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Intravascular Imaging

Ryuichi Matsukawa, Toshiyuki Kozai, Masaki Tokutome, Ryouske Nakashima, Ryouhei Nishimura, Sho Matsumoto, Masato Katsuki, Seigo Masuda, Hiroshi Meno
Cutting balloons (CBs) and other scoring balloons are known to be useful for plaque modification in heavily calcified lesions. There have been some reports of the efficacy of these balloons compared to conventional balloons. However, there have been no reports exploring which balloon is most effective among these three types of balloons. We, therefore, compared these three balloons with respect to effectiveness in plaque modification of calcified lesions. We retrospectively investigated 201 cases using these three balloons from April 2015 to December 2017...
February 15, 2019: Cardiovascular Intervention and Therapeutics
Callum D Little, Radhika K Poduval, Richard Caulfield, Sacha Noimark, Richard J Colchester, Chris D Loder, Manish K Tiwari, Roby D Rakhit, Ioannis Papakonstantinou, Adrien E Desjardins
Microscopic and mesoscale optical imaging techniques allow for three-dimensional (3-D) imaging of biological tissue across millimeter-scale regions, and imaging phantom models are invaluable for system characterization and clinical training. Phantom models that replicate complex 3-D geometries with both structural and molecular contrast, with resolution and lateral dimensions equivalent to those of imaging techniques (<20  μm), have proven elusive. We present a method for fabricating phantom models using a combination of two-photon polymerization (2PP) to print scaffolds, and microinjection of tailored tissue-mimicking materials to simulate healthy and diseased tissue...
February 2019: Journal of Biomedical Optics
Carlo Diaferia, Eliana Gianolio, Antonella Accardo
Magnetic resonance imaging (MRI) is one of the most important clinic diagnostic tool used to obtain high-quality body images. The administration of low-molecular-weight Gd complex-based MRI contrast agents (CAs) permits to increase the 1 H relaxation rate of nearby water molecules, thus modulating signal intensity and contrast enhancement. Even if highly accurate, MRI modality suffers from its low sensitivity. Moreover, low-molecular-weight CAs rapidly equilibrate between the intravascular and extravascular spaces after their administration...
February 15, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
Zenshi Miyake, Yasushi Tomidokoro, Takao Tsurubuchi, Akira Matsumura, Noriaki Sakamoto, Masayuki Noguchi, Akira Tamaoka
RATIONALE: Intravascular large B-cell lymphoma (IVLBCL) is a type of malignant lymphoma in which neoplastic B cells proliferate selectively within the lumina of small- and medium-sized vessels. Patients with IVLBCL frequently develop neurological manifestations during their disease course. Patients are known to often develop various neurological manifestations, but there are only a few reports of IVLBCL whose initial symptoms are deafness and/or disequilibrium. PATIENT CONCERNS: A 66-year-old Japanese man was provisionally diagnosed with sudden sensorineural hearing loss...
February 2019: Medicine (Baltimore)
Takanori Masuda, Takeshi Nakaura, Yoshinori Funama, Tomoyasu Sato, Tomokazu Okimoto, Noritaka Noda, Yoriaki Matsumoto, Yukari Yamashita, Naoyuki Imada, Kazuo Awai
OBJECTIVE: The aim of this study was to compare the diagnostic performance of 100- and 120-kVp coronary computed tomography (CT) angiography (CCTA) scans for the identification of coronary plaque components. METHODS: We included 116 patients with coronary plaques who underwent CCTA and integrated backscatter intravascular ultrasound studies. On 100-kVp scans, we observed 24 fibrous and 24 fatty/fibrofatty plaques; on 120-kVp scans, we noted 27 fibrous and 41 fatty/fibrofatty plaques...
February 11, 2019: Journal of Computer Assisted Tomography
Min Su, Zhiqiang Zhang, Jiehan Hong, Yaocai Huang, Peitian Mu, Yanyan Yu, Rong Liu, Suzi Liang, Hairong Zheng, Weibao Qiu
This study proposes a catheter consisting of dual-frequency transducer for intravascular ultrasound. Both ultrasonic elements with different frequencies were connected to one coaxial cable to make the connection simple. The aperture size of the ultrasound elements were 0.4×0.6 mm2 and 0.3×0.4 mm2 for the low frequency element and high frequency element, respectively. The center frequency and bandwidth of the fabricated low frequency transducer were 33.8 MHz and 49.3%, respectively. Meanwhile, the center frequency and bandwidth of the high frequency transducer were 80...
