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Supercritical Fluids

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https://read.qxmd.com/read/30785083/evaluation-of-global-conformational-changes-in-peptides-and-proteins-following-purification-by-supercritical-fluid-chromatography
#1
Nicole M Schiavone, Raffeal Bennett, Michael B Hicks, Gregory F Pirrone, Erik L Regalado, Ian Mangion, Alexey A Makarov
Supercritical fluid chromatography (SFC) has become the fastest growing analytical tool for chiral and achiral small-molecule pharmaceutical separations. The benefits from savings in cost (as a result of lower solvent and energy consumption), and time have made SFC a proven effective tool for solving many analytical problems for small-molecules over the years. There is, however, a gap in the application of SFC for larger biomolecules, proteins and peptides. There has been a notable increase of protein- and peptide-based drug therapies that contain a higher-order structure important to their efficacy...
February 13, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/30771469/entry-of-therapeutics-into-the-brain-influence-of-exposed-polarity-calculated-in-silico-and-measured-in-vitro-by-supercritical-fluid-chromatography
#2
Giacomo Russo, Francesco Barbato, Lucia Grumetto, Laurence Philippe, Frederic Lynen, Gilles H Goetz
The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of drug permeation through the blood-brain barrier (BBB). For this purpose, EPSA values for 69 structurally unrelated acidic, basic, neutral and amphoteric compounds were determined by a validated SFC method. Additionally, water-accessible surface area (WASA) values for the whole dataset were calculated in silico and compared to experimentally determined EPSA values...
February 13, 2019: International Journal of Pharmaceutics
https://read.qxmd.com/read/30741293/suppressive-effects-of-the-supercritical-carbon-dioxide-fluid-extract-of-chrysanthemum-indicum-on-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-in-mice
#3
Xiaoli Wu, Benqin Tang, Xian Liao, Ziren Su, Simon Ming-Yuen Lee, Yefeng Cai, Chuwen Li
The aim of the present study was to explore whether the supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum (SEC) exhibits antidepressant-like effects in a chronic unpredictable mild stress (CUMS)-induced mice model. Firstly, SEC was found to reverse a CUMS-induced decrease in the body weight gain in mice. Next, SEC was found to alleviate CUMS-induced depressive-like behavior, evidenced by the reversal of the decrease in the sucrose consumption in the sucrose preference test (SPT), the increase in the locomotor activity in the open field test (OPF), and the alleviation of immobility duration in both the forced swimming test (FST), and tail-suspension test (TST)...
February 11, 2019: Food & Function
https://read.qxmd.com/read/30740251/advances-of-supercritical-fluid-chromatography-in-lipid-profiling
#4
REVIEW
Yang Yang, Yanshan Liang, Jina Yang, Fengying Ye, Ting Zhou, Li Gongke
Supercritical fluid chromatography (SFC) meets with great favor due to its high efficiency, low organic solvent consumption, and the specialty for the identification of the isomeric species. This review describes the advances of SFC in targeted and untargeted lipid profiling. The advancement of the SFC instruments and the stationary phases are summarized. Typical applications of SFC to the targeted and untargeted lipid profiling are discussed in detail. Moreover, the perspectives of SFC in the lipid profiling are also proposed...
February 2019: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/30737457/factorial-design-assisted-supercritical-carbon-dioxide-extraction-of-cytotoxic-active-principles-from-carica-papaya-leaf-juice
#5
Kooi-Yeong Khaw, Marie-Odile Parat, Paul Nicholas Shaw, Thao T T Nguyen, Saurabh Pandey, Kristofer J Thurecht, James Robert Falconer
The aims of this study are to investigate the selective cytotoxic activity of supercritical carbon dioxide (scCO2 )-extracted freeze-dried leaf juice (FDLJ) of Carica papaya on squamous cell carcinoma (SCC25) cells, and to delineate the best small scale extraction parameters allowing maximal extract activity. Using scCO2 as a solvent, six operating parameters were studied and the supercritical fluid extraction (SFE) process investigated using a factorial design 26-2 . The processing values promoting cytotoxic activity towards SCC-25 are: high pressure (250 bar), low temperature (35 °C), extended processing time (180 minutes), as well as a large amount of starting material (5 g)...
