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Hemoglobin variability esrd

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https://read.qxmd.com/read/30624364/long-term-blood-pressure-variability-and-development-of-chronic-kidney-disease-in-type-2-diabetes
#1
Francesca Viazzi, Barbara Bonino, Antonio Mirijello, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Pietro Guida, Giuseppina T Russo, Salvatore De Cosmo, Roberto Pontremoli
OBJECTIVE: Long-term visit-to-visit SBP variability (VVV) has been shown to predict cerebro-cardiovascular events and end-stage renal disease in chronic kidney disease (CKD) patients. Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain. We assessed the role of SBP VVV on the development of CKD in patients with type 2 diabetes (T2D) and hypertension in real life. METHODS: Clinical records from 30 851 patients with T2D and hypertension, with normal estimated glomerular filtration rate (eGFR) and regular visits during a 4-year follow-up were analyzed...
January 7, 2019: Journal of Hypertension
https://read.qxmd.com/read/30603365/development-of-a-novel-estimation-method-for-hemoglobin-a1c-using-glycated-albumin-in-type-2-diabetes-mellitus-patients-with-end-stage-renal-disease
#2
Akihiko Nakamura, Ryo Kodera, Noriko Sakamoto, Haruyo Ujike, Jun Wada, Kenichi Shikata, Hirofumi Makino
Aim: We developed a novel estimation method for hemoglobin A1c (HbA1c) in type 2 diabetes (T2D) patients with end-stage renal disease (ESRD). This method is based on the glycated albumin (GA) level. Methods: Of the 788 Japanese patients with T2D included in this study, 545 had normal renal function (NRF group) and 243 had ESRD. Oral glucose tolerance tests (OGTTs) were performed in 80 subjects. The variables GA, body mass index (BMI), hemoglobin (Hb), and estimated glomerular filtration rate (eGFR) were significantly associated with the GA-to-HbA1c ratio and were used to determine the estimated HbA1c (eHbA1c)...
July 2018: Diabetology International
https://read.qxmd.com/read/30583898/outcomes-for-peripheral-vascular-intervention-and-lower-extremity-bypass-in-kidney-transplant-recipients-are-superior-to-outcomes-of-patients-remaining-on-dialysis
#3
Ryan W King, Mahmoud B Malas, Thomas E Brothers
BACKGROUND: Improved survival is reported for patients with end-stage renal disease who are kidney transplant recipients (KTRs) compared with dialysis-dependent patients (DDPs). Whether amputation-free survival (AFS) and freedom from major adverse limb events (MALEs) after peripheral vascular intervention (PVI) or lower extremity bypass (LEB) are superior after renal transplantation remains incompletely defined. METHODS: A retrospective cohort study was undertaken of KTRs and DDPs undergoing infrainguinal PVI or LEB for symptoms of limb-threatening ischemia recorded in the Vascular Quality Initiative from 2003 to 2017...
December 21, 2018: Journal of Vascular Surgery
https://read.qxmd.com/read/30567403/association-of-hba-1c-variability-and-renal-progression-in-patients-with-type-2-diabetes-with-chronic-kidney-disease-stages-3%C3%A2-4
#4
Mei-Yueh Lee, Jiun-Chi Huang, Szu-Chia Chen, Hsin-Ying Clair Chiou, Pei-Yu Wu
Little is known about the predictive value of glycosylated hemoglobin (HbA1C ) variability in patients with advanced chronic kidney disease (CKD). The aim of this study was to investigate whether HbA1C variability is associated with progression to end-stage renal disease in diabetic patients with stages 3⁻5 CKD, and whether different stages of CKD affect these associations. Three hundred and eighty-eight patients with diabetes and stages 3⁻5 CKD were enrolled in this longitudinal study. Intra-individual HbA1C variability was defined as the standard deviation (SD) of HbA1C , and the renal endpoint was defined as commencing dialysis...
