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Human papilloma virus treatment

S Abedin, S K Paul, N Haque, S Ahmed, S A Nasreen, N Akhter, N Haque, S R Sarkar, S Roy, F Nahar, M U Ahmed, J Switzer, N Kobayashi, M A Hossain, U W Chowdhury
Cervical cancer is one of cause of death in women in many developing countries. Persistent infection with Human Papilloma Virus (HPV), primarily high risk types 16 and 18, is recognized as a causal and essential factor for the development of cervical cancer. The objective of this cross sectional observational study is to detect the distribution of HPV-16 and HPV-18 among Onco E6 positive cases. Following universal safety precautions a total of 180 endocervical swabs were collected from Colposcopy clinic of Obstetrics and Gynaecology Department of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from January 2016 to December 2016...
January 2019: Mymensingh Medical Journal: MMJ
Paul A Cohen, Lyndal Anderson, Lois Eva, James Scurry
Vulvar intraepithelial neoplasia (VIN) is a precursor to vulvar squamous cell carcinoma and is defined histopathologically by the presence of atypia. VIN has been classified into two types: usual vulvar intraepithelial neoplasia (uVIN), which is also referred to as a vulvar high-grade squamous intra-epithelial lesion (HSIL), and differentiated VIN (dVIN). The former is associated with chronic infection by sub-types of the human papilloma virus (HPV), whereas dVIN is HPV-independent and frequently associated with lichen sclerosus...
February 7, 2019: International Journal of Gynecological Cancer
Laura Dotta, Lucia Dora Notarangelo, Daniele Moratto, Rajesh Kumar, Fulvio Porta, Annarosa Soresina, Vassilios Lougaris, Alessandro Plebani, C I Edvard Smith, Anna-Carin Norlin, Andrea Cecilia Gòmez Raccio, Eva Bubanska, Patrizia Bertolini, Giovanni Amendola, Marcella Visentini, Massimo Fiorilli, Aldo Venuti, Raffaele Badolato
BACKGROUND: In the Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome variable phenotypic expression may delay diagnosis. Panleukopenia, malignancy and chronic lung disease all affect morbidity and mortality risks. Routinely used treatments include immunoglobulins, granulocyte-colony stimulating factor (G-CSF) and antibiotics; recent trials with a target CXCR4 antagonist show promising results. OBJECTIVE: We sought to characterize the largest cohort of WHIM patients and evaluate their diagnostic and therapeutic management...
February 1, 2019: Journal of Allergy and Clinical Immunology in Practice
David A Davis, Prabha Shrestha, Ashley I Aisabor, Alexandra Stream, Veronica Galli, Cynthia A Pise-Masison, Takanobu Tagawa, Joseph M Ziegelbauer, Genoveffa Franchini, Robert Yarchoan
Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi sarcoma-associated herpesvirus-infected latent and lytic cells and restores ICAM-1 and B7-2 in latent cells. We explored the ability of Pom to increase immune surface marker expression in cells infected by other chronic viruses, including human T-cell leukemia virus type-1 (HTLV-1), Epstein-Barr virus (EBV), human papilloma virus (HPV), Merkel cell polyoma virus (MCV), and human immunodeficiency virus type-1 (HIV-1)...
2019: Oncoimmunology
Małgorzata Wierzbicka, Johannes Hans Berkhof, Frederik G Dikkers
PURPOSE OF REVIEW: To gain the evidence-based knowledge concerning the efficacy of HPV vaccination for oropharyngeal sites and to highlight the trials and strategies for vaccine administration in HPV-dependent head and neck diseases. RECENT FINDINGS: Vaccination can be provided in two injections. There is increasing anecdotal evidence that therapeutic vaccination is effective in treatment of recurrent respiratory papillomatosis. SUMMARY: The availability and broadening spectrum of HPV vaccines make possible the prevention of cervical and other HPV-dependent diseases...
January 28, 2019: Current Opinion in Otolaryngology & Head and Neck Surgery
Andrew G Renehan, Rebecca Muirhead, Lindy Berkman, Lucy McParland, David Sebag-Montefiore
Anal squamous cell carcinoma is an uncommon Human Papilloma Virus (HPV)-related malignancy, the incidence of which has increased two- to four-fold over the past three decades. Results from the first three phase III trials, performed in the 1990s (the largest being the ACT I trial in the UK), established concurrent mitomycin C (MMC), 5-fluorouracil chemotherapy and radiotherapy (CRT) as the main primary treatment. Three subsequent trials (including ACT II in the UK, performed between 1998 and 2008, demonstrated evidence of no benefit from the use of additional chemotherapy before or after CRT, or concurrent cisplatin...
