keyword
https://read.qxmd.com/read/38540212/rhoa-rock-pathway-is-upregulated-in-experimental-autoimmune-myocarditis-and-is-inhibited-by-simvastatin-at-the-stage-of-myosin-light-chain-phosphorylation
#1
JOURNAL ARTICLE
Monika Skrzypiec-Spring, Maciej Kaczorowski, Alina Rak-Pasikowska, Agnieszka Sapa-Wojciechowska, Krzysztof Kujawa, Agnieszka Żuryń, Iwona Bil-Lula, Agnieszka Hałoń, Adam Szeląg
Many studies have proven the involvement of the RhoA/ROCK pathway in autoimmune and cardiovascular diseases and the beneficial effects of its downregulation. Here, we examined whether the effect of simvastatin on experimental autoimmune myocarditis (EAM) may be through targeting the Ras homolog family member A/Rho-associated coiled-coil containing kinases (RhoA/ROCK) pathway and whether previously shown downregulation of metalloproteinase 9 (MMP-9) could be associated with MLC phosphorylation. Two doses of simvastatin were administered to experimental rats with autoimmune myocarditis by gastric gavage for 3 weeks, at the stage of development of the inflammatory process...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38538839/roadway-rock-burst-prediction-based-on-catastrophe-theory
#2
JOURNAL ARTICLE
Wang Pan, Gu Shuan-Cheng, Sun Wei
In order to quantitatively calculate the critical depth and critical load of mines affected by rock burst, and to achieve effective prevention and control of rock burst in coal mines, this paper proposes a mechanical model for predicting the occurrence of rock burst in coal mine roadways based on catastrophe theory. Additionally, a theoretical calculation formula for initiating rock burst is derived. The first step was to establish a mechanical analysis model, which directly correlated with the in-situ stress, physical and mechanical characteristics of the coal-rock mass, and engineering structural parameters...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38532213/development-of-novel-resistivity-chargeability-statistical-relationships-for-subsurface-characterization-at-langkawi-kedah
#3
JOURNAL ARTICLE
Gabriel Abraham Bala, Andy Anderson Bery, Joseph Gnapragasan, Adedibu Sunny Akingboye
The significance of resistivity-chargeability relationships has been acknowledged and applied in various geologic terrains and different environmental conditions. However, there remains an underexplored opportunity to fully utilize these methods in complex geological terrains with a mixture of granitic and sedimentary rocks where empirical relationships have not been established. Such discoveries are crucial for accurately delineating petrophysical and geomechanical properties, which are essential in addressing urgent environmental concerns like landslides, foundation collapse, groundwater shortages, and pollution...
March 27, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38530076/in-situ-phase-transformation-forming-a-bicontinuous-ni-co-ti-and-al-oxide-li-2-co-3-interpenetrating-network-electrolyte-for-solid-oxide-fuel-cells
#4
JOURNAL ARTICLE
Yanyan Liu, Xiaochun Ma, Hongjun Ye, Jitong Yan, Yongfu Tang, Shaozheng Ji
Designing heterogeneous electrolytes with superior interface charge transfer is promising for low-temperature solid oxide fuel cells (LT-SOFCs). However, a rational construction with optimal interfaces to maximize ionic conduction remains a challenge. Here an in situ phase-transformation strategy is demonstrated to prepare a highly conductive heterogeneous electrolyte. A pristine LiNiO2 -TiO2 nanocomposite precursor undergoes chemical reactions and phase-transformation upon heating and feeding H2 , destroying the original phases, and forming new species, including an amorphous Li2 CO3 scaffold within a (Ni, Co, Al, and Ti)-oxide (NCAT) matrix...
