keyword
https://read.qxmd.com/read/38518969/compounds-with-potentialities-as-novel-chemotherapeutic-agents-in-leishmaniasis-at-preclinical-level
#1
REVIEW
Maikel González-Matos, Mirtha Elisa Aguado, Maikel Izquierdo, Lianet Monzote, Jorge González-Bacerio
Leishmaniasis are neglected infectious diseases caused by kinetoplastid protozoan parasites from the genus Leishmania. These sicknesses are present mainly in tropical regions and almost 1 million new cases are reported each year. The absence of vaccines, as well as the high cost, toxicity or resistance to the current drugs determines the necessity of new treatments against these pathologies. In this review, several compounds with potentialities as new antileishmanial drugs are presented. The discussion is restricted to the preclinical level and molecules are organized according to their chemical nature, source and molecular targets...
March 20, 2024: Experimental Parasitology
https://read.qxmd.com/read/38494264/multi-epitope-vaccine-design-against-leishmaniasis-using-ifn-%C3%AE-inducing-epitopes-from-immunodominant-gp46-and-gp63-proteins
#2
JOURNAL ARTICLE
Amir Dehghani, Mina Mamizadeh, Atena Karimi, Seyyed Amir Hosseini, Davood Siamian, Morteza Shams, Shadan Ghiabi, Gholam Basati, Amir Abaszadeh
There is no currently approved human vaccine against leishmaniasis. Utilization of immunogenic antigens and their epitopes capable of enhancing immune responses against leishmaniasis is a crucial step for rational in silico vaccine design. The objective of this study was to generate and evaluate a potential vaccine candidate against leishmaniasis, designed by immunodominant proteins from gp46 and gp63 of Leishmania major, which can stimulate helper T-lymphocytes (HTL) and cytotoxic T-lymphocytes (CTL). For this aim, the IFN-γ-inducing MHC-I and MHC-II binders were predicted for each examined protein (gp46 and gp63) and connected with appropriate linkers, along with an adjuvant (Mycobacterium tuberculosis L7/L12) and a histidine tag...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38492406/in-silico-prediction-of-cd8-and-cd4-t-cell-epitopes-in-leishmania-major-proteome-using-immunoinformatics
#3
JOURNAL ARTICLE
Mohammad Kashif, Mohd Waseem, Naidu Subbarao
The leishmaniases are NDTs (neglected tropical diseases) that affect people all over the world. They are brought on by protozoans from the genus Leishmania and disseminated by phlebotomine flies that are afflicted with the disease. The best option to manage and lower the incidence of these diseases has been thought by the creation of a safe and effective vaccination. This research used an in silico based mining approach to look for high potential epitopes that might bind to MHC Class I and MHC Class II molecules (mainly; HLA-A*02:01 & HLA-DRB1*03:01) from human population in order to promote vaccine development...
March 11, 2024: Journal of Molecular Graphics & Modelling
https://read.qxmd.com/read/38469319/memory-t-cells-promising-biomarkers-for-evaluating-protection-and-vaccine-efficacy-against-leishmaniasis
#4
REVIEW
Mahmoud Nateghi-Rostami, Yahya Sohrabi
Understanding the immune response to Leishmania infection and identifying biomarkers that correlate with protection are crucial for developing effective vaccines. One intriguing aspect of Leishmania infection is the persistence of parasites, even after apparent lesion healing. Various host cells, including dendritic cells, fibroblasts, and Langerhans cells, may serve as safe sites for latent infection. Memory T cells, especially tissue-resident memory T cells (TRM ), play a crucial role in concomitant immunity against cutaneous Leishmania infections...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38467387/gsk-3-kinase-a-putative-therapeutic-target-in-trypanosomatid-parasites
#5
REVIEW
Alfredo Prado Dias, Cristian Alejandro Meneses Canal, Jaider Elian Giraldo Delgado, Ruben Eduardo Varela
Trypanosomatids are an important group of parasites that predominate in tropical and subtropical areas of the planet, which cause diseases that are classified as forgotten and neglected by the world health organization. In this group of parasites, we find Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense and Leishmania spp, for which there is no vaccine available, and its control has focused mainly on pharmacological treatment. Due to the poverty situation where these diseases are found and the biological complexity of these parasites, there are multiple variables to control, including the diversity of species, the complexity of their life cycles, drug resistance, cytotoxicity, the limited use in pregnant women, the high costs of treatment and the little-known pharmacological mechanisms of action, among others...