February 11, 2019: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Emiko Chiba, Kohei Hamamoto, Osamu Tanaka, Fumiaki Watanabe, Hiroshi Noda, Toshiki Rkiyama, Kiyoka Omoto
Leiomyosarcoma of the inferior vena cava is a rare malignant tumor originating from smooth muscle cells of the vascular media. Its preoperative diagnosis by conventional noninvasive examinations such as abdominal ultrasonography, X-ray computed tomography, and magnetic resonance imaging, may be difficult because of their nonspecific findings. We present the case of a 72-year-old woman with leiomyosarcoma of the inferior vena cava diagnosed by intravascular ultrasonography.
February 14, 2019: Journal of Clinical Ultrasound: JCU
Patrycja Molek, Jadwiga Nessler, Jaroslaw Zalewski
Coronary artery dissection following its cannulation for cardioplegia administration as a result of aortic valve replacement (AVR) is a rare but nevertheless life-threatening complication. The three cases of a patient suffering from aortic stenosis illustrated below focus on the issue of how to identify and treat the dissected artery. In all of the patients who had undergone AVR diagnosed was a periprocedural myocardial infarction. Angiography revealed the dissection of the left main in two of the patients, while in the third one that of the right coronary artery...
February 14, 2019: Journal of Cardiac Surgery
Michael J Thrippleton, Gordon W Blair, Maria C Valdes-Hernandez, Andreas Glatz, Scott I K Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David E Newby, Joanna M Wardlaw
A protocol for evaluating ultrasmall superparamagnetic particles of iron oxide (USPIO) uptake and elimination in cerebral small vessel disease patients was developed and piloted. B ₁-insensitive R ₁ measurement was evaluated in vitro. Twelve participants with history of minor stroke were scanned at 3-T MRI including structural imaging, and R ₁ and R ₂* mapping. Participants were scanned (i) before and (ii) after USPIO (ferumoxytol) infusion, and again at (iii) 24⁻30 h and (iv) one month. Absolute and blood-normalised changes in R ₁ and R ₂* were measured in white matter (WM), deep grey matter (GM), white matter hyperintensity (WMH) and stroke lesion regions...
February 12, 2019: International Journal of Molecular Sciences
Sei Haga, Takato Morioka, Katsuharu Kameda, Kenta Takahara, Toshiyuki Amano, Saori Tomohara, Hayato Takaki, Yuichiro Tsurusaki, Shoji Arihiro
Arterial spin-labeling magnetic resonance perfusion imaging is a promising tool for the diagnosis of cerebral hyperperfusion syndrome after carotid endarterectomy. However, arterial spin-labeling with a single post-labeling delay has been reported to show a higher incidence of increased arterial spin-labeling signals in the bilateral hemisphere, probably due to a shortening of the arterial transit time or an arterial transit artifact caused by intravascular stagnant magnetically-labeled spin. To overcome these shortcomings, we used two post-labeling delay settings (1...
February 6, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Raiyan Zaman, Siavash Yousufi, Hidetoshi Chibana, Fumiaki Ikeno, Steven R Long, Sanjiv S Gambhir, Frederick T Chin, Michael V McConnell, Lei Xing, Alan Yeung
Introduction: Thin-cap fibro atheroma (TCFA), unstable lesions in coronary artery disease (CAD), that prones to rupture resulting in substantial morbidity and mortality worldwide. However, their small size and complex morphological/biological features make early detection and risk assessment difficult. To overcome this limitation, we tested our newly developed catheter-based Circumferential-Intravascular-Radioluminescence-Photoacoustic-Imaging (CIRPI) system in vivo rabbit abdominal aorta to detect and characterize TCFA...
February 8, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Muhammad Shabbir Rawala, S Tahira Shah Naqvi, Muhammad Yasin, Syed Bilal Rizvi
BACKGROUND Spontaneous coronary artery dissection (SCAD) is primarily found in females. SCAD can have many precipitating factors such as exercise, trauma, pregnancy, drugs, and connective tissue disease. Prognosis is poor for left main stem, left anterior descending (LAD) artery, and multivessel involvement, especially for females. CASE REPORT We present a case of young African American male with sickle cell disease who presented with chest pain associated with shortness of breath. He was found to have non-ST elevation myocardial infarction (NSTEMI)...
February 6, 2019: American Journal of Case Reports
Xinren Yu, Scott L Diamond
Neutrophils can release extracellular traps (NETs) in infectious, inflammatory and thrombotic diseases. NETs have been detected in deep vein thrombosis, atherothrombosis, stroke, disseminated intravascular coagulation and trauma. We have previously shown that haemodynamic forces trigger rapid NETosis within sterile occlusive thrombi in vitro. Here, we tested the effects of thrombin, fibrin and fibrinolysis on shear-induced NETosis by imaging NETs with Sytox Green during microfluidic perfusion of factor XIIa-inhibited or thrombin-inhibited human whole blood over fibrillar collagen (±tissue factor)...
