keyword
https://read.qxmd.com/read/38646733/crystal-structure-of-a-newly-identified-m61-family-aminopeptidase-with-broad-substrate-specificity-that-is-solely-responsible-for-recycling-acidic-amino-acids
#21
JOURNAL ARTICLE
Sahayog N Jamdar, Pooja Yadav, Bhushan S Kulkarni, Sudesh, Ashwani Kumar, Ravindra D Makde
Aminopeptidases with varied substrate specificities are involved in different crucial physiological processes of cellular homeostasis. They also have wide applications in food and pharma industries. Within the bacterial cell, broad specificity aminopeptidases primarily participate in the recycling of amino acids by degrading oligopeptides generated via primary proteolysis mediated by cellular ATP-dependent proteases. However, in bacteria, a truly broad specificity enzyme, which can cleave off acidic, basic, Gly and hydrophobic amino acid residues, is extremely rare...
April 22, 2024: FEBS Journal
https://read.qxmd.com/read/38646697/novel-pyrazole-4-carboxamide-derivatives-containing-oxime-ether-group-as-potential-sdhis-to-control-rhizoctonia-solani
#22
JOURNAL ARTICLE
Bo Luo, Yuerui Wu, Xinran Ren, Huimin Li, Xuanru Li, Gege Wang, Mengjia Wang, Luqi Dong, Mengxing Liu, Wei Zhou, Lailiang Qu
In the search for novel succinate dehydrogenase inhibitor (SDHI) fungicides to control Rhizoctonia solani , thirty-five novel pyrazole-4-carboxamides bearing either an oxime ether or an oxime ester group were designed and prepared based on the strategy of molecular hybridization, and their antifungal activities against five plant pathogenic fungi were also investigated. The results indicated that the majority of the compounds containing oxime ether demonstrated outstanding in vitro antifungal activity against R...
April 22, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38646631/identification-of-escherichia-coli-multidrug-resistance-transporters-involved-in-anthocyanin-biosynthesis
#23
JOURNAL ARTICLE
Xia Wu, Rongxia Chen, Ping Liang, Jian Zha
The anthocyanin compound cyanidin 3- O -glucoside (C3G) is a natural pigment widely used in food and nutraceutical industries. Its microbial synthesis by E. coli is a promising alternative to the traditional extraction methods. However, part of the synthesized C3G accumulates in the cytoplasm, thus potentially causing growth inhibition and product degradation. Therefore, it is necessary to enhance C3G secretion via exploration of native transporters facilitating C3G export. In this study, we report the screening and verification of native multidrug resistance transporters from 40 candidates in E...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38646578/dairy-calf-transportation-in-the-united-states-challenges-and-strategies-to-improve-animal-welfare
#24
JOURNAL ARTICLE
M C Cramer, J A Pempek, I N Román-Muñiz, L N Edwards-Callaway
The objectives of this symposium review are to summarize relevant research and key welfare issues relative to calf transportation and identify strategies to mitigate welfare challenges. An important animal welfare concern across the US dairy industry is the transportation of preweaning calves from the source dairy to a calf-raising facility (e.g., calf ranches, heifer raising facilities, veal operations), auction, livestock market, or directly to slaughter. Millions of calves are transported annually in the United States and calf transport has garnered increased attention...
May 2024: JDS Commun
https://read.qxmd.com/read/38646564/combined-effect-of-brazilin-rich-extract-and-lawsone-methyl-ether-against-infection-causing-bacteria
#25
JOURNAL ARTICLE
Nilesh Nirmal, Pankaj Koirala, Anandu Chandra Khanashyam, Pharkphoom Panichayupakaranant, Abdi Wira Septama
Bacterial contamination and infection widely affect the food, pharmaceutical and biomedical industries. Additionally, these bacteria developed resistance to synthetic antibiotics causing public health danger, globally. Natural plant extracts (NPE) are suitable alternatives to synthetic antibiotics to tackle antimicrobial resistance problems. Furthermore, a blend or combination of different NPEs exerts a wide spectrum of antimicrobial activity. Therefore, the combined effect of brazilin-rich extract (BRE) and lawsome methyl ether (LME) against infection-causing common bacteria were evaluated...