December 18, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/30412269/definition-and-validation-of-a-novel-metric-of-erythropoiesis-stimulating-agent-response-in-hemodialysis-patients
#5
Calvin J Meaney, Spinel Karas, Ben Robinson, Jamie Gaesser, Alan Forrest, Wojciech Krzyzanski, Mandip Panesar, Gauri G Rao
Erythropoiesis-stimulating agents (eg, epoetin alfa) are the primary treatment for anemia in patients with end-stage renal disease . Hemoglobin variability in and out of a narrow target range is common and associated with higher morbidity and mortality risk. More robust erythropoiesis-stimulating agent response metrics are needed to define optimal dosing and their association with clinical outcomes. In this cross-sectional, single-center, retrospective study, 49 patients with end-stage renal disease on hemodialysis were followed over 12 months...
November 9, 2018: Journal of Clinical Pharmacology
https://read.qxmd.com/read/30180208/executive-function-in-end-stage-renal-disease-acute-effects-of-hemodialysis-and-associations-with-clinical-factors
#6
María Del Mar Sánchez-Fernández, Gustavo A Reyes Del Paso, José Manuel Gil-Cunquero, María José Fernández-Serrano
OBJECTIVE: There is evidence of cognitive impairment in patients with end-stage renal disease in hemodialysis (ESRD-HD). However, few studies have exhaustively analyzed executive functions (EFs) in this population, especially considering the influence of a wide range of clinical variables. This study analyzes performance in different EF components in ESRD-HD patients compared to a group of healthy controls (HCs), in addition to the acute effects of HD and the associations of cognitive performance with clinical variables...
2018: PloS One
https://read.qxmd.com/read/30180144/changes-in-optical-coherence-tomography-findings-in-patients-with-chronic-renal-failure-undergoing-dialysis-for-the-first-time
#7
Hyeseong Hwang, Ju Byung Chae, Jin Young Kim, Byung Gil Moon, Dong Yoon Kim
PURPOSE: To investigate the spectral domain optical coherence tomography findings before and after dialysis in patients with diabetic end-stage renal disease undergoing dialysis for the first time. METHODS: A retrospective medical review of patients with diabetic end-stage renal disease who recently started dialysis was conducted. Spectral domain optical coherence tomography findings before and after initiation of dialysis were analyzed. Systemic blood pressure, body weight, estimated glomerular filtration rate, and serum levels of blood urea nitrogen, creatinine (Cr), albumin, hemoglobin (Hb), and total CO2 were measured before and 1 month after starting dialysis...
August 30, 2018: Retina
https://read.qxmd.com/read/30049300/individualized-anemia-management-in-a-dialysis-facility-long-term-utility-as-a-single-center-quality-improvement-experience
#8
Adam E Gaweda, Alfred A Jacobs, George R Aronoff, Michael E Brier
BACKGROUND: Standard protocol-based approaches to erythropoiesis stimulating agent (ESA) dosing in anemia management of end-stage renal disease (ESRD) fail to address the inter-individual variability in patient's response to ESA. We conducted a single-center quality improvement project to investigate the long-term performance of a computer-designed dosing system. MATERIALS AND METHODS: The study was a retrospective case-control study with long-term follow-up. All hemodialysis patients who received treatment at University Kidney Center (Louisville, KY, USA) between September 1, 2009, and March 31, 2017, were included...
October 2018: Clinical Nephrology
https://read.qxmd.com/read/29788462/clinicopathological-predictors-for-progression-of-chronic-kidney-disease-in-nephrosclerosis-a-biopsy-based-cohort-study
#9
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Miho Shimizu, Kengo Furuichi, Takashi Wada
Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established. Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis...
May 19, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/29682347/prevalence-of-microalbuminuria-in-adult-patients-with-sickle-cell-disease-in-eastern-saudi-arabia
#10
Ahmed M Alkhunaizi, Adil A Al-Khatti, Mansour A Alkhunaizi
Background: Proteinuria is a common feature of sickle cell nephropathy (SCN) that can progress to renal insufficiency and end stage renal disease. Microalbuminuria (MA) is the earliest manifestation of SCN and precedes the development of overt proteinuria. In addition to the renal consequences, MA is linked to cardiovascular complications. Periodic screening and early detection of MA allow early intervention that may reduce the risk of progression to advanced renal failure and cardiovascular diseases...
