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Adverse event radiation therapy

Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato, Jun Itami
BACKGROUND: Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brachytherapy (HBT) seems to be an effective alternative by improving anatomy-oriented dose optimisation. The purpose of this study was to report initial clinical result for LAUCC treated by HBT. METHODS: Between January 2012 and November 2015, 42 patients with LAUCC (T1b2-4a) were treated with primary radiation therapy including HBT...
March 12, 2019: BMC Cancer
Na Li, Guodong Wang, Xiaohong Jiang, Minguang Huang, Huanyong Tian, Feng Xuan, Yufeng Zhang, Yanting Lv, Mengjun Hu, Zhen Wang, Peng Ren, Maoyi Xu
Merkel cell carcinoma (MCC) is a rare, aggressive skin malignancy that has a propensity for local recurrence and metastasis to the lymph nodes. In this case report, we discuss a 54-year-old female with rheumatoid arthritis (RA) who had received treatment with prednisone (15 mg/day) for symptom relief and management. The patient visited our hospital with complaints of a nodule in right preauricular area. Computed tomography (CT) scans revealed no distant metastasis. The patient underwent surgical resection and histopathological evaluation of the nodule led to the diagnosis of MCC...
2019: OncoTargets and Therapy
Gabriele Reinartz, Regina P Pyra, Georg Lenz, Rüdiger Liersch, Georg Stüben, Oliver Micke, Kay Willborn, Clemens F Hess, Andreas Probst, Rainer Fietkau, Ralf Jany, Jürgen Schultze, Christian Rübe, Carsten Hirt, Wolfgang Fischbach, Martin Bentz, Severin Daum, Christiane Pott, Markus Tiemann, Peter Möller, Andreas Neubauer, Martin Wilhelm, Normann Willich, Wolfgang E Berdel, Hans T Eich
PURPOSE: Long-term impact of stage-adapted field reduction in a large cohort of gastric marginal zone lymphoma (gMZL) patients treated conservatively with curative radiation therapy (RT). PATIENTS AND METHODS: Prospective analysis of paper records of 290 patients with stage IE-IIE gMZL, treated in 78 radiotherapeutic institutions in Germany from 1992-2013. Stage-adapted radiation fields decreased from extended field (EF) to involved field (IF) over the course of three consecutive prospective trials of the German Study Group on Gastrointestinal Lymphoma (DSGL)...
March 11, 2019: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
G Francolini, I Desideri, B Detti, V Di Cataldo, L Masi, G Caramia, L Visani, F Terziani, C Muntoni, M Lo Russo, M Loi, L Livi
Urothelial cancer is one of the most common malignancies; after relapse or disease progression available therapeutic options are limited. We analyze efficacy and toxicity of local treatment on metastases using stereotactic body radiation therapy (SBRT) in selected patients with oligometastatic disease from urothelial cancer. A significant percentage of treated lesions achieved local control, with a promising overall response rate. OBJECTIVES: to analyze efficacy and toxicity of local treatment on metastases using stereotactic body radiation therapy (SBRT) in selected patients with oligometastatic disease from urothelial cancer...
February 19, 2019: Cancer Treatment and Research Communications
Jingjing Zhang, Harshad R Kulkarni, Aviral Singh, Christiane Schuchardt, Karin Niepsch, Thomas Langbein, Richard P Baum
The aim of this study was to assess the safety, tolerability and effects on renal function as well as therapeutic efficacy of prostate-specific membrane antigen (PSMA) targeted radioligand therapy (PRLT) using lutetium-177 (177 Lu) labeled PSMA-617 in patients with metastatic castration-resistant prostate cancer (mCRPC) and a single functioning kidney before PRLT. Methods: Sixteen patients (age 53-78 y, mean age 64.7 ± 6.5 y) with a single functioning kidney received PRLT with 177 Lu-PSMA-617 between March 2015 and October 2018...
