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https://read.qxmd.com/read/30762448/the-unique-effects-of-maternal-adhd-symptoms-and-emotion-dysregulation-on-parenting-behavior
#1
Kelsey E Woods, Heather Mazursky-Horowitz, Sharon R Thomas, Lea R Dougherty, Andrea Chronis-Tuscano
OBJECTIVE: Separate literatures have examined the associations between maternal ADHD symptoms and parenting and maternal emotion regulation (ER) and parenting. This study examined the effects of both maternal ADHD symptoms and ER on parenting. METHOD: This cross-sectional study used a multi-method evaluation of parenting behavior to examine the independent and interactive effects of maternal ADHD symptoms and ER on self-reported and observed parenting among 79 demographically diverse families of 5- to 10-year-old children...
February 14, 2019: Journal of Attention Disorders
https://read.qxmd.com/read/30665154/the-diagnostic-accuracy-of-high-resolution-ultrasound-in-screening-for-carpal-tunnel-syndrome-and-grading-its-severity-is-moderated-by-age
#2
Christos Moschovos, Georgios Tsivgoulis, Andreas Kyrozis, Apostolia Ghika, Persefoni Karachalia, Konstantinos Voumvourakis, Elisabeth Chroni
OBJECTIVE: To assess the effect of age on the accuracy of high-resolution ultrasound (HRUS) in the diagnosis and grading of carpal tunnel syndrome (CTS). METHODS: Patients with symptoms and signs of CTS (N = 527 wrists) were evaluated using electrodiagnostic studies (EDx) for CTS diagnosis and grading. Median nerve cross-sectional areas at carpal tunnel inlet (CSA) and at forearm level were measured by HRUS and the ratio of these values was calculated (WFR)...
March 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/30615783/brief-commentary-treating-pain-the-cannabis-conundrum
#3
Chester B Good, Natasha Parekh, Kavita Fischer, James Schuster, Chronis Manolis, William Shrank
No abstract text is available yet for this article.
January 8, 2019: Annals of Internal Medicine
https://read.qxmd.com/read/30609396/the-baf-and-prc2-complex-subunits-dpf2-and-eed-antagonistically-converge-on-tbx3-to-control-esc-differentiation
#4
Wensheng Zhang, Constantinos Chronis, Xi Chen, Heyao Zhang, Rapolas Spalinskas, Mercedes Pardo, Liangliang Chen, Guangming Wu, Zhexin Zhu, Yong Yu, Lu Yu, Jyoti Choudhary, Jennifer Nichols, Mana M Parast, Boris Greber, Pelin Sahlén, Kathrin Plath
BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ESC differentiation potential. Dpf2 co-occupies enhancers with Oct4, Sox2, p300, and the BAF subunit Brg1, and deleting Dpf2 perturbs ESC self-renewal, induces repression of Tbx3, and impairs mesendodermal differentiation without dramatically altering Brg1 localization. Mesendodermal differentiation can be rescued by restoring Tbx3 expression, whose distal enhancer is positively regulated by Dpf2-dependent H3K27ac maintenance and recruitment of pluripotency TFs and Brg1...
January 3, 2019: Cell Stem Cell
https://read.qxmd.com/read/30577748/comparison-of-reprogramming-factor-targets-reveals-both-species-specific-and-conserved-mechanisms-in-early-ipsc-reprogramming
#5
Kai Fu, Constantinos Chronis, Abdenour Soufi, Giancarlo Bonora, Miguel Edwards, Stephen T Smale, Kenneth S Zaret, Kathrin Plath, Matteo Pellegrini
BACKGROUND: Both human and mouse fibroblasts can be reprogrammed to pluripotency with Oct4, Sox2, Klf4, and c-Myc (OSKM) transcription factors. While both systems generate pluripotency, human reprogramming takes considerably longer than mouse. RESULTS: To assess additional similarities and differences, we sought to compare the binding of the reprogramming factors between the two systems. In human fibroblasts, the OSK factors initially target many more closed chromatin sites compared to mouse...
