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H Aizawa, S Yamada, H Sakai, H Otakiri, D Akita, T Gibo, H Kurita
Nuclear protein of the testis (NUT) midline carcinomas (NMC) are malignant epithelial tumours that have chromosomal rearrangements of the gene encoding NUT at 15q14. NMC is typically an aggressive fatal cancer, clinically overlaps with other carcinomas, and differential diagnosis is difficult. The purpose of this study was to investigate NMC in poorly differentiated oral squamous cell carcinoma (OSCC) with a retrospective analysis based on anti-C52B1 immunohistochemical staining. An anti-C52B1 antibody was used for immunohistochemical staining in all 27 primary tumours, and the prevalence and pathological features of NMC in the oral cavity were examined...
March 12, 2019: International Journal of Oral and Maxillofacial Surgery
Mattia Cassanelli, Valentina Prosapio, Ian Norton, Thomas Mills
The effect of three drying processes (freeze, oven and supercritical CO2 drying) on CP Kelco low-acyl gellan gum gel was investigated, highlighting the role of the water removal mechanism (i.e. sublimation, evaporation and solvent replacement/extraction) and the process parameters on the gel structure, rather than focusing on the drying kinetics. It is the first time that a research paper not only compares the drying methods but also discusses and investigates how the molecular and macroscopic levels of gellan gum are affected during drying...
2019: Food and Bioprocess Technology
Nicholas Niemuth, Becky Curtis, Mimi Ngoc Hang, Miranda J Gallagher, D Howard Fairbrother, Robert J Hamers, Rebecca D Klaper
Most studies of nanomaterial environmental impacts have focused on relatively simple first-generation nanomaterials, including metals or metal oxides (e.g. Ag, ZnO) for which dissolution largely accounts for toxicity. Few studies have considered nanomaterials with more complex compositions, such as complex metal oxides, which represent an emerging class of next-generation nanomaterials used in commercial products at large scales. In addition, many nanomaterials are not colloidally stable in aqueous environments and will aggregate and settle, yet most studies use pelagic rather than benthic-dwelling organisms...
March 15, 2019: Environmental Science & Technology
Ignacio Torres Fink, Nuria Tormo Palop, Rafael Borrás Salvador, Javier Buesa Gómez, Concepción Gimeno Cardona, David Navarro Ortega
INTRODUCTION: The AMR Direct Flow Chip assay allows the simultaneous detection of a large variety of antibiotic resistance genetic markers. To assess this kit's performance, we use isolated colonies as starting material. The assay has been approved by the European Economic Area as a suitable device for in vitro diagnosis (CE IVD) using clinical specimens. METHODS: A total of 210 bacterial isolates harbouring either one or more antimicrobial resistance genes including plasmid-encoded extended-spectrum β-lactamases (SHV, CTX-M) and carbapenemases (GES, SME, KPC, NMC/IMI, SIM, GIM, SPM, NDM, VIM, IMP, and OXA), mecA, vanA and vanB, and 30 controls were included...
March 8, 2019: Enfermedades Infecciosas y Microbiología Clínica
Xuehui Shangguan, Gaojie Xu, Zili Cui, Qinglei Wang, Xiaofan Du, Kai Chen, Suqi Huang, Guofeng Jia, Faqiang Li, Xiao Wang, Di Lu, Shanmu Dong, Guanglei Cui
In this study, self-synthesized lithium trifluoro(perfluoro-tert-butyloxyl)borate (LiTFPFB) is combined with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) to formulate a novel 1 m dual-salt electrolyte, which contains lithium difluorophosphate (LiPO2 F2 ) additive and dominant carbonate solvents with low melting point and high boiling point. The addition of LiPO2 F2 into this novel dual-salt electrolyte dramatically improves cycleability and rate capability of a LiNi0.5 Mn0.3 Co0.2 O2 /Li (NMC/Li) battery, ranging from -40 to 90 °C...
March 8, 2019: Small
Nadav Topaz, Dominique A Caugant, Muhamed-Kheir Taha, Ola Brønstad Brynildsrud, Nadia Debech, Eva Hong, Ala-Eddine Deghmane, Rasmata Ouédraogo, Sani Ousmane, Kadidja Gamougame, Berthe-Marie Njanpop-Lafourcade, Seydou Diarra, LeAnne M Fox, Xin Wang
BACKGROUND: Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogroup A conjugate vaccine starting in 2010. We performed whole-genome sequencing on isolates collected post-2010 to assess their phylogenetic relationships and inter-country transmission. METHODS: A total of 716 invasive meningococcal isolates collected between 2011 and 2016 from 11 meningitis belt countries were whole-genome sequenced for molecular characterization by the three WHO Collaborating Centers for Meningitis...
March 4, 2019: EBioMedicine
Yael Jacob, Keren Rosenberg-Katz, Tanya Gurevich, Rick C Helmich, Bastiaan R Bloem, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman, Talma Hendler, Avner Thaler
Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of the motor, default mode (DMN), salience (SAL), and dorsal attention (DAN) networks among this unique population by using two different connectivity measures: interregional functional connectivity analysis and Dependency network analysis (DEP NA)...