March 8, 2024: Brazilian Journal of Infectious Diseases
https://read.qxmd.com/read/38466368/global-dilemma-and-needs-assessment-toward-achieving-sustainable-development-goals-in-controlling-leishmaniasis
#6
REVIEW
Mehdi Bamorovat, Iraj Sharifi, Ahmad Khosravi, Mohammad Reza Aflatoonian, Setareh Agha Kuchak Afshari, Ehsan Salarkia, Fatemeh Sharifi, Behnaz Aflatoonian, Faranak Gharachorloo, Ali Khamesipour, Mehdi Mohebali, Omid Zamani, Mohammad Reza Shirzadi, Mohammad Mahdi Gouya
Leishmaniasis is a disease of poverty that imposes a devastating medical, social, and economic burden on over 1 billion people nationwide. To date, no in-depth study to analyze the major global challenges and needs assessment has been carried out. This investigation aimed to explore a comprehensive narrative review of leishmaniasis's main challenges and initially highlight obstacles that might impede the implementation of control measures. Also, we propose a specific list of priorities for needs assessment...
March 11, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38409720/diagnosis-of-canine-visceral-leishmaniasis-by-flow-cytometry-serology-using-the-rmeleish-multiepitope-antigen-coupled-in-a-functional-bead
#7
JOURNAL ARTICLE
Henrique Bonifácio Moura, Henrique Gama Ker, Luana S Ramos, Lais M Nogueira, Juliana M Machado, Daniel S Dias, Rita Alaíde Leandro Rodrigues, Mariana Campos da Paz, Rafael Gonçalves Teixeira-Neto, Alexandre Barbosa Reis, Alexsandro S Galdino, Eduardo S Silva
BACKGROUND: Visceral leishmaniasis (VL) is a zoonotic disease, with dogs being the main reservoir of the Leishmania infantum parasite. OBJECTIVE: To develop a new flow cytometry test to diagnosis canine VL (CVL) diagnosis. METHODS: The current study addresses a new flow cytometry test using beads coupled to the multiepitope antigen rMELEISH. RESULTS: In the study set of samples a sensitivity (87.1%) and specificity (89...
February 23, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38396573/enhancing-control-of-leishmania-infantum-infection-a-multi-epitope-nanovaccine-for-durable-t-cell-immunity
#8
JOURNAL ARTICLE
Clara Hurtado-Morillas, Abel Martínez-Rodrigo, José A Orden, Laura de Urbina-Fuentes, Alicia Mas, Gustavo Domínguez-Bernal
Canine leishmaniosis (CanL) is a growing health problem for which vaccination is a crucial tool for the control of disease. The successful development of an effective vaccine against this disease relies on eliciting a robust and enduring T-cell immune response involving the activation of CD4+ Th1 and CD8+ T-cells. This study aimed to evaluate the immunogenicity and prophylactic efficacy of a novel nanovaccine comprising a multi-epitope peptide, known as HisDTC, encapsulated in PLGA nanoparticles against Leishmania infantum infection in the murine model...
February 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38393119/in-vitro-and-ex-vivo-synergistic-effect-of-pyrvinium-pamoate-combined-with-miltefosine-and-paromomycin-against-leishmania
#9
JOURNAL ARTICLE
Estela Melcón-Fernández, Giulio Galli, Rafael Balaña-Fouce, Nerea García-Fernández, María Martínez-Valladares, Rosa M Reguera, Carlos García-Estrada, Yolanda Pérez-Pertejo
One of the major drawbacks of current treatments for neglected tropical diseases is the low safety of the drugs used and the emergence of resistance. Leishmaniasis is a group of neglected diseases caused by protozoa of the trypanosomatidae family that lacks preventive vaccines and whose pharmacological treatments are scarce and unsafe. Combination therapy is a strategy that could solve the above-mentioned problems, due to the participation of several mechanisms of action and the reduction in the amount of drug necessary to obtain the therapeutic effect...
January 25, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38392847/comparative-study-of-a-novel-lateral-flow-rapid-test-with-conventional-serological-test-systems-for-the-diagnosis-of-canine-leishmaniosis-in-croatia-and-brazil
#10
JOURNAL ARTICLE
Rouzbeh Mahdavi, Franjo Martinkovic, Hosam Shams-Eldin, Ingrid E Pereira, Alexandre B Reis, Andreas Latz, Daniela Heinz, Cristina Aira, Alba Fresco-Taboada, Elfadil Abass, Jelena Romero-Olmedo, Henrique C Teixeira, Ulrich Steinhoff
Control of canine infections with Leishmania infantum ( L. infantum ), a major zoonotic disease in Brazil and southern Europe, is becoming increasingly important due to its close proximity to humans, the increasing import of dogs from endemic regions and the impact of climate change on vector spreading. Simple, rapid and reliable diagnostic tests are therefore needed to detect infected dogs. Here, we re-evaluated different serological methods for the diagnosis of canine leishmaniosis (CanL) in Croatia and Brazil...
