Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Chan Y Cheah, John F Seymour
DISEASE OVERVIEW: Marginal zone lymphomas (MZL) are collectively the second most common type of indolent lymphoma. DIAGNOSIS: Three subtypes of MZL are recognized: splenic, extranodal, and nodal. The diagnosis is secured following biopsy of an involved nodal or extranodal site demonstrating a clonal B-cell infiltrate with CD5 and CD10 negative immunophenotype most common. Some cases will features IgM paraprotein, but MYD88 L256P mutations are less frequent than in Waldenstrom macroglobulinemia...
October 2023: American Journal of Hematology
#22
Amitabh Upadhyay, Shashank Shekhar, Vanita Pandey, Aaditya Prakash, Kaushik Saha
Synchronous adenocarcinoma of the stomach with lymphoma is extremely rare. We report a case of a 65-year-old male patient with synchronous adenocarcinoma of the stomach with nodal marginal zone lymphoma. Initial endoscopic biopsy suggested invasive moderately differentiated adenocarcinoma and a locoregional disease, per contrast-enhanced computed tomography (CECT) scans. The patient was started on neo-adjuvant chemotherapy with the 5FU, leucovorin, oxaliplatin, docetaxel (FLOT) regime and, after response evaluation, underwent radical gastrectomy...
July 2023: Curēus
#23
JOURNAL ARTICLE
Anna Carbo-Meix, Francesca Guijarro, Luojun Wang, Marta Grau, Romina Royo, Gerard Frigola, Heribert Playa-Albinyana, Marco M Buhler, Guillem Clot, Marti Duran-Ferrer, Junyan Lu, Isabel Granada, Maria-Joao Baptista, Jose-Tomas Navarro, Blanca Espinet, Anna Puiggros, Gustavo Tapia, Laura Bandiera, Gabriella De Canal, Emanuela Bonoldi, Fina Climent, Inmaculada Ribera-Cortada, Mariana Fernandez-Caballero, Esmeralda De la Banda, Janilson Do Nascimento, Alberto Pineda, Dolors Vela, Maria Rozman, Marta Aymerich, Charlotte Syrykh, Pierre Brousset, Miguel Perera, Lucrecia Yanez, Jesus Xavier Ortin, Esperanza Tuset, Thorsten Zenz, James R Cook, Steven H Swerdlow, Jose I Martin-Subero, Dolors Colomer, Estella Matutes, Silvia Bea, Dolors Costa, Ferran Nadeu, Elias Campo
The t(14;19)(q32;q13) often juxtaposes BCL3 with IGH resulting in overexpression of the gene. In contrast to other oncogenic translocations, BCL3-rearrangement (BCL3-R) has been associated with a broad spectrum of lymphoid neoplasms. Here we report an integrative whole-genome sequence, transcriptomic, and DNA methylation analysis of 13 lymphoid neoplasms with BCL3-R. The resolution of the breakpoints at single base-pair revealed that they occur in two clusters at 5' (n=9) and 3' (n=4) regions of BCL3 associated with two different biological and clinical entities...
August 10, 2023: Haematologica
#24
JOURNAL ARTICLE
Christophe Bontoux, Aubiège Marcovich, Samantha Goffinet, Florian Pesce, Virginie Tanga, Doriane Bohly, Myriam Salah, Kevin Washetine, Zeineb Messaoudi, Jean-Marc Felix, Christelle Bonnetaud, Lihui Wang, Geetha Menon, Jean-Philippe Berthet, Charlotte Cohen, Jonathan Benzaquen, Charles-Hugo Marquette, Sandra Lassalle, Elodie Long-Mira, Veronique Hofman, Luc Xerri, Marius Ilié, Paul Hofman
Several therapies to improve the management of lymphoma are currently being investigated, necessitating the development of new biomarkers. However, this requires high-quality and clinically annotated biological material. Therefore, we established a lymphoma biobank including all available biological material (tissue specimens and matched biological resources) along with associated clinical data for lymphoma patients diagnosed, according to the WHO classification, between 2005 and 2022 in the Laboratory of Clinical and Experimental Pathology, Nice, France...