February 21, 2019: Human Brain Mapping
Tesfaye Teka Hagos, Balamurugan Thirumalraj, Chen-Jui Huang, Ljalem Hadush Abrha, Teklay Mezgebe Hagos, Gebregziabher Brhane Berhe, Hailemariam Kassa Bezabh, Jim Cherng, Shuo-Feng Chiu, Wei-Nien Su, Bing-Joe Hwang
Currently, concentrated electrolyte solutions are attracting special attention because of their unique characteristics such as unusually improved oxidative stability on both the cathode and anode side, the absence of free solvent, the presence of more anion content and the improved availability of Li+ ions. Most of the concentrated electrolytes reported are lithium bis(fluorosulfonyl)imide (LiFSI) salt with ether-based solvents due to the high solubility of salts in ether-based solvents. However, their poor anti-oxidation capability hindered their application especially with high potential cathode materials (> 4...
February 21, 2019: ACS Applied Materials & Interfaces
David A Boyd, Luiz F Lisboa, Robert Rennie, George G Zhanel, Tanis C Dingle, Michael R Mulvey
OBJECTIVES: To identify the β-lactamase responsible for the positive detection of carbapenemase production in four clinical isolates of Pseudomonas aeruginosa that were negative by PCR for KPC, OXA-48, NDM, VIM, IMP, GES and NMC/IMI carbapenemase genes. METHODS: WGS using short-read and long-read methods was used to characterize the isolates. Bioinformatic analysis was used to identify the potential gene encoding a carbapenemase. Cloning, antimicrobial susceptibility testing and biochemical and phenotypic characterization were used to determine metallo-enzyme activity...
February 20, 2019: Journal of Antimicrobial Chemotherapy
Alexei A Belik, Lei Zhang, Ran Liu, Dmitry D Khalyavin, Yoshio Katsuya, Masahiko Tanaka, Kazunari Yamaura
Sm2 MnMn(Mn4- x Ti x )O12 with 1 ≤ x ≤ 3 were prepared by a high-pressure, high-temperature method at 6 GPa and about 1570-1670 K. They belong to a family of A-site columnar-ordered quadruple perovskites A2 A'A″B4 O12 , where A' is a site with a square-planar coordination and A″ is a site with a tetrahedral coordination. Their crystal structures were investigated using synchrotron X-ray and neutron powder diffraction. They crystallize in space group P42 / nmc (No. 137) with a = 7.41172 Å and c = 7...
February 15, 2019: Inorganic Chemistry
Tim Sieber, Jana Ducke, Anja Rietig, Thomas Langner, Jörg Acker
Nickel⁻manganese⁻cobalt oxides, with LiNi0.33 Mn0.33 Co0.33 O₂ (NMC) as the most prominent compound, are state-of-the-art cathode materials for lithium-ion batteries in electric vehicles. The growing market for electro mobility has led to a growing global demand for Li, Co, Ni, and Mn, making spent lithium-ion batteries a valuable secondary resource. Going forward, energy- and resource-inefficient pyrometallurgical and hydrometallurgical recycling strategies must be avoided. We presented an approach to recover NMC particles from spent lithium-ion battery cathodes while preserving their chemical and morphological properties, with a minimal use of chemicals...
February 12, 2019: Nanomaterials
Krithika Damodar Shenoy, Nicholas Stanzione, Justin E Caron, Gregory A Fishbein, Fereidoun Abtin, Gentian Lluri, Sharon L Hirschowitz
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive subset of poorly differentiated squamous cell carcinoma that is defined by t(15,19) and typically presents in the midline structures of the head, neck, and mediastinum. We report two cases of NMC that presented uniquely with malignant pleural and pericardial effusions including one with cardiac tamponade at presentation. The first case is of a 25-year-old male patient who presented with progressive dyspnea associated with palpitations and dizziness on standing, found to have large bilateral pleural effusions...
February 8, 2019: Diagnostic Cytopathology
Tong Zhan, Weibing Liu, Junjiang Teng, Chaochao Yue, Dehao Li, Suhua Wang, Hua Tan
N-Doped mesoporous carbons (NMCs) with extra framework magnesium were prepared by a one-pot method and used as supports for Pt catalysts. The surface basicity of NMC improved in the presence of extra framework magnesium (e.g., -Ph-O-Mg), meanwhile, the electron density of Pt was enriched by the electron transfer from graphitic N in NMC to Pt. As a result, the catalytic activity of the supported Pt catalyst was improved to be able to selectively oxidize glycerol (GLY) to tartronic acid (TA) under base-free conditions...
