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Enrique Arciniegas, Luz Marina Carrillo, Héctor Rojas, Richard Ramírez, Marina Chopite
Keloids are defined histopathologically as an inflammatory disorder characterized by exhibiting numerous fibroblasts, abnormal vascularization, increased number of proinflammatory immune cells as well as uncontrolled cell proliferation, and exacerbated and disorganized deposition of extracellular matrix (ECM) molecules. Importantly, many of these ECM molecules display N- and O-linked glycan residues and are considered as potential targets for galectin-1 (Gal-1) and galectin-3 (Gal-3). Nevertheless, the presence and localization of Gal-1 and Gal-3 as well as the interactions with some of their binding partners in keloid tissues have not been considered...
March 2019: American Journal of Dermatopathology
Bojana Stojanovic, Jelena Milovanovic, Aleksandar Arsenijevic, Bojan Stojanovic, Ivana Strazic Geljic, Nebojsa Arsenijevic, Stipan Jonjic, Miodrag L Lukic, Marija Milovanovic
Galectin-3 (Gal-3) has a role in multiple inflammatory pathways. Various, opposite roles of Gal-3 in liver diseases have been described but there are no data about the role of Gal-3 in development of hepatitis induced with cytomegalovirus infection. In this study we aimed to clarify the role of Gal-3 in murine cytomegalovirus (MCMV)-induced hepatitis by using Gal-3-deficient (Gal-3 KO) mice. Here we provide the evidence that Gal-3 has the protective role in MCMV-induced hepatitis. Enhanced hepatitis manifested by more inflammatory and necrotic foci and serum level of ALT, enhanced apoptosis and necroptosis of hepatocytes and enhanced viral replication were detected in MCMV-infected Gal-3 deficient mice...
2019: Frontiers in Microbiology
Reza Rahimian, Starlee Lively, Essam Abdelhamid, Melanie Lalancette-Hebert, Lyanne Schlichter, Sachiko Sato, Jasna Kriz
Galectin-3 (Gal-3), a β-galactoside-binding lectin, has recently emerged as a molecule with immunoregulatory functions. We investigated the effects of Gal-3 on microglia morphology, migration, and secretory profile under physiological conditions and in the context of ischemic injury. We show that in the control conditions, exposure to recombinant Gal-3 increases microglial ramification and motility in vitro and in vivo via an IL-4-dependent mechanism. Importantly, after stroke, Gal-3 exerted marked immune-modulatory properties...
February 23, 2019: Molecular Neurobiology
Eleazar Ramírez, Claudia Sánchez-Maldonado, Miguel A Mayoral, Liliana Mendieta, Victorino Alatriste, Aleidy Patricio-Martínez, I Daniel Limón
Galectins are animal lectins that bind to β-galactosides, such as lactose and N-acetyllactosamine, contained in glycoproteins or glycolipids. Galectin-1 (Gal-1) and Galectin-3 (Gal-3) are involved in pathologies associated with the inflammatory process, cell proliferation, adhesion, migration, and apoptosis. Recent evidence has shown that the administration of Amyloid-β 25-35 (Aβ25-35 ) into the hippocampus of rats increases the inflammatory response that is associated with memory impairment and neurodegeneration...
February 14, 2019: Neuropeptides
E Atay, M Guzel, R Amanvermez, M T Demir, A K Erenler, E Ozgen, M Yucel
OBJECTIVES: We aimed to compare the plasma levels of biomarkers such as: serum Gal-3, H-FABP, cTnI, and CK-MB in patients, who were admitted to the emergency room with chest pain, and to determine whether these biomarkers have early diagnostic value of acute coronary syndrome (ACS). METHODS: The study was performed in 60 patients aged ≥ 18 years, who were admitted to emergency room. These patients were divided into 3 groups: patients with STEMI (group I, n = 20), patients with NSTEMI (group II, n = 20), and patients with USAP (group III, n = 20)...
2019: Bratislavské Lekárske Listy
Juan Lin, Xiaonan Xue, Kathryn Anastos, Mardge H Cohen, Stephen J Gange, Jason M Lazar, Chenglong Liu, Wendy J Mack, Phyllis C Tien, Cathy Tilley, Howard N Hodis, Alan L Landay, Russell P Tracy, Robert C Kaplan, David B Hanna
BACKGROUND: Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women. SETTING: In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart...
February 13, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Michael R Zile, Eileen O'Meara, Brian Claggett, Margaret F Prescott, Scott D Solomon, Karl Swedberg, Milton Packer, John J V McMurray, Victor Shi, Martin Lefkowitz, Jean Rouleau
BACKGROUND: Myocardial fibrosis is an important pathophysiological mechanism underlying the development of heart failure (HF). Given the biochemical targets of sacubitril/valsartan, we hypothesized that circulating biomarkers reflecting the mechanisms that determine extracellular matrix (ECM) homeostasis, including collagen synthesis, processing, and degradation, are altered by sacubitril/valsartan in comparison to enalapril. OBJECTIVES: The purpose of this study was to examine the effects of sacubitril/valsartan on biomarkers of ECM homeostasis and the association between the rate of primary composite outcome (cardiovascular death or HF hospitalization) and these biomarkers...
