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https://read.qxmd.com/read/30759268/modifiable-clinical-correlates-of-vascular-health-in-children-and-adolescents-with-dyslipidemia
#1
David A White, Gautam M Anand, Omar Qayum, Chizitam F Ibezim, Ashley K Sherman, Geetha Raghuveer
Atherosclerosis promoting cardiovascular disease risk factors (CVDrf) are highly prevalent among youth in the U.S. Determining which standard modifiable clinical measures (SMCMs) has the greatest impact on vascular structure and function is valuable for the health care provider to help identify children at highest risk. The aim of this study was to determine modifiable outpatient clinical predictors of vascular health in youth with CVDrf. Children and adolescents with CVDrf (n = 120, 13.1 ± 1.9 years, 49% female) were recruited from a pediatric preventive cardiology clinic...
February 13, 2019: Pediatric Cardiology
https://read.qxmd.com/read/30755213/iron-metabolism-and-its-association-with-dyslipidemia-risk-in-children-and-adolescents-a-cross-sectional-study
#2
Yanna Zhu, Baoting He, Yunjun Xiao, Yajun Chen
BACKGROUND: Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk. METHOD: In total, 1866 children and adolescents aged 7-18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated...
February 12, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/30724974/-high-prevalence-of-dyslipidemia-and-high-atherogenic-index-of-plasma-in-children-and-adolescents
#3
Jorge Sapunar, Nicolás Aguilar-Farías, Juan Navarro, Gustavo Araneda, Damian Chandía-Poblete, Víctor Manríquez, Roberto Brito, Álvaro Cerda
BACKGROUND: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. AIM: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. MATERIAL AND METHODS: Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters...
December 2018: Revista Médica de Chile
https://read.qxmd.com/read/30723311/body-fat-indicators-perform-better-than-body-mass-index-in-identifying-abnormal-lipid-profiles-in-boys-but-not-in-girls
#4
Haibo Li, Tao Huang, Junting Liu, Yinkun Yan, Xiaoyuan Zhao, Pei Xiao, Jie Mi
BACKGROUND: BMI as a body weight indicator, may inadequately represent the biological effect of body fat on lipid profiles. This study aims to assess whether body fat indicators were superior to BMI for recognizing children with dyslipidemia. METHODS: A nationwide cross-sectional study involving 8944 pediatric participants aged 6-18 years. Measures of fat mass index (FMI), fat mass percentage (FMP), BMI, and four lipid profiles were obtained. RESULTS: Among boys, the standard multi-linear regression coefficients of FMI for TC, LDL-C, and TG were higher than those of BMI (P < 0...
January 17, 2019: Pediatric Research
https://read.qxmd.com/read/30651891/circulating-micrornas-are-associated-with-early-childhood-obesity-results-of-the-i-family-study
#5
Giuseppe Iacomino, Paola Russo, Pasquale Marena, Fabio Lauria, Antonella Venezia, Wolfgang Ahrens, Stefaan De Henauw, Pasquale De Luca, Ronja Foraita, Kathrin Günther, Lauren Lissner, Dénes Molnár, Luis A Moreno, Michael Tornaritis, Toomas Veidebaum, Alfonso Siani
Background: Nearly 10 years ago, the World Health Organization reported the increasing prevalence of overweight and obesity worldwide as a challenge for public health due to the associated adverse consequences. Epidemiological studies established a firm relationship between an elevated body mass index and chronic conditions such as diabetes, dyslipidemia, hypertension, heart disease, non-alcoholic fatty liver disease, and some types of cancer. Omic studies demonstrated that microRNA (miRNA) profile changes in tissues correlate with a number of diseases, including obesity...
2019: Genes & Nutrition
https://read.qxmd.com/read/30638928/psoriasis-and-metabolic-and-cardiovascular-comorbidities-in-children-a-systematic-review
#6
A Badaoui, P Tounian, E Mahé
INTRODUCTION: Psoriasis is associated with a higher risk of cardiovascular and/or metabolic comorbidity in adults, but discordant data have been reported in children. OBJECTIVE: To evaluate the frequency of metabolic and cardiovascular comorbidity in children with psoriasis and to establish whether age at onset of psoriasis correlates with metabolic and cardiovascular comorbidity in adulthood. MATERIAL AND METHODS: We conducted a systematic review on MEDLINE, using PubMed and Ovid...