February 5, 2019: Thrombosis and Haemostasis
Morton J Kern, Arnold H Seto
IVUS measurements of luminal area have only modest correlations to FFR. This study used IVUS 3D anatomical data in a computational fluid dynamic model to estimate FFR with a reasonable degree of accuracy. Further studies are needed to refine the models to make them more accurate and practical for routine use.
February 1, 2019: Catheterization and Cardiovascular Interventions
David Marlevi, Bram Ruijsink, Maximilian Balmus, Desmond Dillon-Murphy, Daniel Fovargue, Kuberan Pushparajah, Cristóbal Bertoglio, Massimiliano Colarieti-Tosti, Matilda Larsson, Pablo Lamata, C Alberto Figueroa, Reza Razavi, David A Nordsletten
Many cardiovascular diseases lead to local increases in relative pressure, reflecting the higher costs of driving blood flow. The utility of this biomarker for stratifying the severity of disease has thus driven the development of methods to measure these relative pressures. While intravascular catheterisation remains the most direct measure, its invasiveness limits clinical application in many instances. Non-invasive Doppler ultrasound estimates have partially addressed this gap; however only provide relative pressure estimates for a range of constricted cardiovascular conditions...
February 4, 2019: Scientific Reports
Jaime Viscasillas, Richard Everson, Emma Kate Mapletoft, Charlotte Dawson
OBJECTIVE: To describe a novel ultrasound-guided posterior extraconal block in the dog. STUDY DESIGN: Prospective experimental cadaveric study. ANIMALS: A total of 13 Beagle Cross cadaver heads. METHODS: After describing the ultrasound bony landmarks and posterior extraconal local regional technique in one head, 12 heads were used to evaluate the spreading of contrast and evaluate potential complications. A 5-8 MHz microconvex ultrasound probe was positioned caudal to the orbital ligament, with the beam orientated transversely, and then tilted caudally until the orbital fissure was visualized...
October 11, 2018: Veterinary Anaesthesia and Analgesia
Erica E Neumann, Melissa Young, Ahmet Erdemir
The goal of this study was to develop a pragmatic approach to build patient-specific models of the peripheral artery that are aware of plaque inhomogeneity. Patient-specific models using element-specific material definition (to understand the role of plaque composition) and homogeneous material definition (to understand the role of artery diameter and thickness) were automatically built from intravascular ultrasound images of three artery segments classified with low, average, and high calcification. The element-specific material models had average surface stiffness values of 0...
February 4, 2019: Computer Methods in Biomechanics and Biomedical Engineering
Hiroshi Kondo, Yoshihiro Kiura, Shigeyuki Sakamoto, Takahito Okazaki, Fumiyuki Yamasaki, Koji Iida, Atsushi Tominaga, Kaoru Kurisu
OBJECTIVE: The evaluation of plaque protrusion after carotid artery stenting (CAS) is important for predicting periprocedural ischemic complications. Unlike intravascular ultrasound (IVUS), angioscopy allows direct visualization of the plaque. This study evaluated the utility and safety of angioscopy during CAS, comparing it with IVUS. METHODS: The study included 13 carotid artery stenosis lesions in 11 consecutive patients (mean age, 70.5 years; 10 men) at a single center...
January 29, 2019: World Neurosurgery
Fadi Saab, Brad J Martinsen, Dylan Wrede, Ann Behrens, George L Adams, Jihad A Mustapha
The Orbital Atherectomy System is a novel form of atherectomy that uses orbital sanding and pulsatile forces, an effective method of treatment for peripheral atherosclerotic lesions with varying levels of occlusion. Although the devices only has a general indication from the FDA to treat atherosclerotic lesions, they are effective in treating all kinds of lesions, and can therefore mitigate effects of all severities of peripheral artery disease. This approach to endovascular therapy involves the use of differential sanding to preferentially ablate fibrous, fibrofatty and calcified lesions, while deflecting healthy intima away from the crown...
January 28, 2019: Journal of Cardiovascular Surgery
Kenji Kawai, Hirokuni Akahori, Takahiro Imanaka, Kojiro Miki, Nagataka Yoshihara, Koji Yanaka, Tohru Masuyama, Masaharu Ishihara
In-stent restenosis (ISR) remains a tough problem after percutaneous coronary intervention (PCI) despite advances in technology of drug-eluting stents (DES). A 63-year-old man undergoing hemodialysis was diagnosed with non-ST elevation acute coronary syndrome (NSTE-ACS). An emergency coronary angiography (CAG) revealed severe stenosis in the middle left circumflex artery (LCx). After pre-dilatation with non-compliant balloon, primary PCI was successfully performed with DES implantation. Four months after, CAG was performed again and verified ISR of LCx under diagnosis of recurrent NSTE-ACS...
January 2019: Journal of Cardiology Cases
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