keyword
https://read.qxmd.com/read/38104147/prediction-of-dyskinesia-in-parkinson-s-disease-patients-using-machine-learning-algorithms
#21
JOURNAL ARTICLE
Denisson Augusto Bastos Leal, Carla Michele Vieira Dias, Rodrigo Pereira Ramos, Ivani Brys
Dyskinesias are non preventable abnormal involuntary movements that represent the main challenge of the long term treatment of Parkinson's disease (PD) with the gold standard dopamine precursor levodopa. Applying machine learning techniques on the data extracted from the Parkinson's Progression Marker Initiative (PPMI, Michael J. Fox Foundation), this study was aimed to identify PD patients who are at high risk of developing dyskinesias. Data regarding clinical, behavioral and neurological features from 697 PD patients were included in our study...
December 16, 2023: Scientific Reports
https://read.qxmd.com/read/38085250/cortical-gray-matter-and-cerebral-white-matter-atrophy-and-asymmetry-in-parkinson-s-disease-patients-with-normal-cognitive-precede
#22
JOURNAL ARTICLE
Amirreza Jahanshahi, Nahideh Ghareaghaji, Samaneh Hassanpour, Ali Vafadar, Saeid Mousavi, Davood Khezerloo
BACKGROUND: Parkinson's disease is the second most common neurodegenerative disorder with complex and distributed motor and non-motor symptoms. In this study, cortical gray matter (GM) and cerebral white matter (WM) overall atrophy, and asymmetry of atrophy are investigated in PD with normal cognitive function. METHOD: Forty-eight male Parkinson's disease(PD) patients with normal cognitive precede (PD-NC), and thirty matched healthy control (HC) subjects were selected from the Parkinson's Progression Markers Initiative (PPMI) database...
December 12, 2023: International Journal of Neuroscience
https://read.qxmd.com/read/38083460/comparison-of-anatomical-and-diffusion-mri-for-detecting-parkinson-s-disease-using-deep-convolutional-neural-network
#23
JOURNAL ARTICLE
Tamoghna Chattopadhyay, Amit Singh, Emily Laltoo, Christina P Boyle, Conor Owens-Walton, Yao-Liang Chen, Philip Cook, Corey McMillan, Chih-Chien Tsai, J-J Wang, Yih-Ru Wu, Ysbrand van der Werf, Paul M Thompson
Parkinson's disease (PD) is a progressive neurodegenerative disease that affects over 10 million people worldwide. Brain atrophy and microstructural abnormalities tend to be more subtle in PD than in other age-related conditions such as Alzheimer's disease, so there is interest in how well machine learning methods can detect PD in radiological scans. Deep learning models based on convolutional neural networks (CNNs) can automatically distil diagnostically useful features from raw MRI scans, but most CNN-based deep learning models have only been tested on T1-weighted brain MRI...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38083250/a-reliable-subtyping-of-de-novo-parkinson-disease-biomarkers-medication-effects-and-longitudinal-progression
#24
JOURNAL ARTICLE
Chaoliang Sun, Hengxi Xu, Yuanchao Zhang, Yu Zhang
Divergent clinical symptoms and pathological progression suggest multiple subtypes of Parkinson disease (PD). Here, we proposed a reliable PD subtyping approach that quantifies the disturbance of an individual patient to the reference structural covariance networks derived from healthy controls. We revealed two subtypes of de novo PD patients by using longitudinal data from the PPMI dataset. Compared to the conventional clinical TD/PIGD phenotypes, our subtyping was highly stable in 5 years' visits. The two subtypes of PD showed significant differences in motor symptoms, medication effects, CSF biomarkers, and longitudinal progression...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38077616/optimized-mobilenetv3-a-deep-learning-based-parkinson-s-disease-classification-using-fused-images
#25
JOURNAL ARTICLE
Sukanya Pechetti, Battula Srinivasa Rao
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is a progressive neurological condition that manifests motor and non-motor symptoms. Early in the course of the disease, PD patients frequently experience vocal difficulties. In the beginning, preprocessing procedures were used with multi-focus image fusion to enhance the quality of input images. It is essential to diagnose and treat PD early to ensure that patients live healthy and productive lives. METHODS: Tremors, rigidity in the muscles, slow movement, difficulty balance, and other psychological symptoms are some of the disease's symptoms...
