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prevalence of peripheral arterial disease in hiv

Félicité Kamdem, Yacouba Mapoure, Ba Hamadou, Fanny Souksouna, Marie Solange Doualla, Ahmadou Musa Jingi, Caroline Kenmegne, Fernando Kemta Lekpa, Jaff Kweban Fenkeu, Gisèle Imandy, Jean Pierre Nda Mefo'o, Henry Luma
Background: The prevalence of peripheral artery disease (PAD) is not well known among HIV-infected patients in Africa. The aim of this study was to determine the prevalence and associated risk factors of PAD among HIV-infected patients at the Douala General Hospital (DGH). Methods: This was a cross-sectional descriptive and analytic study between November 2015 and April 2016. We recruited patients aged ≥21 years, diagnosed with HIV infection, and who were receiving care at the DGH...
2018: Vascular Health and Risk Management
L Aurpibul, P Sugandhavesa, K Srithanaviboonchai, W Sitthi, A Tangmunkongvorakul, C Chariyalertsak, K Rerkasem
OBJECTIVES: HIV infection has become a chronic disease requiring long-term treatment. Premature cardiovascular disease resulting from atherosclerosis in the HIV-infected population has been observed. We assessed the prevalence of peripheral artery disease (PAD), a common consequence of atherosclerosis, in HIV-infected patients aged ≥ 50 years receiving antiretroviral treatment (ART). METHODS: This cross-sectional study was conducted in 12 community hospitals in Chiang Mai, Thailand...
August 30, 2018: HIV Medicine
Andreas D Knudsen, Marco Gelpi, Shoaib Afzal, Andreas Ronit, Ashley Roen, Amanda Mocroft, Jens Lundgren, Børge Nordestgaard, Henrik Sillesen, Anne-Mette Lebech, Lars Køber, Klaus F Kofoed, Susanne D Nielsen
OBJECTIVE: Ankle-brachial index is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared with uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors. METHODS: PLWH aged 40 years and older were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study...
November 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Carlos A Hinojosa, Ana E Nunez-Salgado, Javier E Anaya-Ayala, Hugo Laparra-Escareno, Laura J Ortiz-Lopez, Jaime O Herrera-Caceres, Brenda E Crabtree-Ramirez, Juan G Sierra-Madero
Objectives The longer survival of patients with human immunodeficiency virus/acquired immunodeficiency syndrome and the introduction of the highly active antiretroviral therapy have increased the number of chronic conditions; among these, cardiovascular diseases. The aim of this study is to determine patient, disease, and factors associated with peripheral arterial disease in a population of patients with human immunodeficiency virus/acquired immunodeficiency syndrome. Methods A prospective nested case-control study of a cohort of patients with human immunodeficiency virus/acquired immunodeficiency syndrome was conducted in a tertiary medical center in Mexico City...
October 2018: Vascular
Joshua A Beckman, Meredith S Duncan, Charles W Alcorn, Kaku So-Armah, Adeel A Butt, Matthew Bidwell Goetz, Hilary A Tindle, Jason J Sico, Russel P Tracy, Amy C Justice, Matthew S Freiberg
BACKGROUND: The effect of human immunodeficiency virus (HIV) on the development of peripheral artery disease (PAD) remains unclear. We investigated whether HIV infection is associated with an increased risk of PAD after adjustment for traditional atherosclerotic risk factors in a large cohort of HIV-infected (HIV+) and demographically similar HIV-uninfected veterans. METHODS: We studied participants in the Veterans Aging Cohort Study from April 1, 2003 through December 31, 2014...
July 17, 2018: Circulation
Nath Zungsontiporn, Raquel R Tello, Guangxiang Zhang, Brooks I Mitchell, Matthew Budoff, Kalpana J Kallianpur, Beau K Nakamoto, Sheila M Keating, Philip J Norris, Lishomwa C Ndhlovu, Scott A Souza, Cecilia M Shikuma, Dominic C Chow
BACKGROUND: Persistent inflammation and immune activation has been hypothesized to contribute to increased prevalence of subclinical atherosclerosis and cardiovascular disease (CVD) risk in patients with chronic HIV infection. In this study, we examined the correlation of peripheral monocyte subsets and soluble biomarkers of inflammation to coronary artery calcium (CAC) progression, as measured by cardiac computed tomography scan. METHODS: We conducted a longitudinal analysis utilizing baseline data of 78 participants with HIV infection on stable antiretroviral therapy (ART) in the Hawaii Aging with HIV-Cardiovascular study who had available baseline monocyte subset analysis as well as CAC measurement at baseline and at 2-year follow up...
