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Natalia Nowaczyk, Alicja Kalinowska-Łyszczarz, Włodzimierz Paprzycki, Sławomir Michalak, Radosław Kaźmierski, Mikołaj A Pawlak
AIM: The aim of this study was to assess degenerative lesion localisation in the course of relapsing-remitting multiple sclerosis (RRMS) and to identify the association between localisation and the frequency of T1-hypointense lesions (black holes) with cognitive dysfunction. We also searched for neuroradiological predictors of cognitive dysfunction in patients. The clinical rationale for the study was previous research, and our own findings suggest that lesion localisation plays an important role in cognitive performance and neurological disability of MS patients...
February 11, 2019: Neurologia i Neurochirurgia Polska
Markus Horsthemke, Lauryl M J Nutter, Anne C Bachg, Boris V Skryabin, Ulrike Honnert, Thomas Zobel, Sven Bogdan, Monika Stoll, Matthias D Seidl, Frank U Mueller, Ursula Ravens, Andreas Unger, Wolfgang A Linke, Pim R R van Gorp, Antoine A F de Vries, Martin Bähler, Peter J Hanley
Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. Reminiscent of Myo18b, Myo18a was highly expressed in the embryo heart, and cardiac-restricted Myo18a deletion in mice was embryonic lethal. Surprisingly, using Western blot analysis, we were unable to detect the known isoforms of Myo18A, Myo18Aα and Myo18Aβ, in mouse heart using a custom C-terminal antibody...
February 8, 2019: Journal of Biological Chemistry
Cyro de Luna-Dias, Sergio P de Carvalho-E-Silva
Bioacoustical data are useful for studying amphibians, especially their conservation, taxonomy, and evolution, among others. Of the 12 species of the Boanapolytaenia clade, only B.buriti and B.latistriata have no published information about their advertisement calls. We recorded four males of B.latistriata in its type locality at Parque Nacional do Itatiaia, south-eastern Brazil. We used a Roland R26 digital recorder with a Sennheiser ME-67 microphone and analysed the recordings using the Raven Pro 1.5 software...
2019: ZooKeys
Simone Lipinski, Britt-Sabina Petersen, Matthias Barann, Agnes Piecyk, Florian Tran, Gabriele Mayr, Marlene Jentzsch, Konrad Aden, Stephanie T Stengel, Ulrich C Klostermeier, Vrunda Sheth, David Ellinghaus, Tobias Rausch, Jan O Korbel, Michael Nothnagel, Michael Krawczak, Christian Gilissen, Joris A Veltman, Michael Forster, Peter Forster, Clarence C Lee, Annette Fritscher-Ravens, Stefan Schreiber, Andre Franke, Philip Rosenstiel
Whole-genome and whole-exome sequencing of individual patients allow the study of rare and potentially causative genetic variation. In this study, we sequenced DNA of a trio comprising a boy with very-early-onset inflammatory bowel disease (veoIBD) and his unaffected parents. We identified a rare, X-linked missense variant in the NAPDH oxidase NOX1 gene (c.C721T, p.R241C) in heterozygous state in the mother and in hemizygous state in the patient. We discovered that, in addition, the patient was homozygous for a common missense variant in the CYBA gene (c...
February 2019: Cold Spring Harbor Molecular Case Studies
Lynn B Martin, BriAnne Addison, Andrew G D Bean, Katherine L Buchanan, Ondi L Crino, Justin R Eastwood, Andrew S Flies, Rodrigo Hamede, Geoffrey E Hill, Marcel Klaassen, Rebecca E Koch, Johanne M Martens, Constanza Napolitano, Edward J Narayan, Lee Peacock, Alison J Peel, Anne Peters, Nynke Raven, Alice Risely, Michael J Roast, Lee A Rollins, Manuel Ruiz-Aravena, Dan Selechnik, Helena S Stokes, Beata Ujvari, Laura F Grogan
Individual hosts differ extensively in their competence for parasites, but traditional research has discounted this variation, partly because modeling such heterogeneity is difficult. This discounting has diminished as tools have improved and recognition has grown that some hosts, the extremely competent, can have exceptional impacts on disease dynamics. Most prominent among these hosts are the superspreaders, but other forms of extreme competence (EC) exist and others await discovery; each with potentially strong but distinct implications for disease emergence and spread...