January 27, 2019: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
B Daiana Santos, Celia S Moreira, Estela Vilhena, Emilia Carvalho, M Graca Pereira
OBJECTIVE: Human papilloma virus (HPV) is the world's most common causative agent in sexually transmitted viral infections; thus requiring clinical guidance, before and after treatment, to promote a better quality of life in women diagnosed with HPV. HPV Impact Profile (HIP) is a comprehensive instrument used to assess the psychosocial impact of HPV and related interventions in a wide range of domains. The main purpose of this study was to validate the HIP in Portuguese women, so that it can be used in this population, both in research and in clinical settings...
January 28, 2019: Current Medical Research and Opinion
Jeanine N Staples, Linda R Duska
This article provides an up-to-date summary of screening approaches and key strategies in prevention of gynecologic malignancies. The Pap smear is the only proven screening intervention in the field of gynecologic oncology. Women should receive treatment for precancerous conditions of the cervix, vulva, vagina, and endometrial lining. Women with inherited conditions should consider having a risk-reducing surgery once they have finished childbearing. The human papilloma virus vaccination should be offered to all girls and boys aged 11 to 12 years, and can also be given as early as age 9 and through 26 years of age...
March 2019: Obstetrics and Gynecology Clinics of North America
Mohammad Sadegh Rezai, Hiva Ghasempouri, Ozra Asqary Marzidareh, Jamshid Yazdani Cherati, Ghasem Rahmatpour Rokni
Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the intralesional injection of the measles-mumps-rubella (MMR) vaccine into resistant-to- treatment palmoplantar warts and its complications...
January 2019: Iranian Journal of Medical Sciences
Stefan Scholz, Florian Koerber, Kinga Meszaros, Rosa Maya Fassbender, Bernhard Ultsch, Robert R Welte, Wolfgang Greiner
INTRODUCTION: Invasive meningococcal disease (IMD) is a severe disease mainly affecting infants and young children. The most common serogroup causing IMD in Germany is the serogroup type B Neisseria meningitidis (MenB). The aim of the present study is to estimate the economic burden of MenB-related IMD in Germany. METHOD: A bottom-up, model-based costing approach has been used to calculate the diagnose- and age-specific yearly lifetime costs of a hypothetical cohort of MenB-related IMD cases...
January 18, 2019: Vaccine
Wui-Jin Koh, Nadeem R Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M Campos, Kathleen R Cho, Hye Sook Chon, Christina Chu, Rachel Clark, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J Eifel, Christine M Fisher, Peter Frederick, David K Gaffney, Ernest Han, Warner K Huh, John R Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W Remmenga, R Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M Yashar, Nicole R McMillian, Jillian L Scavone
Cervical cancer is a malignant epithelial tumor that forms in the uterine cervix. Most cases of cervical cancer are preventable through human papilloma virus (HPV) vaccination, routine screening, and treatment of precancerous lesions. However, due to inadequate screening protocols in many regions of the world, cervical cancer remains the fourth-most common cancer in women globally. The complete NCCN Guidelines for Cervical Cancer provide recommendations for the diagnosis, evaluation, and treatment of cervical cancer...
January 2019: Journal of the National Comprehensive Cancer Network: JNCCN
József Dudás, Anna Riml, Raphaela Tuertscher, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Susanne Sprung, Rudolf Glueckert, Anneliese Schrott-Fischer, Lejo Johnson Chacko, Herbert Riechelmann
We hypothesized that in head and neck squamous cell carcinoma (HNSCC), the neurotrophin brain-derived neurotrophic factor (BDNF) and its high affinity receptor TrkB regulate tumor cell survival, invasion, and therapy resistance. We used in situ hybridization for BDNF and immunohistochemistry (IHC) for TrkB in 131 HNSCC samples. Brain-derived neurotrophic factor was highly expressed in normal mucosa in HNSCC tissue and in cell lines, whereas only 42.74% of HNSCC tissue was TrkB⁺. One fourth of HNSCC cases was human papilloma virus (HPV)- positive, but the TrkB IHC frequency was not different in HPV-positive (HPV⁺) and negative cases...
January 11, 2019: International Journal of Molecular Sciences
Paul A Cohen, Anjua Jhingran, Ana Oaknin, Lynette Denny
Each year, more than half a million women are diagnosed with cervical cancer and the disease results in over 300 000 deaths worldwide. High-risk subtypes of the human papilloma virus (HPV) are the cause of the disease in most cases. The disease is largely preventable. Approximately 90% of cervical cancers occur in low-income and middle-income countries that lack organised screening and HPV vaccination programmes. In high-income countries, cervical cancer incidence and mortality have more than halved over the past 30 years since the introduction of formal screening programmes...
