Giulia Grisendi, Carlotta Spano, Naomi D'souza, Valeria Rasini, Elena Veronesi, Malvina Prapa, Tiziana Petrachi, Serena Piccinno, Filippo Rossignoli, Jorge S Burns, Stefania Fiorcari, Donatella Granchi, Nicola Baldini, Edwin M Horwitz, Valentina Guarneri, Pierfranco Conte, Paolo Paolucci, Massimo Dominici
Sarcomas are frequent tumors in children and young adults that, despite a relative chemo-sensitivity, show high relapse rates with up to 80% of metastatic patients dying in 5 years from diagnosis. The real ontogeny of sarcomas is still debated and evidences suggest they may derive from precursors identified within mesenchymal stromal/stem cells (MSC) fractions. Recent studies on sarcoma microenvironment additionally indicated that MSC could take active part in generation of a supportive stroma. Based on this knowledge, we conceived to use modified MSC to deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) targeting different sarcoma histotypes...
March 2015: Stem Cells