January 16, 2019: Trends in Ecology & Evolution
Jakub Gryz, Dagny Krauze-Gryz
Carrion plays a crucial role in the raven's diet. In the past, domestic pig carrion was widely available in Poland. This changed with an African swine fever (ASF) outbreak and the introduction of strict procedures aimed at stopping the virus from spreading. We compared data from Central Poland (field and forest mosaic, study area of 105 km²) for two periods, i.e., before (2011⁻2014) and after the ASF outbreak (2015⁻2018). In breeding seasons, nests of ravens were found, juveniles were counted, and the time when juveniles left their nests was recorded...
January 30, 2019: Animals: An Open Access Journal From MDPI
Shankhamala Sen, Pooja Parishar, Arvind Singh Pundir, Anton Reiner, Soumya Iyengar
Birds of the family Corvidae which includes diverse species such as crows, rooks, ravens, magpies, jays and jackdaws are known for their amazing abilities at problem-solving. Since the catecholaminergic system, especially the neurotransmitter dopamine, plays a role in cognition, we decided to study the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines in the brain of house crows (Corvus splendens). We also studied the expression of DARPP-32 (dopamine and cAMP-regulated phosphoprotein), which is expressed in dopaminoceptive neurons...
January 29, 2019: Journal of Comparative Neurology
Catherine Ludden, Kathy E Raven, Dorota Jamrozy, Theodore Gouliouris, Beth Blane, Francesc Coll, Marcus de Goffau, Plamena Naydenova, Carolyne Horner, Juan Hernandez-Garcia, Paul Wood, Nazreen Hadjirin, Milorad Radakovic, Nicholas M Brown, Mark Holmes, Julian Parkhill, Sharon J Peacock
Livestock have been proposed as a reservoir for drug-resistant Escherichia coli that infect humans. We isolated and sequenced 431 E. coli isolates (including 155 extended-spectrum β-lactamase [ESBL]-producing isolates) from cross-sectional surveys of livestock farms and retail meat in the East of England. These were compared with the genomes of 1,517 E. coli bacteria associated with bloodstream infection in the United Kingdom. Phylogenetic core genome comparisons demonstrated that livestock and patient isolates were genetically distinct, suggesting that E...
January 22, 2019: MBio
Hans Wouters, Sarah N Hilmer, Danijela Gnjidic, Jos P Van Campen, Martina Teichert, Helene G Van Der Meer, Laura A Schaap, Martijn Huisman, Hannie C Comijs, Petra Denig, Claudine J Lamoth, Katja Taxis
Background: Anticholinergic and sedative medications are frequently prescribed to older individuals. These medications are associated with short-term cognitive and physical impairment, but less is known about long-term associations. We therefore examined over twenty years whether cumulative exposure to these medications was related to poorer cognitive and physical functioning. Methods: Older adult participants of the Longitudinal Aging Study Amsterdam (LASA) were followed from 1992-2012...
January 21, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Maria C Raven
No abstract text is available yet for this article.
October 5, 2018: JAMA network open
Jennifer Ames, Marcella Warner, Claudia Siracusa, Stefano Signorini, Paolo Brambilla, Paolo Mocarelli, Brenda Eskenazi
BACKGROUND: Prenatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure has been shown to alter sexual differentiation of the brain in animal models, impacting pubertal development, behavior, cortical dominance, and cognition. The effects of early life exposure to dioxin-like compounds on human neurodevelopment, however, are less clear and warrant further investigation. METHODS: The Seveso Women's Health Study (SWHS), initiated in 1996, is a well-characterized cohort of 981 Italian women who lived in proximity to an industrial accident in July 1976 that resulted in one of the highest residential TCDD exposures on record...
