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Yu G Terent'yeva, V M Yashchuk, L A Zaika, O M Snitserova, M Yu Losytsky
A white blood human cells spectral investigation is presented. The aim of this series of experiments was to obtain and analyze the absorption and luminescence (fluorescence and phosphorescence) spectra at room temperature and at 78 K of newly isolated white blood human cells and their organelles. As a result the optical centers and possible biochemical components that form the studied spectra where identified. Also the differences between the spectra of abnormal cells (B-cell chronic lymphocytic leukemia BCLL) and normal ones were studied for the whole cells and individual organelles...
December 7, 2016: Methods and Applications in Fluorescence
R M Green, J J Murphy, J D Norton
In vitro phorbol ester-induced plasmacytoid differentiation of primary B chronic lymphocytic leukaemia (BCLL) cells is accompanied by the rapid, transient increased expression of a large number of early response genes (ERGs) whose expression is highly cell type specific. We have examined phorbol ester-responsive expression of a panel of 13 ERGs in a series of B cell lines representing different stages of differentiation and in primary malignant cells from patients with hairy cell leukaemia and with centroblastic-centrocytic non-Hodgkin's lymphoma...
1991: Leukemia & Lymphoma
Benjamin P Fingerhut, Shaul Mukamel
At the heart of photosynthesis is excitation energy transfer toward and charge separation within highly conserved reaction centers (RCs). The function principles of RCs in purple bacteria offer a blueprint for an optoelectronic device, which efficiently utilizes the near-IR region of the solar spectrum. We present theoretical modeling of the nonlinear optical response of the bacterial RC B. viridis incorporating electron and energy transfer on equal footing. The splitting of special pair excitons P is the origin of distinct cross peaks, which allow monitoring of the kinetics of charge separation...
July 5, 2012: Journal of Physical Chemistry Letters
Nathalie Guriec, Catherine Le Jossic-Corcos, Brigitte Simon, Jean-Christophe Ianotto, Adrian Tempescul, Yvonne Dréano, Jean-Pierre Salaün, Christian Berthou, Laurent Corcos
Deregulation of the oxidative cascade of poly-unsaturated fatty acids (PUFAs) has been associated with several cancers, including chronic lymphocytic leukemia (B-CLL). Leukotriene B4 (LTB4), a metabolite of arachidonic acid (AA), is produced by B-CLL and contributes to their survival. The aim of the present study was to analyze the activity of the oxidative cascade of PUFAs in B-CLL. Purified B cells from patients and normal B CD5 positive cells were subjected to flow cytometry, Western-blot and RT-qPCR analyses...
November 2014: Biochimica et Biophysica Acta
Michaela Waibel, Gareth Gregory, Jake Shortt, Ricky W Johnstone
PURPOSE OF REVIEW: The identification of oncogenic 'driver' mutations and activated survival pathways in selected aggressive B-cell malignancies directs the development of novel adjunctive therapies using targeted small molecule inhibitors. With a focus on diffuse large B-cell lymphoma 'not otherwise specified', Hodgkin lymphoma and childhood B-cell precursor acute lymphoblastic leukemia, this review will provide an up-to-date account of the current literature on the development of new molecularly targeted treatment modalities for aggressive B-cell malignancies...
July 2014: Current Opinion in Hematology
R A M Quax, J A M van Laar, R van Heerebeek, K Greiner, E Ben-Chetrit, M Stanford, G R Wallace, F Fortune, M Ghabra, M Soylu, J M W Hazes, S W J Lamberts, J H Kappen, P M van Hagen, J W Koper, R A Feelders
OBJECTIVE: Glucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-)inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behçet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC sensitivity. METHODS: Healthy controls and patients with BD in three independent cohorts were genotyped for four functional GR gene polymorphisms...
November 1, 2012: Endocrine Connections
Daniela Hauer, Iris-Tatjana Kolassa, Rüdiger Paul Laubender, Ulrich Mansmann, Christian Hagl, Benno Roozendaal, Dominique J-F de Quervain, Gustav Schelling
BACKGROUND: Cardiac surgery is one of the most commonly performed surgical procedures worldwide with >700,000 surgeries in 2006 in the US alone. Cardiac surgery results in a considerable exposure to physical and emotional stress; stress-related disorders such as depression or post-traumatic stress disorder are the most common adverse outcomes of cardiac surgery, seen in up to 20% of patients. Using information from a genome-wide association study to characterize genetic effects on emotional memory, we recently identified a single nucleotide polymorphism of the glucocorticoid receptor gene (the Bcll single nucleotide polymorphism) as a significant genetic risk factor for traumatic memories from cardiac surgery and symptoms of post-traumaticstress disorder...
