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galectin-3 Atrial fibrillation

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https://read.qxmd.com/read/30929988/atrial-contractility-and-fibrotic-biomarkers-are-associated-with-atrial-fibrillation-after-elective-coronary-artery-bypass-grafting
#1
Constanze Bening, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Alhussini, Michal Glanowski, Tanja Kottmann, Rainer Leyh
OBJECTIVE: New-onset postoperative atrial fibrillation is common after cardiac surgery. Less has been reported about the relationship among fibrosis, inflammation, calcium-induced left atrial and right atrial contractile forces, and postoperative atrial fibrillation. We sought to identify predictors of postoperative atrial fibrillation. METHODS: From August 2016 to February 2018, we evaluated 229 patients who had preoperative sinus rhythm before elective primary coronary artery bypass grafting...
February 28, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30712532/predictors-of-the-paroxysmal-atrial-fibrillation-recurrence-following-cryoballoon-based-pulmonary-vein-isolation-assessment-of-left-atrial-volume-left-atrial-volume-index-galectin-3-level-and-neutrophil-to-lymphocyte-ratio
#2
Aziz Inan Celik, Mehmet Kanadasi, Mesut Demir, Ali Deniz, Rabia Eker Akilli, Onur Sinan Deveci, Caglar Emre Cagliyan, Caglar Ozmen, Firat Ikikardes, Muhammet Bugra Karaaslan
BACKGROUND: Cryoballoon-based pulmonary vein isolation (PVI) is a treatment option for atrial fibrillation (AF). Left atrial volume (LAV) and left atrial volume index (LAVi) are important parameters for long term success of PVI. Galectin-3 (Gal-3) and neutrophil to lymphocyte ratio (N/L ratio) are biomarkers to demonstrate the cardiac fibrosis and remodelling. METHODS: 50 patients with symptomatic PAF despite ≥1 antiarrhythmic drug(s), who underwent PVI were enrolled...
January 2019: Indian Pacing and Electrophysiology Journal
https://read.qxmd.com/read/30081800/-relationship-between-levels-of-sex-hormones-and-response-to-cardiac-resynchronisation-therapy-in-men
#3
T N Enina, V A Kuznetsov, A M Soldatova, T I Petelina, D V Krinochkin, S M Dyachkov, A Y Rychkov, T Y Gorbunova
AIM: To study the relationship between levels of sex hormones and effectiveness of cardiac resynchronisation therapy (CRT) in men with chronic heart failure (CHF). MATERIALS AND METHODS: The best response to CRT (mean time, 38 [19,0;53,7] months) was identifed by a maximum decrease in left ventricular end-systolic volume (LVESV) in 58 men (mean age, 54.8±9.6) with CHF (61% IHD). Based on testosterone (TES) level, patients were divided into group 1 (n=28; 48%) - TES < median value (13...
2018: Kardiologiia
https://read.qxmd.com/read/30067817/galectin-3-level-predicts-response-to-ablation-and-outcomes-in-patients-with-persistent-atrial-fibrillation-and-systolic-heart-failure
#4
Nicolas Clementy, Bruno Garcia, Clémentine André, Arnaud Bisson, Nazih Benhenda, Bertrand Pierre, Anne Bernard, Laurent Fauchier, Eric Piver, Dominique Babuty
INTRODUCTION: Mechanisms of maintenance of both atrial fibrillation and structural left ventricular disease are known to include fibrosis. Galectin-3, a biomarker of fibrosis, is elevated both in patients with heart failure and persistent atrial fibrillation. We sought to find whether galectin-3 has a prognostic value in patients with heart failure and a reduced left ventricular ejection fraction undergoing ablation of persistent atrial fibrillation. METHODS: Serum concentrations of galectin-3 were determined in a consecutive series of patients with an ejection fraction ≤40%, addressed for ablation of persistent atrial fibrillation...