June 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38645516/the-untold-story-of-starch-as-a-catalyst-for-organic-reactions
#26
REVIEW
Masoud Sadeghi
Starch is one of the members of the polysaccharide family. This biopolymer has shown many potential applications in different fields such as catalytic reactions, water treatment, packaging, and food industries. In recent years, using starch as a catalyst has attracted much attention. From a catalytic point of view, starch can be used in organic chemistry reactions as a catalyst or catalyst support. Reports show that as a catalyst, simple starch can promote many heterocyclic compound reactions. On the other hand, functionalized starch is not only capable of advancing the synthesis of heterocycles but also is a good candidate catalyst for other reactions including oxidation and coupling reactions...
April 16, 2024: RSC Advances
https://read.qxmd.com/read/38645434/emerging-contaminants-in-food-matrices-an-overview-of-the-occurrence-pathways-impacts-and-detection-techniques-of-per-and-polyfluoroalkyl-substances
#27
REVIEW
Chukwuebuka Gabriel Eze, Emmanuel Sunday Okeke, Chidiebele Emmanuel Nwankwo, Raphael Nyaruaba, Uttpal Anand, Onyekwere Joseph Okoro, Elza Bontempi
Per- and polyfluoroalkyl substances (PFAS) have been used in industrial and consumer applications for ages. The pervasive and persistent nature of PFAS in the environment is a universal concern due to public health risks. Experts acknowledge that exposure to high levels of certain PFAS have consequences, including reduced vaccine efficacy, elevated cholesterol, and increased risk of high blood pressure. While considerable research has been conducted to investigate the presence of PFAS in the environment, the pathways for human exposure through food and food packaging/contact materials (FCM) remain unclear...
June 2024: Toxicology Reports
https://read.qxmd.com/read/38645358/green-enzymatic-synthesis-of-geranyl-butyrate-process-optimization-and-mechanistic-insights
#28
JOURNAL ARTICLE
Francisco Simão Neto, Paulo Gonçalves de Sousa Junior, Carlos José Alves da Silva Filho, Lucas Pinheiro Coutinho, Rafael Leandro Fernandes Melo, Javier Rocha-Martin, Maria Alexsandra de Sousa Rios, Ada Amélia Sanders Lopes, Norberto de K V Monteiro, Marcos Carlos de Mattos, Leonardo Farias Serafim, José Cleiton Sousa Dos Santos
Flavor esters are organic compounds widely used in the food industry to enhance the aroma and taste of products. However, most chemical processes for the production of these flavoring compounds use toxic organic solvents. Some organic solvents derived from petroleum can leave behind residual traces in food products, which may raise concerns about potential health risks and contamination. In this study, we employ Eversa Transform 2.0, a commercial lipase derived from the lipase from Thermomyces lanuginosus , to produce geranyl butyrate in aqueous media...
April 16, 2024: ACS Omega
https://read.qxmd.com/read/38644814/phenolic-profiling-and-bioactivity-assessment-of-in-vitro-propagated-psidium-cattleianum-sabine-a-promising-study
#29
JOURNAL ARTICLE
Eman M El-Deeb, Heba E Elsayed, Hanaa B Ateya, Hussein S Taha, Mohamed R Elgindi, Doaa Abouelenein, Giovanni Caprioli, Kuei-Hung Lai, Ahmed M Mustafa, Fatma A Moharram
Psidium cattleianum Sabine (strawberry guava) is an evergreen shrub that is grown as a fruiting hedge and has received significant consideration in the food and pharmaceutical disciplines. This study aims to set a promising protocol for in vitro propagation of P. cattleianum , along with profiling the phenolic content of the original plant (OP), induced callus (IC), and regenerated plantlets (RP) extracts, ultimately, evaluating their anti-inflammatory, antioxidant, and anticancer potential. Seeds were treated with commercial bleaching, HCl, and H2 O2 to enhance the germination percentage and minimize the contamination percentage...
April 30, 2024: Heliyon
https://read.qxmd.com/read/38644658/recent-advances-in-the-contribution-of-glucosinolates-degradation-products-to-cruciferous-foods-odor-factors-that-influence-degradation-pathways-and-odor-attributes
#30
REVIEW
Xiao Jia, Qi An, Nawei Zhang, Jingnan Ren, Siyi Pan, Chang Zheng, Qi Zhou, Gang Fan
As one of the most important vegetables and oils consumed globally, cruciferous foods are appreciated for their high nutritional value. However, there is no comprehensive knowledge to sufficiently unravel the "flavor mystery" of cruciferous foods. The present review provides a comprehensive literature on the recent advances regarding the contribution of glucosinolates (GSL) degradation products to cruciferous foods odor, which focuses on key GSL degradation products contributing to distinct odor of cruciferous foods ( Brassica oleracea , Brassica rapa , Brassica napus , Brassica juncea , Raphanus sativus ), and key factors affecting GSL degradation pathways (i...
