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Cancer, Stem cell, Anemia, Platelet, Thrombosis

Hans Carl Hasselbalch
Myelofibrosis with myeloid metaplasia (MMM) is the end stage of the Philadelphia-negative chronic myeloproliferative disorders, the classical clinical phenotype being featured by leukoerythroblastic anemia, bone marrow fibrosis and enlargement of the spleen and liver. In the early prefibrotic phase a proportion of the patients may be wrongly classified as having essential thrombocythemia (ET). Some patients with ET may also develop polycythemia vera (PV) and without a history of phlebotomies patients with primary myelofibrosis (PMF) are indistinguishable from those patients developing myelofibrosis during the course of polycythemia vera...
January 2009: Leukemia Research
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