January 10, 2019: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/30584439/nutrition-and-cardio-metabolic-risk-factors-findings-from-20-years-of-the-tehran-lipid-and-glucose-study
#7
REVIEW
Firoozeh Hosseini-Esfahani, Somaye Hosseinpour-Niazi, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh-Sadat Ejtahed, Parvin Mirmiran, Fereidoun Azizi
Context: Genetic and environmental factors contribute to the incidence of metabolic syndrome (MetS). This study aimed to review all findings of studies conducted in framework of the Tehran lipid and glucose study (TLGS) regarding the association of dietary factors with cardio-metabolic risk factors. Evidence Acquisition: All English-language studies were searched using PubMed and Scopus databases from 2000 to 2017. Finally, 105 relevant papers were included in this review...
October 2018: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30572569/gut-microbiota-and-endothelial-dysfunction-markers-in-obese-mexican-children-and-adolescents
#8
Khemlal Nirmalkar, Selvasankar Murugesan, María Luisa Pizano-Zárate, Loan Edel Villalobos-Flores, Cristina García-González, Rosa María Morales-Hernández, Jorge Arturo Nuñez-Hernández, Fernando Hernández-Quiroz, María Del Socorro Romero-Figueroa, César Hernández-Guerrero, Carlos Hoyo-Vadillo, Jaime García-Mena
Obesity is a metabolic disease characterized by low-grade inflammation and accompanied by dyslipidemia and up-regulation of other bioactive molecules, creating a predisposition to endothelial dysfunction and metabolic syndrome. We studied the association between gut microbiota diversity and endothelial dysfunction (EDF) markers in obese Mexican children and adolescents. We examined clinical data including metabolic factors and EDF markers in blood samples. Gut bacterial diversity was characterized by high-throughput sequencing of V3-16S rDNA libraries...
December 19, 2018: Nutrients
https://read.qxmd.com/read/30547005/higher-hemoglobin-a1c-and-atherogenic-lipoprotein-profiles-in-children-and-adolescents-with-type-2-diabetes-mellitus
#9
James Heath Pelham, Lynae Hanks, Stella Aslibekyan, Shima Dowla, Ambika P Ashraf
Aim: Significant knowledge gaps exist regarding lipoprotein profiles in children with type 2 diabetes mellitus (T2DM). The primary objective was to analyze the type and nature of lipoprotein abnormalities present in children with T2DM and to identify determinants of adverse lipoprotein profiles. The secondary objective was to assess associations with elevated glycated hemoglobin (HbA1C), i.e., <8% vs. ≥8.0% and pediatric dyslipidemias in the setting of T2DM. Methods: This retrospective chart review included children with T2DM who had undergone lipoprotein analysis and were not on lipid lowering medications (n = 93)...
March 2019: Journal of Clinical & Translational Endocrinology
https://read.qxmd.com/read/30532105/-efectos-sobre-el-perfil-metab%C3%A3-lico-el-%C3%A3-ndice-de-masa-corporal-la-composici%C3%A3-n-corporal-y-la-comorbilidad-en-adolescentes-con-obesidad-m%C3%A3-rbida-que-han-fallado-al-manejo-conservador-para-bajar-de-peso-operados-de-manga-g%C3%A3-strica-laparosc%C3%A3-pica-reporte-del
#10
Jaime Nieto-Zermeño, Ricardo Ordorica Flores, Blanca Del Río-Navarro, Betzabé Salgado-Arroyo, Jorge Mario Molina-Díaz
Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Method: We analyze the metabolic repercussions, comorbidities and complications in our series of Mexican adolescents with morbid obesity who underwent a gastric sleeve between 2011 and 2015...