February 8, 2019: Scientific Reports
https://read.qxmd.com/read/30736686/mid-ir-spectroscopy-of-supercritical-water-from-dilute-gas-to-dense-fluid
#6
Nicholas J Hestand, Steven E Strong, Liang Shi, J L Skinner
Mixed quantum-classical methods are commonly used to calculate infrared spectra for condensed-phase systems. These methods have been applied to study water in a range of conditions from liquid to solid to supercooled. Here, we show that these methods also predict infrared line shapes in excellent agreement with experiments in supercritical water. Specifically, we study the OD stretching mode of dilute HOD in H2 O. We find no qualitative change in the spectrum upon passing through the near-critical region (Widom line) or the hydrogen-bond percolation line...
February 7, 2019: Journal of Chemical Physics
https://read.qxmd.com/read/30733886/fast-simultaneous-determination-of-eight-sudan-dyes-in-chili-oil-by-ultra-high-performance-supercritical-fluid-chromatography
#7
Yunjia Yang, Jing Zhang, Jie Yin, Yi Yang
A rapid and simple ultra-high-performance supercritical fluid chromatography (UHPSFC) with photodiode array (PDA) method was developed and validated for simultaneous determination of eight Sudan dyes in chili oil. In particular, a pair of isomer, Sudan red B and Sudan IV, was included in the analysis. After being diluted with dichloromethane, the analytes were separated on an Acquity UPC2 HSS C18 SB column with gradient elution using CO2 as the mobile phase and acetonitrile/methanol (v/v, 45/55, containing 0...
2019: Journal of Analytical Methods in Chemistry
https://read.qxmd.com/read/30720234/the-pre-separation-of-oxygen-containing-compounds-in-oxidised-heavy-paraffinic-fractions-and-their-identification-by-gc-ms-with-supersonic-molecular-beams
#8
H Potgieter, P de Coning, R Bekker, E Rohwer, A Amirav
The heavy petroleum fractions produced during refining processes need to be upgraded to useable products to increase their value. Hydrogenated heavy paraffinic fractions can be oxidised to produce high value products that contain a variety of oxygenates. These heavy oxygenated paraffinic fractions need to be characterised to enable the control of oxidation processes and to understand product properties. The accurate identification of the oxygenates present in these fractions by electron ionisation (EI) mass spectrometry is challenging due to the complexity of these heavy fractions...
February 5, 2019: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/30717471/applying-supercritical-fluid-technology-to-prepare-ibuprofen-solid-dispersions-with-improved-oral-bioavailability
#9
Fei Han, Wei Zhang, Ying Wang, Ziyue Xi, Lu Chen, Sanming Li, Lu Xu
In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound. Solid-state characterization of the dispersions was conducted by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The PXRD and DSC results suggested that the amorphous form of IBU was maintained in the solid dispersions. Furthermore, in vitro dissolution and in vivo pharmacokinetic (PK) studies in rats were also performed...
February 3, 2019: Pharmaceutics
https://read.qxmd.com/read/30712818/development-of-a-practical-online-supercritical-fluid-extraction-supercritical-fluid-chromatography-mass-spectrometry-system-with-an-integrated-split-flow-method
#10
Miho Sakai, Yoshihiro Hayakawa, Yasuhiro Funada, Takashi Ando, Eiichiro Fukusaki, Takeshi Bamba
Herein, we describe a practical online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry (SFE-SFC/MS) system with an integrated split-flow method and a pre-column trap method that is well suited for the continuous extraction and separation of a wide range of compounds, including hydrophilic ones. Although an SFE-SFC system with a splitting method is already commercially available, in this study, we added some new features to this system: 1) a splitting method that further reduces the amount of extractant introduced into SFC, 2) a trap column, connected before the analytical column, with a different separation mechanism than the analytical column in the system with the splitting method, and 3) a system for calculating the recovery rate of SFE during online SFE-SFC/MS...
January 19, 2019: Journal of Chromatography. A
https://read.qxmd.com/read/30710733/chemical-and-in-vitro-toxicity-analysis-of-a-supercritical-fluid-extraction-of-kava-kava-piper-methysticum
#11
Greg E Petersen, Yijin Tang, Christine Fields
ETHNOPHARMACOLOGICAL RELEVANCE: Kava and kava extracts have shown great potential as a way to minimize anxiety-associated symptoms and to help alleviate pain. Hepatoxicity has been associated with the consumption of kava products. The chemical compounds, kavalactones (KL) and flavokavains (FK) have been implicated in kava's psychotropic and possible hepatotoxic properties. AIM OF THE STUDY: To investigate the kavalactone and flavokavain content and in vitro toxicity of KAVOA™ , a supercritical carbon dioxide extraction (SFE) of kava...
