Merelijne A Verschoof, Laura C C van Meenen, M Valérie E Andriessen, Daniëlle M C Brinkman, Sylvia Kamphuis, Taco W Kuijpers, Helen L Leavis, G Elizabeth Legger, Catharina M Mulders-Manders, Anne P J de Pagter, Abraham Rutgers, Gijs T J van Well, Jonathan M Coutinho, A Elisabeth Hak, Joris M van Montfrans, Femke C C Klouwer
BACKGROUND: Patients with adenosine deaminase 2 (ADA2) deficiency can present with various neurological manifestations due to vasculopathies and autoinflammation. These include ischemic and hemorrhagic stroke, but less clearly defined neurological symptoms have also been reported. METHODS: In this cohort study, we included patients with confirmed ADA2 deficiency from seven university hospitals in the Netherlands. We analyzed the frequency and recurrence rates of neurological manifestations before and after initiation of TNF-α inhibiting therapy...
August 16, 2023: European Journal of Neurology