March 8, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Sun Young Chae, Sei Hyun Ahn, Sung-Bae Kim, Sangwon Han, Suk Hyun Lee, Seung Jun Oh, Sang Ju Lee, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Jisun Kim, Jin-Hee Ahn, Kyung Hae Jung, Jeong Eun Kim, Seog-Young Kim, Woo Jung Choi, Hee Jung Shin, Gyungyub Gong, Hyo Sang Lee, Jung Bok Lee, Dae Hyuk Moon
BACKGROUND: A biopsy of first recurrence or metastatic disease is recommended to re-evaluate oestrogen receptor status in patients with breast cancer and to select appropriate treatment. However, retesting for oestrogen receptor status with rebiopsy is not always feasible, depending on lesion location and the risk associated with biopsy, and in these cases clinicians continue to treat patients according to the oestrogen receptor status of the primary tumour. Consequently suboptimal therapy might be offered to these patients...
March 4, 2019: Lancet Oncology
Renee Girens, Alex Bukoski, Charles A Maitz, Sarah E Boston, Antonella Borgatti, Megan Sprinkle, Daniel Orrego, Shannon Kesl, Kim Selting
BACKGROUND: Body surface area (BSA) can reflect metabolic rate that might normalize dosing of chemotherapeutics across widely variable weights within a species. The current BSA formula for dogs lacks height, length, and body condition. HYPOTHESIS: Computed tomography (CT) imaging will allow inclusion of morphometric variables in allometric modeling of BSA in dogs resulting in an improved formula for BSA estimation. ANIMALS: Forty-eight dogs from 4 institutions with whole-body CT images...
March 5, 2019: Journal of Veterinary Internal Medicine
Tairo Kashihara, Naoya Murakami, Sakura Iizumi, Yasunari Sakamoto, Satoshi Nakamura, Kotaro Iijima, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuko Nakayama, Takuji Okusaka, Takashi Uno, Jun Itami
INTRODUCTION: Previous studies have shown that simultaneous treatment with sorafenib, a vascular endothelial growth factor receptor tyrosine-kinase inhibitor (VEGFR-TKI), and radiation therapy (RT) can cause gastrointestinal hemorrhage (GH) as an adverse event. However, it is known that sorafenib monotherapy can cause GH. Thus it is essential to know the association between the radiation field and the bleeding site. CASE PRESENTATION: We report a case of bleeding ulcers on the ascending colon in a patient undergoing simultaneous RT and sorafenib administration...
February 27, 2019: Practical Radiation Oncology
Lorenzo Drago
Literature has recently highlighted the enormous scientific interest on the relationship between the gut microbiota and colon cancer, and how the use of some selected probiotics can have a future impact on the adverse events which occur during this disease. Although there is no clear evidence to claim that probiotics are effective in people with cancer, recent reviews have found that probiotics can significantly reduce the incidence of diarrhea and the average frequency of daily bowel movements. However, most of this evidence needs to be more clinically convincing and further discussed...
February 28, 2019: Microorganisms
Emmanuelle Couty, Alexis Vallard, Sandrine Sotton, Sarra Ouni, Max-Adrien Garcia, Sophie Espenel, Chloe Rancoule, Majed Ben Mrad, Anne-Catherine Biron, Jean-Luc Perrot, Julien Langrand-Escure, Nicolas Magné
PURPOSE: To assess the safety of the association of radiotherapy (RT) and systemic treatments for patients with metastatic malignant melanoma (mMM). METHODS: A retrospective analysis included consecutive patients treated with palliative RT, and at least one line of systemic therapy for mMM between 2001 and 2016. Treatments were defined as sequential or concomitant when RT and the systemic drug were administered, respectively, at more or less than five half-lives from each other...
