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Nutrition protein

Xiang Chen, JiaXi Yao, Li Liu, WenZhong Zheng, XiaoYi Hu, YanJun Zhu, Hang Wang, JianMing Guo
BACKGROUND: Serum protein fraction (SPF) is a common parameter reflecting the nutritional and inflammatory status of the human body. However, its role in patients with cancer, particularly those treated with targeted agents, is unknown. OBJECTIVE: We conducted this study to explore the prognostic value of SPF in patients with metastatic renal cell carcinoma (mRCC) treated with tyrosine kinase inhibitors and its association with clinical characteristics. METHODS: Patients with mRCC (n = 213) who initiated first-line sunitinib or sorafenib systemic therapy for metastatic disease between March 2007 and June 2017 at Zhongshan Hospital, Fudan University, were retrospectively included in our analysis...
March 18, 2019: Targeted Oncology
Ke-Cheng Zhu, Ling Song, Hua-Yang Guo, Liang Guo, Nan Zhang, Bao-Suo Liu, Shi-Gui Jiang, Dian-Chang Zhang
The elongases of very long-chain fatty acids (Elovls) are responsible for the rate-limiting elongation process in long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis. The transcription factor, PPARα, regulates lipid metabolism in mammals; however, the detailed mechanism whereby PPARαb regulates Elovls remains largely unknown in fish. In the present study, we report the full length cDNA sequence of Trachinotus ovatus Elovl4a (ToElovl4a), which encodes a 320 amino acid polypeptide that possesses five putative membrane-spanning domains, a conserved HXXHH histidine motif and an ER retrieval signal...
March 18, 2019: Scientific Reports
Ka Li, Yujie Xu, Yanjie Hu, Yuwei Liu, Xinrong Chen, Yong Zhou
BACKGROUNDS: Enteral immunonutrition (EIN) has received increasing attention, however, evidence on its immunomodulatory and anti-inflammatory function in gastric cancer patients undergoing gastrectomy is poorly investigated. Objectives of this study were to evaluate the effect of EIN on immune function, inflammation response and nutrition status when compared to standard enteral nutrition (SEN). METHODS: Totally 124 gastric cancer patients after gastrectomy were randomized to receive early 5-days postoperative EIN (formula enriched with arginine, glutamine, omega-3 fatty acids and nucleotide), or SEN...
March 19, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Rosaria Costa, Gioele Capillo, Ambrogina Albergamo, Rosalia Li Volsi, Giovanni Bartolomeo, Giuseppe Bua, Antonio Ferracane, Serena Savoca, Teresa Gervasi, Rossana Rando, Giacomo Dugo, Nunziacarla Spanò
The phylum Cnidaria is one of the most important contributors in providing abundance of bio- and chemodiversity. In this study, a comprehensive chemical investigation on the nutritional and nutraceutical properties of Mediterranean jellyfish Pelagia noctiluca was carried out. Also, compositional differences between male and female organisms, as well as between their main anatomical parts, namely bell and oral arms, were explored in an attempt to select the best potential sources of nutrients and/or nutraceuticals from jellyfish...
March 17, 2019: Marine Drugs
Wei-Ning Wang, Mei-Fang Yang, Chen-Yu Wang, Chiann-Yi Hsu, Bor-Jen Lee, Pin-Kuei Fu
Small bowel enteral nutrition (SBEN) may improve nutrient delivery to critically ill patients intolerant of gastric enteral nutrition. However, the optimal time and target for evaluating SBEN efficacy are unknown. This retrospective cohort study investigates these parameters in 55 critically ill patients at high nutrition risk (modified NUTRIC score ≥ 5). Daily actual energy intake was recorded from 3 days before SBEN initiation until 7 days thereafter. The energy achievement rate (%) was calculated as follows: (actual energy intake/estimated energy requirement) × 100...