January 30, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30709622/efficient-methodology-for-the-extraction-and-analysis-of-lipids-from-porcine-pulmonary-artery-by-supercritical-fluid-chromatography-coupled-to-mass-spectrometry
#12
Alicia Gil-Ramirez, Said Al-Hamimi, Oskar Rosmark, Oskar Hallgren, Anna-Karin Larsson-Callerfelt, Irene Rodríguez-Meizoso
Pulmonary artery grafts are needed as cardiovascular bioprosthetics. For successful tissue recellularization after transplantation, lipids have to be removed from the donor artery. Developing a selective process to remove lipids without damaging the extracellular matrix greatly depends on knowing the amount and type of lipid compounds in the specific tissue. Here we present an efficient methodology for the study of lipids present in porcine pulmonary arteries. The performance of six extraction methods to recover lipids from artery was evaluated...
January 24, 2019: Journal of Chromatography. A
https://read.qxmd.com/read/30703676/occurrence-of-emerging-persistent-and-mobile-organic-contaminants-in-european-water-samples
#13
Stefanie Schulze, Daniel Zahn, Rosa Montes, Rosario Rodil, José Benito Quintana, Thomas P Knepper, Thorsten Reemtsma, Urs Berger
The release of persistent and mobile organic chemicals (PMOCs) into the aquatic environment puts the quality of water resources at risk. PMOCs are challenging to analyze in water samples, due to their high polarity. The aim of this study was to develop novel analytical methods for PMOCs and to investigate their occurrence in surface and groundwater samples. The target compounds were culled from a prioritized list of industrial chemicals that were modeled to be persistent, mobile, and emitted into the environment...
January 18, 2019: Water Research
https://read.qxmd.com/read/30696092/supercritical-fluid-extraction-of-carotenoids-from-vegetable-waste-matrices
#14
Micael de Andrade Lima, Ioannis Kestekoglou, Dimitris Charalampopoulos, Afroditi Chatzifragkou
The aim of this work was to evaluate a previously-developed model on supercritical fluid extraction (SFE) for carotenoid recovery from carrot peels on various carotenoid-rich fruit and vegetable wastes. To this end, 15 matrices, including flesh and peels of sweet potato, tomato, apricot, pumpkin and peach, as well as flesh and wastes of green, yellow and red peppers, were submitted to SFE under optimised conditions (59 °C, 350 bar, 15 g/min CO₂, 15.5% ( v/v ) ethanol as co-solvent, 30 min of extraction time)...
January 28, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30693528/quantitative-analysis-of-different-batches-of-raw-wine-processed-and-vinegar-processed-paeoniae-alba-radix-using-ultra-performance-convergence-chromatography-coupled-with-photo-diode-array-detection-upc-2-pda
#15
Liu Yang, Hai Jiang, Xinyue Guo, Ajiao Hou, Wenjing Man, Xudong Xing, Meiling Yan, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Supercritical fluid chromatography (SFC) is a safe and ecofriendly analytical technique that has not been fully applied to the analysis of traditional Chinese medicine (TCM). This is the first study on the separation of six quality markers (Q-markers) including paeoniflorin, albiflorin, benzoyl paeoniflorin, oxypaeoniflorin, gallic acid, and benzoic acid from raw, wine-baked, and vinegar-baked Paeoniae Alba Radix (PAR) by SFC. Optimum separation was achieved on an HSS C18 SB column (100×3.0 mm, 1.8 μm particles) with a gradient elution of high-purity carbon dioxide as mobile phase A and methanol/acetonitrile (70:30, v/v) with 0...