February 26, 2019: Journal of the American College of Cardiology
Junbo Qiao, Yongwei Chen, Changxian Dong, Jin Li
Background & objectives: Hepatic venous malformation gradually develops over time and exhibits the malignant biological behaviours of being locally invasive, causing morphological and functional damage to local tissue, and may even cause systemic coagulopathy. Studies show that galectin-3(Gal-3) expression is closely associated with local invasion of malignant tumours. In this study an attempt was made to assess the clinical significance of Gal-3 in local invasion during hepatic venous malformation in patients...
December 2018: Indian Journal of Medical Research
David Fulton, Xueyi Li, Zsuzsanna Bordan, Yusi Wang, Keyvan Mahboubi, Radu Daniel Rudic, Stephen Haigh, Feng Chen, Scott A Barman
SIGNIFICANCE: Pulmonary Arterial Hypertension (PAH) is a progressive disease arising from the narrowing of pulmonary arteries (PA) resulting in high pulmonary arterial blood pressure and ultimately right ventricular (RV) failure. A defining characteristic of PAH is the excessive and unrelenting inward remodeling of PA that includes increased proliferation, inflammation and fibrosis. CRITICAL ISSUES: There is no cure for PAH nor interventions that effectively arrest or reverse PA remodeling and intensive research over the past several decades has sought to identify novel molecular mechanisms of therapeutic value...
February 15, 2019: Antioxidants & Redox Signaling
Xiao-Jun Du, Wei-Bo Zhao, My-Nhan Nguyen, Qun Lu, Helen Kiriazis
Myocardial fibrosis is a key histopathological component that drives the progression of heart disease leading to heart failure and forms a therapeutic target. Recent preclinical and clinical studies have implicated galectin-3 (Gal-3) as a pro-fibrotic molecule and a biomarker of heart disease and fibrosis. However, our knowledge is poor on the mechanism(s) that determine the blood level or regulate cardiac expression of Gal-3. Recent studies have demonstrated that enhanced β-adrenoceptor (βAR) activity is a determinant of both circulating concentration and cardiac expression of Gal-3...
February 12, 2019: British Journal of Pharmacology
Rômulo Medina Mattos, Daniel Escorsim Machado, Jamila Alessandra Perini, Jéssica Alessandra-Perini, Nathália de Oliveira Meireles da Costa, Adalgisa Felippe da Rocha de Oliveira Wiecikowski, Katia Maria Dos Santos Cabral, Christina Maeda Takiya, Renato Sampaio Carvalho, Luiz Eurico Nasciutti
This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Then, WT mice were treated with Gal3C for 15 days. Gal-3 deficiency and Gal3C treatment significantly impaired endometriosis development...
February 9, 2019: Molecular and Cellular Endocrinology
J Sanchez-Serna, M Martinez-Villanueva, Á Hernández-Vicente, M C Asensio-Lopez, J A Noguera, D A Pascual-Figal
INTRODUCTION: In decompensated heart failure (HF), both acute kidney injury (AKI) and high Galectina-3 (Gal-3) levels have been associated with poorer outcomes. Plasma Gal-3 levels are affected by renal function; however, the potential role of Gal-3 as a predictor of AKI has not been established. METHODS: We measured Gal-3 concentrations at admission for 175 patients hospitalised for HF and recorded the onset of AKI according to the Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) analytical criteria...
February 5, 2019: Revista Clínica Española
Scott A Barman, Xueyi Li, Stephen Haigh, Dmitry Kondrikov, Keyvan Mahboubi, Zsuzsanna Bordan, David W Stepp, Jiliang Zhou, Yusi Wang, Daniel S Weintraub, Peter Traber, William Snider, Danny Jonigk, Jennifer C Sullivan, G Ryan Crislip, Joshua T Butcher, Jennifer Thompson, Yunchao Su, Feng Chen, David J R Fulton
A defining characteristic of Pulmonary Hypertension (PH) is the extensive remodeling of pulmonary arteries (PA) that results in progressive increases in vascular resistance and stiffness and eventual failure of the right ventricle. There is no cure for PH and identification of novel molecular mechanisms that underlie increased proliferation, reduced apoptosis and excessive extracellular matrix production in pulmonary artery smooth muscle cells (PASMC) is a vital objective. Galectin-3 (Gal-3) is a chimeric lectin and potent driver of many aspects of fibrosis, but its role in regulating PASMC behavior in PH remains poorly understood...
February 6, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
Aziz Inan Celik, Mehmet Kanadasi, Mesut Demir, Ali Deniz, Rabia Eker Akilli, Onur Sinan Deveci, Caglar Emre Cagliyan, Caglar Ozmen, Firat Ikikardes, Muhammet Bugra Karaaslan
BACKGROUND: Cryoballoon-based pulmonary vein isolation (PVI) is a treatment option for atrial fibrillation (AF). Left atrial volume (LAV) and left atrial volume index (LAVi) are important parameters for long term success of PVI. Galectin-3 (Gal-3) and neutrophil to lymphocyte ratio (N/L ratio) are biomarkers to demonstrate the cardiac fibrosis and remodelling. METHODS: 50 patients with symptomatic PAF despite ≥1 antiarrhythmic drug(s), who underwent PVI were enrolled...