June 29, 2023: Journal of Personalized Medicine
#25
Lily Kou, Nai-Chien Huan, Larry Ellee Nyanti, Jiunn Sheng Chin, Nor Bahiyyah Mohamad, Hema Yamini Ramarmuty
Pulmonary extra-nodal marginal zone B-cell lymphoma, also known as extra-nodal mucosa-associated lymphoid tissue (MALT) lymphoma, is rare among all non-Hodgkin lymphomas and generally among all pulmonary malignancies. We present a 46-year-old lady with persistent right lower lung consolidation despite earlier treatment efforts with intravenous antibiotics for community acquired pneumonia. Apart from initial presentation with a short 3-day history of fever, cough and shortness of breath, she had remained largely asymptomatic throughout the follow-up period...
August 2023: Respirology Case Reports
#26
REVIEW
Robert Stuver, Esther Drill, David Qualls, Michelle Okwali, Connie Lee Batlevi, Philip C Caron, Ahmet Dogan, Zachary D Epstein-Peterson, Lorenzo Falchi, Paul A Hamlin, Steven M Horwitz, Brandon S Imber, Andrew M Intlekofer, William T Johnson, Niloufer Khan, Anita Kumar, Oscar B Lahoud, Jennifer Kimberly Lue, Matthew J Matasar, Alison J Moskowitz, Ariela Noy, Colette N Owens, M Lia Palomba, Heiko Schöder, Santosha A Vardhana, Joachim Yahalom, Andrew D Zelenetz, Gilles Salles, David J Straus
Nodal marginal zone lymphoma (NMZL) is a rare non-Hodgkin B-cell lymphoma that has historically been difficult to define, though is now formally recognized by the World Health Organization Classification. To better characterize the clinical outcomes of patients with NMZL, we reviewed a sequential cohort of 187 patients with NMZL to describe baseline characteristics, survival outcomes, and time-to-event data. Initial management strategies were classified into five categories: observation, radiation, anti-CD20 monoclonal antibody therapy, chemoimmunotherapy, or other...
September 12, 2023: Blood Advances
#27
REVIEW
Emanuele Zucca, Davide Rossi, Francesco Bertoni
The three main types of marginal zone lymphoma (MZL), recognized by the current lymphoma classifications are the extranodal MZL of mucosa-associated lymphoid tissue, the splenic MZL, and the nodal MZL. They share some karyotype lesions (trisomies of chromosomes 3 and 18, deletions at 6q23), and alterations of the nuclear factor kappa B (NFkB) pathway are also common in all of them. However, they differ in the presence of recurrent translocations, mutations affecting the Notch signaling pathway (NOTCH2 and less commonly NOTCH1), the transcription factors Kruppel-like factor 2 (KLF2) or the receptor-type protein tyrosine phosphatase delta (PTPRD)...
June 2023: Hematological Oncology
#28
JOURNAL ARTICLE
Olabisi Afolayan-Oloye, Lili Zhao, Trilokraj Tejasvi, May P Chan, Paul W Harms, Douglas R Fullen, Ryan A Wilcox, Alexandra C Hristov
INTRODUCTION: CD30 expression has been infrequently described in cutaneous B-cell lymphomas (CBCLs). We examined CD30 expression in reactive lymphoid hyperplasia (RLH) and CBCL and correlated expression with clinicopathologic features. METHODS: CD30 was examined in 82 CBCL patients and 10 RLH patients that had been evaluated in our cutaneous lymphoma clinics. The CBCL patients included: primary cutaneous follicle center lymphoma (PCFCL), Grade 1/2 systemic/nodal follicular lymphoma (SFL); primary cutaneous marginal zone lymphoma/lymphoproliferative disorder (PCMZL/LPD); systemic marginal zone lymphoma (SMZL); primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT); and extracutaneous/systemic diffuse large B-cell lymphoma (eDLBCL)...
June 8, 2023: Journal of Cutaneous Pathology
#29
Monika Aleksiejūnaitė, Andrius Talijūnas, Linas Zaleckas, Rūta Rastenienė
Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of B-cell lineage lymphoma that can affect the head and neck region. This report presents a rare case of an extra-nodal marginal zone B-cell MALT lymphoma of a sublingual gland, diagnosed in an 18-year-old male patient. The patient had a history of ranula surgical removal on the right side of the mouth. One year after surgery, the patient presented with complaints of swelling of the left parotid gland, with no significant changes found during the examination and a self-resolving outcome...
