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https://read.qxmd.com/read/30763834/break-point-analyses-of-human-or-environmental-temporal-trends-of-pops
#1
Ronald A Hites
The concentrations of a pollutant in people or in the environment are often changing as a function of time. In many cases, this rate of change may be relatively constant as a function of time; thus, first-order kinetics can be applied to these data. In other cases, the rate at which the concentrations of a pollutant are changing may be different before and after some event, for example before and after their regulation or usage restriction. This time is called a break point, and one needs to be able to determine this break point objectively before one can determine the rates of change on either side of it...
February 2, 2019: Science of the Total Environment
https://read.qxmd.com/read/30763830/multi-task-exclusive-relationship-learning-for-alzheimer-s-disease-progression-prediction-with-longitudinal-data
#2
Mingliang Wang, Daoqiang Zhang, Dinggang Shen, Mingxia Liu
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairment of memory and other cognitive functions. Currently, many multi-task learning approaches have been proposed to predict the disease progression at the early stage using longitudinal data, with each task corresponding to a particular time point. However, the underlying association among different time points in disease progression is still under-explored in previous studies. To this end, we propose a multi-task exclusive relationship learning model to automatically capture the intrinsic relationship among tasks at different time points for estimating clinical measures based on longitudinal imaging data...
January 30, 2019: Medical Image Analysis
https://read.qxmd.com/read/30763798/the-associations-between-subjective-and-objective-cognitive-functioning-across-manic-or-hypomanic-depressed-and-euthymic-states-in-chinese-bipolar-patients
#3
Xiaoling Lin, Dali Lu, Zhixin Huang, Wen Chen, Xia Luo, Yinghua Zhu
BACKGROUND: Patients may present cognitive deficits during all stages of bipolar disorder (BD). Few studies have examined self-reported cognitive difficulties and its relation to neurocognitive dysfunction during symptomatic periods of BD. This study aimed to compare subjective cognitive functioning and explore associations between subjective and objective cognitive functioning across different BD clinical states, and investigate the predicting and moderating roles of mood symptoms. METHODS: Subjective cognitive functioning (measured by Cognitive Complaints in Bipolar Disorder Rating Assessment, COBRA) and several domains of cognitive functioning (assessed by a neuropsychological battery), including executive functions, attention and processing speed, and visual memory, were examined in 48 hypomanic or manic patients, 42 depressed bipolar patients, 50 euthymic bipolar patients and 60 healthy comparisons...
February 6, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30763629/trends-in-the-medical-supply-of-fentanyl-and-fentanyl-analogues-united-states-2006-to-2017
#4
Lacee K Collins, Leana J Pande, Dan Y Chung, Stephanie D Nichols, Kenneth L McCall, Brian J Piper
Fentanyl is an important opioid for pain management, but also has exceptional potential for misuse. Seven states have implemented opioid prescribing laws. The objectives of this study were to: 1) characterize the temporal pattern of fentanyl, fentanyl analogue, and other opioid use over the past decade, and 2) determine whether opioid prescribing laws impacted fentanyl use in the US. Drug weights were obtained from the US Automated Reports of Consolidated Orders System (June 2018), a comprehensive publically available resource, from 2006 to 2017 for fentanyl, sufentanil, remifentanil, alfentanil, other prescription opioids, and analyzed by presence of a state opioid prescribing law...
February 11, 2019: Preventive Medicine
https://read.qxmd.com/read/30763396/is-type-of-depressive-symptoms-associated-with-patient-perceived-need-for-professional-psychological-care-in-depressed-individuals-with-diabetes
#5
L J van der Donk, J Fleer, R Sanderman, P M G Emmelkamp, T P Links, K A Tovote, M J Schroevers
AIMS: The objective of this study is to investigate whether type of depressive symptoms (i.e. cognitive-affective or somatic) is related to a patient-perceived need for professional psychological care in individuals with diabetes. METHODS: In total 2266 participants were recruited as part of the screening procedure for a multi-center randomized controlled trial on the treatment of depressive symptoms among individuals with diabetes. Individuals were invited to complete Beck Depression Inventory-II (BDI-II)...
2019: PloS One
https://read.qxmd.com/read/30763388/characteristics-of-aquatic-rescues-undertaken-by-bystanders-in-australia
#6
Robert W Brander, Nicola Warton, Richard C Franklin, Wendy S Shaw, Eveline J T Rijksen, Shane Daw
An issue of growing importance within the field of drowning prevention is the undertaking of aquatic rescues by bystanders, who sometimes drown in the process. The main objectives of this study were to describe characteristics of bystanders making rescues in different Australian aquatic environments, identify the role of prior water safety training in conducting bystander rescues and provide insights into future public education strategies relating to bystander rescue scenarios. An online survey was disseminated via various social media platforms in 2017 and gathered a total of 243 complete responses...
