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Thomas Longerich, Volker Endris, Olaf Neumann, Eugen Rempel, Martina Kirchner, Zahra Abadi, Sebastian Uhrig, Mark Kriegsmann, Karl Heinz Weiss, Kai Breuhahn, Arianeb Mehrabi, Tim Frederik Weber, Ludwig Wilkens, Beate K Straub, Andreas Rosenwald, Falko Schulze, Benedikt Brors, Stefan Froehling, Rossella Pellegrino, Jan Budczies, Peter Schirmacher, Albrecht Stenzinger
OBJECTIVE: We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN: Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational status of the CTNNB1 gene was determined in ß-catenin-activated HCA (b-HCA) and HCC with at least moderate nuclear CTNNB1 accumulation. Ultra-deep sequencing was used to characterise CTNNB1 wild-type and ß-catenin-activated HCA and HCC...
February 2, 2019: Gut
Angela Schulz, Nicola Victoria Müller, Nina Anne van de Lest, Andreas Eisenreich, Martina Schmidbauer, Andrei Barysenka, Bettina Purfürst, Anje Sporbert, Theodor Lorenzen, Alexander M Meyer, Laura Herlan, Anika Witten, Frank Rühle, Weibin Zhou, Emile de Heer, Marion Scharpfenecker, Daniela Panáková, Monika Stoll, Reinhold Kreutz
Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next generation sequencing, and compartment-specific RNA sequencing analysis in isolated glomeruli. This led to prioritization of transmembrane protein Tmem63c as a novel potential target...
March 22, 2019: ELife
Nadja P Maric, Sanja Andric Petrovic, Martina Rojnic-Kuzman, Anita Riecher-Rössler
AIM: Unequal development of early detection (ED) and early intervention (EI) programs/services for psychosis has been shown across Europe. The present report aims to fill in the knowledge gap regarding the implementation and several other important aspects of ED/EI services in Central and Eastern Europe (CEE), a region with highly underdeveloped mental health service research. METHODS: A 17-item questionnaire was created to address the information regarding ED/EI organization and factors limiting their implementation...
March 22, 2019: Early Intervention in Psychiatry
Martina S Ragettli, Martin Röösli
Since the record-breaking temperatures registered during summer 2003, cantonal health authorities in Switzerland have implemented measures to prevent adverse health effects from hot weather and heatwaves. Six cantons in the west of Switzerland and the canton of Ticino have developed heat-health action plans. Such plans integrate and coordinate the actions at different levels among predefined partners. Measures include the communication of health risks, alert systems, and special actions during heatwaves.This report provides an overview of health strategies and analyses of heat-related mortality in Switzerland between 2004 and 2015...
March 21, 2019: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Till Eichenauer, Mohammad Hussein, Claudia Hube-Magg, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Stefan Steurer, Till S Clauditz, Andreas M Luebke, Eike Burandt, Waldemar Wilczak, Andrea Hinsch, David Dum, Burkhard Beyer, Thomas Steuber, Hartwig Huland, Markus Graefen, Ronald Simon, Guido Sauter, Nathaniel Melling, Thorsten Schlomm, Sarah Minner
Glycogen synthase kinase 3ß (GSK3ß) regulates many cancer relevant cellular processes and represents a potential therapeutic target. GSK3ß overexpression has been linked to adverse tumor features in many cancers, but its role in prostate cancer remains uncertain. We employed immunohistochemical GSK3ß expression analysis on a tissue microarray with 12,427 prostate cancers. Cytoplasmic and nuclear GSK3ß staining was separately analyzed. GSK3ß staining was absent in normal prostate epithelium, whereas 57% of 9,164 interpretable cancers showed detectable GSK3ß expression...
