keyword
https://read.qxmd.com/read/38530926/empirical-characterization-of-false-discovery-rates-of-differentially-expressed-genes-and-transcriptomic-benchmark-concentrations-in-zebrafish-embryos
#1
JOURNAL ARTICLE
Hyojin Lee, John D H Stead, Andrew Williams, Sergio A Cortés Ramírez, Ella Atlas, Jan A Mennigen, Jason M O'Brien, Carole Yauk
High-throughput transcriptomics (HTTr) is increasingly applied to zebrafish embryos to survey the toxicological effects of environmental chemicals. Before the adoption of this approach in regulatory testing, it is essential to characterize background noise in order to guide experimental designs. We thus empirically quantified the HTTr false discovery rate (FDR) across different embryo pool sizes, sample sizes, and concentration groups for toxicology studies. We exposed zebrafish embryos to 0.1% dimethyl sulfoxide (DMSO) for 5 days...
March 26, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38528033/statistical-estimation-of-noise-induced-hearing-loss-among-the-drivers-in-one-of-the-most-polluted-cities-of-india
#2
JOURNAL ARTICLE
Manish Kumar Manar, Shivendra Kumar Singh, Prashant Kumar Bajpai, Veerendra Verma, Sheo Prasad Shukla, Neeraj Kumar Singh, Markandeya
In the present study, an attempt has been made to assess the impact of vehicular noise upon the 3-wheeler tempo drivers and to know whether there is any relationship between hearing loss and cumulative noise exposure. For this purpose, 3-wheeler tempo drivers (Exposed group) and non-commercial light motor vehicle car drivers (Unexposed group) were chosen as study subjects. Three traffic routes were selected to assess the noise level during waiting and running time in the exposed and unexposed groups. Among all three routes, the highest mean noise level (Leq ) was observed on the Chowk to Dubagga route for waiting and en-route noise measurement...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38524820/artificial-intelligence-in-sport-exploring-the-potential-of-using-chatgpt-in-resistance-training-prescription
#3
JOURNAL ARTICLE
Jad Adrian Washif, Jeffrey Pagaduan, Carl James, Ismail Dergaa, Christopher Martyn Beaven
OpenAI's Chat Generative Pre-trained Transformer (ChatGPT) technology enables conversational interactions with applications across various fields, including sport. Here, ChatGPT's proficiency in designing a 12-week resistance training programme, following specific prompts, was investigated. GPT3.5 and GPT4.0 versions were requested to design 12-week resistance training programmes for male and female hypothetical subjects (20-years-old, no injury, and 'intermediate' resistance training experience). Subsequently, GPT4...
March 2024: Biology of Sport
https://read.qxmd.com/read/38523907/efficacy-and-safety-of-a-music-therapy-facilitated-pulmonary-telerehabilitation-program-in-copd-patients-the-copdmelody-study-protocol
#4
JOURNAL ARTICLE
Minghui Shi, Lulu Yang, Shiwei Qumu, Jieping Lei, Ke Huang, Ruoxi He, Hongtao Niu, Fen Dong, Siyuan Wang, Jiaze He, Ting Yang
Despite considerable evidence for the benefit in chronic obstructive pulmonary disease (COPD), the implementation of pulmonary rehabilitation (PR) is insufficient. However, music therapy may help address this gap due to its unique benefits. Therefore, we aimed to develop a music-therapy facilitated pulmonary telerehabilitation program based on rhythm-guided walking, singing, and objective telemonitoring. A supervised, parallel-group, single-blinded, randomized controlled clinical trial will be conducted, including 75 patients with COPD anticipated to be randomized in a 1:1:1 ratio into three groups...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38522825/effect-of-music-therapy-on-pain-during-thyroid-fine-needle-aspiration-biopsy-a-randomized-controlled-clinical-trial
#5
JOURNAL ARTICLE
Burcak Cavnar Helvaci, Sefika Burcak Polat, Belma Tural Balsak, Nagihan Bestepe, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
INTRODUCTION: High-resolution ultrasonography devices have led to the increased detection of thyroid nodules and the need for fine-needle aspiration biopsy (FNAB). However, FNAB is an invasive procedure that can cause discomfort and pain. Music therapy has been used for centuries to alleviate pain, and our clinical trial was conducted to investigate its impact on pain scores during thyroid FNAB. MATERIALS AND METHODS: We conducted a randomized, controlled clinical trial, including adult patients undergoing thyroid FNAB...