2018: Gaceta Médica de México
https://read.qxmd.com/read/30525012/prevalence-of-target-organ-damage-in-chinese-hypertensive-children-and-adolescents
#11
Liu Yang, Lili Yang, Yuanyuan Zhang, Bo Xi
Background: Subclinical target organ damage (TOD) has been common in hypertensive children, but there is limited data in the Chinese pediatric population. This study aimed to investigate the prevalence of subclinical TOD in the Chinese hypertensive children and adolescents. Methods: A cross-sectional study was performed in children and adolescents from four schools in Jinan, China between September 2012 and September 2014. The hypertensive status was confirmed based on elevated blood pressure across three different occasions...
2018: Frontiers in Pediatrics
https://read.qxmd.com/read/30468651/fructose-at-the-crossroads-of-the-metabolic-syndrome-and-obesity-epidemics
#12
Renya Rodriguez Mortera, Yasmin Bains, Alejandro Gugliucci
In this review, we highlight the specific metabolic effects of fructose consumption that are involved in the development of metabolic syndrome non-alcoholic fatty liver disease and its association with obesity. The specifics effects of fructose on the liver are particularly germane to the development of a vicious cycle that starts with liver steatosis driving insulin resistance. These effects include 1) increased de novo lipogenesis, 2) increased liver fat, 3) dyslipidemia 4) increased uric acid production which feeds back on increased fructose metabolism and, 5) increased methylglyoxal and Maillard reaction that may affect adenosyl-monophosphate-dependent kinase Fructose increases cortisol activation especially in visceral fat...
January 1, 2019: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/30458301/performance-of-gender-and-age-specific-cut-points-versus-ncep-pediatric-cutpoints-in-dyslipidemia-screening-among-chinese-children
#13
Pei Xiao, Tao Huang, Yinkun Yan, Xiaoyuan Zhao, Haibo Li, Jie Mi
BACKGROUND AND AIMS: Considerable attention is given nowadays to the presence of cardiovascular diseases risk factors in children. The current blood lipid classification system for Chinese children was based on the United States National Cholesterol Education Program (NCEP) cutpoints, which did not take the age, gender and race differences into consideration. This study aimed to develop gender- and age-specific lipid cutpoints for dyslipidemia screening in Chinese children and compare the ability of new cutpoints and NCEP pediatric cutpoints to predict obesity and unfavorable blood pressure (BP) levels...
November 10, 2018: Atherosclerosis
https://read.qxmd.com/read/30428934/are-non-high-density-lipoprotein-fractions-associated-with-pediatric-metabolic-syndrome-the-caspian-v-study
#14
Pooneh Angoorani, Majid Khademian, Hanieh-Sadat Ejtahed, Ramin Heshmat, Mohammad Esmaeil Motlagh, Mahya Vafaeenia, Gita Shafiee, Armita Mahdivi-Gorabi, Mostafa Qorbani, Roya Kelishadi
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7-18 years...
November 14, 2018: Lipids in Health and Disease
https://read.qxmd.com/read/30419696/-characteristics-of-cardiometabolic-risk-factors-of-children-and-adolescents-aged-6-17-years-in-seven-cities-in-china-from-2013-to-2015
#15
H Cheng, F F Chen, P Y Ye, J Mi
Objective: To describe characteristics of cardiometabolic risk factors of children and adolescents aged 6-17 years in 7 cities in China from 2013 to 2015. Methods: Data was from the China Child and Adolescent Cardiovascular Health (CCACH) study. 12 590 children and adolescents were selected from 24 schools (3 kindergartens, 7 primary schools, 7 junior high schools and 7 senior high schools) in seven cities (Changchun, Yinchuan, Beijing, Jinan, Shanghai, Chongqing and Tianjin) during 2013-2015 by using a stratified cluster random sampling method...
