Keilian MacCulloch, Austin Browning, David O Guarin Bedoya, Stephen J McBride, Mustapha B Abdulmojeed, Carlos Dedesma, Boyd M Goodson, Matthew S Rosen, Eduard Y Chekmenev, Yi-Fen Yen, Patrick TomHon, Thomas Theis
Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude. SABRE has received significant attention in the scientific community since its inception because of its relative experimental simplicity and its broad applicability to a wide range of molecules, however in vivo detection of molecular probes hyperpolarized by SABRE has remained elusive...
December 2023: Journal of Magnetic Resonance Open