2019: PloS One
https://read.qxmd.com/read/30763248/motion-sensor-based-assessment-of-parkinson-s-disease-motor-symptoms-during-leg-agility-tests-results-from-levodopa-challenge
#7
Somayeh Aghanavesi, Filip Bergquist, Dag Nyholm, Marina Senek, Mevludin Memedi
Parkinson's disease (PD) is a degenerative, progressive disorder of the central nervous system that mainly affects motor control. The aim of this study was to develop data-driven methods and test their clinimetric properties to detect and quantify PD motor states using motion sensor data from leg agility tests. Nineteen PD patients were recruited in a levodopa single dose challenge study. PD patients performed leg agility tasks while wearing motion sensors on their lower extremities. Clinical evaluation of video recordings was performed by three movement disorder specialists who used four items from the motor section of the Unified PD Rating Scale (UPDRS), the treatment response scale (TRS) and a dyskinesia score...
February 8, 2019: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/30763093/relative-principal-components-analysis-application-to-analyzing-biomolecular-conformational-changes
#8
Mazen Ahmad, Volkhard Helms, Olga V Kalinina, Thomas Lengauer
A new method termed "Relative Principal Components analysis" (RPCA) is introduced that extracts optimal relevant principal components to describe the change between two data samples representing two macroscopic states. The method is widely applicable in data-driven science. Calculating the components is based on a unified physical framework which introduces the objective function, namely the Kullback-Leibler divergence, appropriate for quantifying the change of the macroscopic state as it is effected by the microscopic features...
February 14, 2019: Journal of Chemical Theory and Computation
https://read.qxmd.com/read/30763030/an-overview-of-radioactivity-measurement-studies-in-pakistan
#9
REVIEW
Wazir Muhammad, Matiulluh, Asad Ullah, Sajjad Tahir, Fawad Ullah, Matiulluh Khan
In our environment, various naturally occurring radionuclides are present (both underground and overground) in several places, which results in lifelong human exposure. The radiation dose received by human beings from the radiation emitted by these naturally occurring radionuclides is approximately 87%. Exposure to radiation poses radiological health hazards. To assess the human health hazards from radiation, the concentration of these naturally occurring radionuclides are measured in soil (used for cultivation), building materials (soil, bricks, sand, marble, etc...
February 12, 2019: Reviews on Environmental Health
https://read.qxmd.com/read/30762974/perioperative-pharmacological-sleep-promotion-and-pain-control-a-systematic-review
#10
REVIEW
Martin F Bjurström, Michael R Irwin
BACKGROUND: Sleep macrostructure is commonly disturbed after surgery. Postoperative pain control remains challenging. Given the bidirectional interaction between sleep and pain, understanding the role of modulation of sleep during the perioperative period on postoperative pain is needed. METHODS: Systematic review. Controlled trials examining the effects of perioperative sleep-promoting pharmacological agents on postoperative pain and analgesic consumption were identified through a systematic search strategy utilizing multiple electronic databases...
February 14, 2019: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/30762836/evaluation-of-current-trends-in-treatment-of-single-level-cervical-radiculopathy
#11
Jung K Mok, Evan D Sheha, Andre M Samuel, Steven J McAnany, Avani S Vaishnav, Todd J Albert, Catherine Himo Gang, Sheeraz Qureshi
STUDY DESIGN: This was a retrospective cohort study. OBJECTIVES: The main objectives of this study were to identify epidemiological trends, differences, and complications in patients undergoing surgical treatment for single-level cervical radiculopathy (SLCR). SUMMARY OF BACKGROUND DATA: SLCR that fails nonoperative management is effectively treated with either anterior cervical discectomy and fusion (ACDF), cervical disc replacement (CDR), or posterior cervical foraminotomy (PCF)...
February 12, 2019: Clinical Spine Surgery
https://read.qxmd.com/read/30762798/amiodarone-and-acupuncture-for-cardiac-arrhythmia-study-protocol-for-a-systematic-review
#12
Xiang-Dong Meng, Wei-Qin Gao, Ze Sun
BACKGROUND: Amiodarone and acupuncture (AA) are commonly used to treat cardiac arrhythmia (CA). The objective of this systematic review is to assess the efficacy and safety of AA for patients with CA. METHODS: Randomized controlled trials (RCTs) of AA for CC will be searched from 9 databases including PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Information, and Wanfang Data from inception to February 1, 2019 without any limitations...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762699/quantitative-multimodal-assessment-of-concussion-recovery-in-youth-athletes
#13
David R Howell, Gregory D Myer, Anna Brilliant, Kim Barber Foss, William P Meehan
OBJECTIVE: To evaluate recovery trajectories among youth athletes with a concussion and healthy controls across different domains using a quantitative and multifaceted protocol. STUDY DESIGN: Prospective repeated measures. PARTICIPANTS: Youth athletes diagnosed with a concussion between the ages of 8 and 18 years were evaluated (1) within 10 days after injury, (2) approximately 3 weeks after injury, and (3) after return-to-play clearance. Control participants completed the same protocol...