2016: PloS One
Luísa Amado Costa, Ana G Almeida
The cardiovascular manifestations of human immunodeficiency virus (HIV) infection have changed significantly following the introduction of highly active antiretroviral therapy (HAART) regimens. On one hand, HAART has altered the course of HIV disease, with longer survival of HIV-infected patients, and cardiovascular complications of HIV infection such as myocarditis have been reduced. On the other hand, HAART is associated with an increase in the prevalence of both peripheral and coronary arterial disease. As longevity increases in HIV-infected individuals, long-term effects, such as cardiovascular disease, are emerging as leading health issues in this population...
July 2015: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Andreas Knudsen, Catarina Anna Evelina Malmberg, Andreas Kjær, Anne-Mette Lebech
BACKGROUND: Patients infected with human immunodeficiency virus (HIV) appear to be at increased risk of cardiovascular disease (CVD). The ankle-brachial index (ABI) is a well-established screening tool for peripheral arterial disease (PAD) and future cardiovascular events in the general population. However, controversies exist on the prevalence of PAD among HIV-infected patients. In this study we aimed to measure the prevalence of PAD among HIV-infected patients and compare the ABI with carotid intima-media thickness (cIMT) and other known CVD risk predictors...
2015: Infectious Diseases
Wiesława Kwiatkowska, Brygida Knysz, Katarzyna Arczyńska, Justyna Drelichowska, Marcin Czarnecki, Jacek Gąsiorowski, Maciej Karczewski, Wojciech Witkiewicz
BACKGROUND: Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis and mainly refers to elderly patients, having a negative impact on their functionality and quality of life. The findings of previous studies in HIV-infected patients have shown that cardiovascular risk is higher and PAD occurs more frequently than in the general population. There are also contradictory observations. Much less is known about the ankle-brachial index (ABI) value in asymptomatic HIV-infected patients...
2014: PloS One
Paweł Balsam, Tomasz Mikuła, Michał Peller, Magdalena Suchacz, Bartosz Puchalski, Łukasz Kołtowski, Renata Główczyńska, Alicja Wiercińska-Drapalo, Grzegorz Opolski, Krzysztof J Filipiak
BACKGROUND: In the era of combination antiretroviral therapy (cART), life expectancy of HIV-infected patients is the same as that of the general population, resulting in increasing prevalence of cardiovascular disease in this patient group. AIM: To assess the prevalence of endothelial dysfunction in HIV-infected patients and to identify factors which affect endothelial function and arterial stiffness. METHODS: Thirty-seven adult HIV-infected patients, regardless of the fact and the type of cART, were enrolled into the study...
2015: Kardiologia Polska
Judith Schouten, Ferdinand W Wit, Ineke G Stolte, Neeltje A Kootstra, Marc van der Valk, Suzanne E Geerlings, Maria Prins, Peter Reiss
BACKGROUND: Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs). METHODS: Cross-sectional analyses of AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) and risk factors in a prospective cohort study of HIV type 1-infected individuals and HIV-uninfected controls, who were aged ≥45 years and comparable regarding most lifestyle and demographic factors...
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Samson Okello, Alexander Millard, Rogers Owori, Stephen Bambeiha Asiimwe, Mark Jacob Siedner, Joselyn Rwebembera, Laurence Anthony Wilson, Christopher Charles Moore, Brian Herb Annex
BACKGROUND: Peripheral artery disease (PAD) is a major complication of atherosclerosis. PAD can be diagnosed with low-cost diagnostic techniques and is associated with significant morbidity and mortality. While the major epidemiologic risk factors for PAD have been established in the western world, data from resource-poor countries are limited. We performed a cross-sectional study to determine the prevalence and correlates of PAD among patients with diabetes at Mbarara Referral Hospital in southwestern Uganda...
June 10, 2014: BMC Cardiovascular Disorders
Raúl Herrera, Carlos M Orantes, Miguel Almaguer, Pedro Alfonso, Héctor D Bayarre, Irma M Leiva, Magaly J Smith, Ricardo A Cubias, Carlos G Torres, Walter O Almendárez, Francisco R Cubias, Fabrizio E Morales, Salvador Magaña, Juan C Amaya, Edgard Perdomo, Mercedes C Ventura, Juan F Villatoro, Xavier F Vela, Susana M Zelaya, Delmy V Granados, Eduardo Vela, Patricia Orellana, Reynaldo Hevia, E Jackeline Fuentes, Reinaldo Mañalich, Raymed Bacallao, Mario Ugarte, María I Arias, Jackelin Chávez, Nelson E Flores, Claudia E Aparicio
INTRODUCTION: Chronic kidney disease is a serious health problem in El Salvador. Since the 1990s, there has been an increase in cases unassociated with traditional risk factors. It is the second leading cause of death in men aged >18 years. In 2009, it was the first cause of in-hospital death for men and the fifth for women. The disease has not been thoroughly studied. OBJECTIVE: Characterize clinical manifestations (including extrarenal) and pathophysiology of chronic kidney disease of nontraditional causes in Salvadoran farming communities...