2023: PeerJ. Computer Science
https://read.qxmd.com/read/38070251/membranous-septum-length-predicts-new-conduction-abnormalities-in-surgical-aortic-valve-replacement-a-novel-predictor-for-permanent-pacemaker-implantation-after-surgical-aortic-valve-replacement
#26
JOURNAL ARTICLE
Makoto Nakashima, Hasan Jilaihawi, Yuxin He, David Williams, Illya Pushkar, Mathew Williams, Kazuhiro Hisamoto
INTRODUCTION: The membranous septum (MS) length measured by cardiac computed tomography (CT) is useful for the prediction of permanent pacemaker implantation (PPMI) and new left bundle branch block (LBBB) after transcatheter aortic valve replacement. However, its predictive value for patients undergoing surgical aortic valve replacement (SAVR) is unknown. METHODS: A total of 2531 consecutive patients were registered in the institutional Society of Thoracic Surgeons database between July 2017 and June 2020...
December 8, 2023: Journal of Surgical Research
https://read.qxmd.com/read/38031415/regulation-of-expression-quantitative-trait-loci-by-sva-retrotransposons-within-the-major-histocompatibility-complex
#27
JOURNAL ARTICLE
Jerzy K Kulski, Abigail L Pfaff, Luke D Marney, Alexander Fröhlich, Vivien J Bubb, John P Quinn, Sulev Koks
Genomic and transcriptomic studies of expression quantitative trait loci (eQTL) revealed that SINE-VNTR-Alu (SVA) retrotransposon insertion polymorphisms (RIPs) within human genomes markedly affect the co-expression of many coding and noncoding genes by coordinated regulatory processes. This study examined the polymorphic SVA modulation of gene co-expression within the major histocompatibility complex (MHC) genomic region where more than 160 coding genes are involved in innate and adaptive immunity. We characterized the modulation of SVA RIPs utilizing the genomic and transcriptomic sequencing data obtained from whole blood of 1266 individuals in the Parkinson's Progression Markers Initiative (PPMI) cohort that included an analysis of human leukocyte antigen ( HLA ) -A regulation in a subpopulation of the cohort...
November 30, 2023: Experimental Biology and Medicine
https://read.qxmd.com/read/38029648/estimating-the-sequence-of-biomarker-changes-in-parkinson-s-disease
#28
JOURNAL ARTICLE
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
OBJECTIVE: To estimate the sequence of several common biomarker changes in Parkinson's disease (PD) using a novel data-driven method. METHODS: We included 374 PD patients and 169 healthy controls (HC) from the Parkinson's Progression Markers Initiative (PPMI). Biomarkers, including the left putamen striatal binding ratio (SBR), right putamen SBR, left caudate SBR, right caudate SBR, cerebrospinal fluid (CSF) α-synuclein, and serum neurofilament light chain (NfL), were selected in our study...
January 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38028447/impact-of-periprocedural-myocardial-injury-after-transcatheter-aortic-valve-implantation-on-long-term-mortality-a-meta-analysis-of-kaplan-meier-derived-individual-patient-data
#29
REVIEW
Mauricio Felippi de Sá Marchi, Pedro Calomeni, Mateus de Miranda Gauza, Gabriel Kanhouche, Lis Victória Ravani, Caio Vinicius Fernandes Rodrigues, Flávio Tarasoutchi, Fábio Sandoli de Brito, Josep Rodés-Cabau, Nicolas M Van Mieghem, Alexandre Abizaid, Henrique Barbosa Ribeiro
BACKGROUND: Periprocedural myocardial injury (PPMI) frequently occurs after transcatheter aortic valve implantation (TAVI), although its impact on long-term mortality is uncertain. METHODS: We performed a pooled analysis of Kaplan-Meier-derived individual patient data to compare survival in patients with and without PPMI after TAVI. Flexible parametric models with B-splines and landmark analyses were used to determine PPMI prognostic value. Subgroup analyses for VARC-2, troponin, and creatine kinase-MB (CK-MB)-defined PPMI were also performed...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38015310/taking-another-look-at-the-pornography-problems-due-to-moral-incongruence-model-does-gender-play-a-role
#30
JOURNAL ARTICLE
Nicholas C Borgogna, David A L Johnson, Michelle Shegedin, Kyle M Brasil
The pornography problems due to moral incongruence (PPMI) model is a premier framework for understanding problematic pornography use (PPU). However, past studies have generally examined men or entered gender as a covariate in primary analyses. Such approaches mask between-gender differences. Additionally, dysregulation constructs are also thought to be relevant to PPU, yet it is unclear the degree to which they incrementally predict PPU beyond moral incongruence constructs in non-pathological populations. We addressed these gaps by gathering a large sample of college students (n = 295 men, n = 838 women)...