March 1, 2019: Oncotarget
Michael J Halaska, Catherine Uzan, Sileny N Han, Robert Fruscio, Karina Dahl Steffensen, Ben Van Calster, Hana Stankusova, Martina Delle Marchette, Astrid Mephon, Roman Rouzier, Petronella O Witteveen, Patrizia Vergani, Kristina Van Calsteren, Lukas Rob, Frederic Amant
BACKGROUND: Treatment of cervical cancer during pregnancy is often complex and challenging. This study aimed to analyze current patterns of practice in the management of pregnant patients diagnosed with cervical cancer. METHODS: This was a matched cohort study comprising patients managed for cervical cancer during pregnancy from six European centers. Patient information was retrieved from the dataset of the International Network for Cancer, Infertility and Pregnancy from 1990 to 2012...
March 20, 2019: International Journal of Gynecological Cancer
Petra Tomášová, Martina Čermáková, Helena Pelantová, Marek Vecka, Helena Kratochvílová, Michal Lipš, Jaroslav Lindner, Blanka Šedivá, Martin Haluzík, Marek Kuzma
Analysis of bioactive lipids in adipose tissue could lead to better understanding of the pathogenesis of obesity and its complications. However, current MS methods are limited by a high content of triacylglycerols (TAGs), which markedly surpasses the amount of other lipids and suppresses their ionization. The aim of our study was thus to optimize the preanalytical phase of lipid analysis in adipose tissue, focusing in particular on less-abundant lipids. Next, the optimized method was used to describe the differences between epicardial and subcutaneous adipose tissues obtained from patients undergoing cardiac surgery...
March 12, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Axel Ducret, Ian James, Sabine Wilson, Martina Feilke, Andreas Tebbe, Nikolaj Dybowski, Sarah Elschenbroich, Martin Klammer, Adele Blackler, Wei-Li Liao, Yuan Tian, Thomas Friess, Birgit Bossenmaier, Gabriele Dietmann, Christoph Schaab, Todd Hembrough, Maurizio Ceppi
Human protein biomarker discovery relies heavily on pre-clinical models, in particular established cell lines and patient-derived xenografts, but confirmation studies in primary tissue are essential to demonstrate clinical relevance. We describe in this study the process that was followed to clinically translate a 5-protein response signature predictive for the activity of an anti-HER3 monoclonal antibody (lumretuzumab) originally measured in fresh frozen xenograft tissue. We detail the development, qualification, and validation of the multiplexed targeted mass spectrometry assay used to assess the signature performance in formalin-fixed, paraffin-embedded human clinical samples collected in a phase Ib trial designed to evaluate lumretuzumab in patients with metastatic breast cancer...
2019: PloS One
Luca Cabrini, Martina Baiardo Redaelli, Lorenzo Ball, Martina Filippini, Evgeny Fominskiy, Margherita Pintaudi, Alessandro Putzu, Carmine D Votta, Massimiliano Sorbello, Massimo Antonelli, Giovanni Landoni, Paolo Pelosi, Alberto Zangrillo
Awake fiberoptic intubation is one of the recommended strategies for surgical patients with anticipated difficult airway, especially when concurrent difficult ventilation is expected. We performed the first systematic review of randomized controlled trials assessing different protocols for awake fiberoptic intubation in anticipated difficult airway, including studies investigating elective awake fiberoptic intubation for scheduled surgery; randomized controlled trials comparing different methods for performing awake fiberoptic intubation; and adult patients with anticipated difficult airway...
March 20, 2019: Anesthesia and Analgesia
Christina M Meade, Martina Badell, Stephanie Hackett, C Christina Mehta, Lisa B Haddad, Andres Camacho-Gonzalez, Joy Ford, Marcia M Holstad, Wendy S Armstrong, Anandi N Sheth
Introduction: While increased healthcare engagement and antiretroviral therapy (ART) adherence occurs during pregnancy, women living with HIV (WLWH) are often lost to follow-up after delivery. We sought to evaluate postpartum retention in care and viral suppression and to identify associated factors among WLWH in a large public hospital in Atlanta, Georgia. Methods: Data from the time of entry into prenatal care until 24 months postpartum were collected by chart review from WLWH who delivered with ≥20 weeks gestational age from 2011 to 2016...