January 9, 2019: International Journal of Hygiene and Environmental Health
Fabian Belau, Katharina Metzner, Torsten Christ, Ursula Ravens, Michael Schaefer, Stephan Künzel, Wener Li, Erich Wettwer, Dobromir Dobrev, Ali El-Armouche, Susanne Kämmerer
BACKGROUND: Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na+ (Nav1.5) and K+ (Kv4.3) channels. Here, we identified the dipeptidyl peptidase-like protein-10 (DPP10), which is known to modulate Kv4.3-current kinetics, as a new regulator of Nav1.5 channels. METHODS: We assessed DPP10 expression in the healthy and diseased human heart and we studied the functional effects of DPP10 on the Na+ current in isolated rat cardiomyocytes expressing DPP10 after adenoviral gene-transfer (DPP10ad)...
January 3, 2019: International Journal of Cardiology
I Adachi, T Adye, H Ahmed, J K Ahn, H Aihara, S Akar, M S Alam, J Albert, F Anulli, N Arnaud, D M Asner, D Aston, H Atmacan, T Aushev, R Ayad, V Babu, I Badhrees, A M Bakich, Sw Banerjee, V Bansal, R J Barlow, G Batignani, A Beaulieu, P Behera, M Bellis, E Ben-Haim, D Bernard, F U Bernlochner, S Bettarini, D Bettoni, A J Bevan, V Bhardwaj, B Bhuyan, F Bianchi, M Biasini, J Biswal, V E Blinov, M Bomben, A Bondar, G R Bonneaud, A Bozek, C Bozzi, M Bračko, T E Browder, D N Brown, D N Brown, C Bünger, P R Burchat, A R Buzykaev, R Calabrese, A Calcaterra, G Calderini, S Di Carlo, M Carpinelli, C Cartaro, G Casarosa, R Cenci, D S Chao, J Chauveau, R Cheaib, A Chen, C Chen, C H Cheng, B G Cheon, K Chilikin, K Cho, Y Choi, S Choudhury, M Chrzaszcz, G Cibinetto, D Cinabro, J Cochran, J P Coleman, M R Convery, G Cowan, R Cowan, L Cremaldi, S Cunliffe, N Dash, M Davier, C L Davis, F De Mori, G De Nardo, A G Denig, R de Sangro, B Dey, F Di Lodovico, S Dittrich, Z Doležal, J Dorfan, Z Drásal, V P Druzhinin, W Dunwoodie, M Ebert, B Echenard, S Eidelman, G Eigen, A M Eisner, S Emery, D Epifanov, J A Ernst, R Faccini, J E Fast, M Feindt, T Ferber, F Ferrarotto, F Ferroni, R C Field, A Filippi, G Finocchiaro, E Fioravanti, K T Flood, F Forti, M Fritsch, B G Fulsom, E Gabathuler, D Gamba, R Garg, A Garmash, J W Gary, I Garzia, V Gaur, A Gaz, M Gelb, T J Gershon, L Li Gioi, M A Giorgi, A Giri, R Godang, P Goldenzweig, B Golob, V B Golubev, R Gorodeisky, W Gradl, M T Graham, E Grauges, K Griessinger, A V Gritsan, O Grünberg, Y Guan, E Guido, N Guttman, J Haba, A Hafner, T Hara, P F Harrison, C Hast, K Hayasaka, H Hayashii, C Hearty, M Heck, M T Hedges, M Heß, S Hirose, D G Hitlin, K Honscheid, W-S Hou, C-L Hsu, Z Huard, C Van Hulse, D E Hutchcroft, K Inami, G Inguglia, W R Innes, A Ishikawa, R Itoh, M Iwasaki, Y Iwasaki, J M Izen, W W Jacobs, A Jawahery, C P Jessop, S Jia, Y Jin, K K Joo, T Julius, A B Kaliyar, K H Kang, G Karyan, R Kass, H Kichimi, D Y Kim, J B Kim, K T Kim, S H Kim, J Kim, P Kim, G J King, K Kinoshita, H Koch, P Kodyš, Yu G Kolomensky, S Korpar, D Kotchetkov, R Kowalewski, E A Kravchenko, P Križan, R Kroeger, P Krokovny, T Kuhr, R Kulasiri, T Kumita, A Kuzmin, Y-J