February 26, 2019: Cancer Chemotherapy and Pharmacology
Yongqiang Yang, Qiteng Liu, Baoqing Jia, Xiaohui Du, Guanghai Dai, Hongyi Liu, Jing Chen, Mingyue Zeng, Ke Wen, Yaqun Zhu, Yunlai Wang, Linchun Feng
The aim of this study was to evaluate the safety and clinical efficacy of a combined preoperative regimen consisting of volumetric modulated arc therapy-simultaneous integrated boost and capecitabine chemotherapy for distal rectal cancer. A total of 26 patients with locally advanced distal rectal cancer were enrolled from March 2015 to May 2016. The radiation dose fractionation was 58.75 Gy/25 fractions (2.35 Gy/fraction) for rectal tumor and pelvic lymph node metastasis and 50 Gy/25 fractions for pelvic lymph node stations, accompanied with simultaneous capecitabine chemotherapy...
January 1, 2019: Technology in Cancer Research & Treatment
Marcher Thompson, Kenneth E Rosenzweig
Stereotactic body radiation therapy (SBRT) is an effective and well tolerated treatment for early stage non-small cell lung cancer (NSCLC). The high doses used in thoracic SBRT can sometimes cause adverse effects ranging from mild fatigue and transient esophagitis to fatal events such as pneumonitis or hemorrhage. Efforts continue to expand in both the utility of this technique as well as our understanding of the mechanisms of the adverse effects it can cause. In this review, we discuss the current literature regarding the potential mechanisms, dosimetric constraints and toxicities associated with SBRT alone and in conjunction with definitive chemoradiotherapy and immunotherapy...
February 2019: Translational Lung Cancer Research
Michael Chao, Daryl Lim Joon, Vincent Khoo, Sandra Spencer, Huong Ho, Mario Guerrieri, Farshad Foroudi, Damien Bolton
INTRODUCTION: This is a retrospective study conducted to report the tumor control and late toxicity outcomes of patients with intermediate-risk prostate cancer undergoing combination external beam radiation therapy and low dose rate brachytherapy (LDR-PB). METHODS AND MATERIALS: Thirty-one patients received 45 Gray (Gy) of external beam radiation therapy to the prostate and seminal vesicles, together with a brachytherapy boost via a transperineal prostate implant of I125 (108 Gy)...
March 2019: Journal of Medical Imaging and Radiation Sciences
Mark H Einstein, Ntokozo Ndlovu, Jeannette Lee, Elizabeth A Stier, Jeffrey Kotzen, Madhur Garg, Kathleen Whitney, Shelly Y Lensing, Mariza Tunmer, Webster Kadzatsa, Joel Palefsky, Susan E Krown
PURPOSE: To determine the feasibility, safety, and tolerability of concomitant chemoradiotherapy administered at standard doses in HIV-infected women with locally-advanced cervical cancer (LACC) receiving antiretroviral therapy (ART). PATIENTS AND METHODS: Eligible participants had HIV infection and untreated, histologically-confirmed, invasive carcinoma of the uterine cervix, FIGO stages IB2, IIA (if tumor >4 cm), IIB, IIIA, IIIB, or IVA and met standard eligibility criteria...
February 15, 2019: Gynecologic Oncology
Carlos E Vargas, Now Bahar Alam, Mitchell Terk, Joshua R Niska, Jamie Cesareti, Douglas Swartz, Apoorva Vashi, Ali Kasraeian, C Shawn West, Marc Blasser, Chris Moore
BACKGROUND: Prior randomized studies have shown a survival benefit using combined androgen deprivation therapy (ADT) and radiation therapy for intermediate-risk prostate cancer. However, these studies either used low doses of radiation (66.6 Gy to isocenter) or imaged guidance was not available. This study reports the initial differences for high dose image guided radiation with or without ADT. METHODS: From 2012 to 2014, 56 patients were treated with and 60 patients without 6 months of ADT (N = 116) in our phase III randomized trial for intermediate-risk prostate cancer...
February 10, 2019: Cancer Treatment and Research Communications
Kan Wu, Xiao Xu, Xiadong Li, Jiahao Wang, Lucheng Zhu, Xueqin Chen, Bing Wang, Minna Zhang, Bing Xia, Shenglin Ma
Background: Few studies to date have assessed the incidence of radiation pneumonitis (RP) in lung cancer patients who have been treated with volumetric modulated arc therapy (VMAT). This study is aimed at reporting the RP incidence rate and the risk factors associated with a symptomatic RP in patients with lung cancer treated with VMAT. Methods: A total of 77 consecutive lung cancer patients treated with VMAT from 2013 through 2015 were reviewed. RP severity was graded according to the Common Terminology Criteria for Adverse Events (CTCEA) v...