2018: PloS One
https://read.qxmd.com/read/29992263/proteomic-profile-of-patients-with-atrial-fibrillation-undergoing-cardiac-surgery
#5
Ilias P Doulamis, George Samanidis, Aspasia Tzani, Asier Antoranz, Anastasios Gkogkos, Panagiotis Konstantopoulos, Vaia Pliaka, Angeliki Minia, Leonidas G Alexopoulos, Despina N Perrea, Konstantinos Perreas
OBJECTIVES: Proteomic analysis of patients with advanced cardiovascular disease was conducted to identify possible biomarkers for atrial fibrillation (AF). METHODS: A total of 123 patients undergoing cardiac surgery (22 with AF and 101 without AF) and 20 healthy subjects were recruited. Demographic data, patient history and blood samples were collected. Growth/differentiation factor 15, resistin, intracellular adhesion molecule-1, galectin-3, trefoil factor 3, tissue inhibitor of metalloproteinases 1, matrix metallopeptidase 9, high-sensitive troponin T, interleukins 6, 1α, 3, 4, 8, 20 and 22, tumour necrosis factor alpha, C-X-C motif chemokines 10 and 11, S100A6 and Type III procollagen were measured in blood serum...
July 9, 2018: Interactive Cardiovascular and Thoracic Surgery
https://read.qxmd.com/read/29861319/circulating-galectin-3-is-associated-with-left-atrial-appendage-remodelling-and-thrombus-formation-in-patients-with-atrial-fibrillation
#6
Zhengde Tang, Lefeng Zeng, Yanjun Lin, Zhihua Han, Jun Gu, Changqian Wang, Huili Zhang
BACKGROUND: Left atrial appendage (LAA) is gaining increasing attention in patients with atrial fibrillation (AF) in the context of cardioembolic stroke. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and is associated with an increased incidence of heart failure. However, the role of Gal-3 in LAA remodelling and thrombus formation in AF has not been evaluated. METHODS: This prospective study included 153 consecutive patients with paroxysmal (n=58), persistent (n=55) or permanent (n=40) nonvalvular AF...
May 14, 2018: Heart, Lung & Circulation
https://read.qxmd.com/read/29807358/activation-of-tgf-%C3%AE-1-%C3%AE-sma-col-i-profibrotic-pathway-in-fibroblasts-by-galectin-3-contributes-to-atrial-fibrosis-in-experimental-models-and-patients
#7
Hua Shen, Jing Wang, Jie Min, Wang Xi, Yang Gao, Liang Yin, Yue Yu, Kai Liu, Jian Xiao, Yu-Feng Zhang, Zhi-Nong Wang
BACKGROUND/AIMS: This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively to atrial fibrosis both in patients and experimental atrial fibrillation (AF) models. METHODS: Mouse HL-1 cardiomyocytes were subjected to rapid electrical stimulation (RES) to explore Gal-3 expression and secretion levels by western blotting (WB) and enzyme linked immunosorbent assay (ELISA). Neonatal rat cardiac fibroblasts were treated with conditioned culture medium and recombinant human Gal-3 to evaluate the activation of the transforming growth factor (TGF)-β1/α-smooth muscle actin (SMA)/collagen I (Col I) profibrotic pathway (WB) and fibroblast proliferation with a Cell Counting Kit-8 (CCK-8)...
2018: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/29587379/galectin-3-in-atrial-fibrillation-mechanisms-and-therapeutic-implications
#8
REVIEW
Nicolas Clementy, Eric Piver, Arnaud Bisson, Clémentine Andre, Anne Bernard, Bertrand Pierre, Laurent Fauchier, Dominique Babuty
Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.
March 25, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/29483593/human-epicardial-adipose-tissue-ctgf-expression-is-an-independent-risk-factor-for-atrial-fibrillation-and-highly-associated-with-atrial-fibrosis
#9
Qing Wang, Wang Xi, Liang Yin, Jing Wang, Hua Shen, Yang Gao, Jie Min, Yufeng Zhang, Zhinong Wang
Epicardial adipose tissue (EAT) is associated with the incidence, perpetuation, and recurrence of atrial fibrillation (AF), with elusive underlying mechanisms. We analyzed adipokine expression in samples from 20 patients with sinus rhythm (SR) and 16 with AF. Quantitative real-time PCR showed that connective tissue growth factor (cTGF) expression was significantly higher in EAT than in subcutaneous adipose tissue (SAT) or paracardial adipose tissue (PAT) from patients with AF, and in EAT from patients with SR (P < 0...