November 28, 2023: Archives of Sexual Behavior
https://read.qxmd.com/read/37965163/free-water-imaging-unravels-unique-patterns-of-longitudinal-structural-brain-changes-in-parkinson-s-disease-subtypes
#31
JOURNAL ARTICLE
Abigail E Bower, Sophia J Crisomia, Jae Woo Chung, Justin P Martello, Roxana G Burciu
BACKGROUND: Research shows that individuals with Parkinson's disease (PD) who have a postural instability and gait difficulties (PIGD) subtype have a faster disease progression compared to those with a tremor dominant (TD) subtype. Nevertheless, our understanding of the structural brain changes contributing to these clinical differences remains limited, primarily because many brain imaging techniques are only capable of detecting changes in the later stages of the disease. OBJECTIVE: Free water (FW) has emerged as a robust progression marker in several studies, showing increased values in the posterior substantia nigra that predict symptom worsening...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37954645/motor-subtypes-and-clinical-characteristics-in-sporadic-and-genetic-parkinson-s-disease-groups-analysis-of-the-ppmi-cohort
#32
JOURNAL ARTICLE
Eun Hye Jeong, Jae Yong Lee, Sun-Ku Han, Yoo Sung Song
INTRODUCTION: The extensive clinical variations observed in Parkinson's disease (PD) pose challenges in early diagnosis and treatment initiation. However, genetic research in PD has significantly transformed the clinical approach to its treatment. Moreover, researchers have adopted a subtyping strategy based on homogeneous clinical symptoms to improve clinical diagnosis and treatment approaches. We conducted a study to explore clinical characteristics in genetic PD groups with motor symptom subtyping...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37953806/cerebrospinal-fluid-biomarkers-profile-in-scans-without-evidence-of-dopaminergic-deficits-swedd
#33
JOURNAL ARTICLE
Fardin Nabizadeh, Sara KamaliZonouzi, Maryam Noori
BACKGROUND: A small proportion of patients with clinical parkinsonism have normal transporter-single photon emission computed tomography (DaTSPECT) which is commonly defined as scans without evidence of dopaminergic deficits (SWEDD). A better understanding of SWEDD can improve the current therapeutic options and appropriate disease monitoring. AIM: We aimed to assess CSF biomarkers levels including α-synuclein (α-syn), amyloid βeta (Aβ1-42), total tau (t-tau), and phosphorylated tau (p-tau) in SWEDD and investigate the longitudinal alteration in the CSF profile...
December 2023: IBRO neuroscience reports
https://read.qxmd.com/read/37946156/prediction-of-lncrna-functions-using-deep-neural-networks-based-on-multiple-networks
#34
JOURNAL ARTICLE
Lei Deng, Shengli Ren, Jingpu Zhang
BACKGROUND: More and more studies show that lncRNA is widely involved in various physiological processes of the organism. However, the functions of the vast majority of them continue to be unknown. In addition, data related to lncRNAs in biological databases are constantly increasing. Therefore, it is quite urgent to develop a computing method to make the utmost of these data. RESULTS: In this paper, we propose a new computational method based on global heterogeneous networks to predict the functions of lncRNAs, called DNGRGO...
November 9, 2023: BMC Genomics
https://read.qxmd.com/read/37923936/baseline-prevalence-and-longitudinal-assessment-of-autonomic-dysfunction-in-early-parkinson-s-disease
#35
JOURNAL ARTICLE
Lanqing Yang, Huan Gao, Min Ye
Autonomic dysfunction (AutD) is common and debilitating in Parkinson's disease (PD). Predictors of AutD are unclear, and data are limited on the biological relevance of AutD in PD. Here, we evaluated the baseline prevalence and 2-year longitudinal assessment of AutD in patients with de novo PD compared with healthy controls (HC). Moreover, we also assessed various variables that could predict longitudinal changes in AutD in early PD. Parkinson's Progression Markers Initiative (PPMI) was utilized to evaluate untreated PD participants at baseline and HC...
