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"Chitosan Nanoparticle"

Fatemeh Graily Moradi, Mir Jalil Hejazi, Hamed Hamishehkar, Ahmad Ali Enayati
A well-known strategy for managing pest resistance is application of mixture of pesticides. Conventionally formulated pesticides have several environmental incompatibilities. The use of biocompatible and biodegradable nanocarriers in formulating pesticides could improve environmental protection. In this study, a mixture of imidacloprid and lambda-cyhalothrin was co-encapsulated for the first time using liposomes as nanocarrier to simultaneously deliver these insecticides. Ethanol injection was used to produce self-assembled liposomes...
March 18, 2019: Ecotoxicology and Environmental Safety
Shanmuga Sundar Saravanabhavan, Muruganantham Rethinasabapathy, Sarang Zsolt, Aravind Bhat Kalambettu, Sundaravadivel Elumalai, Manokaran Janakiraman, Yun Suk Huh, Balasubramanian Natesan
Presently, quite a lot of research that are being carried out to find a potential cure for cancer and many had made to clinical trial stage as well. In the present study, we focus on use of a novel graphene oxide functionalized chitosan nanoparticle targeting Saos-2 and MG-63 osteosarcoma cells. The graphene oxide chitosan nanoparticles were loaded with siRNA, studied for in vitro release with varying concentration & pH, and fitted to peppas model. MTT & ROS assay was used to evaluate biocompatibility of carrier and qPCR to study the inflammatory responses in particular checking gene expression of IL-6, TGF-ß, TNF-α in both RAW 264...
June 2019: Materials Science & Engineering. C, Materials for Biological Applications
Mohammad Taghi Taghizadeh, Habib Ashassi-Sorkhabi, Ramin Afkari, Amir Kazempour
Chitosan nanoparticles and chitosan beads were synthesized through the ionic gelation procedure in which sodium citrate was used as the cross-linking agent. The prepared nanoparticles were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential, and Fourier transform infrared (FT-IR) spectroscopy. The synthesized nanoparticles and beads were examined as drug carriers for controlled release of two important drugs including betamethasone and tetracycline. For this purpose, various characters such as swelling behavior, loading capacity, encapsulation efficiency, and release degree of the particles were obtained...
March 15, 2019: International Journal of Biological Macromolecules
A Anitha, N Deepa, K P Chennazhi, Vinoth-Kumar Lakshmanan, R Jayakumar
No abstract text is available yet for this article.
March 12, 2019: Biochimica et Biophysica Acta. General Subjects
Yibing Jiang, Xiwei Yu, Chang Su, Liang Zhao, Yijie Shi
In recent years, numerous studies have confirmed the role of chitosan nanoparticles (CS NPs) as a promising drug delivery carrier for improving the efficiency of anticancer drug in the treatment of cancer. However, the possible biological effects of CS NPs on tumour cells and underlying mechanisms are still unclear. Recently, reactive oxygen species (ROS)-mediated cell apoptosis has been implicated in the regulation of cell death. In this study, we found that CS NPs induced the massive generation of ROS and resulted in apoptosis of hepatocellular carcinoma cells (SMMC-7721) through activating the mitochondrial pathway and endoplasmic reticulum stress...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Pegah Almasian, Jafar Amani, Fahimeh Baghban Arani, Shahram Nazarian, Rouhollah Kazemi, Niloufar Mirzaee Tabrizi
Background and Objectives: Escherichia coli O157:H7 is one of the most important food pathogens that produces colitis and bloody urine in humans. The Stx2B subunit is considered as one of the candidates for vaccine due to its immunogenic and adjuvant properties. Designing a mucosal vaccine using nanoparticles for protecting the antigen against degradation and controlling the release of antigen are important. The objective of the current study was to prepare nanoparticles containing the Stx2B subunit of E...
December 2018: Iranian Journal of Microbiology
Urban Ajdnik, Lidija Fras Zemljič, Matej Bračič, Uroš Maver, Olivija Plohl, Janez Rebol
Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material...