January 28, 2019: Biomedical Chromatography: BMC
https://read.qxmd.com/read/30692565/rosemary-rosmarinus-officinalis-extract-causes-ros-induced-necrotic-cell-death-and-inhibits-tumor-growth-in-vivo
#16
Almudena Pérez-Sánchez, Enrique Barrajón-Catalán, Verónica Ruiz-Torres, Luz Agulló-Chazarra, María Herranz-López, Alberto Valdés, Alejandro Cifuentes, Vicente Micol
Colorectal cancer is the third most common diagnosed cancer globally. Although substantial advances have been obtained both in treatment and survival rates, there is still a need for new therapeutical approaches. Natural compounds are a realistic source of new bioactive compounds with anticancer activity. Among them, rosemary polyphenols have shown a vast antiproliferative capacity against colon cancer cells in vitro and in animal models. We have investigated the antitumor activity of a rosemary extract (RE) obtained by using supercritical fluid extraction through its capacity to inhibit various signatures of cancer progression and metastasis such as proliferation, migration, invasion and clonogenic survival...
January 28, 2019: Scientific Reports
https://read.qxmd.com/read/30688100/preparation-of-albendazole-loaded-liposomes-by-supercritical-carbon-dioxide-processing
#17
Faheem Maqbool, Peter M Moyle, Madeleine S A Tan, Kristofer J Thurecht, James R Falconer
Supercritical fluid (SCF) technology offers a potential green alternative to organic solvent-based methods for drug formulation. Albendazole (ABZ) has promising anticancer activity when formulated to increase its cellular uptake. Herein, a static volume method was used to determine the solubility of ABZ in supercritical carbon dioxide (scCO2 ) for the future development of such ABZ formulations. The solubility of ABZ in scCO2 (250 bar, 37 °C) was approximately 12 mg/100 mL. The extent of dissolution was measured at various time points to determine when saturation solubility occurred, which was demonstrated from 9 h...
January 28, 2019: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/30678487/gc-ms-analysis-of-metabolites-from-soxhlet-extraction-ultrasound-assisted-extraction-and-supercritical-fluid-extraction-of-salacca-zalacca-flesh-and-its-alpha-glucosidase-inhibitory-activity
#18
Mohammed S M Saleh, Dzatil Awanis Mohd Bukhari, Mohammad Jamshed Ahmad Siddiqui, Abdul Razak Kasmuri, Suganya Murugesu, Alfi Khatib
Different extraction processes were employed to extract bioactive metabolites from Salacca zalacca flesh by a range of aqueous and organic solvents. The highest extraction yield was obtained by 50% ethanol extract of SE (73.18 ± 4.35%), whereas SFE_1 showed the lowest yield (0.42 ± 0.08%). All extracts were evaluated for in vitro α-glucosidase inhibitory activity, measured by their IC50 values in comparison to that of quercetin, the positive control (IC50 = 2.7 ± 0.7 μg/mL). The lowest α-glucosidase inhibitory activity was indicated by water extract of SE (IC50 = 724...
January 25, 2019: Natural Product Research
https://read.qxmd.com/read/30674842/millimeter-size-spherical-polyurea-aerogel-beads-with-narrow-size-distribution
#19
Despoina Chriti, Grigorios Raptopoulos, Maria Papastergiou, Patrina Paraskevopoulou
We report the room temperature synthesis of spherical millimeter-size polyurea (PUA) aerogel beads. Wet-gels of said beads were obtained by dripping a propylene carbonate solution of an aliphatic triisocyanate based on isocyanurate nodes into a mixture of ethylenediamine and heavy mineral oil. Drying the resulting wet spherical gels with supercritical fluid (SCF) CO₂ afforded spherical aerogel beads with a mean diameter of 2.7 mm, and a narrow size distribution (full width at half maximum: 0.4 mm). Spherical PUA aerogel beads had low density (0...
August 6, 2018: Gels
https://read.qxmd.com/read/30672314/evaluation-of-polysaccharide-based-chiral-stationary-phases-in-modern-sfc-ms-ms-for-enantioselective-bioanalysis
#20
Liuxi Chen, Brian Dean, Xiaorong Liang
AIM: The applicability of polysaccharide-based chiral stationary phases in modern supercritical fluid chromatography (SFC)-MS/MS for chiral bioanalysis was evaluated. MATERIALS & METHODS: Ten popular polysaccharide-based chiral stationary phases (CSPs) were tested using a set of 23 drugs against three cosolvents. The effect of temperature and backpressure on separation was examined. RESULTS: The recommended order of CSPs for screening was determined...
January 23, 2019: Bioanalysis
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