April 2023: Curēus
#30
JOURNAL ARTICLE
Misayo Miyake, Seiji Sakata, Naoko Tsuyama, Yuki Togashi, Masaaki Noguchi, Nobuhiro Tsukada, Takashi Kumagai, Yuko Mishima, Kengo Takeuchi
AIMS: Tissue eosinophilia is commonly observed in T-cell and classic Hodgkin lymphomas, but rarely in B-cell lymphomas. Herein, we present the first report of a case series on nodal marginal zone lymphoma (NMZL) with tissue eosinophilia. METHODS AND RESULTS: All 11 patients in this study had nodal disease at primary presentation. The mean age at diagnosis was 64 years. The mean follow-up period was 39 months, and all patients were alive. Nine of the 11 patients (82%) showed no recurrence, but the other two patients experienced recurrence in the lymph nodes or skin...
May 24, 2023: Histopathology
#31
JOURNAL ARTICLE
James R Cook, Catalina Amador, Magdalena Czader, Amy Duffield, John Goodlad, German Ott, Wenbin Xiao, Sandeep Dave, Devang Thakkar, Elizabeth Thacker, Ahmet Dogan, Mariusz Wasik, Reza Nejati
OBJECTIVES: To summarize the conclusions of the 2021 Society for Hematopathology/European Association for Haematopathology workshop regarding transformations of marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL). METHODS: Nineteen cases were submitted to this portion of the workshop. Additional studies were performed in cases with sufficient material. RESULTS: Cases included splenic MZL (n = 4), splenic diffuse red pulp small B-cell lymphoma (n = 2), nodal MZL (n = 4), extranodal MZL (n = 1), and LPL (n = 8)...
April 26, 2023: American Journal of Clinical Pathology
#32
JOURNAL ARTICLE
Ilja Kalashnikov, Tomas Tanskanen, Leevi Viisanen, Nea Malila, Sirkku Jyrkkiö, Sirpa Leppä
Marginal zone lymphoma (MZL) is an indolent B-cell malignancy with heterogeneous anatomical and clinical presentation. While MZLs are generally associated with long survival, some patients experience histological transformation to aggressive large B-cell lymphoma. Population-based long-term data on the transformation of MZL is limited. We conducted a nationwide population-based study to estimate the risk of transformation and relative survival in patients diagnosed with MZL in Finland from 1995-2018. We identified a total of 1454 patients with MZL from the Finnish Cancer Registry (FCR)...
April 25, 2023: Blood Cancer Journal
#33
JOURNAL ARTICLE
Johanna S Enke, Nic G Reitsam, Tina Schaller, Rainer Claus, Constantin Lapa, Alexander Dierks
No abstract text is available yet for this article.
April 26, 2023: European Journal of Nuclear Medicine and Molecular Imaging
#34
JOURNAL ARTICLE
Shan-Chi Yu, Ko-Chen Chen, Ruby Yun-Ju Huang
BACKGROUND: Reactive lymphadenopathies such as toxoplasmosis and cytomegalovirus lymphadenitis are associated with monocytoid cell proliferation. Monocytoid cells are B-lymphocytes with an undetermined subset. METHODS: Using digital spatial profiling whole transcriptome analyses, this study compared monocytoid and control B-cells. The B-cell subset of monocytoid cells was assigned according to gene expression profiles. RESULTS: This study identified 466 differentially expressed genes between monocytoid and control B-cells...
April 11, 2023: Journal of Microbiology Immunology and Infection
#35
JOURNAL ARTICLE
Carmen Auñón, Arantza Sanvisens, Estel Turon, Anna Vidal-Vila, Montse Puigdemont, Gemma Osca-Gelis, Arantxa Eraso, Rafael Marcos-Gragera
OBJECTIVE: To analyze the incidence, incidence trends, and survival of marginal zone lymphomas (MZLs) in Girona and to describe these indicators based on the location in the case of extranodal MZLs. METHODS: Population-based study of MZL collected in the Girona Cancer Registry, 1994-2018. Sociodemographic data, tumor location, and stage were obtained from clinical records. Crude (CR) and age-adjusted (ASRE ) incidence rates expressed per 100,000 person-years (p-y) were calculated...