February 26, 2018: Scientific Reports
https://read.qxmd.com/read/29287900/galectin-3-in-patients-with-coronary-heart-disease-and-atrial-fibrillation
#10
Qi Kang, XiaoLong Li, Mengyun Yang, Taniya Fernando, Zheng Wan
OBJECTIVE: To observe the change of the inflammatory factor Galectin-3 in patients with coronary heart disease, and the correlation between Galectin-3 and the severity of the disease. To observe changes of Galectin-3 in patients with atrial fibrillation (AF) before and after radiofrequency ablation, and the changes of Galectin-3 before and after an interim treatment with a high dose of atorvastatin on patients with acute myocardial infarction(AMI). METHODS: Patients with coronary heart disease and atrial fibrillation having normal heart function were selected, among them, the patients with AMI were given a short term treatment of 80mg atorvastatin before PCI, and patients with atrial fibrillation underwent radiofrequency catheter ablation...
March 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#11
MULTICENTER STUDY
Mariëlle S Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien C M Kremer, Romana T Netea-Maier, Helena J H van der Pal, Robin P Peeters, John T M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in the Netherlands between 1970 and 2009...
December 2017: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/29118378/the-association-between-galectin-3-and-hs-crp-and-the-clinical-outcome-after-non-st-elevation-myocardial-infarction-with-preexisting-atrial-fibrillation
#12
Milan Pavlović, Svetlana Apostolović, Dragana Stokanović, Stefan Momčilović, Tatjana Jevtović-Stoimenov, Snezana Ćirić Zdravković, Sonja Šalinger Martinović, Nebojsa Krstić, Goran Koraćević, Danijela Djordjevic, Vladan Ćosić, Valentina N Nikolic
Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outcome in the Non-ST elevation acute myocardial infarction (NSTEMI) patients with preexisting AF. Thirty-two patients with the first acute NSTEMI and preexisting AF and 22 patients without preexisting AF, were prospectively followed for fifteen months...
November 8, 2017: Scientific Reports
https://read.qxmd.com/read/28938960/galectin-3-and-incidence-of-atrial-fibrillation-the-atherosclerosis-risk-in-communities-aric-study
#13
MULTICENTER STUDY
Oluwaseun E Fashanu, Faye L Norby, David Aguilar, Christie M Ballantyne, Ron C Hoogeveen, Lin Y Chen, Elsayed Z Soliman, Alvaro Alonso, Aaron R Folsom
BACKGROUND: Galectin-3, a β-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. METHODS: We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the Atherosclerosis Risk in Communities study. We ascertained incident AF through 2013 from study visit electrocardiograms, hospitalizations, and death certificates...
October 2017: American Heart Journal
https://read.qxmd.com/read/28525549/the-change-in-circulating-galectin-3-predicts-absence-of-atrial-fibrillation-after-thoracoscopic-surgical-ablation
#14
Wouter R Berger, Benoît Jagu, Nicoline W E van den Berg, Dean R P P Chan Pin Yin, Jan P van Straalen, Onno J de Boer, Antoine H G Driessen, Jolien Neefs, Sébastien P J Krul, WimJan P van Boven, Allard C van der Wal, Joris R de Groot
Aims: Galectin-3 (Gal-3) is an important mediator of cardiac fibrosis, particularly in heart failure. Increased Gal-3 concentration (Gal-3), associated with increased risk of developing atrial fibrillation (AF), may reflect atrial fibrotic remodelling underlying AF progression. We aimed to investigate whether the change in serum Gal-3 reflects alterations of the arrhythmogenic atrial substrate following thoracoscopic AF surgery, and predicts absence of AF. Methods and results: Consecutive patients undergoing thoracoscopic AF surgery were included...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/28339804/intra-cardiac-and-peripheral-levels-of-biochemical-markers-of-fibrosis-in-patients-undergoing-catheter-ablation-for-atrial-fibrillation
#15
COMPARATIVE STUDY
Gordon A Begg, Rashed Karim, Tobias Oesterlein, Lee N Graham, Andrew J Hogarth, Stephen P Page, Christopher B Pepper, Kawal Rhode, Gregory Y H Lip, Arun V Holden, Sven Plein, Muzahir H Tayebjee
Aims: Measurement of circulating biomarkers of fibrosis may have a role in selecting patients and treatment strategy for catheter ablation. Pro-collagen type III N-terminal pro-peptide (PIIINP), C-telopeptide of type I collagen (ICTP), fibroblast growth factor 23 (FGF-23), and galectin 3 (gal-3) have all been suggested as possible biomarkers for this indication, but studies assessing whether peripheral levels reflect intra-cardiac levels are scarce. Methods and results: We studied 93 patients undergoing ablation for paroxysmal atrial fibrillation (AF) (n = 63) or non-paroxysmal AF (n = 30)...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/28318874/metabolic-profile-provides-prognostic-value-better-than-galectin-3-in-patients-with-heart-failure
#16
Chao-Hung Wang, Mei-Ling Cheng, Min-Hui Liu, Li-Tang Kuo, Ming-Shi Shiao
BACKGROUND: Metabolic profiles have been shown to provide prognostic information in patients with heart failure (HF). Galectin-3 (Gal-3), indicating cardiac fibrosis, is a documented biomarker of prognosis in HF. It is unknown whether metabolic profiles provide prognostic value better than Gal-3. METHODS AND RESULTS: This study analyzed 212 hospitalized HF patients, measuring metabolic score (composed by butyrylcarnitine, dimethylarginine/arginine ratio, spermidine, and total essential amino acids) and Gal-3...