December 2018: Journal of Thoracic Disease
Alexandros Papachristofilou, Madeleine M Hipp, Ute Klinkhardt, Martin Früh, Martin Sebastian, Christian Weiss, Miklos Pless, Richard Cathomas, Wolfgang Hilbe, Georg Pall, Thomas Wehler, Jürgen Alt, Helge Bischoff, Michael Geißler, Frank Griesinger, Karl-Josef Kallen, Mariola Fotin-Mleczek, Andreas Schröder, Birgit Scheel, Anke Muth, Tobias Seibel, Claudia Stosnach, Fatma Doener, Henoch S Hong, Sven D Koch, Ulrike Gnad-Vogt, Alfred Zippelius
BACKGROUND: Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses. METHODS: We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy...
February 8, 2019: Journal for Immunotherapy of Cancer
Amar U Kishan, Audrey Dang, Alan J Katz, Constantine A Mantz, Sean P Collins, Nima Aghdam, Fang-I Chu, Irving D Kaplan, Limor Appelbaum, Donald B Fuller, Robert M Meier, D Andrew Loblaw, Patrick Cheung, Huong T Pham, Narek Shaverdian, Naomi Jiang, Ye Yuan, Hilary Bagshaw, Nicolas Prionas, Mark K Buyyounouski, Daniel E Spratt, Patrick W Linson, Robert L Hong, Nicholas G Nickols, Michael L Steinberg, Patrick A Kupelian, Christopher R King
Importance: Stereotactic body radiotherapy harnesses improvements in technology to allow the completion of a course of external beam radiotherapy treatment for prostate cancer in the span of 4 to 5 treatment sessions. Although mounting short-term data support this approach, long-term outcomes have been sparsely reported. Objective: To assess long-term outcomes after stereotactic body radiotherapy for low-risk and intermediate-risk prostate cancer. Design, Setting, and Participants: This cohort study analyzed individual patient data from 2142 men enrolled in 10 single-institution phase 2 trials and 2 multi-institutional phase 2 trials of stereotactic body radiotherapy for low-risk and intermediate-risk prostate cancer between January 1, 2000, and December 31, 2012...
February 1, 2019: JAMA network open
Louis Potters, Zaker Rana, Lucille Lee, Brett W Cox
INTRODUCTION: This study presents a prospective phase I, IRB-approved dose-escalated stereotactic body radiotherapy (SBRT) trial for prostate cancer (CaP) to assess the impact of dose level on quality of life, toxicity, and clinical outcomes. MATERIALS/METHODS: From 2011-2016, 26 patients with low and intermediate-risk CaP received 40, 45, and 50 Gy in five fractions to the prostate in cohorts of 9, 10, and 7 patients. Self-reported QOL was prospectively measured from the Expanded Prostate Cancer Index Composite (EPIC) and American Urological Association (AUA)...
February 2, 2019: International Journal of Radiation Oncology, Biology, Physics
Igor Alexander Harsch, Peter Christopher Konturek
Fecal microbiota transplantation (FMT) is a novel strategy for the therapy of dysbiosis-associated disorders via modulation of the gut microbiota. Intestinal dysbiosis is associated not only with digestive disorders, but also with a variety of extra-digestive disorders. A worldwide increasing number of FMT can be expected in the future as well as an increase in adverse events. We describe the case of a patient with chronic radiation colitis that developed adhesion ileus 2 days after FMT. Since these problems never occured before and the short time interval favours a causality, we speculate about FMT-induced alterations in gut motility causing a "trapping" of the small intestine in an adhesion and other mechanisms beyond "pure" coincidence...
2019: Case Reports in Gastrointestinal Medicine
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