December 22, 2018: BMC Genomics
https://read.qxmd.com/read/30555219/generalization-of-an-early-intervention-for-inhibited-preschoolers-to-the-classroom-setting
#6
Matthew G Barstead, Christina M Danko, Andrea Chronis-Tuscano, Kelly A O'Brien, Robert J Coplan, Kenneth H Rubin
Considerable evidence has accumulated supporting transactional influences between early childhood behavioral inhibition (BI), parent-child and child-peer relationships, and the development of anxiety disorders in adolescence and adulthood. Drawing from this literature, the Turtle Program was designed to treat children high in BI by intervening at the level of both parents and peers. In this pilot study, we sought to determine whether benefits of participating in the Turtle Program extended to children's classrooms in the form of increased positive social interactions with peers...
2018: Journal of Child and Family Studies
https://read.qxmd.com/read/30527662/promoter-enhancer-communication-occurs-primarily-within-insulated-neighborhoods
#7
Fei Sun, Constantinos Chronis, Michael Kronenberg, Xiao-Fen Chen, Trent Su, Fides D Lay, Kathrin Plath, Siavash K Kurdistani, Michael F Carey
Metazoan chromosomes are sequentially partitioned into topologically associating domains (TADs) and then into smaller sub-domains. One class of sub-domains, insulated neighborhoods, are proposed to spatially sequester and insulate the enclosed genes through self-association and chromatin looping. However, it has not been determined functionally whether promoter-enhancer interactions and gene regulation are broadly restricted to within these loops. Here, we employed published datasets from murine embryonic stem cells (mESCs) to identify insulated neighborhoods that confine promoter-enhancer interactions and demarcate gene regulatory regions...
November 14, 2018: Molecular Cell
https://read.qxmd.com/read/30526188/predictors-of-receipt-of-school-services-in-a-national-sample-of-youth-with-adhd
#8
George J DuPaul, Andrea Chronis-Tuscano, Melissa L Danielson, Susanna N Visser
OBJECTIVE: The objective of the study is to describe the extent to which students with ADHD received school-based intervention services and identify demographic, diagnostic, and impairment-related variables that are associated with service receipt in a large, nationally drawn sample. METHOD: Parent-reported data were obtained for 2,495 children with ADHD aged 4 to 17 years from the National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome (NS-DATA)...
December 10, 2018: Journal of Attention Disorders
https://read.qxmd.com/read/30454442/late-type-ia-endoleak-after-open-surgical-repair-of-an-aortic-aneurysm-leading-to-rupture-does-this-really-exist
#9
Nikolaos Kontopodis, Christos Chronis, George Papadopoulos, Nikolaos Daskalakis, Emmanouil Tavlas, Stella Lioudaki, Alexandra Papaioannou, Christos V Ioannou
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
https://read.qxmd.com/read/30401284/late-type-ia-endoleak-after-open-surgical-repair-of-an-aortic-aneurysm-leading-to-rupture-does-this-really-exist
#10
Nikolaos Kontopodis, Christos Chronis, George Papadopoulos, Nikolaos Daskalakis, Emmanouil Tavlas, Stella Lioudaki, Alexandra Papaioannou, Christos V Ioannou
No abstract text is available yet for this article.
April 1, 2018: American Surgeon
https://read.qxmd.com/read/30367942/amyloid-peptide-%C3%AE-42-enhances-the-oligomerization-and-neurotoxicity-of-apoe4-the-c-terminal-residues-leu279-lys282-and-gln284-modulate-the-structural-and-functional-properties-of-apoe4
#11
Ioannis Dafnis, Letta Argyri, Angeliki Chroni
Apolipoprotein E4 (apoE4), one of the three apoE isoforms, is the strongest factor for raising the risk for late-onset Alzheimer's disease (AD) and has been proposed to play a major role in AD pathogenesis. Amyloid-peptide β 42 (Aβ42) has also been proposed to affect neuronal degeneration and AD pathogenesis, possibly by interacting with apoE. Previous studies have shown that the functions of apoE forms can be dictated by their structural and biophysical properties. Here we show that apoE4 can form SDS-stable oligomers, possibly reflecting aggregated forms, which increase following incubation of apoE4 with Aβ42...