2019: Infectious Diseases in Obstetrics and Gynecology
Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, Cristina Paissoni, Paola Rognoni, Martina Maritan, Francesca Brambilla, Paolo Milani, Pierluigi Mauri, Carlo Camilloni, Giovanni Palladini, Giampaolo Merlini, Stefano Ricagno, Martino Bolognesi
Systemic light chain amyloidosis (AL)  is a life-threatening disease caused by aggregation and deposition of monoclonal immunoglobulin light chains (LC) in target organs. Severity of heart involvement is the most important factor determining prognosis. Here, we report the 4.0 Å resolution cryo-electron microscopy map and molecular model of amyloid fibrils extracted from the heart of an AL amyloidosis patient with severe amyloid cardiomyopathy. The helical fibrils are composed of a single protofilament, showing typical 4...
March 20, 2019: Nature Communications
Gernot F Grabner, Nermeen Fawzy, Maria Pribasnig, Markus Trieb, Ulrike Taschler, Michael Holzer, Martina Schweiger, Heimo Wolinski, Dagmar Kolb, Angela Horvath, Rolf Breinbauer, Thomas Ruelicke, Roland Rabl, Achim Lass, Vanessa Stadlbauer, Birgit Hutter-Paier, Rudolf E Stauber, Peter Fickert, Rudolf Zechner, Gunther Marsche, Thomas O Eichmann, Robert Zimmermann
Bis(monoacylglycerol)phosphate (BMP) is a phospholipid crucial for lipid degradation and sorting in acidic organelles. Genetic and drug-induced lysosomal storage disorders (LSD) are associated with increased BMP concentrations in tissues and in the circulation. Data on BMP in disorders other than LSD, however, are scarce and key enzymes regulating BMP metabolism remain elusive. Here, we demonstrate that common metabolic disorders and the intracellular BMP hydrolase alpha/beta hydrolase domain containing 6 (ABHD6) affect BMP metabolism in mice and humans...
March 20, 2019: Journal of Lipid Research
Francesco Santopaolo, Ilaria Lenci, Alessandra Bosa, Mario Angelico, Martina Milana, Leonardo Baiocchi
BACKGROUND: Domino transplant occurs when a recipient explanted graft could be then used for a second recipient. INTRODUCTION: The first experience came from thoracic surgery by the observation that many patients during heart-lung transplantation actually showed a functional heart that could be employed in other subjects with a good result. RESULTS: This concept was then extended in the field of liver transplantation. At present, some patients transplanted for inborn metabolic disease may be considered as excellent domino liver donors...
March 20, 2019: Reviews on Recent Clinical Trials
Clothilde Comby-Zerbino, Martina Perić, Franck Bertorelle, Fabien Chirot, Philippe Dugourd, Vlasta Bonačić-Koutecký, Rodolphe Antoine
Thiolate-protected metal nanoclusters have highly size- and structure-dependent physicochemical properties and are a promising class of nanomaterials. As a consequence, for the rationalization of their synthesis and for the design of new clusters with tailored properties, a precise characterization of their composition and structure at the atomic level is required. We report a combined ion mobility-mass spectrometry approach with density functional theory (DFT) calculations for determination of the structural and optical properties of ultra-small gold nanoclusters protected by thioglycolic acid (TGA) as ligand molecules, Au10 (TGA)10 ...
March 19, 2019: Nanomaterials
Özgür Albayrak, Wilfried Pott, Johannes Hebebrand, Martina de Zwaan, Ursula Pauli-Pott
OBJECTIVE: Current lifestyle interventions for children and adolescents with obesity often exclude patients with an eating pathology, leaving the impact of eating pathologies on treatment outcomes largely unconsidered. We investigated the predictive value of disordered eating symptoms on BMI z-score reduction in a sample of 111 German children and adolescents with overweight (90th percentile ≤ BMI < 97th percentile) and obesity (BMI > 97th percentile) aged 7-15 years in an outpatient lifestyle intervention program...