March 22, 2024: Endocrine Practice
https://read.qxmd.com/read/38521946/comparison-of-low-dose-maximal-intent-versus-controlled-tempo-resistance-training-on-quality-of-life-functional-capacity-and-strength-in-untrained-healthy-adults-a-comparative-effectiveness-study
#6
JOURNAL ARTICLE
Liam T Pearson, Kai T Fox, Ashleigh Keenan, David G Behm, Sam Stuart, Stuart Goodall, Gill Barry
Lack of physical activity is a global issue for adults that can lead to sedentary behaviour and a higher prevalence of health complications and chronic diseases, resulting in reduced quality-of-life (QoL) and functional capacity (FC). A potential strategy to mitigate this inactivity is low-dose resistance training (RT); however, physiological, and psychological responses are limited in evidence. Twenty untrained participants aged 30-60 years old (mean ± SD age 42 ± 7 years, mass 77 ± 13 kg, stature 166 ± 8 cm; 18 females and two males) were recruited and randomly assigned to maximal velocity-intent (MI, n = 10) or controlled-tempo (CT, n = 10) RT according to CONsolidated Standards of Reporting Trials (CONSORT) guidelines...
March 23, 2024: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/38519634/primitive-purine-biosynthesis-connects-ancient-geochemistry-to-modern-metabolism
#7
JOURNAL ARTICLE
Joshua E Goldford, Harrison B Smith, Liam M Longo, Boswell A Wing, Shawn Erin McGlynn
An unresolved question in the origin and evolution of life is whether a continuous path from geochemical precursors to the majority of molecules in the biosphere can be reconstructed from modern-day biochemistry. Here we identified a feasible path by simulating the evolution of biosphere-scale metabolism, using only known biochemical reactions and models of primitive coenzymes. We find that purine synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents...
March 22, 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38513679/music-and-medicine-quickening-the-tempo-of-progress
#8
JOURNAL ARTICLE
Wen G Chen, Emmeline Edwards, Sunil Iyengar, Robert Finkelstein, Deborah F Rutter, Renée Fleming, Francis S Collins
No abstract text is available yet for this article.
March 18, 2024: Lancet
https://read.qxmd.com/read/38511237/temperate-woody-species-across-the-angiosperm-phylogeny-acquire-tolerance-to-water-deficit-stress-during-the-growing-season
#9
JOURNAL ARTICLE
Jake J Grossman, Henry B Coe, Olivia Fey, Natalie Fraser, Musa Salaam, Chelsea Semper, Ceci G Williamson
Understanding the capacity of temperate trees to acclimate to limited soil water has become essential in the face of increasing drought risk due to climate change. We documented seasonal - or phenological - patterns in acclimation to water deficit stress in stems and leaves of tree species spanning the angiosperm phylogeny. Over 3 yr of field observations carried out in two US arboreta, we measured stem vulnerability to embolism (36 individuals of 7 Species) and turgor loss point (119 individuals of 27 species) over the growing season...
March 21, 2024: New Phytologist
https://read.qxmd.com/read/38507131/exploring-the-accuracy-of-musical-tempo-memory-the-effects-of-reproduction-method-reference-tempo-and-musical-expertise
#10
JOURNAL ARTICLE
Julia Vigl, Friederike Koehler, Heike Henning
Although people commonly remember and recreate the tempo of musical pieces with high accuracy, comparatively less is known regarding sources of potential variation in musical tempo memory. This study therefore aimed to investigate musical tempo memory accuracy and the effects of reference tempo, reproduction method, musical expertise, and their interaction. A sample of 403 individuals with varying levels of musical training participated in the experimental online study, including nonmusicians, amateur musicians, and professional musicians...
