Xiaowen Xu, Wenjun Chang, Jie Yuan, Xue Han, Xiaojie Tan, Yibo Ding, Yanxin Luo, Hui Cai, Yan Liu, Xianhua Gao, Qizhi Liu, Yongwei Yu, Yan Du, Hao Wang, Liye Ma, Jianping Wang, Kun Chen, Yanqing Ding, Chuangang Fu, Guangwen Cao
Periostin (POSTN) expression in cancer cells and circulation has been related to poor prognosis of colorectal carcinoma (CRC). However, the role of POSTN expressed in intra-tumoral stroma on CRC progression remains largely unknown. This study enrolled 1098 CRC patients who received surgical treatment in Shanghai and Guangzhou, Mainland China. In Shanghai cohort, immunohistochemistry score of stromal POSTN expression increased consecutively from adjacent mucosa, primary CRC tissues, to metastatic CRC tissues (P < 0...
January 5, 2016: Oncotarget