Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C Morris, Suzanne E Schindler, Anne M Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S Perlmutter, Laura Ibanez, Richard J Perrin, Yun Ju Sung, Carlos Cruchaga
Common and rare variants in the LRRK2 locus are associated with Parkinson's disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7006 aptamers (6138 unique proteins) in 3107 individuals). The dataset comprised six different and independent cohorts (five using the SomaScan7K (ADNI, DIAN, MAP, Barcelona-1 (Pau), and Fundació ACE (Ruiz)) and the PPMI cohort using the SomaScan5K panel)...
July 8, 2023: NPJ Parkinson's Disease