December 1, 2018: Neuroscience
https://read.qxmd.com/read/30366109/an-experimental-paradigm-examining-the-influence-of-frustration-on-risk-taking-behavior
#12
Jennifer M Loya, Katherine L McCauley, Andrea Chronis-Tuscano, Starr Z Chen, Abanoub Gad, Laura MacPherson, C W Lejuez
The present study examined the impact of frustration on risk-taking in college students with low and high ADHD symptomatology (L-ADHD and H-ADHD). Participants completed the Balloon Analogue Risk Task (BART) following induced frustration from a mood manipulation task (experimental session) and following no mood manipulation (control session). A manipulation check revealed a significant three-way interaction where the H-ADHD group reported higher frustration levels compared to the L-ADHD group, particularly in response to the frustration induction in the experimental condition...
October 23, 2018: Behavioural Processes
https://read.qxmd.com/read/30309894/thermodynamic-destabilization-and-aggregation-propensity-as-the-underlying-mechanism-behind-the-genetic-association-of-apoe3-mutants-and-lipoprotein-glomerulopathy
#13
Maria Katsarou, Efstratios Stratikos, Angeliki Chroni
Lipoprotein glomerulopathy (LPG) is a rare renal disease, characterized by lipoprotein thrombi in glomerular capillaries. A series of apolipoprotein E (apoE) mutations have been associated with LPG development. We previously showed that three mutants based on apoE3 sequence, in which an arginine was substituted by proline, are thermodynamically destabilized and aggregation-prone. To examine whether other LPG-associated apoE3 mutations induce similar effects, we characterized three non-proline LPG-associated apoE3 mutations, namely the R25C (apoEKyoto), R114C (apoETsukuba) and A152D (apoELasVegas)...
October 11, 2018: Journal of Lipid Research
https://read.qxmd.com/read/30246448/delirium-detection-by-a-novel-bispectral-electroencephalography-device-in-general-hospital
#14
Gen Shinozaki, Aubrey C Chan, Nicholas A Sparr, Kasra Zarei, Lindsey N Gaul, Jonathan T Heinzman, Julian Robles, Kumi Yuki, Theodosis J Chronis, Timothy Ando, Terrence Wong, Sayeh Sabbagh, Michelle T Weckmann, Sangil Lee, Thoru Yamada, Matthew D Karam, Nicolas O Noiseux, Eri Shinozaki, John W Cromwell
AIM: Delirium is common and dangerous among elderly inpatients; yet, it is underdiagnosed and thus undertreated. This study aimed to test the diagnostic characteristics of a noninvasive point-of-care device with two-channel (bispectral) electroencephalography (EEG) for the screening of delirium in the hospital. METHODS: Patients admitted to the University of Iowa Hospitals and Clinics were assessed for the presence of delirium with a clinical assessment, the Confusion Assessment Method for Intensive Care Unit and Delirium Rating Scale...
September 24, 2018: Psychiatry and Clinical Neurosciences
https://read.qxmd.com/read/30198579/study-of-the-involvement-of-phosphatidic-acid-formation-in-the-expression-of-wound-responsive-genes-in-cotton
#15
Angeliki Bourtsala, Ioannis Dafnis, Angeliki Chroni, Theodora Farmaki, Dia Galanopoulou
Plants use phospholipase D (PLD, EC 3.1.4.4)/phosphatidic acid (PtdOH) for the transduction of environmental signals including those coming from wounding. Based on our previous findings suggesting that wound-induced PLDα-derived PtdOH can act as a local signaling molecule in cotton (Gossypium hirsutum), we show that wounding immediately increases local NADPH oxidase (NADPHox) and cellulose synthase A (CeSA) gene expression. After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding...
September 10, 2018: Lipids
https://read.qxmd.com/read/30092430/spontaneous-type-ia-endoleak-sealing-in-patients-undergoing-endovascular-aneurysm-repair-with-the-ovation-stent-graft
#16
Nikolaos Kontopodis, Emmanouel Tavlas, Nikolaos Galanakis, Christos Chronis, Alexandros Kafetzakis, Dimitrios Tsetis, Christos V Ioannou
BACKGROUND: Type Ia endoleak may lead to continuous sac pressurization and late rupture after endovascular aneurysm repair (EVAR). Nevertheless, there have been scarce reports suggesting that these endoleaks may occasionally present spontaneous sealing. Taking into account the original sealing mechanism of the Ovation endograft that exploits 2 polymer-filled O-rings, we hypothesize that spontaneous type Ia endoleak sealing may sometimes incur following implantation of this device. We aim to report our experience with spontaneous type Ia endoleak sealing in patients treated with the Ovation endograft...