March 26, 2024: Small
https://read.qxmd.com/read/38528085/elastic-wave-prospecting-of-water-conducting-fractured-zones-in-coal-mining
#5
JOURNAL ARTICLE
Bingchao Zhao, Shenglin He, Kun Bai, Xiaoxiao Lu, Wei Wang
In order to understand the development law of water-conducting fractures in overlying strata during the mining process of coal seam, an elastic wave exploration method based on key stratum theory is proposed to predict the height of water-conducting fracture zone. Taking Yushen mining area as the background, the development and evolution of fractures and the three-dimensional distribution characteristics of water-conducting fracture zone are studied by combining well-ground microseismic monitoring, high-density three-dimensional seismic exploration, borehole investigation, FLAC3D numerical simulation and similar physical simulation tests...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38524474/experimental-and-numerical-simulation-research-on-controllable-shock-wave-induced-shale-fracturing-under-repeated-action
#6
JOURNAL ARTICLE
Jianghui Ding, Meijuan Liu, Yang Zhang, Xun Sun, Qinghe Niu, Wen Wang, Wei Wang, Yongxiang Zheng, Chao Yin
Low permeability is a key geological factor constraining the development of shale gas, and reservoir modification to improve its permeability is a prerequisite. Controlled shock wave fracturing can induce the formation of complex fractures in reservoirs and is expected to become an important means of reservoir modification. However, the mechanism of controlled shock wave fracturing in shale and the geological engineering control factors are unclear. Therefore, this article reveals the mechanism and effect of shock wave modification through small-scale experiments and large-scale numerical simulations...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524431/analysis-and-prevention-of-rock-burst-risk-of-working-face-under-the-influence-of-continuous-irregular-triangular-coal-pillar-stress-concentration-area
#7
JOURNAL ARTICLE
Xuehua Chen, Da Zhou, Songtao Zhang, Xuyang Liang, Yuhui Dong
Irregular coal pillars inevitably appear in the layout of the current long-wall mining method, which easily forms stress concentrations and becomes a heavy disaster area of rock burst. In order to solve the impact risk of irregular coal pillar working face, it is necessary to study the instability mechanism of the coal pillar and put forward effective prevention and control measures. Based on the research background of 14320 working face of the Dongtan Coal Mine in the Yanzhou mining area of China, this paper studies the prediction and prevention of rock bursts in this kind of coal pillar by means of theoretical calculation, numerical simulation, engineering analogy, and field monitoring...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38519594/case-study-on-long-term-deformation-monitoring-and-numerical-simulation-of-layered-rock-slopes-on-both-sides-of-wudongde-dam-reservoir-area
#8
JOURNAL ARTICLE
Chen Ding, Kaixi Xue, Chaohui Zhou
Layered rock slope exists widely. Because of its special slope structure, it is prone to bending deformation and toppling failure, which is a serious threat to engineering construction and safety operation. At present, the research of layered rock slope still has great innovation potential. During the construction of Wudongde Hydropower Station on Jinsha River, safety and stability problems such as slope geological structure development, face rock unloading and relaxation, and even slip and large deformation were encountered...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38491144/excavation-method-optimization-and-mechanical-responses-investigating-of-a-shallow-buried-super-large-section-tunnels-a-case-study-in-zhejiang
#9
JOURNAL ARTICLE
Yunteng Chen, Xiaoliang Geng, Jianjun Li, Mingfeng Zhang, Chengfeng Zhu, Mingcheng Cai, Wenlin Zhao, Xin Zhou, Tianzuo Wang
The construction of super large section (SLS) shallow buried tunnels involves challenges related to their large span, high flat rate, and complex construction process. Selecting an appropriate excavation method is crucial for ensuring stability, controlling costs, and managing the construction timeline. This study focuses on the selection of excavation methods and the mechanical responses of SLS tunnels in different types of surrounding rock. The research is based on the Yangjiashan tunnel project in Zhejiang Province, China, which is a four-line highway tunnel with a span of 21...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491036/experimental-research-on-mechanical-performance-of-grouting-plugging-material-with-large-amount-of-fly-ash
#10
JOURNAL ARTICLE
Wang Pengshuai, Cao Zhengzheng, Li Zhenhua, Du Feng, Wang Wenqiang, Zhai Minglei, Hong Zijie