January 12, 2019: Lancet
Tatiane Karen Cabeça, Alice de Mello Abreu, Rafael Andrette, Vanesca de Souza Lino, Mirian Galliote Morale, Francisco Aguayo, Lara Termini, Luisa Lina Villa, Ana Paula Lepique, Enrique Boccardo
Persistent infection with high-risk human papilloma virus (HR-HPV) is the main risk factor for the development of invasive cervical cancer although is not sufficient to cause cervical cancer. Several host and environmental factors play a key role in cancer initiation/progression, including cytokines and other immune-response mediators. Here, we characterized the response to the individual and combined action of the pro-inflammatory cytokines tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL) on HPV-transformed cells and human keratinocytes ectopically expressing E6 and E7 early proteins from different HPV types...
January 8, 2019: International Journal of Molecular Sciences
Filipa Godoy-Vitorino, Gilmary Ortiz-Morales, Josefina Romaguera, Maria M Sanchez, Magaly Martinez-Ferrer, Natalyia Chorna
Genital human papillomavirus (HPV) is the world's most commonly diagnosed sexually transmitted infection, and high-risk HPV types are strongly linked to cervical dysplasia and carcinoma. Puerto Ricans are among the US citizens with higher HPV prevalence and lower screening rates and access to treatment. This bleak statistic was as a motivation to detect biomarkers for early diagnosis of HPV in this population. We collected both urine and cervical swabs from 43 patients attending San Juan Clinics. Cervical swabs were used for genomic DNA extractions and HPV genotyping with the HPV SPF10-LiPA25 kit, and gas chromatography-mass spectrometry (GC-MS) was employed on the urine-derived products for metabolomics analyses...
2018: PloS One
Andy Karabajakian, Max Gau, Thibault Reverdy, Eve-Marie Neidhardt, Jérôme Fayette
Induction chemotherapy (IC) in locally advanced head and neck squamous cell carcinoma (LA HNSCC) has been used for decades. However, its role is yet to be clearly defined outside of larynx preservation. Patients with high risk of distant failure might potentially benefit from sequential treatment. It is now widely accepted that TPF (docetaxel, cisplatin, and fluorouracil) is the standard IC regimen. Essays that have compared this approach with the standard of care, concurrent chemoradiotherapy (CCRT), are mostly inconclusive...
December 22, 2018: Cancers
Hu Shaoshan, Yang Yun, Jiang Bingbing, Su Dongqiang, Zhang Likun, Huang Zheng, Zhang Feng
BACKGROUND: Human papilloma virus (HPV) infection and condyloma acuminatum (CA) in the genital area are often existence in extensive and multi-point fashion. Laser ablation combined with topical photodynamic therapy (PDT) is a feasible approach for genital CA but its effectiveness and limitation need to be evaluated. METHODS: This single-arm prospective study consisted of 100 newly diagnosed CA cases of both sexes. All patients underwent laser ablation and three times of aminolaevulinic acid-based photodynamic therapy (ALA-PDT)...
December 20, 2018: Photodiagnosis and Photodynamic Therapy
Kedar Kirtane, Cristina P Rodriguez
Patients who undergo upfront curative intent resection for locally advanced squamous cell carcinomas and who have adverse pathologic features benefit from adjuvant therapy. Concurrent cisplatin based chemoradiation is an established standard of care endorsed by national guidelines. Controversy now exists on the applicability of this strategy to the good risk human papilloma virus (HPV) related oropharynx cancer (OPC) patient. Ongoing clinical studies are exploring therapeutic de-escalation in the postoperative setting for this distinct patient population...
2018: Frontiers in Oncology
Diana V Pastrana, Alberto Peretti, Nicole L Welch, Cinzia Borgogna, Carlotta Olivero, Raffaele Badolato, Lucia D Notarangelo, Marisa Gariglio, Peter C FitzGerald, Carl E McIntosh, Jesse Reeves, Gabriel J Starrett, Valery Bliskovsky, Daniel Velez, Isaac Brownell, Robert Yarchoan, Kathleen M Wyvill, Thomas S Uldrick, Frank Maldarelli, Andrea Lisco, Irini Sereti, Christopher M Gonzalez, Elliot J Androphy, Alison A McBride, Koenraad Van Doorslaer, Francisco Garcia, Israel Dvoretzky, Joceline S Liu, Justin Han, Philip M Murphy, David H McDermott, Christopher B Buck
Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV)...
December 12, 2018: MSphere
Berrin Göktuğ Kadıoğlu, Esra Çınar Tanrıverdi, Handan Alay, Mahmut Uçar
Cervical cancer is a common female cancer that could be diagnosed early with screening methods. Almost all cases are caused by human papilloma virus (HPV) infection. Therefore, detecting the presence of HPV DNA is important for early diagnosis and treatment. Regular determination of screening tests enables early detection of patients with the risk of cervical cancer. For this purpose, since August 2014 a new screening program has been carried out by Early Diagnosis, Screening and Training of Cancer Centers (KETEM)...
October 2018: Mikrobiyoloji Bülteni
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