March 13, 2019: Materials
Arokia Vijaya Anand Mariadoss, Ramachandran Vinayagam, Vijayalakshmi Senthilkumar, Paulpandi Manickam, Murugan Kadarkarai, Baojun Xu, K M Gothandam, Venkata Subbaiah Kotakadi, Ernest David
The aim of the present investigation is to explore the innovative platform for the synthesis of plant-based nanoparticles, which contain biocompatible and biodegradable carrier of chitosan loaded with phloretin hydrophobic phytochemical applied as a stable anticancer agent. Treatment of cancer uses chemotherapeutic drugs as the cells are resistant to other drugs. However, the usage of therapeutic drug is limited by its poor solubility and low bioavailability. To overcome this problem, we fabricated the phloretin loaded chitosan nanoparticles (PhCsNPs) and physicochemical properties of PhCsNPs were characterized by FTIR, XRD, DLS, SEM and TEM...
March 4, 2019: International Journal of Biological Macromolecules
Nagihan Ugˇurlu, Mehmet Dogˇan Aşık, Hasan Basri Çakmak, Sema Tuncer, Mustafa Turk, Nurullah Çagˇıl, Emir Baki Denkbas
Purpose : The aim of this study was to synthesize bevacizumab-loaded nanoparticles and evaluate their effects on the treatment of posterior segment diseases via subtenon injections. Methods : Bevacizumab-loaded chitosan nanoparticles (BLCNs) were synthesized by the ionic gelation method, and their physicochemical characteristics and in vitro release profile were studied. The BLCNs were characterized using atomic force microscopy (AFM), FTIR spectroscopy, dynamic light scattering, and scanning electron microscopy...
April 1, 2019: Journal of Biomedical Nanotechnology
Mohsen Abdel-Tawwab, Nashwa Abdel Razek, Azza M Abdel-Rahman
The current study was conducted to evaluate the effect of dietary chitosan nanoparticles (CNP) on growth performance, antioxidant activity, and innate immunity of Nile tilapia, Oreochromis niloticus (L.). Fish (19.8 ± 0.59 g) were fed on diets enriched with 0.0, 0.25, 0.5, 1.0, and 2.0 g CNP/kg diet for 45 days. Fish performance improved significantly with increasing CNP levels over the control diet with optimum level of 1.0 g CNP/kg diet. Antioxidant-stimulated activity was observed due to dietary CNP supplementation over the control diet in a dose-dependent manner...
March 2, 2019: Fish & Shellfish Immunology
Pengyu Li, Xiaonan Chen, Yuanna Shen, Huatian Li, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu
The resistance of Helicobacter pylori (H. pylori) to conventional antibiotic treatments becomes prevalent recently. The biofilm formation was found to be highly correlated with the antibiotic resistance of H. pylori in the last decades. Moreover, H. pylori colonizes on the digestive tract epithelium located under the mucus layers, which further reduces therapeutic efficacy as mucus layers trap and remove exogenous substances including drugs. Herein, we reported a novel lipid polymer nanoparticles (LPNs) to overcome both biofilm and mucus layers obstruction...
February 27, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Dileep Urimi, Ashish Kumar Agrawal, Varun Kushwah, Sanyog Jain
In the present study, stable chitosan nanoparticles (Ch-NPs) were developed using the ionotropic gelation method, where poly(sodium 4-styrenesulfonate) (PSS) was used as a cross-linking agent while polyglutamic acid (PGA) for functionalization to improve the oral uptake through calcium-sensing receptors and amino acid transporters present in intestinal epithelium. Formulation was optimized by the design of experiments (DoE) approach using a three-level central composite design and characterized for in vitro parameters such as morphology, particle size, polydispersity index (PDI), entrapment efficiency and zeta potential...
February 27, 2019: AAPS PharmSciTech
Dian Agustina Permatasari, Deantari Karliana, Iskandarsyah Iskandarsyah, Ade Arsianti, Anton Bahtiar
Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase (MMP-9) expression. Target of osteoarthritis (OA) treatment was in the synovial joint that requiring a drug delivery system. The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) β, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions...
January 2019: Journal of Advanced Pharmaceutical Technology & Research
Filipa Lebre, Ed C Lavelle, Olga Borges
OBJECTIVES: The cationic biopolymer chitosan (CH) has emerged as a promising candidate adjuvant due to its safety profile and immunostimulatory properties. The presence of endotoxin contamination in biomaterials is generally underappreciated and can generate misleading results. It is important to establish a convenient methodology to obtain large amounts of high quality chitosan nanoparticles for biomedical applications. METHODS: We developed an easy method to generate endotoxin-free chitosan and assessed its purity using the Limulus amebocyte lysate assay and by measuring dendritic cell activation...
