Eleonora Brambilla, Rafał Ciaputa, Paola Crepaldi, Stanislaw Dzimira, Marcin Nowak, Piotr Dziegiel, Aleksandra Piotrowska, Veronica Mollica Govoni, Carlos Eduardo Fonseca-Alves, Renée Laufer-Amorim, Damiano Stefanello, Stefano Romussi, Valeria Grieco
The tumor microenvironment is considered one of the main players in cancer development and progression and may influence the behavior of cancer cells. Periostin (POSTN) is an extracellular matrix protein, and its main functions are induction of fibrillogenesis, fibroblastic cell proliferation and migration, enhancing regeneration in normal tissue, and promoting metastasis in case of neoplasia. POSTN has already been studied in humans in several normal tissues, inflammatory processes, and neoplasms, revealing an important role in tumor progression in various types of cancer, such as colon, lung, head and neck, breast, ovarian, and prostate...
2023: Frontiers in Veterinary Science