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L P A Thai, F Mousseau, E K Oikonomou, J-F Berret
The role of pulmonary surfactant is to reduce the surface tension in the lungs and to facilitate breathing. Surfactant replacement therapy (SRT) aims at bringing a substitute by instillation into the airways, a technique that has proven to be efficient and lifesaving for preterm infants. Adapting this therapy to adults requires to scale the administered dose to the patient body weight and to increase the lipid concentration, whilst maintaining its surface and flow properties similar. Here, we exploit a magnetic wire-based microrheology technique to measure the viscosity of the exogenous pulmonary surfactant Curosurf® in various experimental conditions...
March 11, 2019: Colloids and Surfaces. B, Biointerfaces
Lingxi Zhou, Meichen Guo, Yao Li, Qin Gu, Wenqian Zhang, Chun Li, Fengyu Xie, Dunmin Lin, Qiaoji Zheng
Developing high-performance, robust and cost-effective oxygen evolution reaction (OER) catalysts for electrochemical water splitting is a promising way to produce energy-saving electrolytic hydrogen fuels. Herein, a series of rational wire-in-plate nanostructured CoFe LDH electrocatalysts grown on a Ni foam were developed via a one-step hydrothermal method. In this series of catalysts, Co4Fe2-LDHs/Co(OH)2-NWs exhibit excellent OER performance which is attributed to the most rational wire-in-plate nanostructure: the overpotentials of only 220 and 231 mV to drive current densities of 50 mA cm-2 and 100 mA cm-2, respectively, with a small Tafel slope of 51 mV dec-1...
March 21, 2019: Chemical Communications: Chem Comm
Xing Qing, Yuedan Wang, Yang Zhang, Xingcheng Ding, Weibing Zhong, Dong Wang, Wenwen Wang, Qiongzhen Liu, Ke Liu, Mufang Li, Zhentan Lu
Fiber-based organic electrochemical transistors (FECTs) provide a new platform for the realization of ultrafast and ultrasensitive biosensor, especially for the wearable dopamine (DA) monitoring device. Here, we presented a fully filament integrated fabric, it exhibited remarkable mechanical compatibility with human body, and the minimum sensing unit was an organic electrochemical transistor (OECT) based on PVA-co-PE nanofibers (NFs) and polypyrrole (PPy) nanofiber network. The introduction of NFs notably increased the specific surface area and hydrophilicity of the PA6 filament, resulting in the formation of a large area of intertwined PPy nanofiber network...
March 21, 2019: ACS Applied Materials & Interfaces
Jennifer A Brooks, Mallory McKeon, Jeanne S Chow, Karen Watters
OBJECTIVES: This paper reports the utilization of intraoperative ultrasound in the removal of an accidentally ingested wire grill-brush bristle from the pharyngeal space of a child. METHODS: Standard procedures for obtaining imaging of an accidentally ingested foreign body were performed, including radiograph, computed tomography (CT) imaging, and preoperative ultrasonography. Despite preoperative imaging, the object could neither be located nor removed. Ultrasonography was performed intraoperatively for real-time localization...
March 21, 2019: Annals of Otology, Rhinology, and Laryngology
Takashi Usui, Toshio Iwata, Shinjiro Miyake, Takero Otsuka, So Koizumi, Nobukazu Shirakawa, Toshitsugu Kawata
Background/purpose: Although aesthetic wire coating has been increasing in demand, it has problems that changes in mechanical properties and increase in frictional force. The aim of this study was to evaluate the coating of the wire, as characterized by aesthetics, in terms of low and constant friction and mechanical properties. Materials and methods: Hard chrome carbide-plated (HCCP) wires (HCCP group), commercially available polymer-coated wires (P group), rhodium-coated wires (R group), and uncoated wires (control group) were used...
June 2018: Journal of Dental Sciences
Ayush Kumar Singh, Mangal Parihar, Syed Bokhari
AIM: The aims of this investigation were: 1) to study the Functional outcome of performing distraction osteogenesis in cases of infected non-union of tibia treated with Ilizarov and Limb Reconstruction System, and 2) to study the Radiological outcome of performing distraction osteogenesis in cases of infected non-union of tibia treated with Ilizarov and Limb Reconstruction System. METHODS: The study was done with 27 patients of infected gap nonunions of the tibia at Sir JJ Hospitals, Mumbai from 2013-2016...