April 21, 2024: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/38644629/the-potential-for-current-sodium-and-potassium-production-to-support-a-global-switch-to-the-use-of-potassium-enriched-salt-a-desktop-research-study
#31
JOURNAL ARTICLE
James Bullen, Katrina Kissock, Xuejun Yin, Penjani Mkambula, Kathy Trieu, Bradley Hastings, Bruce Neal, Ellie Paige
OBJECTIVE: Switching regular salt (sodium chloride) for salt enriched with potassium chloride (25% potassium chloride, 75% sodium chloride) has been shown to reduce blood pressure and the risk of cardiovascular diseases. We sought to define the potential for current production of sodium chloride and potassium chloride to support a global switch to the use of potassium-enriched salt. DESIGN: We summarised data from geological surveys, government reports and trade organisations describing the global production and supply of sodium chloride and potash (the primary source of potassium chloride) and compared this to potential requirements for potassium-enriched salt...
April 22, 2024: Public Health Nutrition
https://read.qxmd.com/read/38644462/evaluation-of-ornidazole-tablets-bioequivalence-in-chinese-healthy-participants-under-fasted-and-fed-conditions-using-pharmacokinetic-parameters
#32
JOURNAL ARTICLE
Yanrong Wang, Yuanyuan He, Weihong Li, Hongmin Li, Liyuan Tang, Xinya Dai, Yingzi Pei, Lijing Gao
BACKGROUND AND OBJECTIVE: Ornidazole, the third generation of nitroimidazole derivatives after metronidazole and tinidazole, it exerts both bactericidal and antiprotozoal effects. The purpose of this study was to evaluate the pharmacokinetic and bioequivalence of two ornidazole tablets manufactured by two different manufacturers based on their pharmacokinetic parameters. PATIENTS AND METHODS: Fasted and fed healthy Chinese volunteers participated in a randomized sequence, single-dose, open-label, two-period crossover trial...
April 22, 2024: Drugs in R&D
https://read.qxmd.com/read/38644439/a-catalytic-membrane-approach-as-a-way-to-obtain-sweet-and-unsweet-lactose-free-milk
#33
JOURNAL ARTICLE
Katarzyna Czyżewska, Anna Trusek
The growing need in the current market for innovative solutions to obtain lactose-free (L-F) milk is caused by the annual increase in the prevalence of lactose intolerance inside as well as the newborn, children, and adults. Various configurations of enzymes can yield two distinct L-F products: sweet (β-galactosidase) and unsweet (β-galactosidase and glucose oxidase) L-F milk. In addition, the reduction of sweetness through glucose decomposition should be performed in a one-pot mode with catalase to eliminate product inhibition caused by H2 O2 ...
April 22, 2024: Bioprocess and Biosystems Engineering
https://read.qxmd.com/read/38644047/seroprevalence-and-risk-factors-of-toxoplasma-gondii-infection-in-goats-from-south-punjab-province-pakistan
#34
JOURNAL ARTICLE
Muhammad Yaser Khan, Alessandra Barlaam, Alessia Libera Gazzonis, Nicola Ferrari, Annunziata Giangaspero
Layyah District in South Punjab Province of Pakistan offers the most intensive caprine economy in the country; its Indus riverine and desert environment makes the area peculiar and worthy of specific investigations. This study aimed to investigate the prevalence of anti-Toxoplasma gondii (T. gondii) IgG-antibody in goats in serum samples and the potential risk factors. The prevalence of T. gondii infection was estimated using a two-stage sample design. All caprine farms in the study area were stratified by size, and from these 110 were randomly selected...
May 2024: Veterinary Parasitology (Amsterdam)
https://read.qxmd.com/read/38643912/oleic-acid-decorated-kraft-lignin-as-a-hydrophobic-and-functional-filler-of-cellulose-acetate-films
#35
JOURNAL ARTICLE
Rohan Shorey, Tizazu H Mekonnen
The packaging industry has primarily been dominated by single-use, petrochemical-sourced plastic materials despite their short-term use. Their leakage into the ecosystem after their use poses substantial environmental concerns. As a result, compostable and renewable packaging material alternatives are garnering significant attention. Cellulose acetate is a derivative of cellulose that exhibits excellent tensile properties, transparency, melt processability, and intermediate compostability. However, its application in the food packaging industry is limited due to its hygroscopic behavior and lack of dimensional stability...
