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Alopecia androgenetic

Suzana Polonca da Silveira, Sandra Rojas Urquizas Moita, Silvia Vicente da Silva, Maria Fernanda Setúbal Destro Rodrigues, Daniela de Fátima Teixeira da Silva, Christiane Pavani
The female hair loss pattern was originally described as a synonym for androgenetic alopecia. It has been defined as progressive miniaturizations of the hair follicles, with a great impact on the quality of life of affected patients, causing significant psychosocial limitations. It was recently proven that photobiomodulation is a safe and effective way to treat the different types of hair loss. It was also known that microneedling is a minimally invasive dermatological procedure that is applied to a wide range of dermatological conditions, including androgenic alopecia, telogen effluvium, as well as other facial and bodily conditions...
March 2019: Medicine (Baltimore)
Mousa Bayat, Mohammad Javad Yazdanpanah, Daryoush Hamidi Alamdari, Mahnaz Banihashemi, Maryam Salehi
BACKGROUND: Androgenetic alopecia is the most common type of hair loss in men, which is manifested by a progressive terminal hair loss in specific areas of scalp. Platelet-rich plasma (PRP) is among treatment options for androgenetic alopecia. PRP is a human platelet concentrate in a small volume of plasma containing certain cytokines. AIM: The aim of this study was to evaluate the efficacy and safety of autologous PRP in treatment of male androgenetic alopecia...
March 20, 2019: Journal of Cosmetic Dermatology
Qian Qu, Yong Miao, Zhen-He Guo, Chuan-Bo Feng, Qian Chen, Yang Liu, Fang Liu, Pan-Li Shi, Dan-Xia Cao, Zhi-Qi Hu
BACKGROUND: Cranial hair loss is one of the characteristics of age. Hairline recession has been confirmed adversely to affect the perceptions of age in Western males. However, comparatively little is known about the effect of frontal recession on the perceived facial age (PFA) of East Asian males. Moreover, specific roles of different types of hairline recession in PFA of different age groups still remain a mystery. OBJECTIVE: To investigate and quantify the effect of different types of hairline recession on PFA in East Asian young males of different age groups...
March 19, 2019: International Journal of Dermatology
Muriki K Kumar, Arun C Inamadar, Aparna Palit
Background: Androgenetic alopecia (AGA) is the most common form of hair loss in adults, which is generally progressive in the absence of treatment. As a head full of healthy hair adds to the cosmetic appeal of the individual, the consequences of AGA are predominantly psychological. Currently, topical minoxidil is the first-line treatment for AGA. Many adjuvant treatment modalities have been used synergistically with minoxidil. Microneedling is one among such adjuvant treatments, which works by various mechanisms to stimulate the dermal papillary cells that play a key role in hair growth...
October 2018: Journal of Cutaneous and Aesthetic Surgery
Philip R Cohen
Platelet-rich plasma, which contains numerous growth factors that promote hair growth, is a nonsurgical treatment available for patients with androgenetic alopecia. However, neither the quantity nor the location and depth of platelet-rich plasma placement in the scalp is uniform; in addition, multiple painful injections are required. Vertical uniform channels from the skin surface into the dermis, created by ablative laser fractional photothermolysis, can be used to enhance the cutaneous delivery of medications...
February 15, 2019: Dermatology Online Journal
Zhongbao Zhou, Shiqiang Song, Zhenli Gao, Jitao Wu, Jiajia Ma, Yuanshan Cui
Aim: We performed a meta-analysis to evaluate the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA) during a 24-week treatment cycle. Methods: Randomized controlled trials of dutasteride and finasteride for treating AGA were searched using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The data were calculated using Rev Man v5.3.0. The reference lists of retrieved studies were also investigated. Results: Three articles including 576 participants which compared dutasteride with finasteride were selected for our analysis...
2019: Clinical Interventions in Aging
F J Navarro-Triviño, S Arias-Santiago, Y Gilaberte-Calzada
In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer...
March 8, 2019: Actas Dermo-sifiliográficas
Leopoldo Duailibe Nogueira Santos, Jerry Shapiro
The treatment of hair loss is a challenge for all dermatologists. New medications are needed due to lack of efficacy of many treatments or their side-effect profile. This article discusses the most recent literature updates on the use of retinoids in frontal fibrosing alopecia, platelet-rich plasma in androgenetic alopecia, and JAK inhibitors in alopecia areata.
April 2019: Dermatologic Clinics
Ratchathorn Panchaprateep, Trairak Pisitkun, Nuttiya Kalpongnukul
BACKGROUND: Currently, low-level laser therapy (LLLT) has been approved as a new treatment for androgenetic alopecia (AGA). However, it has not been elucidated how LLLT promotes hair growth in vivo. OBJECTIVES: To investigate the change in protein expression from dermal papilla (DP) tissues in male AGA patients after LLLT treatment using liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. METHODS: This is an open-label, prospective, single-arm study obtained punch scalp biopsy specimens from patients with AGA before and after LLLT treatment...
March 7, 2019: Lasers in Surgery and Medicine
Cynthia M Magro, Garron J Solomon, Mary Jo J Kendrick, Shabnam Momtahen
Primary systemic amyloidosis has a varied clinical presentation, making it one of the great masqueraders of other disease entities in clinical medicine. The association of amyloidosis with alopecia is uncommon with at least 22 cases reported in the literature mostly in the setting of systemic amyloidosis. Alopecia in these patients occurs either as the initial presentation of the systemic amyloidosis or it happens during the disease course. The occurrence of amyloid alopecia associated with light chain (LC) restricted plasmacytic infiltrates in the absence of systemic amyloidosis, however, it is not well known...