In order to achieve the purpose of long-term stable mining of roadway, the strength and stability of rock mass are improved by means of grouting of fractured rock mass. In this paper, orthogonal test and numerical simulation methods were used to study the plugging performance of large amount of fly ash grouting slurry. The fluidity, water separation rate, compressive strength, setting time, stone rate and viscosity of the slurry were analyzed, and the optimal slurry ratio scheme was obtained. Under the optimal ratio scheme, the slurry transport process of the fractured rock mass was simulated, and the dynamic evolution law of the permeability of the slurry in the fractured rock mass was obtained...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38485735/gas-entry-pressure-impact-on-the-evaluation-of-hydrogen-migration-at-different-scales-of-a-deep-geological-disposal-of-radioactive-waste
#11
JOURNAL ARTICLE
Zakaria Saâdi
Although the importance of gas-entry pressure in simulating two-phase liquid-gas flow in porous media has been studied at the column and borehole scales, its impact on the simulation of transient hydraulic-gas at different scales of a deep geological repository of radioactive waste (DGR) in low permeability clay rock during the post-closure phase has not yet been studied. The purpose of this work is to show that neglecting this phenomenon can lead to underestimation of the maximum gas pressure and water-gas fluxes simulated within the host rock and backfilled drift network...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38480782/characteristics-of-resistivity-variation-in-deep-granite-and-in-situ-detection-applications
#12
JOURNAL ARTICLE
Zhen Fu, Yuezheng Zhang, Hongguang Ji, Chunrui Zhang, Dongsheng Chen, Yuan Qin
During the construction of deep vertical shafts, water inrush and flooding accidents are prone to occur, which seriously affect construction safety. Accurately determining the groundwater conditions is a prerequisite for effectively controlling water hazards and conducting risk management. In order to ensure the accuracy of the resistivity method in deep vertical well water exploration construction, a combination of indoor rock physics, mechanical testing, and on-site engineering measurements was used to analyze the influencing factors of granite resistivity...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38478071/riparian-habitat-connectivity-restoration-in-an-anthropized-landscape-a-multi-species-approach-based-on-landscape-graph-and-soil-bioengineering-structures
#13
JOURNAL ARTICLE
Etienne Boncourt, Laurent Bergès, Maria Alp, Blandine Dupont, Timothée Herviault, André Evette
In urbanized areas, rivers and riparian ecosystems are often the only ecological corridors available for wildlife movement. There, riverbanks are often stabilised by civil engineering structures (dykes, riprap). This can lead to habitat degradation and loss of landscape connectivity. Fascines (willow bundles tied together) could be an alternative to riprap, since they maintain the quality of the natural ecosystems by using native vegetal species instead of rocks, but their potential positive impact needs to be assessed...
March 13, 2024: Environmental Management
https://read.qxmd.com/read/38477015/environmental-cleaning-and-disinfection-in-the-operating-room-a-systematic-scoping-review-through-a-human-factors-and-systems-engineering-lens
#14
JOURNAL ARTICLE
Anping Xie, Hugo Sax, Oluseyi Daodu, Lamia Alam, Marium Sultan, Clare Rock, C Matthew Stewart, Shawna J Perry, Ayse P Gurses
OBJECTIVE: To synthesize evidence and identify gaps in the literature on environmental cleaning and disinfection in the operating room based on a human factors and systems engineering approach guided by the Systems Engineering Initiative for Patient Safety (SEIPS) model. DESIGN: A systematic scoping review. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched 4 databases (ie, PubMed, EMBASE, OVID, CINAHL) for empirical studies on operating-room cleaning and disinfection...
March 13, 2024: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/38473638/research-progress-on-the-geomechanical-properties-of-block-in-matrix-rocks
#15
REVIEW
Songfeng Guo, Qianhui Wei, Shengwen Qi, Lei Xue, Bowen Zheng, Hongjian Wang, Jinxuan Li, Shuaihua Song, Ning Liang, Yu Zou, Zhiquan Huang
The differences in geomechanical properties and the uncertainty in the spatial distribution of Bimrock pose significant challenges to the construction and disaster prediction of geotechnical engineering. To clarify the geomechanical characteristics of Bimrock, this paper summarizes the basic concepts and classification methods of Bimrock at home and abroad. It discusses the methods and characteristics of determining the geometric features of Bimrock blocks and explores the influencing factors and laws of failure modes and strength under different stress states of Bimrock...
