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https://read.qxmd.com/read/30781692/plug-n-harvest-architecture-for-secure-and-intelligent-management-of-near-zero-energy-buildings
#1
Rafael Marin-Perez, Iakovos T Michailidis, Dan Garcia-Carrillo, Christos D Korkas, Elias B Kosmatopoulos, Antonio Skarmeta
Building Automation (BA) is key to encourage the growth of more sustainable cities and smart homes. However, current BA systems are not able to manage new constructions based on Adaptable/Dynamic Building Envelopes (ADBE) achieving near-zero energy-efficiency. The ADBE buildings integrate Renewable Energy Sources (RES) and Envelope Retrofitting (ER) that must be managed by new BA systems based on Artificial Intelligence (AI) and Internet of Things (IoT) through secure protocols. This paper presents the PLUG-N-HARVEST architecture based on cloud AI systems and security-by-design IoT networks to manage near-zero ADBE constructions in both residential and commercial buildings...
February 18, 2019: Sensors
https://read.qxmd.com/read/30778656/influence-of-external-ear-occlusion-on-food-perception
#2
Benoît Jutras, Antonia Lüönd, Flurin Honegger, Christof Stieger, Thomas Hummel, Antje Welge-Lüssen
PURPOSE: The present study aimed to explore if food perception can be influenced by sound mastication level when the external ear canal was occluded. METHODS: Fifty-nine adults (38 women) with normal hearing, smell, and taste participated in the study. They tasted five crispy and five soft food items over two sessions: one with and one without an earplug inserted in the external ear canal. Participants were asked to rate freshness and taste of the food as well as their willingness to eat more of it and how much they usually like this kind of food...
February 18, 2019: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/30777139/temporal-bone-meningoencephaloceles-and-cerebrospinal-fluid-leaks-experience-in-a-tertiary-care-hospital
#3
A Gupta, K Sikka, D V K Irugu, H Verma, A S Bhalla, A Thakar
OBJECTIVE: To recount experience with cerebrospinal fluid otorrhoea and temporal bone meningoencephalocele repair in a tertiary care hospital. METHOD: A retrospective review was conducted of 16 cerebrospinal fluid otorrhoea and meningoencephalic herniation patients managed surgically from 1991 to 2016. RESULTS: Aetiology was: congenital (n = 3), post-traumatic (n = 2), spontaneous (n = 1) or post-mastoidectomy (n = 10). Surgical repair was undertaken by combined middle cranial fossa and transmastoid approach in 3 patients, transmastoid approach in 2, oval window plugging in 1, and subtotal petrosectomy with middle-ear obliteration in 10...
February 19, 2019: Journal of Laryngology and Otology
https://read.qxmd.com/read/30776757/modeling-mesobionano-systems-with-mbn-studio-made-easy
#4
Gennady B Sushko, Ilia A Solov'yov, Andrey V Solov'yov
This paper introduces MesoBioNano (MBN) Studio - a graphical user interface for a popular multiscale simulation package MBN Explorer. MBN Studio has been developed to facilitate setting up and starting MBN Explorer calculations, monitoring their progress and examining the calculation results. It is tailored for any calculations that are supported by MBN Explorer, such as for example the single-point energy calculations, structure optimization, molecular dynamics, and kinetic Monte Carlo simulations. Apart from that MBN Studio has built-in tools allowing the calculation and analysis of specific characteristics that are determined by the output of the simulations, such as the diffusion coefficients of molecular species, melting temperatures and associated heat capacities, radial distribution function; a dedicated modeling plug-in allows constructing molecular systems in a quick and efficient manner...
February 7, 2019: Journal of Molecular Graphics & Modelling
https://read.qxmd.com/read/30775971/cryo-em-structures-of-the-dcpib-inhibited-volume-regulated-anion-channel-lrrc8a-in-lipid-nanodiscs
#5
David M Kern, SeCheol Oh, Richard K Hite, Stephen Graf Brohawn
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here we present single-particle cryo-electron microscopy structures of Mus musculus LRRC8A in complex with the inhibitor DCPIB reconstituted in lipid nanodiscs. DCPIB plugs the channel like a cork in a bottle - binding in the extracellular selectivity filter and sterically occluding ion conduction...
February 18, 2019: ELife
https://read.qxmd.com/read/30775411/fracture-resistance-of-simulated-immature-teeth-treated-with-a-regenerative-endodontic-protocol
#6
Mohamed Raouf W Ali, Manal Mustafa, Asgeir Bårdsen, Athanasia Bletsa
This study aims to evaluate fracture resistance of simulated immature teeth after treatment with regenerative endodontic procedure (REP) using tricalcium silicate cements (TSCs) as cervical plugs. Bovine incisors were sectioned to standard crown/root ratio. Pulp tissue was removed and canals were enlarged to a standardized diameter. Teeth were then treated with a REP protocol consisting of NaOCl and EDTA irrigation, intracanal medication with triple-antibiotic paste for 14 days followed by a TSC cervical seal and composite restoration...