Kwon, H M Lacker, G D Lafferty, L Lanceri, J S Lange, D J Lange, A J Lankford, T E Latham, T Leddig, F Le Diberder, I S Lee, S C Lee, J P Lees, D W G S Leith, L K Li, Y B Li, Y Li, J Libby, D Liventsev, W S Lockman, O Long, J M LoSecco, X C Lou, M Lubej, T Lueck, S Luitz, T Luo, E Luppi, A Lusiani, A M Lutz, D B MacFarlane, J MacNaughton, U Mallik, E Manoni, G Marchiori, M Margoni, S Martellotti, F Martinez-Vidal, M Masuda, T Matsuda, T S Mattison, D Matvienko, J A McKenna, B T Meadows, M Merola, K Miyabayashi, T S Miyashita, H Miyata, R Mizuk, G B Mohanty, H K Moon, T Mori, D R Muller, T Müller, R Mussa, E Nakano, M Nakao, T Nanut, K J Nath, M Nayak, H Neal, N Neri, N K Nisar, S Nishida, I M Nugent, B Oberhof, J Ocariz, S Ogawa, P Ongmongkolkul, H Ono, A P Onuchin, Y Onuki, A Oyanguren, P Pakhlov, G Pakhlova, B Pal, A Palano, F Palombo, W Panduro Vazquez, E Paoloni, S Pardi, H Park, S Passaggio, C Patrignani, P Patteri, S Paul, I Pavelkin, D J Payne, T K Pedlar, D R Peimer, I M Peruzzi, R Pestotnik, M Piccolo, L E Piilonen, A Pilloni, G Piredda, V Poireau, V Popov, F C Porter, M Posocco, S Prell, R Prepost, E M T Puccio, M V Purohit, B G Pushpawela, M Rama, A Randle-Conde, B N Ratcliff, G Raven, P K Resmi, J L Ritchie, M Ritter, G Rizzo, D A Roberts, S H Robertson, M Röhrken, J M Roney, A Roodman, A Rossi, M Rotondo, M Rozanska, G Russo, R Sacco, S Al Said, Y Sakai, M Salehi, S Sandilya, L Santelj, V Santoro, T Sanuki, V Savinov, O Schneider, G Schnell, T Schroeder, K R Schubert, C Schwanda, A J Schwartz, R F Schwitters, C Sciacca, R M Seddon, Y Seino, S J Sekula, K Senyo, O Seon, S I Serednyakov, M E Sevior, V Shebalin, C P Shen, T-A Shibata, N Shimizu, J-G Shiu, G Simi, F Simon, F Simonetto, Yu I Skovpen, J G Smith, A J S Smith, R Y So, R J Sobie, A Soffer, M D Sokoloff, E P Solodov, E Solovieva, S M Spanier, M Starič, R Stroili, M K Sullivan, K Sumisawa, T Sumiyoshi, D J Summers, L Sun, M Takizawa, U Tamponi, K Tanida, P Taras, N Tasneem, F Tenchini, V Tisserand, K Yu Todyshevx, C Touramanis, M Uchida, T Uglov, Y Unno, S Uno, S E Vahsen, G Varner, G Vasseur, J Va'vra, D Červenkov, M Verderi, L Vitale, V Vorobyev, C Voß, S R Wagner, E Waheed, R Waldi, J J Walsh, B Wang, C H Wang, M-Z Wang, P Wang, Y Watanabe, F F Wilson, J R Wilson, W J Wisniewski, E Won, G Wormser, D M Wright, S L Wu, H Ye, C Z Yuan, Y Yusa, S Zakharov, A Zallo, L Zani, Z P Zhang, V Zhilich, V Zhukova, V Zhulanov, A Zupanc
We present first evidence that the cosine of the CP-violating weak phase 2β is positive, and hence exclude trigonometric multifold solutions of the Cabibbo-Kobayashi-Maskawa (CKM) Unitarity Triangle using a time-dependent Dalitz plot analysis of B^{0}→D^{(*)}h^{0} with D→K_{S}^{0}π^{+}π^{-} decays, where h^{0}∈{π^{0},η,ω} denotes a light unflavored and neutral hadron. The measurement is performed combining the final data sets of the BABAR and Belle experiments collected at the ϒ(4S) resonance at the asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively...