March 1, 2024: Materials
https://read.qxmd.com/read/38473520/study-of-the-cold-curing-characteristics-of-isocyanate-modified-asphalt
#16
JOURNAL ARTICLE
Changhong Zhou, Mingli Peng, Xue Yang, Yating Qi, Bin Xu
Isocyanate esters are widely recognized for their superior curing capabilities. Leveraging this attribute, the current research formulated a modified cold-mixed asphalt blend using 4,4'-methylene diphenyl diisocyanate (MDI). Tests and analyses of the MDI-modified asphalt with varying inclusion percentages of MDI revealed that a mixture containing 15% rock asphalt and 15% MDI-modified asphalt exhibited a more balanced, comprehensive performance. We also conducted an examination of the role and properties of MDI in asphalt modification using molecular dynamics simulations...
February 24, 2024: Materials
https://read.qxmd.com/read/38472410/evidence-for-tactile-3d-shape-discrimination-by-octopus
#17
JOURNAL ARTICLE
Kendra C Buresch, Noelle D Huget, William C Brister, Elaine Y Zhou, Abraham S Lineaweaver, Chloe Rifai, Jinyang Hu, Zoe E Stevenson, Jean G Boal, Roger T Hanlon
Octopuses integrate visual, chemical and tactile sensory information while foraging and feeding in complex marine habitats. The respective roles of these modes are of interest ecologically, neurobiologically, and for development of engineered soft robotic arms. While vision guides their foraging path, benthic octopuses primarily search "blindly" with their arms to find visually hidden prey amidst rocks, crevices and coral heads. Each octopus arm is lined with hundreds of suckers that possess a combination of chemo- and mechanoreceptors to distinguish prey...
March 12, 2024: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://read.qxmd.com/read/38471921/-hydrochemical-characteristics-and-genesis-mechanism-of-groundwater-in-the-dry-period-in-the-zhangjiakou-area
#18
JOURNAL ARTICLE
Ai-Fang Jin, Xiu-Lan Yin, Chang-Qing Li, Wen-Juan Li, Ju-Mei Pang, Xiao-Mei Jin
In order to better support the construction of the capital water conservation functional area and ecological environment support area, research on the chemical characteristics of groundwater and its formation mechanism in the dry period in the Zhangjiakou area can provide a great reference for the rational development and utilization of groundwater resources. A total of 41 groups of groundwater samples were collected, and the hydrochemical types, composition characteristics, and control factors of groundwater in the study area were analyzed by using the combined method of descriptive statistical analysis, Piper triplot, correlation analysis, Gibbs plot, and ion ratio...
February 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
https://read.qxmd.com/read/38471920/-hydrochemical-characteristics-and-its-origin-of-surface-water-and-groundwater-in-dianbu-river-basin
#19
JOURNAL ARTICLE
Tao Zheng, Xian-Yan Qin, Jian-Xiong Wu
Chaohu lake is a key water body for water pollution prevention and treatment in our country. However, it has been at a higher eutrophication level recently. Here, the surface water and groundwater in the Dianbu River Basin, a secondary tributary of Chaohu Lake, were taken as the research object. In order to test the hydrochemical composition and hydrogen and oxygen isotope values of different water bodies, 30 groups of surface water samples, 36 groups of groundwater samples, 16 groups of hydrogen and oxygen stable isotope samples, and 18 groups of groundwater hydrogen and oxygen stable isotope samples were collected in August 2021 (wet season), November 2021 (normal season), and February 2022 (dry season)...
February 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
https://read.qxmd.com/read/38471919/-chemical-characteristics-and-genetic-analysis-of-karst-groundwater-in-the-beijing-xishan-area
#20
JOURNAL ARTICLE
Gao-Xuan Guo, Yin-Dong Dai, Liang Xu, Lin Zhu, Zhi-Liang Ou, Qi Qi, Bao-Dong Xin
As an important water supply source in Beijing, karst groundwater has played an irreplaceable role in the security of urban water supply and ecological environment protection in the past 70 years. The Xishan karst groundwater system, located in the upper reaches of western Beijing, belongs to ecological conservation areas. There are several centralized water supply fields in this area. In this study, the Xishan karst groundwater system was taken as the research object. A total of 120 karst groundwater samples in this area were investigated by using statistical analysis, ion ratio, and principal component analysis (PCA) methods to explore the spatial distribution characteristics and formation mechanism of groundwater hydrochemistry...
February 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
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