February 6, 2019: Chemical Communications: Chem Comm
Peter Dreger, Anna Sureda, Kwang Woo Ahn, Mary Eapen, Carlos Litovich, Herve Finel, Ariane Boumendil, Ajay Gopal, Alex F Herrera, Christoph Schmid, José Luis Diez-Martin, Ephraim Fuchs, Javier Bolaños-Meade, Mahasweta Gooptu, Monzr M Al Malki, Luca Castagna, Stefan O Ciurea, Alida Dominietto, Didier Blaise, Fabio Ciceri, Johanna Tischer, Paolo Corradini, Silvia Montoto, Stephen Robinson, Zafer Gülbas, Mehdi Hamadani
This study retrospectively compared long-term outcomes of nonmyeloablative/reduced intensity conditioning (NMC/RIC) allogeneic hematopoietic cell transplantation (allo-HCT) from a haploidentical family donor (haplo-HCT) using posttransplant cyclophosphamide (PTCy) with those of matched sibling donor (MSD) and matched unrelated donor (MUD) with or without T-cell depletion (TCD+/TCD-) in patients with relapsed diffuse large B-cell lymphoma (DLBCL). Adult patients with DLBCL who had undergone their first NMC/RIC allo-HCT between 2008 and 2015 were included...
February 12, 2019: Blood Advances
Dawei Wang, Qian Sun, Jing Luo, Jianneng Liang, Yipeng Sun, Ruying Li, Keegan Adair, Li Zhang, Rong Yang, Shigang Lu, Huan Huang, Xueliang Sun
Solid-state lithium batteries (SSLBs) are the promising next-generation energy storage systems due to their attractive advantages in terms of energy density and safety. However, the interfacial engineering and battery building are of huge challenges, especially for stiff oxide-based electrolytes. Herein, we construct the SSLBs by co-sintering method using Li3BO3 as a sintering agent to bind the cathode materials LiNi0.6Mn0.2Co0.2O2 (NMC) and solid-state electrolytes Li6.4La3Zr1.4Ta0.6O12. Small NMC primary particles are compared with large secondary particles to study the effects on interfacial adhesion, mechanical retention, internal resistance evolution, and electrochemical performance...
January 16, 2019: ACS Applied Materials & Interfaces
Fatih Alper Akcan, Yusuf Dündar, Hümeyra Bayram Akcan, Ahmet Uluat, Derya Cebeci, İlhan Ünlü
OBJECTIVES: The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency. METHODS: A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency. RESULTS: The mean 25(HO)Vitamin-D levels were 14...
January 14, 2019: European Archives of Oto-rhino-laryngology
Huhu Wang, Linlin Cai, Haijing Hu, Xinglian Xu, Guanghong Zhou
Here, we report the complete genome sequence of strain NMC 61 of Salmonella enterica serovar Enteritidis, which was previously isolated from conveyor belts during chicken slaughter and has the potential to form biofilms on several surfaces. The genome is predicted to contain 110 noncoding small RNAs on the chromosome.
January 2019: Microbiology Resource Announcements
Shonoi Ming, Natalee Caro, Nicholas Lanz, Justine Vionnet, Willie Vann
Polysialic acids (PSA) are important extracellular virulence factors of the human pathogens Neisseria meningitidis and Escherichia coli. The importance of these polysaccharides in virulence makes the polysialyltransferases (PST) that synthesize them targets for therapeutic drugs and protein engineering to facilitate efficient vaccine production. Here, we have generated recombinant bovine nucleotide monophosphate kinase to facilitate steady state kinetic assays of the PST. We have characterized the N. meningitidis Group C (NmC) PST kinetically, using substrate analogs to describe the polymerization reaction...
January 2, 2019: Biochemistry
Sreetama Ghosh, R Sarathi, Sundara Ramaprabhu
In this particular work, a simple, cost-effective and single step process to synthesize magnesium oxide modified nitrogen doped porous carbon (MgO/NMC) by thermal decomposition technique has been elaborated and its high-pressure performance as CO2 and CH4 gas adsorbent is demonstrated. The uniformly distributed porous network in the samples was identified from the morphological studies by FESEM and TEM. Elemental analysis and XPS studies were carried out to understand the Mg and N contents. It has been observed that MgO/NMC shows appreciably high CO2 (30 mmol g-1 at 20 bar and 25 °C) as well as CH4 (12 mmol g-1 at 30 bar and 25 °C) adsorption capacity...
December 17, 2018: Journal of Colloid and Interface Science
Kun Chen, Liang Zhang, Yi Wang
The aim of the present study was to investigate whether drug-loaded microbubbles combined with ultrasound promotes the apoptosis of cancer cells by regulating Bcl-2 and Bax expression. Adriamycin-loaded PLGA nanoparticles (ADM-NP) were fabricated using a modified emulsification process. Lipid microbubbles (NH2 -MB) were prepared by mechanical vibration. The carboxyl groups of ADM-NP and NH2 -MB underwent a condensation reaction after 48 h and adriamycin-loaded PLGA nanoparticles microbubble complexes (ADM-NMC) were obtained...
December 21, 2018: Bioscience Reports
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