April 2014: MEDICC Review
Mateja Pirs, Barbara Eržen, Mišo Sabović, Primož Karner, Ludvik Vidmar, Mario Poljak, Borut Jug, Mojca Mikac, Janez Tomažič
BACKGROUND: Increased life expectancy of human immunodeficiency virus (HIV)-infected patients appears to be coupled with increased incidence of cardiovascular disease (CVD). AIM: The aim of our study was to determine the presence of early atherosclerosis among Slovenian HIV-infected patients below the age of 55 years. METHODS: A total of 86 HIV-infected male patients below the age of 55 years participated in our study. Ankle-brachial index (ABI) was measured using a handheld Doppler ultrasonic probe and a blood pressure cuff...
May 2014: Wiener Klinische Wochenschrift
Marta Mauri Pont, Rosa Maria Borrallo Almansa, Guido Almada Rivas, Miriam Carbó Díez, Rosa Solé Arnau, Enric García Restoy
INTRODUCTION: Cardiovascular disease among human immunodeficiency virus (HIV) infected patients is more frequent than in the general population. Peripheral arterial disease measured by ankle-brachial index (ABI) and cardiovascular risk factors (CVRF) is not well known in all groups of HIV-infected patients. METHODS: Transversal study of HIV-infected patients >45 years, seen as outpatients in hospital (HO) in 2008 and patients institutionalized in a prison in 2009...
May 2014: Clínica e Investigación en Arteriosclerosis
Stefan Esser, Götz Gelbrich, Norbert Brockmeyer, Alexander Goehler, Dirk Schadendorf, Raimund Erbel, Till Neumann, Nico Reinsch
BACKGROUND: Recent studies suggest a rising rate of cardiovascular disease (CVD) in HIV-infected subjects. Although most countries have an aging HIV-infected population, there remains a lack of knowledge about associated cardiovascular diseases. METHODS: This ongoing prospective multicentre observational cohort study aims to elucidate CVD prevalence in HIV-infected outpatients by standardized non-invasive cardiovascular screening. Cardiovascular and coronary risk was calculated using Framingham risk scores...
March 2013: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
A Y Qaqa, V A Debari, K El-Kersh, K Elkersh, R Sison, A Isbitan, N Mohammad, J Slim, G Perez, F E Shamoon
AIM: HIV infection is strongly associated with accelerated vascular atherosclerosis and increased cardiovascular events. The prevalence of peripheral arterial disease (PAD) in HIV infected patients is not clearly defined and the results of different reports are contradicting. OBJECTIVE: To determine the prevalence of abnormal Ankle Brachial Index (ABI) and associated risk factors in HIV infected population. METHODS: The ABI was measured manually using 5...
June 2012: International Angiology: a Journal of the International Union of Angiology
Adolfo Baloira, Marta Núñez, José Cifrian, Carlos Vilariño, María Ojeda, Diana Valverde
UNLABELLED: Serotonin is a potent vasoconstrictor and pulmonary vascular growth factor whose concentration is increased in patients with pulmonary arterial hypertension (PAH). Its functions are mediated in part by the serotonin transporter protein (SERT) whose gene can have two allelic forms, both long (L) and short (S). The first was associated with greater function. OBJECTIVES: To determine whether the prevalence of the L allelic form of SERT is higher in patients with PAH than in the general population...
March 2012: Archivos de Bronconeumología
Eduardo Canalejo, Noemí Cabello, Isabel Perales, Sonia Allodi, Aquilino Sánchez-Purificación
INTRODUCTION: Human immunodeficiency virus (HIV) infection has been associated with a higher risk of subclinical atherosclerosis and cardiovascular events. Peripheral arterial disease (PAD) is a good marker of systemic atherosclerosis and a powerful predictor of cardiovascular morbidity and mortality. The objective of this study was to determine the prevalence of asymptomatic PAD and associated risk factors in HIV-infected people. METHODS: Cross-sectional study was conducted on all consecutive HIV-positive patients older than 20 years without symptoms of intermittent claudication who attended our clinic between November 2008 and December 2009...
November 2011: Enfermedades Infecciosas y Microbiología Clínica
Ashraf Y Qaqa, Vincent A DeBari, A Isbitan, N Mohammad, R Sison, Jihad Slim, George Perez, Fayez E Shamoon
Peripheral arterial disease (PAD) is a marker of atherosclerosis, which is not well studied in the population with human immunodeficiency virus (HIV). We prospectively enrolled HIV-infected patients who had normal resting ankle-brachial index (rABI) readings. All participants performed either a treadmill walking test (TT) or pedal plantar flexion test (PFT). Patients were divided into 2 groups according to postexercise changes; PAD and No-PAD group. The 2 groups were compared with regard to established cardiovascular disease risk factors and other HIV infection parameters...
January 2011: Angiology
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