2018: International Journal of Nephrology
https://read.qxmd.com/read/29555434/kidney-failure-risk-prediction-equations-in-iga-nephropathy-a-multicenter-risk-assessment-study-in-chinese-patients
#11
Jingyuan Xie, Jicheng Lv, Weiming Wang, Guisen Li, Zhangsuo Liu, Hongyu Chen, Feifei Xu, Jing Sun, Yan Ouyang, Xiaoyan Zhang, Meng Yang, Manman Shi, Wen Zhang, Hong Ren, Krzysztof Kiryluk, Hong Zhang, Nan Chen
BACKGROUND: The clinical course of immunoglobulin A (IgA) nephropathy (IgAN) is highly variable, making it difficult to predict which patients are at risk for rapid progression. The aim of this study was to develop and validate a kidney failure risk prediction equation for adults with IgAN. STUDY DESIGN: Multicenter retrospective cohort study of 2,155 Chinese patients with IgAN. CANDIDATE PREDICTORS: Clinical and histology variables. OUTCOMES: Time to end-stage renal disease (ESRD)...
September 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/29449502/the-crescentic-implication-of-renal-outcomes-in-proliferative-lupus-nephritis
#12
Fanghao Cai, Fei Han, Hongya Wang, Haidongqin Han, Jingyun Le, Lan Lan, Ying Xu, Jianghua Chen
OBJECTIVE: To determine the association between crescents and renal outcomes, and the implications on therapeutic choices. METHODS: There were 231 patients with biopsy-proven proliferative lupus nephritis (PLN) who were divided into 4 groups: 59 patients were in the noncrescent group (NC); 59 patients exclusively with segmental crescents were in the segmental crescent group (SC); patients with circumferential crescents were categorized into 2 groups according to the crescentic ratio (C1 had 64 patients with ≤ 25%, and C2 had 49 patients with > 25%)...
April 2018: Journal of Rheumatology
https://read.qxmd.com/read/29282123/impact-of-risk-factors-on-functional-status-in-maintenance-hemodialysis-patients
#13
Jin-Bor Chen, Wen-Chin Lee, Ben-Chung Cheng, Sin-Hua Moi, Cheng-Hong Yang, Yu-Da Lin
OBJECTIVES: To survey by measuring patient's functional status which is crucial when end-stage renal disease patients begin a dialysis program. The influence of the disease on patients can be examined by the measurement of Karnofsky Performance Status (KPS) scores, together with a quality of life survey, and clinical variables. METHODS: The details for the dataset in the study were collected from patients receiving regular hemodialysis (HD) in one hospital, which were available retrospectively for 1166 patients during the 5-year study period...
December 28, 2017: European Journal of Medical Research
https://read.qxmd.com/read/29223661/-is-cancer-incidence-different-between-type-2-diabetes-patients-compared-to-non-diabetics-in-hemodialysis-a-study-from-the-rein-registry
#14
MULTICENTER STUDY
Aurélie Le Guillou, Adelaide Pladys, Wahida Kihal, Muriel Siebert, Atman Haddj-Elmrabet, Charlotte Cernon, Anne Bernard, Christophe Charasse, Lise Mandart, Didier Hamel, Tugdual Tanquerel, Bernard Strullu, Christine Richer, Pascale Siohan, Théophile Sawadogo, Juliette Baleynaud, Simona Baluta, Sahar Bayat, Cécile Vigneau
BACKGROUND AND OBJECTIVES: In France, diabetes mellitus is now the second cause of end stage renal disease. In a large previous French national study, we observed that dialyzed diabetics have a significant lower risk of death by cancer. This first study was focused on cancer death but did not investigate cancer incidence. In this context, the aim of this second study was to compare the incidence of cancer in diabetic dialyzed patients compared to non-diabetic dialyzed patients in a French region...
May 2018: Néphrologie & Thérapeutique
https://read.qxmd.com/read/29130991/pre-end-stage-renal-disease-hemoglobin-variability-predicts-post-end-stage-renal-disease-mortality-in-patients-transitioning-to-dialysis
#15
Keiichi Sumida, Charles Dyer Diskin, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Connie M Rhee, Elani Streja, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Hemoglobin variability (Hb-var) has been associated with increased mortality both in non-dialysis dependent chronic kidney disease (NDD-CKD) and end-stage renal disease (ESRD) patients. However, the impact of Hb-var in advanced NDD-CKD on outcomes after dialysis initiation remains unknown. METHODS: Among 11,872 US veterans with advanced NDD-CKD transitioning to dialysis between October 2007 through September 2011, we assessed Hb-var calculated from the residual SD of at least 3 Hb values during the last 6 months before dialysis initiation (prelude period) using within-subject linear regression models, and stratified into quartiles...