March 16, 2019: Nutrients
Iryna Liauchonak, Bessi Qorri, Fady Dawoud, Yatin Riat, Myron R Szewczuk
Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data that support the safety of consuming NNS. However, recent studies have suggested that NNS consumption can induce gut microbiota dysbiosis and promote glucose intolerance in healthy individuals that may result in the development of type 2 diabetes mellitus (T2DM). This sequence of events may result in changes in the gut microbiota composition through microRNA (miRNA)-mediated changes...
March 16, 2019: Nutrients
Amit Ranjan, Narottam Prasad Sahu, Ashutosh Dharmendra Deo, Sarvendra Kumar
An experiment was conducted to study the effect of solid state fermentation of de-oiled rice bran (DORB) with Rhizopus oryzae on in vitro protein digestibility, anti-nutritional factors and fatty acid profile. The fermentation of DORB with Rhizopus oryzae significantly reduced the in vitro protein digestibility of DORB (p < .05). The fermentation of DORB with Rhizopus oryzae increased the saturated fatty acid (SFA) content by 46.83%, while decreased the MUFA and PUFA contents by 14.01 and 8.76%, respectively...
May 2019: Food Research International
Ambika Gupta, Kirti M Naranje, Anita Singh, Aakash Pandita, Girish Gupta, Kaushik Mandal, Mandakini Pradhan
Congenital chylothorax is a relatively uncommon condition seen in newborn period. Treatment comprises of adequate pleural fluid drainage, octreotide infusion, total parenteral nutrition followed by medium chain triglyceride (MCT) based low fat milk preparations. The authors present a case of Cornelia de Lange syndrome with a rare presentation of antenatally diagnosed chlyothorax presenting at birth with respiratory distress. The baby was managed with skimmed milk formulation fortified with coconut oil providing low fat and high proteins...
March 16, 2019: Indian Journal of Pediatrics
Mahdieh Abbasalizad Farhangi
Current study was aimed to evaluate the relationship between emotional eating and night eating syndrome (NES) with sleep quality among adolescents in Tabriz-Iran. The current study was conducted among eighty adolescent boys aged 12-16 years old from Tabriz-Iran. Night eating syndrome and Emotional eating were measured by validated specific questionnaires. Pittsburgh Sleep Quality Index questionnaire (PSQI) was used for assessment of sleep quality. Emotional and very emotional eaters had significantly higher protein and fat intake...
March 16, 2019: Community Mental Health Journal
Anurag Bhargava, Madhavi Bhargava, Tripti Pande, Raghuram Rao, Malik Parmar
Undernutrition is the most prevalent comorbidity in patients with tuberculosis (TB) in India. Undernutrition is often severe and results in higher risk of death, drug toxicity during treatment, poor functional status at end of treatment and a higher risk of relapse after successful treatment. A World Health Organization guideline has recommended nutritional assessment, counseling, and care as integral parts of TB care. The Revised National Tuberculosis Control Programme has recognized undernutrition as a significant comorbidity, released a guidance document for improving nutritional care and support, and launched a scheme for direct bank transfer of monthly cash benefit to TB patients...
January 2019: Indian Journal of Tuberculosis
Di Shao, Chunxiang Yao, Maya H Kim, Jessica Fry, Richard A Cohen, Catherine E Costello, Reiko Matsui, Francesca Seta, Mark E McComb, Markus M Bachschmid
Sirtuin-1 (SirT1) catalyzes NAD+ -dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. Activation of SirT1 mitigates metabolic perturbations associated with diabetes and obesity. Pharmacologic molecules, cellular redox, and nutritional states can regulate SirT1 activity. Technical barriers against measuring endogenous SirT1 activity have limited characterization of SirT1 in disease and its activation by small molecules...
March 5, 2019: Redox Biology
Miles Flitton, Nicholas Rielly, Rhian Warman, Donald Warden, A David Smith, Ian A Macdonald, Helen Miranda Knight
Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of DNA methylation. We investigated the effect of a damaging coding variant within the DNA methyltransferase gene DNMT3L (R278G, A/G) by examining B vitamin intake, homocysteine levels, cognitive performance, and brain atrophy in individuals in the VITACOG study of mild cognitive impairment and the TwinsUK cohort...
