Maria Agustina Perusini, Daniela Zackova, TaeHyung Kim, Katia B B Pagnano, Carolina Pavlovsky, Ivana Jeziskova, Anežka Kvetková, Tomas Jurcek, Jaeyoon John Kim, Young Seok Yoo, Seongyoon Yi, Hyewon Lee, Kyoung Ha Kim, Myunghee Chang, Jose-Mario Capo-Chichi, Jessie Medeiros, Andrea Arruda, Mark D Minden, Zhaolei Zhang, Sagi Abelson, Jiri Mayer, Dennis Dong Hwan Kim
Advancements in genomics are transforming the clinical management of chronic myeloid leukemia (CML) towards precision medicine. The impact of somatic mutations on treatment outcomes is still under debate. We studied the association of somatic mutations in epigenetic modifiers genes and activated signaling/myeloid transcription factor (AS/MTF), with disease progression and treatment failure in CML patients following tyrosine kinase inhibitor (TKI) therapy. A total of 394 CML samples were sequenced, including 254 samples collected at initial diagnosis, and 140 samples taken during follow-up...
March 6, 2024: Blood Advances