February 28, 2019: Open Access Macedonian Journal of Medical Sciences
Katia Schoeler, Bojana Jakic, Julia Heppke, Claudia Soratroi, Andreas Aufschnaiter, Natascha Hermann-Kleiter, Andreas Villunger, Verena Labi
Germinal center (GC) B cells are among the fastest replicating cells in our body, dividing every 4-8 h. DNA replication errors are intrinsically toxic to cells. How GC B cells exert control over the DNA damage response while introducing mutations in their antibody genes is poorly understood. Here, we show that the DNA damage response regulator Checkpoint kinase 1 (CHK1) is essential for GC B cell survival. Remarkably, effective antibody-mediated immunity relies on optimal CHK1 dosage. Chemical CHK1 inhibition or loss of one Chk1 allele impairs the survival of class-switched cells and curbs the amplitude of antibody production...
March 20, 2019: Cell Death and Differentiation
Anna Payne-Tobin Jost, Jennifer C Waters
Images generated by a microscope are never a perfect representation of the biological specimen. Microscopes and specimen preparation methods are prone to error and can impart images with unintended attributes that might be misconstrued as belonging to the biological specimen. In addition, our brains are wired to quickly interpret what we see, and with an unconscious bias toward that which makes the most sense to us based on our current understanding. Unaddressed errors in microscopy images combined with the bias we bring to visual interpretation of images can lead to false conclusions and irreproducible imaging data...
March 20, 2019: Journal of Cell Biology
Sung Min Nam, Jin Seok Seo, Sang-Soep Nahm, Byung-Joon Chang
Osteopontin (OPN) is a multi-functional protein that binds to integrin and calcium-binding phosphoprotein. OPN is required for normal neuronal development and its axonal myelination. We studied the combined effect of lead (Pb) and ascorbic acid treatment on OPN expression in the developing cerebellum. We randomly divided pregnant female rats into three groups: control, Pb (lead acetate, 0.3%, drinking water), and Pb plus ascorbic acid (PA; ascorbic acid, 100 mg/kg, oral intubation) groups. The blood level of Pb was significantly increased, while ascorbic acid reduced Pb levels in the dams and pups...
March 19, 2019: International Journal of Environmental Research and Public Health
Jae-Woo Cho, William T Kent, Won-Tae Cho, Jin-Kak Kim, Ki-Ho Moon, Do-Hyun Yeo, Beom-Soo Kim, Chang-Wug Oh, Jong-Keon Oh
The aim of this study was to introduce various applications of miniplate augmented tension-band wiring (TBW) for comminuted patella fractures and to evaluate the clinical outcomes. Comminuted articular patella fractures were managed with anterior cortical miniplate fixation with a TBW technique from January 2014 to January 2016. The primary end point was radiographic union. Secondary end points were complications related to the procedure. Functional outcomes including range of motion were also evaluated. Thirty patients were followed up for a mean of 20 months (range, 12-28) postoperatively...
April 2019: Journal of Orthopaedic Trauma
Fernando Mut, Bong Jae Chung, Jorge Chudyk, Pedro Lylyk, Ramanathan Kadirvel, David F Kallmes, Juan R Cebral
INTRODUCTION: Modeling the flow dynamics in cerebral aneurysms after the implantation of intra-saccular devices is important for understanding the relationship between flow conditions created immediately post-treatment and the subsequent outcomes. This information, ideally available a priori based on computational modeling prior to implantation, is valuable to identify which aneurysms will occlude immediately and which aneurysms will likely remain patent and would benefit from a different procedure or device...
March 20, 2019: International Journal for Numerical Methods in Biomedical Engineering
Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valero
New neurons are continuously generated from stem cells and integrated into the adult hippocampal circuitry, contributing to memory function. Several environmental, cellular, and molecular factors regulate the formation of new neurons, but the mechanisms that govern their incorporation into memory circuits are less explored. Herein we will focus on microglia, the resident immune cells of the CNS, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration...
2019: Frontiers in Cell and Developmental Biology
Wesley H Chou, Tanya N Rinderknecht, Paul K Mohabir, Andrew W Phillips
Rapid infusion catheters (RICs) allow expedient conversion of peripheral intravenous (PIV) catheters to peripheral sheaths; however, little is known about potential complications. In this case, a 64-year-old male polytrauma patient had a 20-gauge PIV catheter in the right cephalic vein upsized to an 8.5 French (Fr) RIC without incident during an arrest with pulseless electrical activity (PEA). On RIC post-placement day two, the patient developed edema and ecchymosis extending from the right dorsal mid-hand to the antecubital fossa, just distal to the RIC insertion point...
January 8, 2019: Curēus
Alexandra Witze
No abstract text is available yet for this article.