February 13, 2019: Neurobiology of Aging
Rie Oka, Akihiro Nomura, Ayaka Yasugi, Mitsuhiro Kometani, Yuko Gondoh, Kenichi Yoshimura, Takashi Yoneda
INTRODUCTION: Nutritional intervention is effective in improving glycemic control in patients with type 2 diabetes but requires large inputs of manpower. Recent improvements in photo analysis technology facilitated by artificial intelligence (AI) and remote communication technologies have enabled automated evaluations of nutrient intakes. AI- and mobile-supported nutritional intervention is expected to be an alternative approach to conventional in-person nutritional intervention, but with less human resources, although supporting evidence is not yet complete...
March 15, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Amanda R Vest, Michael Chan, Anita Deswal, Michael M Givertz, Carolyn Lekavich, Terry Lennie, Sheldon E Litwin, Lauren Parsly, Jo Ellen Rodgers, Michael W Rich, P Christian Schulze, Aaron Slader, Akshay Desai
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited...
March 12, 2019: Journal of Cardiac Failure
Ali M Omari, Leen S Omari, Hazar H Dagash, Waleed M Sweileh, Nehal Natour, Sa'ed H Zyoud
BACKGROUND: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Therefore this study aimed to assess the nutritional status among HDP and to establish the factors associated with MN in these patients...
March 15, 2019: BMC Nephrology
Hiraku Ono
Insulin exists in the central nervous system, where it executes two important functions in the hypothalamus: the suppression of food intake and the improvement of glucose metabolism. Recent studies have shown that both are exerted robustly in rodents and humans. If intact, these functions exert beneficial effects on obesity and diabetes, respectively. Disruption of both occurs due to a condition known as hypothalamic insulin resistance, which is caused by obesity and the overconsumption of saturated fat. An enormous volume of literature addresses the molecular mechanisms of hypothalamic insulin resistance...
March 15, 2019: International Journal of Molecular Sciences
Ha-Na Kim, Sang-Wook Song
Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. We used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted in 2014 and 2016, and data on a total of 7374 participants were analyzed...
March 14, 2019: Nutrients
F Li, M X Shan, X Gao, Y Yang, X Yang, Y Y Zhang, J W Hu, A S Shan, B J Cheng
To evaluate the effects of maternal undernutrition on the performance, blood biochemical indexes, and hormone levels of broiler chicks, two broiler breeder lines (a fat line and lean line) were given either 100% or 75% of the daily feed intake recommended by the Chinese Ministry of Agriculture from 27 to 54 wk. All hens were fed the same basal corn-soybean diet. Fertile eggs were collected and hatched. All chicks were fed the same basal diet for 56 d. Then, chick performance, blood biochemical indexes, and hormone levels were measured...
February 5, 2019: Domestic Animal Endocrinology
Mohsen Mazidi, Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
BACKGROUND AND AIMS: We aimed to evaluate the link between inflammatory score [consisting of C-reactive protein (CRP) and white blood cells], serum uric acid (SUA) and atherogenic index of plasma (AIP) and the cardiovascular health (CVH) score. METHODS: We used the cross-sectional National Health and Nutrition Examination Survey database. Statistical analyses accounted for the survey design and sample weights. RESULTS: Overall, there were 23,004 participants (mean age = 47...
September 15, 2018: Atherosclerosis
Horst Malke
Of the eight phylogenetic groups comprising the genus Streptococcus , Lancefield group C and G streptococci (GCS and GGS, resp.) occupy four of them, including the Pyogenic, Anginosus, and Mitis groups, and one Unnamed group so far. These organisms thrive as opportunistic commensals in both humans and animals but may also be associated with clinically serious infections, often resembling those due to their closest genetic relatives, the group A streptoccci (GAS). Advances in molecular genetics, taxonomic approaches and phylogenomic studies have led to the establishment of at least 12 species, several of which being subdivided into subspecies...
March 2019: Microbiology Spectrum
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