March 20, 2024: Memory & Cognition
https://read.qxmd.com/read/38505998/preparation-and-assessment-of-agar-tempo-oxidized-bacterial-cellulose-cryogels-for-hemostatic-applications
#11
JOURNAL ARTICLE
Kaushal R Shakya, Kuldeep Nigam, Arpit Sharma, Kousar Jahan, Amit Kumar Tyagi, Vivek Verma
In this work, we have demonstrated agar and oxidized bacterial cellulose cryogels as a potential hemostatic dressing material. TEMPO-oxidized bacterial cellulose (OBC) was incorporated into the agar matrix, improving its mechanical and hemostatic properties. The oxidation of bacterial cellulose (BC) was evidenced by chemical characterization studies, confirming the presence of carboxyl groups. The in vitro blood clotting test conducted on agar/OBC composite cryogels demonstrated complete blood clotting within 90 seconds, indicating their excellent hemostatic efficacy...
March 20, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38505710/muscular-performance-analysis-in-cross-modalities-comparison-between-amrap-emom-and-rft-configurations
#12
JOURNAL ARTICLE
Manuel Barba-Ruíz, Francisco Hermosilla-Perona, Juan Ramon Heredia-Elvar, Noelia Gómez-González, Marzo Edir Da Silva-Grigoletto, Diego Muriarte-Solana
Introduction: In recent years, a surge of interest in high-intensity training methods, associated with "cross" modalities has emerged as a promising approach for improving performance and overall health. Therefore, the main aim of this study was to compare the acute effects on heart rate, mean propulsive velocity and intra and inter-set velocity loss in "Cross" modalities. Materials and methods: Twelve athletes, 10 men's and 2 women's (age: 31.5 ± 6.74 years; height: 174.17 ± 6.05 cm; weight: 75...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38501830/temporal-dynamics-of-candida-albicans-morphogenesis-and-gene-expression-reveals-distinctions-between-in-vitro-and-in-vivo-filamentation
#13
JOURNAL ARTICLE
Rohan S Wakade, Melanie Wellington, Damian J Krysan
Candida albicans is a common human fungal pathogen that is also a commensal of the oral cavity and gastrointestinal tract. C. albicans pathogenesis is linked to its transition from budding yeast to filamentous morphologies including hyphae and pseudohyphae. The centrality of this virulence trait to C. albicans pathobiology has resulted in extensive characterization of a wide range of factors associated with filamentation with a strong focus on transcriptional regulation. The vast majority of these experiments have used in vitro conditions to induce the yeast-to-filament transition...
March 19, 2024: MSphere
https://read.qxmd.com/read/38499432/ion-transfer-mediated-by-tempo-in-ionophore-doped-thin-films-for-multi-ion-sensing-by-cyclic-voltammetry
#14
JOURNAL ARTICLE
Gabriel J Mattos, Justine A Rothen, Nikolai Yu Tiuftiakov, Eric Bakker
We report here on the development of thin-layer ion-selective membranes containing lipophilic TEMPO as a phase-transfer redox mediator for the simultaneous detection of non-redoxactive ions. This redox probe was recently introduced by our group and provides ideal ion-transfer waves when the membrane is interrogated by cyclic voltammetry. To perform multianalyte detection in the same sensing film, plasticized PVC-based membranes were doped with lithium and potassium ionophores in addition to a lipophilic cation-exchanger...
April 22, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38497930/er-stress-promotes-mitochondrial-calcium-overload-and-activates-the-ros-nlrp3-axis-to-mediate-fatty-liver-ischemic-injury
#15
JOURNAL ARTICLE
Fei Li, Zhu Guan, Yiyun Gao, Yan Bai, Xinyu Zhan, Xingyue Ji, Jian Xu, Haoming Zhou, Zhuqing Rao
BACKGROUND: Fatty livers are widely accepted as marginal donors for liver transplantation but are more susceptible to liver ischemia and reperfusion (IR) injury. Increased macrophage-related inflammation plays an important role in the aggravation of fatty liver IR injury. Here, we investigate the precise mechanism by which endoplasmic reticulum (ER) stress activates macrophage NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signaling by regulating mitochondrial calcium overload in fatty liver IR...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497561/microwave-assisted-one-pot-telescoped-synthesis-of-2-amino-1-3-thiazoles-selenazoles-imidazo-1-2-a-pyridines-and-other-heterocycles-from-alcohols
#16
JOURNAL ARTICLE
Pablo Macías-Benítez, Alfonso Sierra-Padilla, Francisco M Guerra, F Javier Moreno-Dorado
Primary and secondary alcohols have been converted into 2-amino-1,3-thiazoles under microwave irradiation, employing trichloroisocyanuric acid (TCCA) as a dual oxidant and chlorine source, TEMPO as a co-oxidant, and thiourea. Secondary alcohols underwent a single-stage, one-pot conversion process, while primary alcohols required a two-stage, one-pot procedure. Both transformations were completed within minutes (25-45 min). The versatility of this protocol extends to the synthesis of other heterocycles, including 1,3-selenazoles, 2-aminoimidazoles, imidazo[1,2- a ]pyridines, quinoxalines, and hydrazino thiazoles by replacing thiourea with the appropriate surrogates...