January 2019: Indian Pacing and Electrophysiology Journal
Dalibor Stajic, Dragica Selakovic, Nemanja Jovicic, Jovana Joksimovic, Nebojsa Arsenijevic, Miodrag L Lukic, Gvozden Rosic
Galectin-3 (Gal-3), a member of lectin family that binds to oligosaccharides, is involved in several biological processes, including maturation and function of nervous system. It had been reported that Gal-3 regulates oligodendrocytes differentiation and that Gal-3/Toll-like receptor-4 (TLR4) axis is involved in neuroinflammation. As both, central nervous system (CNS) maturation and neuroinflammation may affect behavior, the principle aim of this study was to examine the effects of Gal-3 gene deletion on behavior...
January 22, 2019: Brain, Behavior, and Immunity
Kamil Wdowiak, Enrique Gallego-Colon, Tomasz Francuz, Paulina Czajka-Francuz, Natalia Ruiz-Agamez, Marcin Kubeczko, Iga Grochoła, Maciej T Wybraniec, Jerzy Chudek, Jerzy Wojnar
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults. Despite improvements in treatment, CLL is still considered an incurable disease. The aim of the present study was to evaluate galectin-1, -3 and -9 (Gal-1, -3 and -9) and Gal-3 binding protein (Gal-3BP) as prognostic and predictive factors in patients with CLL. Serum concentrations of Gal-1, -3 and -9 and Gal-3BP were measured in 48 patients with CLL and 30 control patients, using multiplex bead arrays. In patients with CLL, galectin concentrations were assessed prior to, during and following treatment...
January 2019: Oncology Letters
Yumiko Hayashi, Weizhen Jia, Hiroyasu Kidoya, Fumitaka Muramatsu, Yohei Tsukada, Nobuyuki Takakura
Galectin-3 (Gal-3; gene LGALS3) is a member of the beta-galactose-binding lectin family. Previous studies showed that Gal-3 is expressed in several tissues across species and functions as a regulator of cell proliferation, apoptosis, adhesion, and migration, thus affecting many aspects of events such as angiogenesis and tumorigenesis. Although several reports have suggested that the level of Gal-3 expression correlates positively with tumor progression, here we show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential...
January 14, 2019: American Journal of Pathology
Dawei Wang, Dong You, Lei Li
Galectin-3 (Gal-3) is a multifunctional carbohydrate-binding protein associated with cell migration, cell proliferation, cell adhesion, and cell-cell interaction in tumor cells. It has been implied to be involved in the tumor progression and chemoresistance of epithelial ovarian cancer (EOC). However, it is unclear whether the Gal-3-mediated regulation on the EOC chemosensitivity is associated with hypoxia or mitochondrial dysfunction. In the present study, we examined the regulation by Gal-3 overexpression on cisplatin-sensitivity or cisplatin-resistance in EOC cells in vitro...
2019: Journal of Toxicological Sciences
Ernesto Martínez-Martínez, Cristina Brugnolaro, Jaime Ibarrola, Susana Ravassa, Mathieu Buonafine, Begoña López, Amaya Fernández-Celis, Ramón Querejeta, Enrique Santamaria, Joaquín Fernández-Irigoyen, Gregorio Rábago, María U Moreno, Frédéric Jaisser, Javier Díez, Arantxa González, Natalia López-Andrés
Myocardial fibrosis is a main contributor to the development of heart failure (HF). CT-1 (cardiotrophin-1) and Gal-3 (galectin-3) are increased in HF and associated with myocardial fibrosis. The aim of this study is to analyze whether CT-1 regulates Gal-3. Proteomic analysis revealed that Gal-3 was upregulated by CT-1 in human cardiac fibroblasts in parallel with other profibrotic and proinflammatory markers. CT-1 upregulation of Gal-3 was mediated by ERK (extracellular signal-regulated kinase) 1/2 and Stat-3 (signal transducer and activator of transcription 3) pathways...
January 7, 2019: Hypertension
Anahita Ghorbani, Vijeta Bhambhani, Robert H Christenson, Wouter C Meijers, Rudolf A deBoer, Daniel Levy, Martin G Larson, Jennifer E Ho
BACKGROUND: Galectin-3 (Gal-3) has been associated with heart failure (HF) and poor cardiovascular outcomes. However, the effect of longitudinal changes in Gal-3 on clinical outcomes remains unclear. OBJECTIVES: The authors sought to study clinical determinants of change in Gal-3 among community-dwelling individuals. Further, they sought to examine the role of serial Gal-3 measurements in predicting risk of future HF, cardiovascular disease (CVD), and mortality...
December 25, 2018: Journal of the American College of Cardiology
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