March 2019: Nature
Patrick Ziegler, Hans-Peter Kaps, Stephanie Goerke, Gauri Tendulkar, Alfred Buck Sen, Andreas Nuessler, Werner Schmoelz
BACKGROUND: Total disc replacement is a possible treatment alternative for patients with degenerative disc disease, especially in the cervical spine. The aim is to restore the physiological flexibility and biomechanical behavior. A new approach based on these requirements is the novel nucleus prosthesis made of knitted titanium wires. METHODS: The biomechanical functionalities of eight human cervical (C4-C7) spine segments were investigated. The range of motion was quantified using an ultra-sound based motion analysis system...
March 5, 2019: Clinical Biomechanics
Ying Wang, Hai Lu Wang, Hua Yang Li, Xiao Yan Wei, Zhong Lin Wang, Guang Zhu
Transforming dynamic mechanical interactions into visualized luminescence represents a research frontier in the detection of tactile stimuli. Here, we report a self-powered high-resolution triboelectrification-induced electroluminescence (HR-TIEL) sensor for visualizing the contact profile and the dynamic trajectory of a contact object. As dynamic interactions occurs, triboelectric charges at the contact interface generates a transient electric field that excites the phosphor. From numerical simulation, a conductive layer based on transparent silver nanowires (AgNWs) guides the direction of the electric field and confines it within the profile boundary of the connect object...
March 19, 2019: ACS Applied Materials & Interfaces
Sertac Kirnaz, Rodrigo Navarro-Ramirez, Christoph Wipplinger, Franziska Anna Schmidt, Ibrahim Hussain, Eliana Kim, Roger Härtl
This video demonstrates the workflow of a minimally invasive transforaminal interbody fusion (MIS-TLIF) using a portable intraoperative CT (iCT) scanner, (Airo®, Brainlab AG, Feldkirchen, Germany), combined with state-of-the-art total 3D computer navigation. The navigation is used not only for instrumentation but also for intraoperative planning throughout the procedure, inserting the cage, therefore, completely eliminating the need for fluoroscopy. In this video, we present a case of a 72-yr-old female patient with a history of lower back pain, right lower extremity radicular pain and weakness for 2 yr due to L4-L5 spondylolisthesis with instability and severe lumbar spinal stenosis...
March 19, 2019: Operative Neurosurgery (Hagerstown, Md.)
Yoshinobu Murasato, Takahiro Mori, Takayuki Okamura, Ryoji Nagoshi, Tatsuhiro Fujimura, Masahiro Yamawaki, Shiro Ono, Takeshi Serikawa, Fumiaki Nakao, Junya Shite
AIM: We sought to investigate the efficacy of the proximal optimization technique (POT) on crossover stenting followed by side branch (SB) dilation under optical coherence tomography guidance in a multicenter registry study. METHODS AND RESULTS: A total of 135 bifurcation lesions in 134 patients were divided into POT (n = 52) and non-POT groups (n = 83). The POT was performed before SB dilatation (pre-POT; n = 26), finally (final-POT; n = 12), at both timing (re-POT; n = 13), and uncertain (n = 1)...
March 18, 2019: International Journal of Cardiovascular Imaging
Richard V Remigio, Garazi Zulaika, Renata S Rabello, John Bryan, Daniel M Sheehan, Sandro Galea, Marilia S Carvalho, Andrew Rundle, Gina S Lovasi
Street-level environment characteristics influence the health behaviors and safety of urban residents, and may particularly threaten health within informal communities. However, available data on how such characteristics vary within and among informal communities is limited. We sought to adapt street audit strategies designed to characterize the physical environment for use in a large informal community, Rio das Pedras (RdP) located in Rio de Janeiro, Brazil. A smartphone-based systematic observation protocol was used to gather street-level information for a high-density convenience sample of street segments (N = 630, estimated as 86% of all street segments in the community)...
March 18, 2019: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Juan Altafulla, Emre Yilmaz, Stefan Lachkar, Joe Iwanaga, Jacob Peacock, Zachary Litvack, R Shane Tubbs
Background: Cervical transforaminal epidural steroid injections (CTFESIs) are sometimes performed in patients with cervical radiculopathy secondary to nerve-root compression. Neck movements for patient positioning may include rotation, flexion, and extension. As physicians performing such procedures do not move the neck for fear of injuring the vertebral artery, we performed fluoroscopy and cadaveric dissection to analyze any movement of the vertebral artery during head movement and its relation to the foramina in the setting of CTFESI...
March 2019: Acta Radiologica Open
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