2017: American Journal of Nephrology
https://read.qxmd.com/read/28535187/serum-levels-of-1-5-anhydroglucitol-and-risk-of-incident-end-stage-renal-disease
#16
Casey M Rebholz, Morgan E Grams, Yuan Chen, Alden L Gross, Yingying Sang, Josef Coresh, Elizabeth Selvin
Glycemic excursions, independent of average glucose, have been implicated in the development of diabetic complications. It is unknown whether low levels of 1,5-anhydroglucitol (1,5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycemia. In the Atherosclerosis Risk in Communities Study (n = 13,277 from 4 US communities), we used structural equation modeling to estimate the association between serum 1,5-AG levels and end-stage renal disease (ESRD) from baseline (1990-1992) through 2013 with adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting glucose, glycated hemoglobin (HbA1c), fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, β2-microglobulin)...
October 15, 2017: American Journal of Epidemiology
https://read.qxmd.com/read/28186645/occult-gastrointestinal-bleeding-is-a-common-finding-in-dogs-with-chronic-kidney-disease
#17
Leandro Z Crivellenti, Sofia Borin-Crivellenti, Kristi L Fertal, Catarina M Contin, Caroline M J Miranda, Aureo E Santana
BACKGROUND: The risk of occult gastrointestinal bleeding (OGIB) is known to be increased among human dialysis patients suffering from end-stage renal disease. However, there are no studies to date that investigate the incidence of OGIB in either dogs or people with chronic kidney disease (CKD), irrespective of dialysis. OBJECTIVES: The purpose of the study was to determine whether the incidence of OGIB is greater in dogs with CKD as compared to a control population, and if this pathology is associated with changes in serum variables related to iron metabolism...
March 2017: Veterinary Clinical Pathology
https://read.qxmd.com/read/27629729/the-content-of-reticulocyte-hemoglobin-and-serum-concentration-of-the-soluble-transferrin-receptor-for-diagnostics-of-anemia-in-chronically-hemodialyzed-patients
#18
Teresa Kurzawa, Aleksander Owczarek, Joanna K Strzelczyk, Karolina Gołąbek, Andrzej Wiczkowski
BACKGROUND: Chronic renal disease constitutes a serious worldwide clinical problem. An important issue arising early during the treatment of renal failure is anemia. Patients in the end-stage of renal disease chronically treated with hemodialysis frequently suffer from anemia with iron deficiency. OBJECTIVES: The aim of the study was to evaluate the usefulness of determining the reticulocyte hemoglobin content and serum concentration of soluble transferrin receptor in the detection of anemia caused by iron deficiency in comparison with the classic markers of iron circulation in serum in chronic dialysis patients with ESRD...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/27611091/underweight-is-an-independent-risk-factor-for-renal-function-deterioration-in-patients-with-iga-nephropathy
#19
Yan Ouyang, Jingyuan Xie, Meng Yang, Xiaoyan Zhang, Hong Ren, Weiming Wang, Nan Chen
Studies on the relationship between body mass index (BMI) and renal progression in IgA Nephropathy (IgAN) were limited, especially for underweight patients with IgAN. To elucidate the clinical features and effect of underweight on renal function deterioration in this disease, we recruited IgAN patients with diagnostic age ≥18 years old and a baseline estimated glomerular filtration rate (eGFR) ≥15 ml/min/1.73m2 from our center between 1985 and 2014. Patients secondary to systemic diseases or follow-up less than 6 months were excluded...
2016: PloS One
https://read.qxmd.com/read/27416751/increased-serum-renalase-in-hemodialysis-patients-is-it-related-to-left-ventricular-hypertrophy
#20
Ebru Gok Oguz, Guner Karaveli Gursoy, Ozlem Yayar, Tolga Yildirim, Tolga Cimen, Cengiz Bulut, Barıs Eser, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
INTRODUCTION: Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment...
September 2016: Renal Failure
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