November 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/30419694/-the-baseline-characteristics-of-school-based-cardiovascular-and-bone-health-promotion-program-in-beijing
#16
D Q Hou, A Y Gao, Z X Zhu, Z C Yu, N X Lin, J T Liu, X Y Zhao, G M Huang, S Y Chang, J Mi
Objective: To describe the baseline characteristics of School-based Cardiovascular and Bone Health Promotion Program(SCVBH) in Beijing. Methods: Children and adolescents were selected in 30 schools (8 primary schools, 21 middle schools and one 12-year education school) from Dongcheng, Tongzhou, Fangshan and Miyun districts of Beijing by using a stratified cluster sampling method. 15 391 students in grade 1 to 4 from primary schools, grade 1 from junior and senior high schools were enrolled in the investigation with an exclusion of students who were not able to participate due to trauma or other uncomfortable physical conditions...
November 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/30334928/hepatotoxicity-of-statins-as-determined-by-serum-alanine-aminotransferase-in-a-pediatric-cohort-with-dyslipidemia
#17
Nirav K Desai, Michael M Mendelson, Annette Baker, Heather Harker Ryan, Suzanne Griggs, Meera Boghani, Elizabeth Yellen, Lucy Buckley, Mathew W Gillman, Justin P Zachariah, Dionne Graham, Maureen M Jonas, Sarah D de Ferranti
OBJECTIVE: To evaluate the hepatotoxicity of statins, as determined by serum alanine aminotransferase (ALT), in children and adolescents with dyslipidemia in real world clinical practice. STUDY DESIGN: Clinical and laboratory data were prospectively collected between September 2010 and March 2014. We compared ALT levels between patients prescribed versus not prescribed 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins), and then compared ALT before and after initiation of statins...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/30261473/serum-non-cholesterol-sterols-and-cholesterol-metabolism-in-childhood-and-adolescence
#18
Helena Gylling, Matilda Korhonen, Annika Mutanen, Markku J Nissinen, Mikko Pakarinen, Piia Simonen
BACKGROUND AND AIMS: The profile of cholesterol metabolism, i.e., high absorption vs. high synthesis, may have a role in the development of atherosclerosis, the early lesions of which can be present already in childhood. Since there is no information on cholesterol metabolism in children from birth to adolescence, we evaluated cholesterol metabolism in 0-15 year-old children and adolescents without dyslipidemia. METHODS: The study population consisted of 96 children (39 girls, 57 boys) divided into age groups <1 (n = 14), 1-5 (n = 37), 6-10 (n = 24), and 11-15 (n = 21) years...
September 15, 2018: Atherosclerosis
https://read.qxmd.com/read/30253939/integrating-lipid-screening-with-ideal-cardiovascular-health-assessment-in-pediatric-settings
#19
REVIEW
Piers Blackett, Minu George, Don P Wilson
Pediatric lipid screening and management with the aim of reducing and preventing adult disease is an internationally accepted concept, and guidelines have been published in several countries. However, implementation by the practicing pediatric community in the United States has been less than expected and delays have been attributed to uncertainty among providers. Reduced screening rates have also been reported for conditions contributing to arterial wall pathology such as obesity, hypertension, and prediabetes despite accumulating evidence that detection and intervention can lead to risk reversal...
August 29, 2018: Journal of Clinical Lipidology
https://read.qxmd.com/read/30107712/-the-epidemiological-characteristics-and-related-factors-of-dyslipidemia-among-children-and-adolescents-aged-6-17-years-from-7-provinces-in-china-2012
#20
Z H Wang, Z Y Zou, Y D Yang, S Wang, Y H Dong, Z G Yang, Z P Yang, X J Wang, Y H Li, D Gao, J Ma
Objective: To investigate the prevalence and related factors of dyslipidemia among children and adolescents aged 6-17 years in 7 provinces in China. Methods: Using the method of stratified cluster random sampling, 93 primary and secondary schools were selected from Guangdong, Hunan, Liaoning provinces, Shanghai, Chongqing, Tianjin municipalities and Ningxia Hui Autonomous Region in China, 2012. A total of 16 434 students aged 6-17 years old with completed physical and lipid profiles parameters were selected into this study from above 93 primary and secondary schools...
August 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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