2019: Acta Biomaterialia Odontologica Scandinavica
https://read.qxmd.com/read/30772634/biodiesel-production-through-algal-cultivation-in-urban-wastewater-using-algal-floway
#7
Thomas Kiran Marella, Aviraj Datta, Mukund D Patil, Sreenath Dixit, Archana Tiwari
The aim of this work was to study algal floway (AFW) to treat urban wastewater and to evaluate biomass productivity, lipid contents and biodiesel production. The results indicated the seasonal average algae productivity of 34.83 g dry weight m2  d-1 with a nutrient removal rate of 2.52 g m2  d-1 N and 1.25 g m2  d-1 P while the lipid content ranged between 14 and 22% of dry cell weight with the highest lipid productivity of 9.29 g m-2  d-1 during summer. Biodiesel quality was superior during summer with high centane number and cold filter plugging point values...
February 6, 2019: Bioresource Technology
https://read.qxmd.com/read/30772002/cost-effectiveness-of-hydrogel-plugs-in-ct-guided-lung-biopsies
#8
S F Marco-Doménech, P Fernández-García, A Navarro-Ballester, M Cifrián-Pérez, Á Escobar-Valero, M V Ibáñez-Gual
OBJECTIVE: Using a hydrogel plug decreases the number of cases of pneumothorax and reduces the need for pleural drainage tubes in CT-guided lung biopsies. We aimed to analyze the cost-effectiveness of using hydrogel plugs. MATERIAL AND METHODS: We analyzed 171 lung biopsies divided into three groups: Group 1 (n=22): fine-needle aspiration cytology (FNAC) without hydrogel plugs; Group 2 (n=89): FNAC with hydrogel plugs; and Group 3 (n=60): FNAC plus core-needle biopsy (CNB) with hydrogel plugs...
February 13, 2019: Radiología
https://read.qxmd.com/read/30769863/anti-invasion-and-antiangiogenic-effects-of-stellettin-b-through-inhibition-of-the-akt-girdin-signaling-pathway-and-vegf-in-glioblastoma-cells
#9
Shu-Yu Cheng, Nan-Fu Chen, Pi-Yu Lin, Jui-Hsin Su, Bing-Hung Chen, Hsiao-Mei Kuo, Chun-Sung Sung, Ping-Jyun Sung, Zhi-Hong Wen, Wu-Fu Chen
Angiogenesis and invasion are highly related with tumor metastatic potential and recurrence prediction in the most aggressive brain cancer, glioblastoma multiforme (GBM). For the first time, this study reveals that marine-sponge-derived stellettin B reduces angiogenesis and invasion. We discovered that stellettin B reduces migration of glioblastoma cells by scratch wound healing assay and invasion via chamber transwell assay. Further, stellettin B downregulates Akt/Mammalian Target of Rapamycin (Akt/mTOR) and Signal transducer and activator of transcription 3 (Stat3) signaling pathways, which are essential for invasion and angiogenesis in glioblastoma...
February 14, 2019: Cancers
https://read.qxmd.com/read/30767357/a-concise-modular-antibody-oligonucleotide-conjugation-strategy-based-on-disuccinimidyl-ester-activation-chemistry
#10
Gang Li, Raymond Moellering
Synthesis of antibody-oligonucleotide conjugates has enabled the development of highly sensitive bioassays for specific epitopes in the laboratory and clinic. Most synthetic schemes to generate these hybrid molecules require expensive reagents, significant quantities of input antibody, and multi-step purification routes, thus limiting widespread application. Here we report a facile and robust conjugation strategy that involves "plug-and-play" antibody conjugation with succinimidyl-functionalized oligonucleotides, which are high-yielding and compatible for use directly after buffer exchange...
February 14, 2019: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/30765958/punctal-plug-as-a-treatment-option-for-dry-eye-associated-with-congenital-supernumary-puncta
#11
Alicia Galindo-Ferreiro, Laila AlGhafri, Patricia Akaishi, Alberto Galvez-Ruiz, Julio Galindo-Alonso, Silvana Schellini, Augusto Cruz
This study aims to describe a case of double lower lacrimal punctum-canaliculi in a dry eye patient treated with a punctal plug. A 60-year-old healthy female presented with complaints of tearing, itchy eyes, and foreign body sensation in the right eye for many years. There was no history of trauma or inflammation. Two patent independent supernumerary puncta and canaliculi were present on the right lower eyelid. The Schirmer Test II (with anesthesia) was zero, the tear breakup time was 2 s, and superficial punctate erosions were present in the right eye...
July 2018: Middle East African Journal of Ophthalmology
https://read.qxmd.com/read/30765182/ct-evaluation-of-hyperattenuating-mucus-to-diagnose-allergic-bronchopulmonary-aspergillosis-in-the-special-condition-of-cystic-fibrosis
#12
John Refait, Julie Macey, Stephanie Bui, Michaël Fayon, Patrick Berger, Laurence Delhaes, François Laurent, Gaël Dournes
BACKGROUND: Mucus plugging (MP), central bronchiectasis (CB), and consolidation/atelectasia (CA) are conventional CT signs to diagnose allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Hyperattenuating mucus (HAM) has recently been described and may improve diagnostic accuracy. The goal of our study was to compare HAM versus conventional CT signs to diagnose ABPA in CF. Secondary objectives were to determine the optimal threshold of HAM quantitatively and to assess the diagnostic value of HAM using chest radiograph (CXR)...