March 18, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38497006/robust-supercooled-liquid-formation-enables-all-optical-switching-between-liquid-and-solid-phases-of-tempo
#17
JOURNAL ARTICLE
Jacob B Rodriguez, Kevin Lam, Touhid Bin Anwar, Christopher J Bardeen
Organic molecules that undergo supercooling can provide the basis for novel stimuli-responsive materials, but the number of such compounds is limited. Results in this paper show that the stable organic radical 2,2,6,6-tetramethyl-1-piperidine-1-oxyl (TEMPO) can form a stable supercooled liquid (SCL). Upon melting and cooling back to room temperature, the TEMPO SCL can persist for months, even after mild physical agitation. Its high vapor pressure can enable crystal growth at remote locations within the sample container over the course of days...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38490727/considering-decoupled-phenotypic-diversification-between-ontogenetic-phases-in-macroevolution-an-example-using-triggerfishes-balistidae
#18
JOURNAL ARTICLE
Alex Dornburg, Katerina L Zapfe, Rachel Williams, Michael E Alfaro, Richard Morris, Haruka Adachi, Joseph Flores, Francesco Santini, Thomas J Near, Bruno Frédérich
Across the Tree of Life, most studies of phenotypic disparity and diversification have been restricted to adult organisms. However, many lineages have distinct ontogenetic phases that differ from their adult forms in morphology and ecology. Focusing disproportionately on the evolution of adult forms unnecessarily hinders our understanding of the pressures shaping evolution over time. Non-adult disparity patterns are particularly important to consider for coastal ray-finned fishes, which often have juvenile phases with distinct phenotypes...
March 15, 2024: Systematic Biology
https://read.qxmd.com/read/38489748/navigating-pubertal-goldilocks-the-optimal-pace-for-hierarchical-brain-organization
#19
JOURNAL ARTICLE
Hanna Szakács, Murat Can Mutlu, Giulio Balestrieri, Ferenc Gombos, Jochen Braun, Morten L Kringelbach, Gustavo Deco, Ilona Kovács
Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially the pace of maturation, remains an insufficiently studied aspect of developmental progression. The primary objective is to estimate the precise influence of pubertal maturational tempo on the configuration of associative brain regions. To this end, the connection between maturational stages and the level of hierarchical organization of large-scale brain networks in 12-13-year-old females is analyzed...
March 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38484522/nitroxyl-radical-triggered-the-construction-of-a-molecular-protective-layer-for-achieving-durable-zn-metal-anodes
#20
JOURNAL ARTICLE
Xipo Ma, Huaming Yu, Chunshuang Yan, Qihao Chen, Zheng Wang, Yuejiao Chen, Gang Chen, Chade Lv
The issues of dendrite growth, hydrogen evolution reaction, and zinc anode corrosion have significantly hindered the widespread implementation of aqueous zinc-ion batteries (AZIBs). Herein, trace amounts of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) additive is introduced into AZIBs to protect the zinc metal anode. Trace amounts of the TEMPO additive with nitroxyl radical can provide fast Zn2+ transport and anode protection ability by forming an adsorbed molecular layer via Zn-O bond. This interface not only provides strong interfacial compatibility and promotes dynamic transport of Zn2+ , but also induces deposition of Zn2+ along Zn (002) plane...
March 12, 2024: Journal of Colloid and Interface Science
keyword
keyword
160100
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.