January 26, 2024: Pathogens
https://read.qxmd.com/read/38389494/lasap-vaccine-immunotherapy-and-immunochemotherapy-associated-with-allopurinol-in-dogs-naturally-infected-with-leishmania-infantum
#11
JOURNAL ARTICLE
Ricardo B Clasta, Açucena Veleh Rivas, Adrieli Barboza Souza, Angelo G V Dos Santos, Andrés Hernán Mojoli Le Quesne, Ana Alice Maia Gonçalves, Alex Sander R Cangussu, Rodolfo C Giunchetti, Kelvinson F Viana
Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty-four symptomatic and naturally infected dogs with Leishmania infantum were tested with two treatment protocols (i) immunotherapy with LaSap vaccine and (ii) immunochemotherapy with LaSap vaccine plus allopurinol. At 90 days after the end of the treatment, it was verified that, although both protocols had generated significant clinical improvements with a greater production of IFN-γ/IL-10, in relation to the parasite load, mainly in the skin, the dogs treated only with immunotherapy maintained the same profile...
February 2024: Parasite Immunology
https://read.qxmd.com/read/38381805/involving-patients-in-drug-development-for-neglected-tropical-diseases-ntds-a-qualitative-study-exploring-and-incorporating-preferences-of-patients-with-cutaneous-leishmaniasis-into-target-product-profile-development
#12
JOURNAL ARTICLE
María Del Mar Castro, Astrid C Erber, Byron Arana, Gláucia Cota, Claudia M Denkinger, Nicole Harrison, Julia Kutyi, Liliana López-Carvajal, Emma Plugge, Julia Walochnik, Piero Olliaro
BACKGROUND: Target Product Profiles (TPPs) are instrumental to help optimise the design and development of therapeutics, vaccines, and diagnostics-these products, in order to achieve the intended impact, should be aligned with users' preferences and needs. However, patients are rarely involved as key stakeholders in building a TPP. METHODOLOGY: Thirty-three cutaneous leishmaniasis (CL) patients from Brazil, Colombia, and Austria, infected with New-World Leishmania species, were recruited using a maximum variation approach along geographic, sociodemographic and clinical criteria...
February 21, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38362504/synthetic-biology-for-combating-leishmaniasis
#13
JOURNAL ARTICLE
Shweta Khandibharad, Shailza Singh
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the Leishmania genus. Despite the efforts to control and treat the disease, it still remains a major public health problem in many countries. Synthetic biology is a rapidly evolving interdisciplinary field that combines biology, engineering, and computer science to design and construct novel biological systems. In recent years, synthetic biology approaches have shown great promise for developing new and effective strategies to combat leishmaniasis...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38319102/beyond-schistosomiasis-unraveling-co-infections-and-altered-immunity
#14
REVIEW
Dilhan J Perera, Cal Koger-Pease, Kayla Paulini, Mohamed Daoudi, Momar Ndao
SUMMARYSchistosomiasis is a neglected tropical disease caused by the helminth Schistosoma spp. and has the second highest global impact of all parasites. Schistosoma are transmitted through contact with contaminated fresh water predominantly in Africa, Asia, the Middle East, and South America. Due to the widespread prevalence of Schistosoma , co-infection with other infectious agents is common but often poorly described. Herein, we review recent literature describing the impact of Schistosoma co-infection between species and Schistosoma co-infection with blood-borne protozoa, soil-transmitted helminths, various intestinal protozoa, Mycobacterium , Salmonella , various urinary tract infection-causing agents, and viral pathogens...
March 14, 2024: Clinical Microbiology Reviews
https://read.qxmd.com/read/38318831/immunoinformatic-analysis-of-leishmania-major-gp46-protein-and-potential-targets-for-vaccination-against-leishmaniasis
#15
JOURNAL ARTICLE
Mohammad Reza Hafezi Ahmadi, Mina Mamizadeh, Davood Siamian, Mehdi Ali Asghari Touyeh, Morteza Shams, Yasaman Rashidi
BACKGROUND: Cutaneous leishmaniasis (CL) is a parasitic disease with a significant burden in the Old World countries. OBJECTIVE: In the current study, some of the primary biochemical properties and IFN-γ inducing epitopes with specific binding capacity to human and mouse MHC alleles were predicted for Leishmania major gp46 antigenic protein. METHODS: Several online servers were used to predict physico-chemical traits, allergenicity, antigenicity, transmembrane domain and signal peptide, subcellular localization, post-translational modifications (PTMs), secondary and tertiary structures, tertiary model refining with validations...
