Weiting Tang, Jacob T Beckley, Jin Zhang, Rui Song, Yuchen Xu, Sukhan Kim, Michael C Quirk, Albert J Robichaud, Eva Sarai Diaz, Scott J Myers, James J Doherty, Michael A Ackley, Stephen F Traynelis, Hongjie Yuan
N-methyl-D-aspartate receptors (NMDARs) play vital roles in normal brain functions (i.e., learning, memory, and neuronal development) and various neuropathological conditions, such as epilepsy, autism, Parkinson's disease, Alzheimer's disease, and traumatic brain injury. Endogenous neuroactive steroids such as 24(S)-hydroxycholesterol (24(S)-HC) have been shown to influence NMDAR activity, and positive allosteric modulators (PAMs) derived from 24(S)-hydroxycholesterol scaffold can also enhance NMDAR function...
January 16, 2023: Cellular and Molecular Life Sciences: CMLS