December 28, 2018: Physical Review Letters
Matthew J Niedzwiecki, Hemal K Kanzaria, Juan Carlos Montoy, Renee Y Hsia, Maria C Raven
Little is known about mortality risk among frequent emergency department (ED) users. Using California hospital data for 2005-13 linked to vital statistics data, we found that frequent ED use in the past year was predictive of mortality among the nonelderly in both the short and longer terms.
January 2019: Health Affairs
María Raquel Huerta-Franco, Miguel Vargas-Luna, Ximena Somoza, Isabel Delgadillo-Holtfort, Marco Balleza-Ordaz, Svetlana Kashina
OBJECTIVE: Women exhibit reduced ovarian sex hormones during the menopausal period that result in well-known physical and psychological symptoms. However, symptoms related to gastric motility (GM) have not been thoroughly investigated. We hypothesized that stress response gastric motility (SRGM) is lower in postmenopausal (PM) and perimenopausal (PERIM) women than in premenopausal (PREM) women. Estrogenic decline leads to neuroendocrine changes in different areas of the brain. These changes can result in hypothalamic vasomotor symptoms, disorders in eating behaviours, and altered blood pressure, in addition to psychological disorders such as stress, anxiety, depression, and irritability related to alterations in the limbic system...
December 21, 2018: Menopause: the Journal of the North American Menopause Society
Irena Tsui, Brian J Song, Chyuan-Sheng Lin, Stephen H Tsang
Genomic approaches to developing new diagnostic and therapeutic strategies in retinal dystrophies are among the most advanced applications of genetics (Tsang SH, Gouras P (1996) Molecular physiology and pathology of the retina. In: Duane TD, Tasman W, Jaeger AE (eds) Duane's clinical opthalmology. Lippincott-Raven, Philadelphia). The notion that "nothing can be done" for patients with retinal dystrophies is no longer true. Electrophysiological testing and autofluorescence imaging help to diagnose and predict the patient's course of disease...
2018: Advances in Experimental Medicine and Biology
S Baral, H N Subedi, P Paudel, P B Chand, M P Shrestha, A McCullough, J Raven, S Theobald, T Martineau, H Elsey
AIM: To test and refine a performance-based management system to improve health worker performance in Nepal. METHODS: A mixed-methods implementation research in three districts. The study assessed health workers' job satisfaction at the start and end of the study. Qualitative techniques were used to document processes, and routine health service data were analysed to measure outcomes. RESULTS: Job satisfaction significantly increased in six of nine key areas, and the proportion of staff absenteeism significantly declined in the study districts...
December 2018: Acta Paediatrica
Katherine M Lucarelli, Meisha L Raven, Mark J Lucarelli
No abstract text is available yet for this article.
December 20, 2018: JAMA Ophthalmology
Sam Liu, Casandra Husband, Henry La, Madeline Juba, Raven Loucks, Aimee Harrison, Ryan E Rhodes
Purpose: Physical activity promotion has mostly focused on theories of intention-formation, with the assumption that positive intentions will lead to behaviour. Though necessary, exercise intentions alone are often not sufficient to improve physical activity behaviour. The Multi-Process Action Control (M-PAC) framework builds on previous intention-based theories by including both determinants of intention formation and its translation into behaviour. The purpose of this study was to describe the process of developing a self-guided web-based intervention to promote physical activity among adults using the M-PAC model...
March 2019: Internet Interventions: the Application of Information Technology in Mental and Behavioural Health
Johan Lind
There is a new associative learning paradox. The power of associative learning for producing flexible behaviour in non-human animals is downplayed or ignored by researchers in animal cognition, whereas artificial intelligence research shows that associative learning models can beat humans in chess. One phenomenon in which associative learning often is ruled out as an explanation for animal behaviour is flexible planning. However, planning studies have been criticized and questions have been raised regarding both methodological validity and interpretations of results...
November 2018: Royal Society Open Science
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