November 4, 2023: Journal of Neural Transmission
https://read.qxmd.com/read/37891792/magnetic-resonance-imaging-biomarkers-of-punding-in-parkinson-s-disease
#36
JOURNAL ARTICLE
Chenglu Mao, Yang Zhang, Jialiu Jiang, Ruomeng Qin, Qing Ye, Xiaolei Zhu, Jiayong Wu
Punding is a rare condition triggered by dopaminergic therapy in Parkinson's disease (PD), characterized by a complex, excessive, repetitive, and purposeless abnormal movement, and its pathogenesis remains unclear. We aimed to assess the brain structure alterations related to punding by using multipametric magnetic resonance imaging (MRI). Thirty-eight PD patients (19 with punding and 19 without punding) from the Parkinson's Progression Marker Initiative (PPMI) were included in this study. Cortical thickness was assessed with FreeSurfer, and the integrity of white matter fiber tracts and network topologies were analyzed by using FMRIB Software Library (FSL) and Pipeline for Analyzing braiN Diffusion imAges (PANDA)...
October 7, 2023: Brain Sciences
https://read.qxmd.com/read/37882495/a-water-soluble-conjugated-polyelectrolyte-for-selective-and-sensitive-detection-of-carcinogenic-chromium-vi
#37
JOURNAL ARTICLE
Arvin Sain Tanwar, Mst Nasima Khatun, Moirangthem Anita Chanu, Tapashi Sarmah, Yeon-Ho Im, Parameswar Krishnan Iyer
Environmental water pollution caused by hexavalent chromium (Cr(VI)) is a threat to living beings due to its carcinogenic nature. Herein, we report the synthesis of a highly fluorescent water-soluble conjugated polyelectrolyte PPMI and its application as a fluorescence sensor to monitor traces of carcinogenic Cr(VI) ions in water. PPMI was synthesized via the oxidative polymerization method followed by post-polymer functionalization. Fluorescent PPMI exhibited a photoluminescence quantum yield of 23.87 and displayed a rapid, very selective, and sensitive turn-off fluorescence signal in response to Cr(VI), with a significantly high quenching constant of 1...
October 26, 2023: Analyst
https://read.qxmd.com/read/37873396/salience-network-and-cognitive-impairment-in-parkinson-s-disease
#38
Brooke E Yeager, Hunter P Twedt, Joel Bruss, Jordan Schultz, Nandakumar S Narayanan
UNLABELLED: Parkinson's disease (PD) is a neurodegenerative disease with cognitive as well as motor impairments. While much is known about the brain networks leading to motor impairments in PD, less is known about the brain networks contributing to cognitive impairments. Here, we leveraged resting-state functional magnetic resonance imaging (rs-fMRI) data from the Parkinson's Progression Marker Initiative (PPMI) to examine network dysfunction in PD patients with cognitive impairment. We tested the hypothesis that cognitive impairments in PD involve altered connectivity of the salience network (SN), a key cortical network that detects and integrates responses to salient stimuli...
October 14, 2023: medRxiv
https://read.qxmd.com/read/37867011/anxiety-change-after-dopamine-therapy-in-parkinson-disease-is-independent-of-motor-improvement
#39
JOURNAL ARTICLE
Jared T Hinkle, Kelly A Mills, Christopher B Morrow, Gregory M Pontone
BACKGROUND: Several anxiety syndromes have been associated with Parkinson disease (PD), but their interactions with dopamine replacement therapy (DRT) and motor function dynamics are not completely understood. We sought to delineate how DRT impacts anxiety phenomenology in PD and whether these changes are dissociable from improved motoric function. METHODS: We compared anxiety responses to DRT in two cohorts: 1) a study of 200 PD participants who completed neuropsychiatric assessments before and after taking their dopaminergic medications ("On-Off"); 2) participants in the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort who completed the State-Trait Anxiety Inventory (STAI) at the time of DRT initiation and a subsequent study visit (n = 113, mean 8-month interval)...
February 2024: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37840928/crispr-deletion-of-a-sine-vntr-alu-sva_67-retrotransposon-demonstrates-its-ability-to-differentially-modulate-gene-expression-at-the-mapt-locus
#40
JOURNAL ARTICLE
Alexander Fröhlich, Lauren S Hughes, Ben Middlehurst, Abigail L Pfaff, Vivien J Bubb, Sulev Koks, John P Quinn
BACKGROUND: SINE-VNTR- Alu (SVA) retrotransposons are hominid-specific elements which have been shown to play important roles in processes such as chromatin structure remodelling and regulation of gene expression demonstrating that these repetitive elements exert regulatory functions. We have previously shown that the presence or absence of a specific SVA element, termed SVA_67, was associated with differential expression of several genes at the MAPT locus, a locus associated with Parkinson's Disease (PD) and frontotemporal dementia...
2023: Frontiers in Neurology
keyword
keyword
159932
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.