February 25, 2019: Journal of Pharmacy and Pharmacology
Thaís Ribeiro Santiago, Cínthia Caetano Bonatto, Maurício Rossato, Cláudio Afonso Pinho Lopes, Carlos Alberto Lopes, Eduardo Seiti Gomide Mizubuti, Luciano Paulino Silva
BACKGROUND: Silver nanoparticles (AgNPs), particularly those entrapped in polymeric nanosystems, have arisen as options to manage plant bacterial diseases. Among biopolymers useful for entrapment of AgNPs, chitosan is promising due to its low cost, good biocompatibility, antimicrobial properties, and biodegradability. The goals of this study were: (i) to greenly-synthesize AgNPs using different concentrations of aqueous extract of tomato leaves followed by AgNPs entrapment with chitosan (CH-AgNPs); (ii) to characterize the optical, structural, and biological properties of the produced nanosystems; (iii) to evaluate the antimicrobial activities of AgNPs and nanomaterials; and (iv) to assess the effectiveness of AgNPs and nanomaterials to control tomato bacterial wilt caused by Ralstonia solanacearum...
February 22, 2019: Journal of the Science of Food and Agriculture
Yuanyuan Ma, Lei Fu, Zahoor Hussain, Dandan Huang, Shuhua Zhu
Sweet cherries rapidly depreciate in market value owing to decay and the quick loss of fruit quality after harvest. Therefore, optimum postharvest treatment is crucial for maintaining the qualities of cherries during storage. Here, we tested a new method of postharvest treatment by immersing sweet cherries in nitric oxide-releasing chitosan nanoparticles (GSNO-CS NPs), storing them at 0 °C and evaluating fruit quality over time. The results indicated that GSNO-CS NPs more effectively preserved the quality of cherries during cold storage compared to other methods...
July 1, 2019: Food Chemistry
Deepa Narayanan, A Anitha, R Jayakumar, K P Chennazhi
No abstract text is available yet for this article.
February 22, 2019: Molecular Pharmaceutics
Sang Hee Soh, Soojin Shim, Young Bin Im, Hong-Tae Park, Chong-Su Cho, Han Sang Yoo
The aim of this study was to investigate the induction of mucosal immune responses by an important Brucella abortus antigen, malate dehydrogenase (Mdh), loaded in mucoadhesive chitosan nanoparticles (CNs) and immunized intranasally in a BALB/c mouse model. The production of cytokines was investigated in human leukemic monocyte cells (THP-1 cells) after stimulation with the nanoparticles. Mdh-loaded CNs (CNs-Mdh) induced higher interleukin (IL)-6 production than unloaded antigens and TF loaded CNs (CNs-TF). Using ELISpot to quantify cytokines and antibody-secreting cells in the intranasally immunized mice, IL-4 and IgG-secreting cells were found to be significantly increased at 4 weeks and 6 weeks post-immunization in the CNs-Mdh immunized group, respectively...
February 18, 2019: Vaccine
Lu Wang, Xiaoyu Li, Hongchao Wang
BSA and chitosan were used to prepare nanoparticles of polyphenols from the pine cones of Pinus koraiensis (PKP-NPs). The physicochemical properties including the average particle size, zeta potential, crystal characteristics and morphology of PKP-NPs were measured. PKP-NPs were semi-crystalline, and possessed spherical and almost uniformly sized morphological features. The rheological particle size of PKP-NPs was 187.9 ± 16.32 nm, and the zeta potential was -7.34 ± 0.24 mV. In addition, PKP-NPs showed excellent storage stability at room temperature...
February 20, 2019: Food & Function
Hala S Abuelmakarem, Mahmoud A Sliem, Jala El-Azab, Moustafa M A Farghaly, Wafaa A Ahmed
Chitosan-tripolyphosphate nanoparticles (C-TPP NPs) were synthesized to investigate their cytotoxicity against colon cancer cells (Caco2 cells) in the absence and the presence of a near-infrared (NIR) laser to evaluate their influence in cancer detection using the NIR laser and to evaluate the NIR laser on cancer treatment. The synthesized NPs were characterized by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), zeta potential (ZP), and transmission electronic microscope (TEM)...
February 18, 2019: Biosensors
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