February 28, 2019: American Journal of Dermatopathology
R S Haber, A K Gupta, E Epstein, J L Carviel, K A Foley
BACKGROUND: The occurrence of sexual dysfunction side effects associated with finasteride use in men with androgenetic alopecia (AGA) is thought to be less prevalent than is publicized. There is a need to investigate sexual dysfunction among finasteride users with population-based controls. OBJECTIVE: To evaluate presence of sexual dysfunction in men using finasteride or not using finasteride. METHOD: Adult men visiting a dermatologist's office for any reason were asked to complete a survey including a modified version of the Arizona Sexual Experience Scale (ASEX) to assess presence of sexual dysfunction with and without finasteride use...
March 5, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Ralph Michel Trüeb, Hudson Dutra, Maria Fernanda Reis Gavazzoni Dias
Medical trichology is the branch of dermatology that deals with the scientific study of the hair and scalp in health and disease. As any discipline, the practice of medical trichology is not immune to malpractice, either deliberately or carelessly. In his publication "Autistic Undisciplined Thinking in Medicine and How to Overcome It," Swiss psychiatrist Eugen Bleuler describes yet another form of malpractice in medicine reflecting autistic-undisciplined thinking. Autism is not limited to psychopathology, but inherent to the thinking of man throughout history in his drive for knowledge, with thousands of theories lacking any basis in reality...
January 2019: International Journal of Trichology
Caridad Rosette, Niccolette Rosette, Alessandro Mazzetti, Luigi Moro, Mara Gerloni
Cortexolone 17α-propionate (clascoterone) is a novel androgen antagonist that is currently being analyzed in a large phase 2 clinical trial for the topical treatment of androgenetic alopecia (AGA). While the pathogenesis of AGA is still debated, the consensus is that AGA is an androgen-dependent hair disorder with strong genetic links, and that the testosterone metabolite, dihydrotestosterone (DHT), plays a causal role in its development. DHT binds to the androgen receptor (AR) in scalp dermal papilla cells (DPC) to induce AR-mediated transcription of genes that contribute to AGA in genetically predisposed individuals...
February 1, 2019: Journal of Drugs in Dermatology: JDD
J Stevens, S Khetarpal
Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. By the age of 60 years, 45% of men and 35% of women develop AGA. Currently, U.S. Food and Drug Administration-approved treatments for AGA include oral finasteride and topical minoxidil. Due to the limited number of effective therapies for AGA, platelet-rich plasma (PRP) has become an effective alternative treatment...
February 2019: International Journal of Women's Dermatology
Calvin T. Sung, Margit L.W. Juhasz, Franchesca D. Choi, Natasha Atanaskova Mesinkovska
Introduction: Topical minoxidil is the first-line therapy for treating both male and female androgenetic alopecia. Currently there are no comprehensive reviews on the clinical efficacy of minoxidil on hair loss. Method: A literature search was conducted to identify clinically relevant studies regarding the efficacy of topical minoxidil for human subjects for hair loss. Results: Twenty-three pertinent studies were identified for inclusion in this review. Topical minoxidil has been studied in concentrations ranging from 0...
February 1, 2019: Journal of Drugs in Dermatology: JDD
E Carmina, R Azziz, W Bergfeld, H F Escobar Morreale, W Futterweit, H Huddleston, R A Lobo, E Olsen
OBJECTIVE: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved. PARTICIPANTS: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
Mankul Goyal, Sujay Khandpur, M Ramam, Vinod Kumar Sharma, Manoj Kumar Singh
Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections. Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies. Methods: It was a descriptive study. Clinically confirmed cases of noncicatricial and cicatricial alopecias were subjected to 4 mm scalp biopsies, which were sectioned transversely and analyzed...
January 2019: Indian Journal of Dermatology
Mukunda Ranga Swaroop, B Manohara Kumar, B D Sathyanarayana, D Yogesh, J C Raghavendra, Priyanka Kumari
Background: Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome (MS), diabetes mellitus and hypertension, and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. The aim of this study was to assess the strength of association between MS and/or insulin resistance (IR) in males with early-onset AGA. Methods: A total of 50 male patients with premature AGA and equal number of age-matched controls were enrolled in the study...
January 2019: Indian Journal of Dermatology
Fatma Mohamed El-Esawy, Mohamed Saber Hussein, Amira Ibrahim Mansour
BACKGROUND: Male androgenetic alopecia (MAGA) is caused by the conversion of the terminal to vellus hair. Zinc is one of the most studied trace elements in hair disorders and biotin is one of the most prescribed supplement for its treatment. OBJECTIVES: The study aimed to evaluate serum zinc and biotin levels in MAGA patients to answer the question if there is a value to add zinc or biotin as a supplements in the MAGA treatment. PATIENTS AND METHODS: Sixty MAGA patients and 60 age, sex, and body mass index-matched healthy volunteers were included...
February 3, 2019: Journal of Cosmetic Dermatology
Abhijeet Kumar Jha, Keshavamurthy Vinay, Md Zeeshan, Prasoon Kumar Roy, R K P Chaudhary, Aditi Priya
BACKGROUND: Platelet-rich plasma (PRP) is a popular procedure for the treatment of androgenetic alopecia (AGA). AIM: To ascertain the role of minoxidil 5% lotion alone versus minoxidil 5% lotion and PRP versus minoxidil 5% lotion, PRP with microneedling in AGA. MATERIAL AND METHODS: Ninety-three AGA patients with Hamilton-Norwood score 1-5 were grouped into three groups A, B, and C. Patients in group A (control group) were treated with minoxidil 5% lotion twice daily (n = 31), whereas patients in group B underwent treatment with minoxidil 5% lotion twice daily and PRP (n = 31), and group C patients received minoxidil 5% lotion twice daily, PRP, and microneedling (n = 31)...
January 28, 2019: Journal of Cosmetic Dermatology
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