2013: Trials
Laurent Amiset, Laetitia Fend, Tania Gatard-Scheikl, Karola Rittner, Vanessa Duong, Ronald Rooke, Sylviane Muller, Jean-Yves Bonnefoy, Xavier Préville, Hélène Haegel
Cancer immunotherapy is hampered by the immunosuppression maintained by regulatory T cells (Tregs) in tumor-bearing hosts. Stimulation of the Toll-like receptor 2 (TLR2) by Pam3Cys is known to affect Treg-mediated suppression. We found that Pam3Cys increases the proliferation of both CD4(+) effector T cells (Teffs) and Tregs co-cultured in vitro, but did not induce the proliferation of Tregs alone upon CD3 and CD28 stimulation. In a mouse model of RMA-MUC1 tumors, Pam3Cys was administered either alone or in combination with a modified vaccinia ankara (MVA)-based mucin 1 (MUC1) therapeutic vaccine...
November 1, 2012: Oncoimmunology
I L Ross, N S Levitt, L Van der Merwe, D A Schatz, G Johannsson, C Dandara, T S Pillay, D J Blom
BACKGROUND: Uncertainty exists whether glucocorticoid receptor (GCR) polymorphisms play a role in steroid-related side effects in Addison's disease (AD) patients on hydrocortisone. The polymorphisms Bcll and N363S appear to increase sensitivity to cortisol, while the ER22/23EK polymorphism has been associated with resistance to cortisol. METHOD: One hundred and forty seven AD patients, and gender, and ethnicity-matched controls were recruited in South Africa. Three polymorphisms in the GCR were studied, using PCR followed by restriction fragment length analysis...
March 2013: European Journal of Endocrinology
Sandra Ackermann, Angela Heck, Björn Rasch, Andreas Papassotiropoulos, Dominique J-F de Quervain
Glucocorticoids, stress hormones released from the adrenal cortex, are important players in the regulation of emotional memory. Specifically, in animals and in humans, glucocorticoids enhance memory consolidation of emotionally arousing experiences, but impair memory retrieval. These glucocorticoid actions are partly mediated by glucocorticoid receptors in the hippocampus, amygdala and prefrontal cortex, key brain regions for emotional memory. In a recent study in patients who underwent cardiac surgery, the BclI polymorphism of the glucocorticoid receptor gene (NR3C1) was associated with traumatic memories and posttraumatic stress disorder symptoms after intensive care therapy...
July 2013: Psychoneuroendocrinology
Evan Ingley
Src family kinases such as Lyn are important signaling intermediaries, relaying and modulating different inputs to regulate various outputs, such as proliferation, differentiation, apoptosis, migration and metabolism. Intriguingly, Lyn can mediate both positive and negative signaling processes within the same or different cellular contexts. This duality is exemplified by the B-cell defect in Lyn-/- mice in which Lyn is essential for negative regulation of the B-cell receptor; conversely, B-cells expressing a dominant active mutant of Lyn (Lynup/up) have elevated activities of positive regulators of the B-cell receptor due to this hyperactive kinase...
2012: Cell Communication and Signaling: CCS
Sabine Rohrmann, Jakob Linseisen, Marianne Uhre Jakobsen, Kim Overvad, Ole Raaschou-Nielsen, Anne Tjonneland, Marie Christine Boutron-Ruault, Rudolf Kaaks, Nikolaus Becker, Manuela Bergmann, Heiner Boeing, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Ruth Travis, Vassiliki Benetou, Androniki Naska, Antonia Trichopoulou, Valeria Pala, Rosario Tumino, Giovanna Masala, Amalia Mattiello, Magritt Brustad, Eiliv Lund, Guri Skeie, H Bas Bueno-de-Mesquita, Petra H M Peeters, Roel C H Vermeulen, Paula Jakszyn, Miren Dorronsoro, Aurelio Barricarte, Maria-Jose Tormo, Esther Molina, Marcial Argüelles, Beatrice Melin, Ulrika Ericson, Jonas Manjer, Sabina Rinaldi, Nadia Slimani, Paolo Boffetta, Anne-Claire Vergnaud, Aneire Khan, Teresa Norat, Paolo Vineis
The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires...
February 1, 2011: International Journal of Cancer. Journal International du Cancer
Silke Hermann, Sabine Rohrmann, Jakob Linseisen, Alexandra Nieters, Aneire Khan, Valentina Gallo, Kim Overvad, Anne Tjønneland, Ole Raaschou-Nielsen, Manuela M Bergmann, Heiner Boeing, Nikolaus Becker, Rudolf Kaaks, H Bas Bueno-de-Mesquita, Anne M May, Roel C H Vermeulen, Sheila Bingham, Kay-Tee Khaw, Timothy J Key, Ruth C Travis, Antonia Trichopoulou, Christina Georgila, Dimitra Triantafylou, Egidio Celentano, Vittorio Krogh, Giovanna Masala, Rosario Tumino, Antonio Agudo, Jone M Altzibar, Eva Ardanaz, Carmen Martínez-García, Marcial Vicente Argüelles Suárez, Maria José Tormo, Tonje Braaten, Eiliv Lund, Jonas Manjer, Sophia Zackrisson, Göran Hallmans, Beatrice Malmer, Paolo Boffetta, Paul Brennan, Nadia Slimani, Paolo Vineis, Elio Riboli
INTRODUCTION: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. MATERIALS AND METHODS: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk...