February 2, 2024: Recent advances in inflammation & allergy drug discovery
https://read.qxmd.com/read/38295092/comparative-genomics-of-leishmania-donovani-progeny-from-genetic-crosses-in-two-sand-fly-species-and-impact-on-the-diversity-of-diagnostic-and-vaccine-candidates
#16
JOURNAL ARTICLE
Jovana Sádlová, Matthew Yeo, David S Mateus, Jody Phelan, Le Anh Hai, Tapan Bhattacharyya, Stefan Kurtev, Ondrej Sebesta, Jitka Myskova, Veronika Seblova, Björn Andersson, Paola Florez de Sessions, Petr Volf, Michael A Miles
Sand fly transmitted Leishmania species are responsible for severe, wide ranging, visceral and cutaneous leishmaniases. Genetic exchange can occur among natural Leishmania populations and hybrids can now be produced experimentally, with limitations. Feeding Phlebotomus orientalis or Phlebotomus argentipes on two strains of Leishmania donovani yielded hybrid progeny, selected using double drug resistance and fluorescence markers. Fluorescence activated cell sorting of cultured clones derived from these hybrids indicated diploid progeny...
January 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38280636/intranasal-delivery-of-laag-vaccine-improves-immunity-of-aged-mice-against-visceral-leishmaniasis
#17
JOURNAL ARTICLE
Caio Loureiro Salgado, Andrés Felipe Mendéz Corea, Luciana Polaco Covre, Alessandra Marcia Fonseca-Martins, Aloisio Falqueto, Herbert Leonel DE Matos Guedes, Bartira Rossi-Bergmann, Daniel Cláudio Oliviera Gomes
There are no approved vaccines yet for human visceral leishmaniasis (VL), the most severe form of the leishmaniasis clinical manifestations that is fatal in over 95% of untreated cases. It is well-accepted that immunological changes during ageing have deleterious impact on the efficacy of vaccines and response to infections. In this work, we compared the response of young and aged mice to intranasal vaccination with killed Leishmania amazonensis promastigote antigens (LaAg) that were then challenged with L...
January 25, 2024: Acta Tropica
https://read.qxmd.com/read/38257870/antileishmanial-and-antitrypanosomes-drugs-for-the-current-century
#18
EDITORIAL
José María Alunda
Human infections by trypanosomatids are widely distributed and prevalent in the tropical and subtropical regions. Diseases caused by Trypanosoma and Leishmania have variable clinical outcomes, ranging from self-healing to fatality, and are considered Neglected Tropical Diseases (NTD). In addition, animal trypanosomiases have a significant impact on animal health and production, apart from their potential role as reservoirs in zoonotic species. Control of these infections is progressing and, in some cases (such as human African trypanomiasis (HAT)), significant reductions have been achieved...
December 26, 2023: Microorganisms
https://read.qxmd.com/read/38227109/recognition-of-immunoreactive-proteins-in-leishmania-infantum-amastigote-like-and-promastigote-using-sera-of-visceral-leishmaniasis-patients-a-preliminary-study
#19
JOURNAL ARTICLE
Soudabeh Heidari, Homa Hajjaran, Mehdi Mohebali, Behnaz Akhoundi, Javad Gharechahi
PURPOSE: Visceral leishmaniasis (VL) is a systemic and parasitic disease that is usually fatal if left untreated. VL is endemic in different parts of Iran and is caused mainly by Leishmania infantum. This study aimed to recognition immunoreactive proteins in amastigote-like and promastigote stages of L. infantum (Iranian strain) by antibodies present in the sera of VL patients. METHODS: Total protein extract from amastigote-like and promastigote cells was separated by two-dimensional electrophoresis (2DE)...
January 16, 2024: Acta Parasitologica
https://read.qxmd.com/read/38226373/molecular-identification-of-cutaneous-leishmaniasis-vectors-in-alborz-province-north-of-iran
#20
JOURNAL ARTICLE
T Nouroozi Kouh, N Hoghooghi Rad, Sh Navidpour, S Shirali, K Esmailnia
Cutaneous leishmaniasis (CL) is a vector-borne disease widely distributed in tropical and subtropical areas of North and South America, Europe, Asia, and Africa. Considering the increasing number of CL cases in recent years and the fact that no study has been conducted to identify CL fauna and vectors in Alborz province, this study was carried out to identify sand flies and CL vectors in this region. Sand flies were collected from August to October 2021 from plain and mountainous indoor and outdoor areas of the region using sticky paper traps and were detected morphologically...
August 2023: Archives of Razi Institute
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