April 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38643911/potential-inhibitory-effect-of-highland-barley-protein-hydrolysates-on-the-formation-of-advanced-glycation-end-products-ages-a-mechanism-study
#36
JOURNAL ARTICLE
Su Hlaing Phyo, Mohamed Ghamry, Guina Bao, Aoqiong Zeng, Wei Zhao
Advanced glycation end products (AGEs) can be caused during a glycoxidation reaction. This reaction is associated with complications of diabetes and the consequences of health problems. Therefore, we are exploring the prohibitory effect of highland barley protein hydrolysates (HBPHs) on AGE formation. Herein, first extracted the protein from highland barley with various pH conditions and then hydrolyzed using four different proteolytic enzymes (flavourzyme, trypsin, papain, pepsin) under different degrees of hydrolysis...
April 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38643844/foraging-animal-origin-food-samples-as-passive-indicators-of-dioxin-like-pops-contamination-in-industry-sites-method-development-characterisation-and-risk-assessment
#37
JOURNAL ARTICLE
Amala Varghese, Kirankumar P S, Ajay S V, Prathish K P
Titanium dioxide (TiO2 ) is an important industrial chemical, and studies suggest its major production route - the chloride process could lead to the generation of unintentional dl-POPs. However, no relevant studies assessed the occurrence of dl-POPs associated with TiO2 production in the industrial zones, which is mostly due to the ultra-trace level distribution of these compounds in environmental compartments. The present study explored the novel possibility of utilising foraging animal-origin foods as sensitive indicators for addressing this challenge and generated a globally beneficial dataset by assessing the background levels of dl-POPs in the vicinity of a TiO2 production house in Southern India...
April 19, 2024: Chemosphere
https://read.qxmd.com/read/38643823/hexafluoropropylene-oxide-trimer-acid-hfpo-ta-exerts-cytotoxic-effects-on-leydig-cells-via-the-er-stress-jnk-%C3%AE-trcp-mcl-1-axis
#38
JOURNAL ARTICLE
Hongping Shen, Lingling Fu, Yili Cai, Keqi Zhu, Xueqin Chen
Hexafluoropropylene oxide trimer acid (HFPO-TA) is an alternative to perfluorooctanoic acid (PFOA) and is widely used in various industries. The effects of HFPO-TA on the male reproductive system and the underlying mechanisms are still not fully understood. In this study, TM3 mouse Leydig cells were used as the main model to evaluate the cytotoxicity of HFPO-TA in vitro. HFPO-TA inhibited the viability and expression of multiple biomarkers of Leydig cells. HFPO-TA also induced Leydig cell apoptosis in a caspase-dependent manner...
April 19, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38643647/multimode-ultrasonic-assisted-decontamination-of-fruits-and-vegetables-a-review
#39
REVIEW
Yanhua Yu, Yuqing Wang, Clinton Emeka Okonkwo, Li Chen, Cunshan Zhou
Fruits and vegetables (F&V) are a significant part of our diet consumption. Microbial and pesticide residues are the predominant safety hazards of F&V consumption. Ordinary water washing has a very limited effect on removing microorganisms and pesticide residues and requires high water usage. Ultrasound, as an environmentally friendly technology, shows excellent potential for reducing microbial contamination and pesticide residue. This paper summarizes the research on ultrasound application in F&V washing, including the removal of microbial and pesticide residues and the comprehensive effect on their physicochemical characteristics...
April 15, 2024: Food Chemistry
https://read.qxmd.com/read/38642807/validation-of-a-simulated-commercial-english-muffin-baking-process-to-control-salmonella-contamination
#40
JOURNAL ARTICLE
Arshdeep Singh, Conor Hunt, Lakshmikantha H Channaiah
A validation study was conducted to investigate the effect of the English muffin baking process to control Salmonella contamination and to study the thermal inactivation kinetic parameters (D- and z-values) of Salmonella in English muffin dough. The unbleached bread flour was inoculated with 3 serovar Salmonella cocktail (Salmonella serovars viz., Newport, Typhimurium, and Senftenberg), and dried back to its pre-inoculated water activity levels with 7.46±0.12 log CFU/g of Salmonella concentration. The Salmonella inoculated flour was used to prepare English muffin batter and baked at 204...
April 18, 2024: Journal of Food Protection
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