August 6, 2018: Annals of Vascular Surgery
https://read.qxmd.com/read/30008420/thank-you-a-journal-is-as-good-as-its-reviewers
#17
EDITORIAL
Umberto Arena, Morton Barlaz, Pinjing He, Ing I D'Adamo, Sergi Astals, Jean E Bogner, Stephanie C Bolyard, Jorge Manuel Caliço Lopes de Brito, Paolo S Calabrò, Paolo Canu, Christina Chroni, Bill Clarke, Hervé Corvellec, Giulia Costa, Malcolm Richard Gent, Antonio Gallardo Izquierdo, Jacek A Koziel, Nuno Lapa, Bo Leckner, Lidia Lombardi, Massimiliano Materazzi, Hans Oonk, Kostyantyn Pivnenko, Krishna R Reddy, Hans van der Sloot, Jan-Olov Sundqvist, Fabio Tatàno, Timothy Townsend, David Turner, Juergen Vehlow, Tianfeng Wang, Yongjiang Wang, Jim White, Yang Zeng, Christian Zurbrügg
No abstract text is available yet for this article.
July 2018: Waste Management
https://read.qxmd.com/read/29889314/infant-temperament-reactivity-and-early-maternal-caregiving-independent-and-interactive-links-to-later-childhood-attention-deficit-hyperactivity-disorder-symptoms
#18
Natalie V Miller, Kathryn A Degnan, Amie A Hane, Nathan A Fox, Andrea Chronis-Tuscano
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with origins early in life. There is growing evidence that individual differences in temperament reactivity are predictive of ADHD symptoms, yet little is known about the relations between temperament reactivity in early infancy and later ADHD symptoms or the combined effect of reactivity with early environmental factors on ADHD symptom development. Using a 9-year prospective longitudinal design, this study tested the independent and interactive contributions of infant reactivity and maternal caregiving behaviors (MCB) on parent- and teacher-reported childhood ADHD symptoms...
June 11, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/29886211/has-anatomic-complexity-of-abdominal-aortic-aneurysms-undergoing-open-surgical-repair-changed-after-the-introduction-of-endovascular-treatment-systematic-review-and-meta-analysis-of-comparative-studies
#19
REVIEW
Nikolaos Kontopodis, Emmanouil Tavlas, Efstratios Georgakarakos, Nikolaos Galanakis, Christos Chronis, Dimitrios Tsetis, Christos V Ioannou
BACKGROUND: At a time when endovascular aneurysm repair (EVAR) is increasingly used to treat abdominal aortic aneurysms (AAAs), lesions undergoing open surgical repair (OSR) may present significant differences compared with those treated before wide EVAR availability. We aim to record discrepancies in AAAs surgically treated before and after the introduction of EVAR. METHODS: We conducted a systematic review of the literature and meta-analysis of comparative studies...
October 2018: Annals of Vascular Surgery
https://read.qxmd.com/read/29808926/outcome-of-patients-with-myelofibrosis-relapsing-after-allogeneic-stem-cell-transplant-a-retrospective-study-by-the-chronic-malignancies-working-party-of-ebmt
#20
Donal P McLornan, Richard Szydlo, Marie Robin, Anja van Biezen, Linda Koster, Henrik J P Blok, Maria T Van Lint, Jürgen Finke, Antonin Vitek, Kristina Carlson, Laimonas Griskevicius, Ernst Holler, Maija Itälä-Remes, Michel Schaap, Gerard Socié, Jacques-Olivier Bay, Yves Beguin, Benedetto Bruno, Jan J Cornelissen, Tobias Gedde-Dahl, Per Ljungman, Marie T Rubio, Ibrahim Yakoub-Agha, Evgeny Klyuchnikov, Eduardo Olavarria, Yves Chalandon, Nicolaus Kröger
Allogeneic Haematopoietic Stem Cell Transplant (allo-HSCT) remains the only curative approach for Myelofibrosis (MF). Scarce information exists in the literature on the outcome and, indeed, management of those MF patients who relapse following transplant. We hereby report on the management and outcome of 202 patients who relapsed post allo-HSCT for MF.
May 29, 2018: British Journal of Haematology
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