April 19, 2023: Cancer Medicine
#36
JOURNAL ARTICLE
Abdalrahim M Ali, Alaa A Makki, Walaa Ibraheem, Mohammed Abdelrahman, Wadah Osman, Asmaa E Sherif, Ahmed Ashour, Sabrin R M Ibrahim, Kholoud F Ghazawi, Waad A Samman, Abdulrahim A Alzain
Non-Hodgkin's lymphomas are a diverse collection of lymphoproliferative cancers that are much less predictable than Hodgkin's lymphomas with a far greater tendency to metastasize to extranodal sites. A quarter of non-Hodgkin's lymphoma cases develop at extranodal sites and the majority of them involve nodal and extranodal sites. The most common subtypes include follicular lymphoma, chronic/small lymphocytic leukaemia, mantel cell lymphoma, and marginal zone lymphoma. Umbralisib is one of the latest PI3Kδ inhibitors in clinical trials for several hematologic cancer indications...
March 1, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#37
JOURNAL ARTICLE
Neha Gupta, Sudarhana Roychoudry, Kristin L Sticco, Peihong Hsu, Xinmin Zhang, Silvat Sheikh-Fayyaz
Myeloid cell nuclear differentiation antigen (MNDA) is normally expressed on myelomonocytic cells and a subset of B lymphocytes. It was found to be differentially expressed between nodal marginal zone lymphoma (MZL) and follicular lymphoma (FL). However, MNDA has not been widely used as a diagnostic marker in clinical practice. To validate its utility, we studied the expression of MNDA by immunohistochemistry in 313 cases of small B-cell lymphomas. Our results showed that MNDA was positive in 77.9% of MZL, 21...
March 6, 2023: Applied Immunohistochemistry & Molecular Morphology: AIMM
#38
JOURNAL ARTICLE
Come Sesboue, Jean Galtier, Marie Jeanneau, Annick Chauvel, Elodie Laharanne, Samuel Amintas, Jean-Philippe Merlio, Krimo Bouabdallah, François-Xavier Gros, Laurence de Leval, Audrey Gros, Marie Parrens
Distinguishing between follicular lymphoma (FL) and nodal marginal zone lymphoma (NMZL) can be difficult when morphologic and phenotypic features are unusual and characteristic cytogenetic rearrangements are absent. We evaluated the diagnostic contribution of ancillary techniques-including fluorescence in situ hybridization (FISH)-detected 1p36 deletion; reverse-transcriptase, multiplex, ligation-dependent probe amplification (RT-MLPA); and next-generation sequencing (NGS)-for tumors that remain unclassified according to standard criteria...
February 2023: Modern Pathology
#39
REVIEW
Anthea Peters, Mary-Margaret Keating, Anna Nikonova, Sarah Doucette, Anca Prica
Marginal zone lymphomas (MZL) are a rare, heterogenous group of lymphomas, accounting for 5-17% of indolent non-Hodgkin lymphomas in the western world. They can be further divided into three subtypes: extranodal MZL, splenic MZL, and nodal MZL. These subtypes differ in clinical presentation and behavior, which influences how they are managed. There is currently no standard of care for the treatment of MZL, owing to the difficulty in conducting phase 3 randomized trials in MZL, and the fact that there are limited data on the efficacy of therapy in individual subtypes...
February 1, 2023: Current Oncology
#40
Esmat M Mahmoud, Emily Howard, Humera Ahsan, Joseph P Cousins, Ayman Nada
Extra-nodal Non-Hodgkin lymphoma (ENHL) of the head and neck is not uncommon and has variable clinical and imaging presentations. It represents about 25% of extra-nodal lymphomas. In addition, lymphoma is the third most common malignancy of the head and neck just after squamous cell carcinoma (SCC) and salivary gland neoplasms. Unlike SCC, ENHL usually presents as a well-defined mass in the oral cavity, along the pharyngeal mucosa, sinonasal cavity, orbit, and other different neck spaces. One of the common presentations of ENHL is the glandular type which can arise within the salivary or thyroid glands as marginal zone non-Hodgkin lymphoma...
2023: Journal of Clinical Imaging Science
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