January 2010: Journal of Cancer Research and Clinical Oncology
E Jablonska, B Kiersnowska-Rogowska, M Aleksandrowicz-Bukin, F Rogowski, J Sawicka-Powierza
Great importance in the course of chronic B-cell lymphocytic leukemia (B-CLL) has been ascribed to cytokines belonging to the superfamily of the tumor necrosis factor (TNF), including TRAIL (TNF-related apoptosis inducing ligand) and its specific receptors: TRAIL receptor 1 (TRAIL-R1), TRAIL receptor 2 (TRAIL-R2), TRAIL receptor 3 (TRAIL-R3), TRAIL receptor 4 (TRAIL-R4) and osteoprotegerin (OPG). Both the molecule and the receptors may occur in membrane and soluble forms, except for OPG which has only a soluble form...
2008: Neoplasma
Carmen D Schweighofer, Gerd Fätkenheuer, Peter Staib, Michael Hallek, Marcel Reiser
BACKGROUND: Involvement of the central nervous system (CNS) is a rare complication of chronic lymphocytic leukemia (CLL) and seems to be more frequent in patients with Richter's syndrome or prolymphocytic transformation. Cases with leptomeningeal involvement reported in the literature mostly do not discuss the definition of CLL-associated meningeosis and the exclusion of neuroborreliosis. PATIENT AND METHODS: We present the case of a 75-year-old male patient who was admitted to a rural hospital with ataxia, disorientation, and signs of progressive CLL disease...
November 2007: Onkologie
Priyabrata Mukherjee, Resham Bhattacharya, Nancy Bone, Yean K Lee, Chitta Ranjan Patra, Shanfeng Wang, Lichun Lu, Charla Secreto, Pataki C Banerjee, Michael J Yaszemski, Neil E Kay, Debabrata Mukhopadhyay
B-Chronic Lymphocytic Leukemia (CLL) is an incurable disease predominantly characterized by apoptosis resistance. We have previously described a VEGF signaling pathway that generates apoptosis resistance in CLL B cells. We found induction of significantly more apoptosis in CLL B cells by co-culture with an anti-VEGF antibody. To increase the efficacy of these agents in CLL therapy we have focused on the use of gold nanoparticles (GNP). Gold nanoparticles were chosen based on their biocompatibility, very high surface area, ease of characterization and surface functionalization...
May 8, 2007: Journal of Nanobiotechnology
Xiao-fei Sun, Zi-jun Zhen, Yi Xia, Qun-ying Yang, Zhi-hui Wang, Jia-yu Ling
OBJECTIVE: To analyse the clinical features of patients with B cell lymphoblastic lymphoma(BCLL) and the outcomes after modified BFM-90 protocol therapy. METHODS: The clinical features of 14 patients with BCLL were analysed, and compared with that of T cell lymphoblastic lymphoma in the same period. The efficacy and toxicity of modified BFM-90 protocol were analysed. RESULTS: The 14 patients were aged 3 to 18 and diagnosed as BCLL by morphology and immunohistology...
October 2006: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Nancy Yousef Asaad, Moshira Mohamed Abd El-Wahed, Marwa Mohammed Dawoud
BACKGROUND: B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL) show many overlapping morphologic and immunophenotyping features, however they have great difference in therapeutic regimens and prognosis. THE AIM OF THE STUDY: Is to determine the diagnostic and prognostic role of clinico-pathologic variables, CD23 and Cyclin D1 oncoprotiens in B-SLL/CLL and MCL. PATIENTS AND METHODS: This study included 25 BCLL/ SLL cases and 25 MCL cases...
December 2005: Journal of the Egyptian National Cancer Institute
Ignazio Majolino, Marco Ladetto, Anna Locasciulli, Daniela Drandi, Fabio Benedetti, Andrea Gallamini, Teodoro Chisesi, Angelo De Blasio, Mario Boccadoro, Corrado Tarella
B-CLL patients with resistant/relapsed disease or adverse prognostic factors at presentation are suitable for alternative treatments. In the present pilot study we investigated a novel intensive chemo-immunotherapy approach for high-risk, fludarabine pretreated patients. Ten patients with resistant/relapsed, advanced stage BCLL were included. Age was 37-60 yr (median 53). All but one had an unmutated IgVH status. The treatment schedule included debulking with two DHAP courses followed by alemtuzumab (30 mg, eight doses), followed by peripheral blood progenitor cell (PBPC) mobilization with intermediate/high-dose cyclophosphamide and by autografting after high-dose mitoxantrone+L-Pam...
2006: Medical Oncology
Meritxell Garcia Alzamora, Markus Schmidli, Urs Hess, Richard Cathomas, Roger von Moos
BACKGROUND: So far, only 9 cases of minimal change glomerulonephritis (MCGN) related to chronic lymphocytic leukemia (CLL) have been described. CASE REPORT: Our patient presented with severe nephrotic syndrome. Diagnostic biopsies confirmed MCGN and early-stage BCLL (Binet A). In contrast to previously described cases, kappa monoclonal IgM and cryoglobulins were also detected. The patient was treated with chlorambucil and prednisone. 3 weeks later, renal function and white blood cell (WBC) count were completely normal...
April 2006: Onkologie
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