March 20, 2019: Obesity Facts
Anna Maria Orani, Emilia Vassileva, Christophe Renac, Sabine Schmidt, Michael O Angelidis, Martina Rozmaric, Deon Louw
Trace elements (TEs), Rare Earth Elements (REEs) and Pb isotope ratios were determined in six small cores sampled along the Namibian coast and different indices, such as Enrichment Factor, Geo-accumulation Index and Pollution load index, were calculated to evaluate possible metal contamination in the area. Concentrations of Pb, Cu, As and Cd were strongly enhanced at the upper 7 cm of core C5, which is located at Walvis Bay, at the major harbor and urban/industrial center of Namibia, indicating the impact from the recent anthropogenic activities...
March 6, 2019: Science of the Total Environment
Benjamin Ascher, Berthold Rzany, Philippe Kestemont, Said Hilton, Marc Heckmann, Isaac Bodokh, Ernst Magnus Noah, Dominique Boineau, Martina Kerscher, Magali Volteau, Philippe Le Berre, Philippe Picaut
BACKGROUND: Safety and efficacy of botulinum toxin A for glabellar line (GL) treatment are well established. Currently approved formulations require reconstitution before injection. OBJECTIVE: The authors sought to assess 6-month efficacy, safety, and patient satisfaction of new ready-to-use abobotulinumtoxinA solution for injection (ASI) in patients with moderate-to-severe GL at maximum frown. METHODS: The authors conducted a phase 3, double-blind, randomized, placebo-controlled trial (NCT02353871)...
March 20, 2019: Aesthetic Surgery Journal
Saori Mukaida, Masaaki Sato, Anette I Oberg, Nodi Dehvari, Jessica M Olsen, Martina Kocan, Michelle Louise Halls, Jon Merlin, Anna L Sandstrom, Robert I Csikasz, Bronwyn Anne Evans, Roger James Summers, Dana Sabine Hutchinson, Tore Bengtsson
The type 2 diabetes epidemic makes it important to find insulin independent ways to improve glucose homeostasis. This study examines the mechanisms activated by a dual β2 -/β3 -adrenoceptor agonist BRL37344 to increase glucose uptake in skeletal muscle, and its effects on glucose homeostasis in vivo. We measured the effect of BRL37344 on glucose uptake, GLUT4 translocation, cAMP levels, β2 -adrenoceptor desensitization, β-arrestin recruitment, Akt, AMPK and mTOR phosphorylation using L6 skeletal muscle cells as a model...
March 20, 2019: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Stefania Perrotta, Rosaria Bucci, Vittorio Simeon, Stefano Martina, Ambra Michelotti, Rosa Valletta
BACKGROUND: The prevalence of malocclusion, temporomandibular disorders, oral parafunctions is highly debated in children population. OBJECTIVES: To investigate the prevalence of malocclusion, self-reported oral parafunctions and temporomandibular disorder-pain in Italian schoolchildren, and to assess the association between the examined factors. METHODS: 700 children aged 9-11 years old were selected among six public Schools in Campania region(Italy)...
March 20, 2019: Journal of Oral Rehabilitation
Sara Ballabio, Ilaria Craparotta, Lara Paracchini, Laura Mannarino, Silvia Corso, Maria Grazia Pezzotta, Martina Vescio, Robert Fruscio, Chiara Romualdi, Emanuele Dainese, Lorenzo Ceppi, Enrica Calura, Silvana Pileggi, Giulia Siravegna, Linda Pattini, Paolo Martini, Martina Delle Marchette, Costantino Mangioni, Antonio Ardizzoia, Antonio Pellegrino, Fabio Landoni, Maurizio D'Incalci, Luca Beltrame, Sergio Marchini
High grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and inter patient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the genome of all tumor cells across the different anatomically districts. This knowledge is the first step to reveal those molecular determinants that characterize the tumor biology of HGS-EOC and their route towards malignancy...
March 20, 2019: International Journal of Cancer. Journal International du Cancer
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