February 12, 2019: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/30763871/application-of-iron-crosslinked-sodium-alginate-for-efficient-sulfide-control-and-reduction-of-oilfield-produced-water
#13
Jun Wu, Raymond Jianxiong Zeng, Fang Zhang, Zhiguo Yuan
Sulfide production and oilfield produced water are considered as environmental challenges in the oil industry. Iron-crosslinked sodium alginate (SA-Fe) was used to address these problems simultaneously. A pair of columns containing one coarse-sand column and one fine-sand column was designed to simulate heterogeneous rock layers and evaluate the plugging effect of SA-Fe. Generation of FeS precipitates led to decreases of sulfide in the gas phase by 45 ± 3.2% and in the aqueous solution by 75 ± 4.7%...
January 31, 2019: Water Research
https://read.qxmd.com/read/30761000/tmem16a-in-cystic-fibrosis-activating-or-inhibiting
#14
REVIEW
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although CF pathogenesis is still disputed, activation of alternative Cl- channels is assumed to improve lung function in CF. Two suitable non-CFTR Cl- channels are present in the airway epithelium, the Ca2+ activated channel TMEM16A and SLC26A9...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30760958/patterned-surface-charges-coupled-with-thermal-gradients-may-create-giant-augmentations-of-solute-dispersion-in-electro-osmosis-of-viscoelastic-fluids
#15
Siddhartha Mukherjee, Jayabrata Dhar, Sunando DasGupta, Suman Chakraborty
Augmenting the dispersion of a solute species and fluidic mixing remains a challenging proposition in electrically actuated microfluidic devices, primarily due to an inherent plug-like nature of the velocity profile under uniform surface charge conditions. While a judicious patterning of surface charges may obviate some of the concerning challenges, the consequent improvement in solute dispersion may turn out to be marginal. Here, we show that by exploiting a unique coupling of patterned surface charges with intrinsically induced thermal gradients, it may be possible to realize giant augmentations in solute dispersion in electro-osmotic flows...
January 2019: Proceedings. Mathematical, Physical, and Engineering Sciences
https://read.qxmd.com/read/30759072/survival-in-a-bad-neighborhood-pancreatic-islets-in-cystic-fibrosis
#16
REVIEW
Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt, Rebecca L Hull
In cystic fibrosis (CF), ductal plugging and acinar loss result in rapid decline of exocrine pancreatic function. This destructive process results in remodeled islets, with only a modest reduction in insulin producing β cells. However, β-cell function is profoundly impaired, with decreased insulin release and abnormal glucose tolerance being present even in infants with CF. Ultimately, roughly half of CF subjects develop diabetes (termed CF-related diabetes, CFRD). Importantly, CFRD increases CF morbidity and mortality via worsening catabolism and pulmonary disease...
February 1, 2019: Journal of Endocrinology
https://read.qxmd.com/read/30747015/-plugged-in
#17
John G Nolan, Matthew Vestal, Scellig Stone, Linda R Dagi
No abstract text is available yet for this article.
February 12, 2019: Orbit
https://read.qxmd.com/read/30746263/preventing-mucus-plugging-in-invasively-ventilated-intensive-care-unit-patients-routine-or-personalized-care-and-primum-non-nocere
#18
COMMENT
Willemke Stilma, Marcus J Schultz, Frederique Paulus
No abstract text is available yet for this article.
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30746010/embolization-of-head-and-neck-vascular-malformations-using-serial-arterial-embolization-followed-by-dominant-arterial-embolization-with-two-microcatheter-technique
#19
David Case, Zach Folzenlogen, Paul Rochon, David Kumpe, Christopher Roark, Joshua Seinfeld
Purpose: Head and neck arteriovenous malformation (AVM) and fistulae treatment without reflux and with nidal penetration are challenging. We describe a case series including adult and pediatric patients utilizing a specific two-microcatheter technique using Onyx with strategic embolization of small feeding branches prior to dominant branch embolization. We aim to demonstrate the safety and efficacy of this technique. Methods: <AbstractText Label="Patient Selection" NlmCategory="UNASSIGNED">Head and neck vascular malformation cases were reviewed from 2010 to 2017...
November 2018: Journal of Vascular and Interventional Neurology
https://read.qxmd.com/read/30745100/assessment-of-masticatory-performance-by-geometric-measurement-of-the-mixing-ability-with-2-color-chewing-gum
#20
Yaman Yousof, Nosizana M Salleh, Farazila Yusof
STATEMENT OF PROBLEM: The 2-color mixing ability test has been recently introduced for objective assessment of masticatory performance. However, the ideal bicolor specimens have not yet been identified, and the color analysis of digital images requires improvement. PURPOSE: The purpose of this clinical study was to formulate a custom-made, 2-color chewing gum for the mixing ability test and to develop an image-processing method for color mixing analysis. MATERIAL AND METHODS: Specimens of red-green (RG) chewing gum were prepared as a test food...
February 8, 2019: Journal of Prosthetic Dentistry
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