K Fukawa, K Bando, Y Hatanaka, S Ohba, H Honda, K Saitoh, K Nakazato, O Irino, Y Nagawa, A Nagaoka
The pharmacological actions of iprazochrome (IC) on the vascular system were studied, and the following results were obtained: No death nor abnormal behaviors were observed in acute toxicity tests conducted on male and female mice and rats despite the administration of large doses of IC (10,000 mg/kg, p.o. and 80 mg/kg, i.v., respectively). IC inhibited dose-dependently platelet aggregation in vitro induced by arachidonate and ADP, whereas no effect was observed on ADP-induced respiratory depression in mice, which is closely related to platelet aggregation in vivo...
July 1985: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica