses-to-cognitive-testing
#14
Lucy Beishon, Jatinder S Minhas, Kate Patrick, Iswariya Shanmugam, Claire A L Williams, Ronney B Panerai, Thompson G Robinson, Victoria J Haunton
Background Transcranial Doppler Ultrasonography (TCD) can be utilised to measure the tight coupling of cerebral blood flow velocity (CBFv) in response to cognitive demand by task activation, termed neurovascular coupling. AIMS: To investigate the differences in neurovascular coupling between healthy older (>50 years) and younger (18-49 years) adults in response to cognitive testing. METHODS: Fifty-four older (n=25) and younger (n=29) adults underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (ETCO2; capnography) monitoring...
January 31, 2019: Current Aging Science
https://read.qxmd.com/read/30704726/response-to-ecg-january-2019
#15
Pablo Martínez-Vives, Ana Fernández-Vega, Victoria Cañadas-Godoy
No abstract text is available yet for this article.
February 2019: Revista Española de Cardiología
https://read.qxmd.com/read/30704273/intracardiac-delineation-of-septal-conduction-in-left-bundle-branch-block-patterns-mechanistic-evidence-of-left-intra-hisian-block-circumvented-by-his-pacing
#16
Gaurav A Upadhyay, Tharian Cherian, Dalise Y Shatz, Andrew D Beaser, Zaid Aziz, Cevher Ozcan, Michael T Broman, Hemal Nayak, Roderick Tung
BACKGROUND: Septal activation in patients with left bundle branch block patterns has not been previously described. We performed detailed intracardiac mapping of left septal conduction to assess for the presence and level of complete conduction block in the His-Purkinje system. Response to His pacing was assessed in patients with and without complete conduction block in the left bundle. METHODS: Left septal mapping was performed with a linear multielectrode catheter in consecutive patients with LBBB pattern referred for device implant (n=38) or substrate mapping (n=47)...
February 1, 2019: Circulation
https://read.qxmd.com/read/30701837/role-of-electrocardiographic-and-echocardiographic-types-of-left-bundle-branch-block-in-prediction-of-response-to-cardiac-resynchronization-therapy
#17
S Yu Kashtanova, N A Mironova, V N Shitov, E M Gupalo, V G Kiktev, M A Saidova, S P Golitsyn
AIM: To assess the value of the complex analysis of electrocardiographic (ECG) variants and echocardiographic (echo) manifestation of left bundle branch block (LBBB) in predicting the success of cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 39 patients (mean age 61.49±9.0 years) on sinus rhythm with LBBB, QRS duration ≥130 ms, left ventricular ejection fraction (LVEF) ≤35%, heart failure (HF) NYHA II-IV despite optimal pharmacological therapy during 3 month...
December 30, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30689434/a-new-modified-wavelet-based-ecg-denoising
#18
Zhaoyang Wang, Junjiang Zhu, Tianhong Yan, Lulu Yang
PURPOSE: Wavelet denoising is one of the denoising methods commonly used for ECG signals. However, due to the frequency overlap between the EMG and ECG, the feeble characteristics of ECG signals exists the risk of being weakened in the process of filtering noise. This paper presents a method of modified wavelet design and applies it to the denoising of ECG signals. MATERIALS AND METHODS: The optimized filter coefficients are obtained by approximating the amplitude-frequency response of the ideal filter, and the wavelet is constructed with the optimized filter coefficients...
January 28, 2019: Computer Assisted Surgery (Abingdon, England)
https://read.qxmd.com/read/30682433/dynamic-programming-of-atrioventricular-delay-improves-electrical-synchrony-in-a-multicenter-cardiac-resynchronization-therapy-study
#19
Bernard Thibault, Philippe Ritter, Kerstin Bode, Leonardo Calò, Blandine Mondésert, Jan O Mangual, Nima Badie, Luke C McSpadden, Carlo Pappone, Niraj Varma
BACKGROUND: Patient-specific programming of cardiac resynchronization therapy (CRT) is often neglected, despite significant non-response rates. The device-based SyncAV CRT algorithm dynamically adjusts atrioventricular delays (AVD) to the intrinsic AV interval, reduced by a programmable offset, to accommodate each patient's changing needs. OBJECTIVE: Evaluate the acute impact of biventricular (BiV) pacing enhanced by SyncAV on electrical synchrony in a broad patient population...
January 22, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30682040/habituation-of-the-electrodermal-response-a-biological-correlate-of-resilience
#20
Frederick R Walker, Ashley Thomson, Kane Pfingst, Elke Vlemincx, Eugene Aidman, Eugene Nalivaiko
Current approaches to quantifying resilience make extensive use of self-reported data. Problematically, this type of scales is plagued by response distortions-both deliberate and unintentional, particularly in occupational populations. The aim of the current study was to develop an objective index of resilience. The study was conducted in 30 young healthy adults. Following completion of the Connor-Davidson Resilience Scale (CD-RISC) and Depression/Anxiety/Stress Scale (DASS), they were subjected to a series of 15 acoustic startle stimuli (95 dB, 50 ms) presented at random intervals, with respiration, skin conductance and ECG recorded...
2019: PloS One
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