February 11, 2019: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://read.qxmd.com/read/30762578/benchmark-problems-and-performance-indicators-for-search-of-knee-points-in-multiobjective-optimization
#14
Guo Yu, Yaochu Jin, Markus Olhofer
In multiobjective optimization, it is nontrivial for decision makers to articulate preferences without a priori knowledge, which is particularly true when the number of objectives becomes large. Depending on the shape of the Pareto front, optimal solutions such as knee points may be of interest. Although several multi- and many-objective optimization test suites have been proposed, little work has been reported focusing on designing multiobjective problems whose Pareto front contains complex knee regions. Likewise, few performance indicators dedicated to evaluate an algorithm's ability of accurately locating all knee points in high-dimensional objective space have been suggested...
February 11, 2019: IEEE Transactions on Cybernetics
https://read.qxmd.com/read/30762562/predicting-object-mediated-gestures-from-brain-activity-an-eeg-study-on-gender-differences
#15
Vincenzo Catrambone, Alberto Greco, Giuseppe Averta, Matteo Bianchi, Gaetano Valenza, Enzo Pasquale Scilingo
Recent functional magnetic resonance imaging (fMRI) studies have identified specific neural patterns related to three different categories of movements: intransitive (i.e., meaningful gestures that do not include the use of objects), transitive (i.e., actions involving an object), and tool-mediated (i.e., actions involving a tool to interact with an object). However, fMRI intrinsically limits the exploitation of these results in a real scenario, such as a brain-machine interface (BMI). In this study, we propose a new approach to automatically predict intransitive, transitive, or tool-mediated movements of the upper limb using electroencephalography (EEG) spectra estimated during a motor planning phase...
February 11, 2019: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/30762528/measuring-shapes-with-desired-convex-polygons
#16
Jovisa Zunic, Paul Rosin
In this paper we have developed a family of shape measures. All the measures from the family evaluate the degree to which a shape looks like a predefined convex polygon. A quite new approach in designing object shape based measures has been applied. In the most cases such measures were defined by exploiting some of shape properties. An illustrative example might be the shape circularity measure derived by exploiting the well-know result that the circle has the largest area among all the shapes with the same perimeter...
February 12, 2019: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://read.qxmd.com/read/30762290/body-weight-and-egfr-during-dulaglutide-treatment-in-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7
#17
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
In patients with T2D and moderate-to-severe CKD, dulaglutide treatment led to body weight (BW) loss and lesser eGFR decline compared to insulin glargine. Since BW may affect muscle mass, creatinine-based eGFR can be altered independent of kidney function. Cystatin C-based eGFR is not affected by muscle mass. The objective of this post-hoc analysis was to evaluate if lesser eGFR decline with dulaglutide was related to BW loss. Baseline characteristics were similar between treatments ([mean±SD] age: 64...
February 14, 2019: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/30762233/the-digestive-tube-of-piaractus-brachypomus-gross-morphology-histology-histochemistry-of-the-mucosal-layer-and-the-effects-of-parasitism-by-neoechinorhynchus-sp
#18
M I B de Oliveira, L V de Matos, L A da Silva, E C Chagas, G S da Silva, A L S Gomes
The objective of the present study was to describe the histology and histochemistry of the mucosal layer of the digestive tube of Piaractus brachypomus, and the histopathology associated with parasitism by Neoechinorhynchus sp. The digestive tube of P. brachypomus consists of three macroscopically distinct portions: short, rectilinear and elastic-walled ooesophagus, J-shaped siphon stomach and a long intestine with rectilinear and curved portions, defined by patterns of villi as foregut, midgut, and hindgut...
February 14, 2019: Journal of Fish Biology
https://read.qxmd.com/read/30762232/a-rapid-method-for-analyzing-well-log-records-in-preparation-for-water-resource-mapping
#19
Kurt O Thomsen
The needs of sub-regional and local entities for water resource management are immediate, and required information is not forthcoming in a timely and relatively inexpensive manner. The following method allows one to use all available well record data to produce baseline hydrogeologic unit maps using geographic information system (GIS) querying and mapping techniques. Subjective borehole and geophysical strata descriptions are converted to objective equivalent numerical values by establishing the average hydraulic conductivity of the combined soils making up the stratum of interest...
February 14, 2019: Ground Water
https://read.qxmd.com/read/30762027/hymenoptera-sting-in-the-head-and-neck-region-is-not-a-risk-factor-for-grade-iv-allergic-reaction-in-venom-allergic-patients
#20
Ewa Cichocka-Jarosz, Marita Nittner-Marszalska, Nina Mól, Marcin Stobiecki, Piotr Brzyski, Ewa Chruszczewska, Urszula Jedynak-Wąsowicz, Tomasz Tomasik, Ewa Czarnobilska, Grzegorz Lis
INTRODUCTION Hymenoptera insects stings (ISs) in the head and neck (H&N) region are commonly considered to be a risk factor for grade IV systemic reactions (IV-SYS-R) in Hymenoptera Venom Allergic patients (HVA). However, clinical data addressing this topic is scarce. OBJECTIVES The aim of our study was to verify whether ISs in the H&N region were related to a higher risk of IV-SYS-R in HVA patients. PATIENTS AND METHODS A cross-sectional retrospective study of a group of 195 patients aged 2-74 years treated with venom immunotherapy because of at least grade II systemic reaction to IS...
February 14, 2019: Polish Archives of Internal Medicine
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