July 2017: Journal of Cardiology
https://read.qxmd.com/read/28295609/serum-galectin-3-level-as-a-marker-of-thrombogenicity-in-atrial-fibrillation
#17
Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin, Hande Canpinar, Ugur Canpolat, Banu Evranos, Hikmet Yorgun, Necla Ozer, Dicle Guc, Kudret Aytemir
BACKGROUND: Left atrial appendage flow velocity (LAAFV) and presence of spontaneous echo contrast (SEC) have been reported to be predictors of thromboembolism in atrial fibrillation (AF) patients. Galectin-3 is a biomarker reflecting pro-inflammatory status, whose role in AF has recently drawn attention, particularly in persistent AF population. AIM: In this study we aimed to investigate the association between serum galectin-3 levels and echocardiographic predictors of thromboembolism in persistent AF patients...
November 2017: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/28290846/-galectin-3-in-patients-with-paroxysmal-and-persistent-atrial-fibrillation-and-metabolic-syndrome
#18
V A A, E L Zaslavskaya, A V Soboleva, E I Baranova, O V Listopad, S E Nifontov, A O Nrady, E V Shlyakhto
OBJECTIVE: To evaluate serum galectin 3 and to determine the potential clinical value of this parameter in patients with atrial fibrillation - AF (paroxysmal and persistent) and metabolic syndrome (MS). DESIGN AND METHODS: We examined 100 patients with MS (50 with paroxysmal or persistent AF and 50 without arrhythmia) and 50 healthy persons. Serum galectin 3 measured by ELISA method, ECHO cardiography was performed to all examined persons. RESULTS: Galectin 3 in patients with MS and AF was higher, than in patients with MS without arrhythmia and much more higher than galectin 3 in healthy persons 0,72 (0,44;1,36), 0,44 (0,42;1,22) and 0,32 (0,28;0,42) ng/ml (<0,01)...
June 2016: Kardiologiia
https://read.qxmd.com/read/28150280/galectin-3-is-associated-with-coronary-plaque-burden-and-obstructive-sleep-apnoea-syndrome-severity
#19
Hamdi Pusuroglu, Umut Somuncu, Ismail Bolat, Ozgur Akgul, Vesile Ornek, Hayriye Ak Yıldırım, Emre Akkaya, Huseyin Karakurt, Aydın Yıldırım, Ayfer Utku Savaş
BACKGROUND: Obstructive sleep apnoea syndrome (OSAS) is reported to be associated with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis, and remodelling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 diabetes mellitus has been reported. AIM: The aim of this study was to investigate the association between galectin-3 level and coronary plaque burden as well as OSAS severity in patients with OSAS...
2017: Kardiologia Polska
https://read.qxmd.com/read/28079145/galectin-3-as-a-marker-of-interstitial-atrial-remodelling-involved-in-atrial-fibrillation
#20
Diana Hernández-Romero, Juan Antonio Vílchez, Álvaro Lahoz, Ana I Romero-Aniorte, Eva Jover, Arcadio García-Alberola, Rubén Jara-Rubio, Carlos M Martínez, Mariano Valdés, Francisco Marín
Remodelling in the atria could appear as a result of hypertension, diabetes or ischaemic heart disease. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and a potential biomarker of cardiac remodelling. We prospectively recruited consecutive patients undergoing elective cardiac surgery. Preoperative Gal-3 levels were determined from serum samples, and the presence of fibrosis was assessed from atrial appendage tissue samples obtained during cardiac surgery. We included 100 patients with aortic valve or ischaemic heart diseases and 15 controls with permanent AF...
January 12, 2017: Scientific Reports
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